O08615 (OXLA_MUSSP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L-amino-acid oxidase
Short name=LAAO
Short name=LAO
EC=1.4.3.2

Alternative name(s):
Interleukin-4-induced protein 1
Short name=IL4-induced protein 1
Protein Fig-1

Gene names

Name:	Il4i1
Synonyms:	Fig1

Organism

Mus spretus (Western Mediterranean mouse) (Algerian mouse)

Taxonomic identifier

10096 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	46 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in lysosomal antigen processing and presentation By similarity.
Catalytic activity	An L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2.
Cofactor	FAD By similarity.
Subcellular location	Lysosome By similarity.
Induction	By interleukin-4. Ref.1
Sequence similarities	Belongs to the flavin monoamine oxidase family. FIG1 subfamily.

Ontologies

Keywords
Cellular component	Lysosome
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
PTM	Glycoprotein
Gene Ontology (GO)
Cellular_component	lysosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	L-amino-acid oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›46	›46	L-amino-acid oxidase		PRO_0000099873
Amino acid modifications
	Glycosylation	31	1	N-linked (GlcNAc...) Potential
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	46	1

Sequences

	Sequence		Length	Mass (Da)
	O08615 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: 483CBE1F75610164	FASTA	46	5,165
	10 20 30 40 AFKDLKALGC KKAMNKFNKH TLLEYLLEEG NLSRPAVQLL GDVMSE

References

[1]	"Fig1, an interleukin 4-induced mouse B cell gene isolated by cDNA representational difference analysis." Chu C.C., Paul W.E. Proc. Natl. Acad. Sci. U.S.A. 94:2507-2512(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U80211 Genomic DNA. Translation: AAB51360.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:109552. Il4i1.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

OXLA_MUSSP

Accession

Primary (citable) accession number: O08615

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2002
Last sequence update:	July 1, 1997
Last modified:	April 3, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program