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O08615 (OXLA_MUSSP) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
L-amino-acid oxidase

Short name=LAAO
Short name=LAO
EC=1.4.3.2
Alternative name(s):
Interleukin-4-induced protein 1
Short name=IL4-induced protein 1
Protein Fig-1
Gene names
Name:Il4i1
Synonyms:Fig1
OrganismMus spretus (Western Mediterranean mouse) (Algerian mouse)
Taxonomic identifier10096 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length46 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in lysosomal antigen processing and presentation By similarity.

Catalytic activity

An L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2.

Cofactor

FAD By similarity.

Subcellular location

Lysosome By similarity.

Induction

By interleukin-4. Ref.1

Sequence similarities

Belongs to the flavin monoamine oxidase family. FIG1 subfamily.

Ontologies

Keywords
   Cellular componentLysosome
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
   PTMGlycoprotein
Gene Ontology (GO)
   Cellular_componentlysosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionL-amino-acid oxidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›46›46L-amino-acid oxidase
PRO_0000099873

Amino acid modifications

Glycosylation311N-linked (GlcNAc...) Potential

Experimental info

Non-terminal residue11
Non-terminal residue461

Sequences

Sequence LengthMass (Da)Tools
O08615 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 483CBE1F75610164

FASTA465,165
        10         20         30         40 
AFKDLKALGC KKAMNKFNKH TLLEYLLEEG NLSRPAVQLL GDVMSE 

« Hide

References

[1]"Fig1, an interleukin 4-induced mouse B cell gene isolated by cDNA representational difference analysis."
Chu C.C., Paul W.E.
Proc. Natl. Acad. Sci. U.S.A. 94:2507-2512(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U80211 Genomic DNA. Translation: AAB51360.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:109552. Il4i1.

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameOXLA_MUSSP
AccessionPrimary (citable) accession number: O08615
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: July 1, 1997
Last modified: October 16, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot