Reviewed, UniProtKB/Swiss-Prot O08615 (OXLA_MUSSP)

Names and origin

Protein names

Recommended name:
    L-amino-acid oxidase
      Short name=LAAO
      Short name=LAO
    EC=1.4.3.2
Alternative name(s):
    Interleukin-4-induced protein 1
      Short name=IL4-induced protein 1
    Protein Fig-1

Gene names

Name:	Il4i1
Synonyms:	Fig1

Organism

Mus spretus (Western wild mouse)

Taxonomic identifier

10096 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	46 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in lysosomal antigen processing and presentation By similarity.
Catalytic activity	An L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2.
Cofactor	FAD By similarity.
Subcellular location	Lysosome By similarity.
Induction	By interleukin-4. Ref.1
Sequence similarities	Belongs to the flavin monoamine oxidase family. FIG1 subfamily.

Ontologies

Keywords
Cellular component	Lysosome
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	lysosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	L-amino-acid oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›46	›46	L-amino-acid oxidase		PRO_0000099873
Amino acid modifications
	Glycosylation	31	1	N-linked (GlcNAc...) Potential
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	46	1

Sequences

	Sequence		Length	Mass (Da)
	O08615-1 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: 483CBE1F75610164	FASTA	46	5,165
	10 20 30 40 AFKDLKALGC KKAMNKFNKH TLLEYLLEEG NLSRPAVQLL GDVMSE

References

[1]	"Fig1, an interleukin 4-induced mouse B cell gene isolated by cDNA representational difference analysis." Chu C.C., Paul W.E. Proc. Natl. Acad. Sci. U.S.A. 94:2507-2512(1997) [PubMed: 9122225] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U80211 Genomic DNA. Translation: AAB51360.1.
3D structure databases
ModBase	Search...
Organism-specific databases
MGI	MGI:109552. Il4i1.
Phylogenomic databases
HOVERGEN	O08615.
Enzyme and pathway databases
BRENDA	1.4.3.2. 291401.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

OXLA_MUSSP

Accession

Primary (citable) accession number: O08615

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2002
Last sequence update:	July 1, 1997
Last modified:	June 16, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)