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O08617

- PTPRR_RAT

UniProt

O08617 - PTPRR_RAT

Protein

Receptor-type tyrosine-protein phosphatase R

Gene

Ptprr

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 2 (15 Nov 2002)
      Previous versions | rss
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    Functioni

    Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus By similarity.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei553 – 5531SubstrateBy similarity
    Active sitei587 – 5871Phosphocysteine intermediatePROSITE-ProRule annotation
    Binding sitei631 – 6311SubstrateBy similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. protein tyrosine phosphatase activity Source: RGD

    GO - Biological processi

    1. in utero embryonic development Source: UniProtKB
    2. nervous system development Source: RGD
    3. neuron differentiation Source: RGD
    4. peptidyl-tyrosine dephosphorylation Source: GOC

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase, Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Receptor-type tyrosine-protein phosphatase R (EC:3.1.3.48)
    Short name:
    R-PTP-R
    Alternative name(s):
    PC12-PTP1
    Protein-tyrosine phosphatase PCPTP1
    Tyrosine phosphatase CBPTP
    Gene namesi
    Name:Ptprr
    Synonyms:Ptp
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi620780. Ptprr.

    Subcellular locationi

    Isoform 3 : Cytoplasm By similarity
    Isoform 2 : Cytoplasm By similarity
    Isoform 1 : Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 656633Receptor-type tyrosine-protein phosphatase RPRO_0000025461Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi128 – 1281N-linked (GlcNAc...)Sequence Analysis
    Modified residuei338 – 3381Phosphoserine; by PKABy similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PRIDEiO08617.

    Expressioni

    Tissue specificityi

    Widely expressed in the brain, most abundant in cerebellum, midbrain, cerebral cortex and hippocampus. Also expressed in heart and skeletal muscle.2 Publications

    Inductioni

    By nerve growth factor; isoform 2 is induced in adrenal tumor cells 2 hours after exposure, levels are down-regulated 24 hours after treatment.1 Publication

    Gene expression databases

    GenevestigatoriO08617.

    Interactioni

    Subunit structurei

    Interacts with MAPKs.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SrcQ9WUD92EBI-8584374,EBI-7784541

    Protein-protein interaction databases

    BioGridi250182. 1 interaction.
    IntActiO08617. 1 interaction.
    MINTiMINT-4581737.

    Structurei

    3D structure databases

    ProteinModelPortaliO08617.
    SMRiO08617. Positions 360-655.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 225201ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini249 – 656408CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei226 – 24823HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini392 – 646255Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni587 – 5937Substrate bindingBy similarity

    Sequence similaritiesi

    Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5599.
    HOGENOMiHOG000294188.
    HOVERGENiHBG001594.
    InParanoidiO08617.
    KOiK04458.
    PhylomeDBiO08617.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR008356. Tyr_Pase_KIM-con.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    IPR016334. Tyr_Pase_rcpt_R/non-rcpt_5.
    [Graphical view]
    PfamiPF00102. Y_phosphatase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001997. PTPRR. 1 hit.
    PRINTSiPR01778. KIMPTPASE.
    PR00700. PRTYPHPHTASE.
    SMARTiSM00194. PTPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 4 (identifier: O08617-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRRAVGFPAL CLLLNLHAAG CFSRNNDHFL AIRQKKSWKP MFIYDHSQDI    50
    KKSLDIAQEA YKHNYPAPSE VQISKRHQIV DSAFPRPAYD PSLNLLAASG 100
    QDLEIENLPI PAANVIVVTL QMDIDKLNIT LLRIFRQGVA AALGLLPQQV 150
    HINRLIEKKS QIELFVSPGN RKPGEPQALQ AEEVLRSLNV DVLRQSLPQF 200
    GSIDVSPEKN VLQGQHEADK IWSKEGFYAV VIFLSIFIII VTCLMIIYRL 250
    KERLQLSFRQ DKEKNQEIHL SPIALQQAQS EAKAAHSMVQ PDQAPKVLNV 300
    VVDPQGQCTP EIRNTASTSV CPSPFRMKPI GLQERRGSNV SLTLDMSSLG 350
    NVEPFVAVST PREKVAMEYL QSASRVLTSP QLRDVVASSH LLQSEFMEIP 400
    MNFVDPKEID IPRHGTKNRY KTILPNPLSR VCLRPKNITD PLSTYINANY 450
    IRGYSGKEKA FIATQGPMIN TVNDFWQMVW QEDSPVIVMI TKLKEKNEKC 500
    VLYWPEKRGI YGKVEVLVIG VNECDNYTIR NLVLKRGSHT QHVKHYWYTS 550
    WPDHKTPDSA QPLLQLMLDV EEDRLASEGR GPVVVHCSAG IGRTGCFIAT 600
    SIGCQQLKEE GVVDALSIVC QLRVDRGGMV QTSEQYEFVH HALCLFESRL 650
    SPETVQ 656
    Length:656
    Mass (Da):73,907
    Last modified:November 15, 2002 - v2
    Checksum:iE929E5473B6A9DE9
    GO
    Isoform 1 (identifier: O08617-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-121: Missing.

    Show »
    Length:535
    Mass (Da):60,317
    Checksum:i7412831F3C61670F
    GO
    Isoform 2 (identifier: O08617-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-244: Missing.

    Show »
    Length:412
    Mass (Da):46,530
    Checksum:i0AFCF5266F96680D
    GO
    Isoform 3 (identifier: O08617-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-287: Missing.

    Show »
    Length:369
    Mass (Da):41,500
    Checksum:iEE02807E41EC871A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti202 – 2021S → I in BAA19530. (PubMed:7557444)Curated
    Sequence conflicti258 – 2581F → L(PubMed:7557444)Curated
    Sequence conflicti258 – 2581F → L(PubMed:7814416)Curated
    Sequence conflicti379 – 3791S → R(PubMed:7557444)Curated
    Sequence conflicti379 – 3791S → R(PubMed:7814416)Curated
    Sequence conflicti510 – 5112IY → TH in AAA64485. (PubMed:7814416)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 287287Missing in isoform 3. 1 PublicationVSP_005164Add
    BLAST
    Alternative sequencei1 – 244244Missing in isoform 2. 1 PublicationVSP_005163Add
    BLAST
    Alternative sequencei1 – 121121Missing in isoform 1. 1 PublicationVSP_005162Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D64050 mRNA. Translation: BAA19530.1.
    D38292 mRNA. Translation: BAA07414.1.
    U14914 mRNA. Translation: AAA64485.1.
    PIRiJC4263.
    RefSeqiNP_001106861.1. NM_001113390.1.
    NP_446046.2. NM_053594.2.
    UniGeneiRn.6277.

    Genome annotation databases

    GeneIDi94202.
    KEGGirno:94202.
    UCSCiRGD:620780. rat. [O08617-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D64050 mRNA. Translation: BAA19530.1 .
    D38292 mRNA. Translation: BAA07414.1 .
    U14914 mRNA. Translation: AAA64485.1 .
    PIRi JC4263.
    RefSeqi NP_001106861.1. NM_001113390.1.
    NP_446046.2. NM_053594.2.
    UniGenei Rn.6277.

    3D structure databases

    ProteinModelPortali O08617.
    SMRi O08617. Positions 360-655.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 250182. 1 interaction.
    IntActi O08617. 1 interaction.
    MINTi MINT-4581737.

    Proteomic databases

    PRIDEi O08617.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 94202.
    KEGGi rno:94202.
    UCSCi RGD:620780. rat. [O08617-1 ]

    Organism-specific databases

    CTDi 5801.
    RGDi 620780. Ptprr.

    Phylogenomic databases

    eggNOGi COG5599.
    HOGENOMi HOG000294188.
    HOVERGENi HBG001594.
    InParanoidi O08617.
    KOi K04458.
    PhylomeDBi O08617.

    Miscellaneous databases

    NextBioi 617875.
    PROi O08617.

    Gene expression databases

    Genevestigatori O08617.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR008356. Tyr_Pase_KIM-con.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    IPR016334. Tyr_Pase_rcpt_R/non-rcpt_5.
    [Graphical view ]
    Pfami PF00102. Y_phosphatase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001997. PTPRR. 1 hit.
    PRINTSi PR01778. KIMPTPASE.
    PR00700. PRTYPHPHTASE.
    SMARTi SM00194. PTPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of PCPTP1 encoding protein tyrosine phosphatase."
      Shiozuka K., Watanabe Y., Ikeda T., Hashimoto S., Kawashima H.
      Gene 162:279-284(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3 AND 4), TISSUE SPECIFICITY.
      Strain: Wistar.
      Tissue: Cerebellum.
    2. "A neuronal protein tyrosine phosphatase induced by nerve growth factor."
      Sharma E., Lombroso P.J.
      J. Biol. Chem. 270:49-53(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INDUCTION, TISSUE SPECIFICITY.
      Tissue: Adrenal tumor.

    Entry informationi

    Entry nameiPTPRR_RAT
    AccessioniPrimary (citable) accession number: O08617
    Secondary accession number(s): Q62695, Q63419
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 15, 2002
    Last sequence update: November 15, 2002
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3