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O08617

- PTPRR_RAT

UniProt

O08617 - PTPRR_RAT

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Protein
Receptor-type tyrosine-protein phosphatase R
Gene
Ptprr, Ptp
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus By similarity.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei553 – 5531Substrate By similarity
Active sitei587 – 5871Phosphocysteine intermediate By similarity
Binding sitei631 – 6311Substrate By similarity

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. protein tyrosine phosphatase activity Source: RGD
Complete GO annotation...

GO - Biological processi

  1. in utero embryonic development Source: UniProtKB
  2. nervous system development Source: RGD
  3. neuron differentiation Source: RGD
  4. peptidyl-tyrosine dephosphorylation Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase, Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase R (EC:3.1.3.48)
Short name:
R-PTP-R
Alternative name(s):
PC12-PTP1
Protein-tyrosine phosphatase PCPTP1
Tyrosine phosphatase CBPTP
Gene namesi
Name:Ptprr
Synonyms:Ptp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi620780. Ptprr.

Subcellular locationi

Isoform 3 : Cytoplasm By similarity
Isoform 2 : Cytoplasm By similarity
Isoform 1 : Cytoplasm By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 225201Extracellular Reviewed prediction
Add
BLAST
Transmembranei226 – 24823Helical; Reviewed prediction
Add
BLAST
Topological domaini249 – 656408Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 656633Receptor-type tyrosine-protein phosphatase R
PRO_0000025461Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi128 – 1281N-linked (GlcNAc...) Reviewed prediction
Modified residuei338 – 3381Phosphoserine; by PKA By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiO08617.

Expressioni

Tissue specificityi

Widely expressed in the brain, most abundant in cerebellum, midbrain, cerebral cortex and hippocampus. Also expressed in heart and skeletal muscle.2 Publications

Inductioni

By nerve growth factor; isoform 2 is induced in adrenal tumor cells 2 hours after exposure, levels are down-regulated 24 hours after treatment.1 Publication

Gene expression databases

GenevestigatoriO08617.

Interactioni

Subunit structurei

Interacts with MAPKs By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
SrcQ9WUD92EBI-8584374,EBI-7784541

Protein-protein interaction databases

BioGridi250182. 1 interaction.
IntActiO08617. 1 interaction.
MINTiMINT-4581737.

Structurei

3D structure databases

ProteinModelPortaliO08617.
SMRiO08617. Positions 360-655.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini392 – 646255Tyrosine-protein phosphatase
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni587 – 5937Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5599.
HOGENOMiHOG000294188.
HOVERGENiHBG001594.
InParanoidiO08617.
KOiK04458.
PhylomeDBiO08617.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR008356. Tyr_Pase_KIM-con.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
IPR016334. Tyr_Pase_rcpt_R/non-rcpt_5.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFiPIRSF001997. PTPRR. 1 hit.
PRINTSiPR01778. KIMPTPASE.
PR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 4 (identifier: O08617-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MRRAVGFPAL CLLLNLHAAG CFSRNNDHFL AIRQKKSWKP MFIYDHSQDI    50
KKSLDIAQEA YKHNYPAPSE VQISKRHQIV DSAFPRPAYD PSLNLLAASG 100
QDLEIENLPI PAANVIVVTL QMDIDKLNIT LLRIFRQGVA AALGLLPQQV 150
HINRLIEKKS QIELFVSPGN RKPGEPQALQ AEEVLRSLNV DVLRQSLPQF 200
GSIDVSPEKN VLQGQHEADK IWSKEGFYAV VIFLSIFIII VTCLMIIYRL 250
KERLQLSFRQ DKEKNQEIHL SPIALQQAQS EAKAAHSMVQ PDQAPKVLNV 300
VVDPQGQCTP EIRNTASTSV CPSPFRMKPI GLQERRGSNV SLTLDMSSLG 350
NVEPFVAVST PREKVAMEYL QSASRVLTSP QLRDVVASSH LLQSEFMEIP 400
MNFVDPKEID IPRHGTKNRY KTILPNPLSR VCLRPKNITD PLSTYINANY 450
IRGYSGKEKA FIATQGPMIN TVNDFWQMVW QEDSPVIVMI TKLKEKNEKC 500
VLYWPEKRGI YGKVEVLVIG VNECDNYTIR NLVLKRGSHT QHVKHYWYTS 550
WPDHKTPDSA QPLLQLMLDV EEDRLASEGR GPVVVHCSAG IGRTGCFIAT 600
SIGCQQLKEE GVVDALSIVC QLRVDRGGMV QTSEQYEFVH HALCLFESRL 650
SPETVQ 656
Length:656
Mass (Da):73,907
Last modified:November 15, 2002 - v2
Checksum:iE929E5473B6A9DE9
GO
Isoform 1 (identifier: O08617-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-121: Missing.

Show »
Length:535
Mass (Da):60,317
Checksum:i7412831F3C61670F
GO
Isoform 2 (identifier: O08617-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-244: Missing.

Show »
Length:412
Mass (Da):46,530
Checksum:i0AFCF5266F96680D
GO
Isoform 3 (identifier: O08617-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-287: Missing.

Show »
Length:369
Mass (Da):41,500
Checksum:iEE02807E41EC871A
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 287287Missing in isoform 3.
VSP_005164Add
BLAST
Alternative sequencei1 – 244244Missing in isoform 2.
VSP_005163Add
BLAST
Alternative sequencei1 – 121121Missing in isoform 1.
VSP_005162Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti202 – 2021S → I in BAA19530. 1 Publication
Sequence conflicti258 – 2581F → L1 Publication
Sequence conflicti258 – 2581F → L1 Publication
Sequence conflicti379 – 3791S → R1 Publication
Sequence conflicti379 – 3791S → R1 Publication
Sequence conflicti510 – 5112IY → TH in AAA64485. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D64050 mRNA. Translation: BAA19530.1.
D38292 mRNA. Translation: BAA07414.1.
U14914 mRNA. Translation: AAA64485.1.
PIRiJC4263.
RefSeqiNP_001106861.1. NM_001113390.1.
NP_446046.2. NM_053594.2.
UniGeneiRn.6277.

Genome annotation databases

GeneIDi94202.
KEGGirno:94202.
UCSCiRGD:620780. rat. [O08617-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D64050 mRNA. Translation: BAA19530.1 .
D38292 mRNA. Translation: BAA07414.1 .
U14914 mRNA. Translation: AAA64485.1 .
PIRi JC4263.
RefSeqi NP_001106861.1. NM_001113390.1.
NP_446046.2. NM_053594.2.
UniGenei Rn.6277.

3D structure databases

ProteinModelPortali O08617.
SMRi O08617. Positions 360-655.
ModBasei Search...

Protein-protein interaction databases

BioGridi 250182. 1 interaction.
IntActi O08617. 1 interaction.
MINTi MINT-4581737.

Proteomic databases

PRIDEi O08617.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 94202.
KEGGi rno:94202.
UCSCi RGD:620780. rat. [O08617-1 ]

Organism-specific databases

CTDi 5801.
RGDi 620780. Ptprr.

Phylogenomic databases

eggNOGi COG5599.
HOGENOMi HOG000294188.
HOVERGENi HBG001594.
InParanoidi O08617.
KOi K04458.
PhylomeDBi O08617.

Miscellaneous databases

NextBioi 617875.
PROi O08617.

Gene expression databases

Genevestigatori O08617.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR008356. Tyr_Pase_KIM-con.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
IPR016334. Tyr_Pase_rcpt_R/non-rcpt_5.
[Graphical view ]
Pfami PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001997. PTPRR. 1 hit.
PRINTSi PR01778. KIMPTPASE.
PR00700. PRTYPHPHTASE.
SMARTi SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and expression of PCPTP1 encoding protein tyrosine phosphatase."
    Shiozuka K., Watanabe Y., Ikeda T., Hashimoto S., Kawashima H.
    Gene 162:279-284(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3 AND 4), TISSUE SPECIFICITY.
    Strain: Wistar.
    Tissue: Cerebellum.
  2. "A neuronal protein tyrosine phosphatase induced by nerve growth factor."
    Sharma E., Lombroso P.J.
    J. Biol. Chem. 270:49-53(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INDUCTION, TISSUE SPECIFICITY.
    Tissue: Adrenal tumor.

Entry informationi

Entry nameiPTPRR_RAT
AccessioniPrimary (citable) accession number: O08617
Secondary accession number(s): Q62695, Q63419
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 15, 2002
Last modified: June 11, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi