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O08617 (PTPRR_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Receptor-type tyrosine-protein phosphatase R

Short name=R-PTP-R
EC=3.1.3.48
Alternative name(s):
PC12-PTP1
Protein-tyrosine phosphatase PCPTP1
Tyrosine phosphatase CBPTP
Gene names
Name:Ptprr
Synonyms:Ptp
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length656 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subunit structure

Interacts with MAPKs By similarity.

Subcellular location

Isoform 3: Cytoplasm By similarity.

Isoform 2: Cytoplasm By similarity.

Isoform 1: Cytoplasm By similarity.

Isoform 4: Cell membrane; Single-pass type I membrane protein By similarity.

Tissue specificity

Widely expressed in the brain, most abundant in cerebellum, midbrain, cerebral cortex and hippocampus. Also expressed in heart and skeletal muscle. Ref.1 Ref.2

Induction

By nerve growth factor; isoform 2 is induced in adrenal tumor cells 2 hours after exposure, levels are down-regulated 24 hours after treatment. Ref.2

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Receptor class 7 subfamily.

Contains 1 tyrosine-protein phosphatase domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

SrcQ9WUD92EBI-8584374,EBI-7784541

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 4 (identifier: O08617-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 1 (identifier: O08617-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-121: Missing.
Isoform 2 (identifier: O08617-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-244: Missing.
Isoform 3 (identifier: O08617-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-287: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 656633Receptor-type tyrosine-protein phosphatase R
PRO_0000025461

Regions

Topological domain25 – 225201Extracellular Potential
Transmembrane226 – 24823Helical; Potential
Topological domain249 – 656408Cytoplasmic Potential
Domain392 – 646255Tyrosine-protein phosphatase
Region587 – 5937Substrate binding By similarity

Sites

Active site5871Phosphocysteine intermediate By similarity
Binding site5531Substrate By similarity
Binding site6311Substrate By similarity

Amino acid modifications

Modified residue3381Phosphoserine; by PKA By similarity
Glycosylation1281N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence1 – 287287Missing in isoform 3.
VSP_005164
Alternative sequence1 – 244244Missing in isoform 2.
VSP_005163
Alternative sequence1 – 121121Missing in isoform 1.
VSP_005162

Experimental info

Sequence conflict2021S → I in BAA19530. Ref.1
Sequence conflict2581F → L Ref.1
Sequence conflict2581F → L Ref.2
Sequence conflict3791S → R Ref.1
Sequence conflict3791S → R Ref.2
Sequence conflict510 – 5112IY → TH in AAA64485. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 4 [UniParc].

Last modified November 15, 2002. Version 2.
Checksum: E929E5473B6A9DE9

FASTA65673,907
        10         20         30         40         50         60 
MRRAVGFPAL CLLLNLHAAG CFSRNNDHFL AIRQKKSWKP MFIYDHSQDI KKSLDIAQEA 

        70         80         90        100        110        120 
YKHNYPAPSE VQISKRHQIV DSAFPRPAYD PSLNLLAASG QDLEIENLPI PAANVIVVTL 

       130        140        150        160        170        180 
QMDIDKLNIT LLRIFRQGVA AALGLLPQQV HINRLIEKKS QIELFVSPGN RKPGEPQALQ 

       190        200        210        220        230        240 
AEEVLRSLNV DVLRQSLPQF GSIDVSPEKN VLQGQHEADK IWSKEGFYAV VIFLSIFIII 

       250        260        270        280        290        300 
VTCLMIIYRL KERLQLSFRQ DKEKNQEIHL SPIALQQAQS EAKAAHSMVQ PDQAPKVLNV 

       310        320        330        340        350        360 
VVDPQGQCTP EIRNTASTSV CPSPFRMKPI GLQERRGSNV SLTLDMSSLG NVEPFVAVST 

       370        380        390        400        410        420 
PREKVAMEYL QSASRVLTSP QLRDVVASSH LLQSEFMEIP MNFVDPKEID IPRHGTKNRY 

       430        440        450        460        470        480 
KTILPNPLSR VCLRPKNITD PLSTYINANY IRGYSGKEKA FIATQGPMIN TVNDFWQMVW 

       490        500        510        520        530        540 
QEDSPVIVMI TKLKEKNEKC VLYWPEKRGI YGKVEVLVIG VNECDNYTIR NLVLKRGSHT 

       550        560        570        580        590        600 
QHVKHYWYTS WPDHKTPDSA QPLLQLMLDV EEDRLASEGR GPVVVHCSAG IGRTGCFIAT 

       610        620        630        640        650 
SIGCQQLKEE GVVDALSIVC QLRVDRGGMV QTSEQYEFVH HALCLFESRL SPETVQ 

« Hide

Isoform 1 [UniParc].

Checksum: 7412831F3C61670F
Show »

FASTA53560,317
Isoform 2 [UniParc].

Checksum: 0AFCF5266F96680D
Show »

FASTA41246,530
Isoform 3 [UniParc].

Checksum: EE02807E41EC871A
Show »

FASTA36941,500

References

[1]"Cloning and expression of PCPTP1 encoding protein tyrosine phosphatase."
Shiozuka K., Watanabe Y., Ikeda T., Hashimoto S., Kawashima H.
Gene 162:279-284(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3 AND 4), TISSUE SPECIFICITY.
Strain: Wistar.
Tissue: Cerebellum.
[2]"A neuronal protein tyrosine phosphatase induced by nerve growth factor."
Sharma E., Lombroso P.J.
J. Biol. Chem. 270:49-53(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INDUCTION, TISSUE SPECIFICITY.
Tissue: Adrenal tumor.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D64050 mRNA. Translation: BAA19530.1.
D38292 mRNA. Translation: BAA07414.1.
U14914 mRNA. Translation: AAA64485.1.
PIRJC4263.
RefSeqNP_001106861.1. NM_001113390.1.
NP_446046.2. NM_053594.2.
UniGeneRn.6277.

3D structure databases

ProteinModelPortalO08617.
SMRO08617. Positions 360-655.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid250182. 1 interaction.
IntActO08617. 1 interaction.
MINTMINT-4581737.

Proteomic databases

PRIDEO08617.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID94202.
KEGGrno:94202.
UCSCRGD:620780. rat. [O08617-1]

Organism-specific databases

CTD5801.
RGD620780. Ptprr.

Phylogenomic databases

eggNOGCOG5599.
HOGENOMHOG000294188.
HOVERGENHBG001594.
InParanoidO08617.
KOK04458.
PhylomeDBO08617.

Gene expression databases

GenevestigatorO08617.

Family and domain databases

InterProIPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR008356. Tyr_Pase_KIM-con.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
IPR016334. Tyr_Pase_rcpt_R/non-rcpt_5.
[Graphical view]
PfamPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFPIRSF001997. PTPRR. 1 hit.
PRINTSPR01778. KIMPTPASE.
PR00700. PRTYPHPHTASE.
SMARTSM00194. PTPc. 1 hit.
[Graphical view]
PROSITEPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio617875.
PROO08617.

Entry information

Entry namePTPRR_RAT
AccessionPrimary (citable) accession number: O08617
Secondary accession number(s): Q62695, Q63419
Entry history
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 15, 2002
Last modified: April 16, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families