Receptor-type tyrosine-protein phosphatase R precursor

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O08617 (PTPRR_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 105. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Receptor-type tyrosine-protein phosphatase R
Short name=R-PTP-R
EC=3.1.3.48

Alternative name(s):
PC12-PTP1
Protein-tyrosine phosphatase PCPTP1
Tyrosine phosphatase CBPTP

Gene names

Name:	Ptprr
Synonyms:	Ptp

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	656 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus By similarity.
Catalytic activity	Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate.
Subunit structure	Interacts with MAPKs By similarity.
Subcellular location	Isoform 3: Cytoplasm By similarity. Isoform 2: Cytoplasm By similarity. Isoform 1: Cytoplasm By similarity. Isoform 4: Cell membrane; Single-pass type I membrane protein By similarity.
Tissue specificity	Widely expressed in the brain, most abundant in cerebellum, midbrain, cerebral cortex and hippocampus. Also expressed in heart and skeletal muscle. Ref.1 Ref.2
Induction	By nerve growth factor; isoform 2 is induced in adrenal tumor cells 2 hours after exposure, levels are down-regulated 24 hours after treatment. Ref.2
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Receptor class 7 subfamily. Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
Cellular component	Cell membrane Cytoplasm Membrane
Coding sequence diversity	Alternative splicing
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Hydrolase Protein phosphatase Receptor
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	in utero embryonic development Inferred from sequence or structural similarity. Source: UniProtKB neuron differentiation Inferred from expression pattern Ref.2. Source: RGD
Cellular_component	cell surface Inferred from sequence or structural similarity. Source: UniProtKB cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	protein tyrosine phosphatase activity Traceable author statement Ref.2. Source: RGD
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 4 (identifier: O08617-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1 (identifier: O08617-2) The sequence of this isoform differs from the canonical sequence as follows: 1-121: Missing.

Isoform 2 (identifier: O08617-3) The sequence of this isoform differs from the canonical sequence as follows: 1-244: Missing.

Isoform 3 (identifier: O08617-4) The sequence of this isoform differs from the canonical sequence as follows: 1-287: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 23

Potential

Chain

24 – 656

633

Receptor-type tyrosine-protein phosphatase R

PRO_0000025461

Regions

Topological domain

25 – 225

201

Extracellular Potential

Transmembrane

226 – 248

Helical; Potential

Topological domain

249 – 656

408

Cytoplasmic Potential

Domain

392 – 646

255

Tyrosine-protein phosphatase

Region

587 – 593

Substrate binding By similarity

Sites

Active site

587

Phosphocysteine intermediate By similarity

Binding site

553

Substrate By similarity

Binding site

631

Substrate By similarity

Amino acid modifications

Modified residue

338

Phosphoserine; by PKA By similarity

Glycosylation

128

N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence

1 – 287

287

Missing in isoform 3.

VSP_005164

Alternative sequence

1 – 244

244

Missing in isoform 2.

VSP_005163

Alternative sequence

1 – 121

121

Missing in isoform 1.

VSP_005162

Experimental info

Sequence conflict

202

S → I in BAA19530. Ref.1

Sequence conflict

258

F → L Ref.1

Sequence conflict

258

F → L Ref.2

Sequence conflict

379

S → R Ref.1

Sequence conflict

379

S → R Ref.2

Sequence conflict

510 – 511

IY → TH in AAA64485. Ref.2

Sequences

Sequence		Length	Mass (Da)
Isoform 4 [UniParc]. Last modified November 15, 2002. Version 2. Checksum: E929E5473B6A9DE9 Show »	FASTA	656	73,907
10 20 30 40 50 60 MRRAVGFPAL CLLLNLHAAG CFSRNNDHFL AIRQKKSWKP MFIYDHSQDI KKSLDIAQEA 70 80 90 100 110 120 YKHNYPAPSE VQISKRHQIV DSAFPRPAYD PSLNLLAASG QDLEIENLPI PAANVIVVTL 130 140 150 160 170 180 QMDIDKLNIT LLRIFRQGVA AALGLLPQQV HINRLIEKKS QIELFVSPGN RKPGEPQALQ 190 200 210 220 230 240 AEEVLRSLNV DVLRQSLPQF GSIDVSPEKN VLQGQHEADK IWSKEGFYAV VIFLSIFIII 250 260 270 280 290 300 VTCLMIIYRL KERLQLSFRQ DKEKNQEIHL SPIALQQAQS EAKAAHSMVQ PDQAPKVLNV 310 320 330 340 350 360 VVDPQGQCTP EIRNTASTSV CPSPFRMKPI GLQERRGSNV SLTLDMSSLG NVEPFVAVST 370 380 390 400 410 420 PREKVAMEYL QSASRVLTSP QLRDVVASSH LLQSEFMEIP MNFVDPKEID IPRHGTKNRY 430 440 450 460 470 480 KTILPNPLSR VCLRPKNITD PLSTYINANY IRGYSGKEKA FIATQGPMIN TVNDFWQMVW 490 500 510 520 530 540 QEDSPVIVMI TKLKEKNEKC VLYWPEKRGI YGKVEVLVIG VNECDNYTIR NLVLKRGSHT 550 560 570 580 590 600 QHVKHYWYTS WPDHKTPDSA QPLLQLMLDV EEDRLASEGR GPVVVHCSAG IGRTGCFIAT 610 620 630 640 650 SIGCQQLKEE GVVDALSIVC QLRVDRGGMV QTSEQYEFVH HALCLFESRL SPETVQ « Hide
Isoform 1 [UniParc]. Checksum: 7412831F3C61670F Show »	FASTA	535	60,317
10 20 30 40 50 60 MDIDKLNITL LRIFRQGVAA ALGLLPQQVH INRLIEKKSQ IELFVSPGNR KPGEPQALQA 70 80 90 100 110 120 EEVLRSLNVD VLRQSLPQFG SIDVSPEKNV LQGQHEADKI WSKEGFYAVV IFLSIFIIIV 130 140 150 160 170 180 TCLMIIYRLK ERLQLSFRQD KEKNQEIHLS PIALQQAQSE AKAAHSMVQP DQAPKVLNVV 190 200 210 220 230 240 VDPQGQCTPE IRNTASTSVC PSPFRMKPIG LQERRGSNVS LTLDMSSLGN VEPFVAVSTP 250 260 270 280 290 300 REKVAMEYLQ SASRVLTSPQ LRDVVASSHL LQSEFMEIPM NFVDPKEIDI PRHGTKNRYK 310 320 330 340 350 360 TILPNPLSRV CLRPKNITDP LSTYINANYI RGYSGKEKAF IATQGPMINT VNDFWQMVWQ 370 380 390 400 410 420 EDSPVIVMIT KLKEKNEKCV LYWPEKRGIY GKVEVLVIGV NECDNYTIRN LVLKRGSHTQ 430 440 450 460 470 480 HVKHYWYTSW PDHKTPDSAQ PLLQLMLDVE EDRLASEGRG PVVVHCSAGI GRTGCFIATS 490 500 510 520 530 IGCQQLKEEG VVDALSIVCQ LRVDRGGMVQ TSEQYEFVHH ALCLFESRLS PETVQ « Hide
Isoform 2 [UniParc]. Checksum: 0AFCF5266F96680D Show »	FASTA	412	46,530
10 20 30 40 50 60 MIIYRLKERL QLSFRQDKEK NQEIHLSPIA LQQAQSEAKA AHSMVQPDQA PKVLNVVVDP 70 80 90 100 110 120 QGQCTPEIRN TASTSVCPSP FRMKPIGLQE RRGSNVSLTL DMSSLGNVEP FVAVSTPREK 130 140 150 160 170 180 VAMEYLQSAS RVLTSPQLRD VVASSHLLQS EFMEIPMNFV DPKEIDIPRH GTKNRYKTIL 190 200 210 220 230 240 PNPLSRVCLR PKNITDPLST YINANYIRGY SGKEKAFIAT QGPMINTVND FWQMVWQEDS 250 260 270 280 290 300 PVIVMITKLK EKNEKCVLYW PEKRGIYGKV EVLVIGVNEC DNYTIRNLVL KRGSHTQHVK 310 320 330 340 350 360 HYWYTSWPDH KTPDSAQPLL QLMLDVEEDR LASEGRGPVV VHCSAGIGRT GCFIATSIGC 370 380 390 400 410 QQLKEEGVVD ALSIVCQLRV DRGGMVQTSE QYEFVHHALC LFESRLSPET VQ « Hide
Isoform 3 [UniParc]. Checksum: EE02807E41EC871A Show »	FASTA	369	41,500
10 20 30 40 50 60 MVQPDQAPKV LNVVVDPQGQ CTPEIRNTAS TSVCPSPFRM KPIGLQERRG SNVSLTLDMS 70 80 90 100 110 120 SLGNVEPFVA VSTPREKVAM EYLQSASRVL TSPQLRDVVA SSHLLQSEFM EIPMNFVDPK 130 140 150 160 170 180 EIDIPRHGTK NRYKTILPNP LSRVCLRPKN ITDPLSTYIN ANYIRGYSGK EKAFIATQGP 190 200 210 220 230 240 MINTVNDFWQ MVWQEDSPVI VMITKLKEKN EKCVLYWPEK RGIYGKVEVL VIGVNECDNY 250 260 270 280 290 300 TIRNLVLKRG SHTQHVKHYW YTSWPDHKTP DSAQPLLQLM LDVEEDRLAS EGRGPVVVHC 310 320 330 340 350 360 SAGIGRTGCF IATSIGCQQL KEEGVVDALS IVCQLRVDRG GMVQTSEQYE FVHHALCLFE SRLSPETVQ « Hide

References

[1]	"Cloning and expression of PCPTP1 encoding protein tyrosine phosphatase." Shiozuka K., Watanabe Y., Ikeda T., Hashimoto S., Kawashima H. Gene 162:279-284(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3 AND 4), TISSUE SPECIFICITY. Strain: Wistar. Tissue: Cerebellum.
[2]	"A neuronal protein tyrosine phosphatase induced by nerve growth factor." Sharma E., Lombroso P.J. J. Biol. Chem. 270:49-53(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INDUCTION, TISSUE SPECIFICITY. Tissue: Adrenal tumor.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D64050 mRNA. Translation: BAA19530.1. D38292 mRNA. Translation: BAA07414.1. U14914 mRNA. Translation: AAA64485.1.
IPI	IPI00231431. IPI00231432. IPI00231433. IPI00231646.
PIR	JC4263.
RefSeq	NP_001106861.1. NM_001113390.1. NP_446046.2. NM_053594.2.
UniGene	Rn.6277.
3D structure databases
ProteinModelPortal	O08617.
SMR	O08617. Positions 360-655.
ModBase	Search...
Proteomic databases
PRIDE	O08617.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	94202.
KEGG	rno:94202.
UCSC	RGD:620780. rat.
Organism-specific databases
CTD	5801.
RGD	620780. Ptprr.
Phylogenomic databases
eggNOG	COG5599.
HOGENOM	HOG000294188.
HOVERGEN	HBG001594.
InParanoid	O08617.
KO	K04458.
OrthoDB	EOG4B8JD5.
Gene expression databases
ArrayExpress	O08617.
Genevestigator	O08617.
Family and domain databases
InterPro	IPR000387. Tyr/Dual-sp_Pase. IPR016130. Tyr_Pase_AS. IPR008356. Tyr_Pase_KIM-con. IPR000242. Tyr_Pase_rcpt/non-rcpt. IPR016334. Tyr_Pase_rcpt_R/non-rcpt_5. [Graphical view]
Pfam	PF00102. Y_phosphatase. 1 hit. [Graphical view]
PIRSF	PIRSF001997. PTPRR. 1 hit.
PRINTS	PR01778. KIMPTPASE. PR00700. PRTYPHPHTASE.
SMART	SM00194. PTPc. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50055. TYR_PHOSPHATASE_PTP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	617875.

Entry information

Entry name

PTPRR_RAT

Accession

Primary (citable) accession number: O08617
Secondary accession number(s): Q62695, Q63419

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	November 15, 2002
Last modified:	April 3, 2013
This is version 105 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents