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Protein

Phosphoribosyl pyrophosphate synthase-associated protein 2

Gene

Prpsap2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Nucleotide biosynthesis

Enzyme and pathway databases

SABIO-RKO08618.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosyl pyrophosphate synthase-associated protein 2
Short name:
PRPP synthase-associated protein 2
Alternative name(s):
41 kDa phosphoribosypyrophosphate synthetase-associated protein
Short name:
PAP41
Gene namesi
Name:Prpsap2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi620207. Prpsap2.

Subcellular locationi

GO - Cellular componenti

  • protein complex Source: RGD
  • ribose phosphate diphosphokinase complex Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369Phosphoribosyl pyrophosphate synthase-associated protein 2PRO_0000141084Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei219 – 2191PhosphoserineBy similarity
Modified residuei227 – 2271PhosphoserineCombined sources
Modified residuei233 – 2331PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiO08618.
PRIDEiO08618.

PTM databases

iPTMnetiO08618.
PhosphoSiteiO08618.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSRNOG00000002724.
ExpressionAtlasiO08618. baseline and differential.
GenevisibleiO08618. RN.

Interactioni

Subunit structurei

Binds to PRPS1 and PRPS2.

Protein-protein interaction databases

IntActiO08618. 1 interaction.
STRINGi10116.ENSRNOP00000003697.

Structurei

3D structure databases

ProteinModelPortaliO08618.
SMRiO08618. Positions 19-368.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1503. Eukaryota.
COG0462. LUCA.
GeneTreeiENSGT00550000074583.
HOGENOMiHOG000210451.
HOVERGENiHBG001520.
InParanoidiO08618.
OMAiMVYACRT.
OrthoDBiEOG091G0ZG8.
PhylomeDBiO08618.
TreeFamiTF106367.

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
Gene3Di3.40.50.2020. 3 hits.
InterProiIPR029099. Pribosyltran_N.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR005946. Rib-P_diPkinase.
[Graphical view]
PfamiPF14572. Pribosyl_synth. 1 hit.
PF13793. Pribosyltran_N. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 2 hits.
TIGRFAMsiTIGR01251. ribP_PPkin. 1 hit.

Sequencei

Sequence statusi: Complete.

O08618-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFCVAPPELE TKMNITKGGL VLFSANSNSS CMELSKKIAE RLGVEMGKVQ
60 70 80 90 100
VYQEPNRETR VQIQESVRGK DVFIIQTVSK DVNTTIMELL IMVYACKTSC
110 120 130 140 150
AKSIIGVIPY FPYSKQCKMR KRGSIVSKLL ASMMCKAGLT HLITMDLHQK
160 170 180 190 200
EIQGFFNIPV DNLRASPFLL QYIQEEIPDY RNAVIVAKSP ASAKRAQSFA
210 220 230 240 250
ERLRLGIAVI HGEAQDAESD LVDGRHSPPM VRSVAAIHPS LEIPMLIPKE
260 270 280 290 300
KPPITVVGDV GGRIAIIVDD IIDDVDSFLA AAETLKERGA YKIFVMATHG
310 320 330 340 350
LLSSDAPRLI EESAIDEVVV TNTIPHEIQK LQCPKIKTVD ISMILSEAIR
360
RIHNGESMSY LFRNIGLDD
Length:369
Mass (Da):40,867
Last modified:July 1, 1997 - v1
Checksum:iE7436F13F1D34F0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84434 mRNA. Translation: BAA19517.1.
RefSeqiNP_476472.1. NM_057131.1.
XP_006246496.1. XM_006246434.2.
XP_006246497.1. XM_006246435.2.
XP_006246498.1. XM_006246436.2.
XP_006246499.1. XM_006246437.2.
XP_006246500.1. XM_006246438.2.
UniGeneiRn.2681.

Genome annotation databases

EnsembliENSRNOT00000003697; ENSRNOP00000003697; ENSRNOG00000002724.
GeneIDi117272.
KEGGirno:117272.
UCSCiRGD:620207. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84434 mRNA. Translation: BAA19517.1.
RefSeqiNP_476472.1. NM_057131.1.
XP_006246496.1. XM_006246434.2.
XP_006246497.1. XM_006246435.2.
XP_006246498.1. XM_006246436.2.
XP_006246499.1. XM_006246437.2.
XP_006246500.1. XM_006246438.2.
UniGeneiRn.2681.

3D structure databases

ProteinModelPortaliO08618.
SMRiO08618. Positions 19-368.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO08618. 1 interaction.
STRINGi10116.ENSRNOP00000003697.

PTM databases

iPTMnetiO08618.
PhosphoSiteiO08618.

Proteomic databases

PaxDbiO08618.
PRIDEiO08618.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003697; ENSRNOP00000003697; ENSRNOG00000002724.
GeneIDi117272.
KEGGirno:117272.
UCSCiRGD:620207. rat.

Organism-specific databases

CTDi5636.
RGDi620207. Prpsap2.

Phylogenomic databases

eggNOGiKOG1503. Eukaryota.
COG0462. LUCA.
GeneTreeiENSGT00550000074583.
HOGENOMiHOG000210451.
HOVERGENiHBG001520.
InParanoidiO08618.
OMAiMVYACRT.
OrthoDBiEOG091G0ZG8.
PhylomeDBiO08618.
TreeFamiTF106367.

Enzyme and pathway databases

SABIO-RKO08618.

Miscellaneous databases

PROiO08618.

Gene expression databases

BgeeiENSRNOG00000002724.
ExpressionAtlasiO08618. baseline and differential.
GenevisibleiO08618. RN.

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
Gene3Di3.40.50.2020. 3 hits.
InterProiIPR029099. Pribosyltran_N.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR005946. Rib-P_diPkinase.
[Graphical view]
PfamiPF14572. Pribosyl_synth. 1 hit.
PF13793. Pribosyltran_N. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 2 hits.
TIGRFAMsiTIGR01251. ribP_PPkin. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKPRB_RAT
AccessioniPrimary (citable) accession number: O08618
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: July 1, 1997
Last modified: September 7, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.