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Protein
Submitted name:

Cytoskeletal protein

Gene

Utrn

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • adult somatic muscle development Source: MGI
  • positive regulation of cell-matrix adhesion Source: MGI
  • regulation of sodium ion transmembrane transporter activity Source: BHF-UCL

Keywordsi

Molecular functionActin-bindingUniRule annotationSAAS annotation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Cytoskeletal proteinImported
Gene namesi
Name:UtrnImported
Synonyms:utrophinImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:104631 Utrn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membraneUniRule annotation, Cytoplasm, CytoskeletonUniRule annotation, Membrane, Postsynaptic cell membraneUniRule annotation, Synapse

PTM / Processingi

Proteomic databases

PeptideAtlasiO08614
PRIDEiO08614

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

CORUMiO08614
IntActiO08614, 3 interactors
MINTiO08614

Structurei

3D structure databases

ProteinModelPortaliO08614
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 135Calponin-homology (CH)InterPro annotationAdd BLAST105
Domaini150 – 255Calponin-homology (CH)InterPro annotationAdd BLAST106
Domaini2809 – 2842WWInterPro annotationAdd BLAST34
Domaini3061 – 3108ZZ-typeInterPro annotationAdd BLAST48

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili453 – 476Sequence analysisAdd BLAST24
Coiled coili573 – 593Sequence analysisAdd BLAST21
Coiled coili793 – 813Sequence analysisAdd BLAST21
Coiled coili879 – 906Sequence analysisAdd BLAST28
Coiled coili943 – 977Sequence analysisAdd BLAST35
Coiled coili1098 – 1118Sequence analysisAdd BLAST21
Coiled coili1126 – 1146Sequence analysisAdd BLAST21
Coiled coili1160 – 1180Sequence analysisAdd BLAST21
Coiled coili1376 – 1396Sequence analysisAdd BLAST21
Coiled coili1682 – 1709Sequence analysisAdd BLAST28
Coiled coili1768 – 1788Sequence analysisAdd BLAST21
Coiled coili1801 – 1821Sequence analysisAdd BLAST21
Coiled coili2256 – 2276Sequence analysisAdd BLAST21
Coiled coili2482 – 2502Sequence analysisAdd BLAST21
Coiled coili2548 – 2582Sequence analysisAdd BLAST35
Coiled coili2683 – 2710Sequence analysisAdd BLAST28
Coiled coili3250 – 3287Sequence analysisAdd BLAST38
Coiled coili3322 – 3352Sequence analysisAdd BLAST31

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG4286 Eukaryota
COG5069 LUCA
HOGENOMiHOG000231173
HOVERGENiHBG005495

Family and domain databases

CDDicd00014 CH, 2 hits
cd00201 WW, 1 hit
Gene3Di1.10.418.10, 2 hits
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR035436 Dystrophin/utrophin
IPR011992 EF-hand-dom_pair
IPR015153 EF-hand_dom_typ1
IPR015154 EF-hand_dom_typ2
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
IPR001202 WW_dom
IPR036020 WW_dom_sf
IPR000433 Znf_ZZ
PfamiView protein in Pfam
PF00307 CH, 2 hits
PF09068 EF-hand_2, 1 hit
PF09069 EF-hand_3, 1 hit
PF00435 Spectrin, 7 hits
PF00397 WW, 1 hit
PF00569 ZZ, 1 hit
PIRSFiPIRSF002341 Dystrophin/utrophin, 3 hits
SMARTiView protein in SMART
SM00033 CH, 2 hits
SM00150 SPEC, 20 hits
SM00456 WW, 1 hit
SM00291 ZnF_ZZ, 1 hit
SUPFAMiSSF47473 SSF47473, 2 hits
SSF47576 SSF47576, 1 hit
SSF51045 SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit
PS01357 ZF_ZZ_1, 1 hit
PS50135 ZF_ZZ_2, 1 hit

Sequencei

Sequence statusi: Complete.

O08614-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKYGDLEAR PDDGQNEFSD IIKSRSDEHN DVQKKTFTKW INARFSKSGK
60 70 80 90 100
PPISDMFSDL KDGRKLLDLL EGLTGTSLPK ERGSTRVHAL NNVNRVLQVL
110 120 130 140 150
HQNNVDLVNI GGTDIVAGNP KLTLGLLWSI ILHWQVKDVM KDIMSDLQQT
160 170 180 190 200
NSEKILLSWV RQTTRPYSQV NVLNFTTSWT DGLAFNAVLH RHKPDLFDWD
210 220 230 240 250
EMVKMSPIER LDHAFDKAHT SLGIEKLLSP ETVAVHLPDK KSIIMYLTSL
260 270 280 290 300
FEVLPQQVTI DAIREVETLP RKYKKECEEE EIHIQSAVLA EEGQSPRAET
310 320 330 340 350
PSTVTEVDMD LDSYQIALEE VLTWLLSAED TFQEQHDISD DVEEVKEQFA
360 370 380 390 400
THETFMMELT AHQSSVGSVL QAGNQLMTQG TLSREEEFEI QEQMTLLNAR
410 420 430 440 450
WEALRVESME RQSRLHDALM ELQKKQLQQL SSWLALTEER IQKMESLPLG
460 470 480 490 500
DDLPSLQKLL QEHKSLQNDL EAEQVKVNSL THMVVIVDEN SGESATALLE
510 520 530 540 550
DQLQKLGERW TAVCRWTEER WNRLQEISIL WQELLEEQCL LEAWLTEKEE
560 570 580 590 600
ALDKVQTSNF KDQKELSVSV RRLAILKEDM EMKRQTLDQL SEIGQDVGQL
610 620 630 640 650
LSNPKASKKM NSDSEELTQR WDSLVQRLED SSNQVTQAVA KLGMSQIPQK
660 670 680 690 700
DLLETVHVRE QGMVKKPKQE LPPPPPPKKR QIHVDVEAKK KFDAISTELL
710 720 730 740 750
NWILKSKTAI QNTEMKEYKK SQETSGMKKK LKGLEKEQKE NLPRLDELNQ
760 770 780 790 800
TGQTLREQMG KEGLPLKEVN DVLERVSLEW KMISQQLEDL GRKIQLQEDI
810 820 830 840 850
NAYFKQLDAI EETIKEKEEW LRGTPISESP RQPLPGLKDS CQRELTDLLG
860 870 880 890 900
LHPRIETLCA SCSALKSQPC VPGFVQQGFD DLRHHYQAVA KALEEYQQQL
910 920 930 940 950
ENELKSQPGP EYLDTLNTLK KMLSESEKAA QASLNALNDP IAVEQALQEK
960 970 980 990 1000
KALDETLENQ KHTLHKLSEE TKTLEKNMLP DVGKMYKQEF DDVQGRWNKV
1010 1020 1030 1040 1050
KTKVSRDLHL LEEITPRLRD FEADSEVIEK WVSGIKDFLM KEQAAQGDAA
1060 1070 1080 1090 1100
AQSQLDQCAT FANEIETIES SLKNMREVET SLQRCPVTGV KTWVQARLVD
1110 1120 1130 1140 1150
YQSQLEKFSK EIAIQKSRLL DSQEKALNLK KDLAEMQEWM AQAEEDYLER
1160 1170 1180 1190 1200
DFEYKSPEEL ESAVEEMKRA KEDVLQKEVR VKILKDSIKL VAAKVPSGGQ
1210 1220 1230 1240 1250
ELTSEFNEVL ESYQLLCNRI RGKCHTLEEV WSCWVELLHY LDLETTWLNT
1260 1270 1280 1290 1300
LEERVRSTEA LPERAEAVHE ALESLESVLR HPADNRTQIR ELGQTLIDGG
1310 1320 1330 1340 1350
ILDDIISEKL EAFNSRYEEL SHLAESKQIS LEKQLQVLRE TDHMLQVLKE
1360 1370 1380 1390 1400
SLGELDKQLT TYLTDRIDAF QLPQEAQKIQ AEISAHELTL EELRKNVRSQ
1410 1420 1430 1440 1450
PPTSPEGRAT RGGSQMDMLQ RKLREVSTKF QLFQKPANFE QRMLDCKRVL
1460 1470 1480 1490 1500
EGVKAELHVL DVRDVDPDVI QAHLDKCMKL YKTLSEVKLE VETVIKTGRH
1510 1520 1530 1540 1550
IVQKQQTDNP KSMDEQLTSL KVLYNDLGAQ VTEGKQDLER ASQLSRKMKK
1560 1570 1580 1590 1600
EAAVLSEWLS ATEAELVQKS TSEGVIGDLD TEISWAKSIL KDLEKRKVDL
1610 1620 1630 1640 1650
NGITESSAAL QHLVLGSESV LEENLCVLNA GWSRVRTWTE DWCNTLLNHQ
1660 1670 1680 1690 1700
NQLELFDGHV AHISTWLYQA EALLDEIEKK PASKQEEIVK RLLSELDDAS
1710 1720 1730 1740 1750
LQVENVREQA IILVNARGSA SRELVEPKLA ELSRNFEKVS QHIKSARMLI
1760 1770 1780 1790 1800
GQDPSSYQGL DPAGTVQAAE SFSDLENLEQ DIENMLKVVE KHLDPNNDEK
1810 1820 1830 1840 1850
MDEEQAQIEE VLQRGEHLLH EPMEDSKKEK IRLQLLLLHT RYNKIKTIPI
1860 1870 1880 1890 1900
QQRKTIPVSS GITSSALPAD YLVEINKILL TLDDIELSLN MPELNTTVYK
1910 1920 1930 1940 1950
DFSFQEDSLK SIKGQLDRLG EQIAVVHEKQ PDVIVEASGP EAIQIRDMLA
1960 1970 1980 1990 2000
QLNAKWDRVN RVYSDRRGSF ARAVEEWRQF HHDLDDLTQW LSEAEDLLVD
2010 2020 2030 2040 2050
TCAPDGSLDL EKARAQQLEL EEGLSSHQPS LIKVNRKGED LVQRLRPSEA
2060 2070 2080 2090 2100
SFLKEKLAGF NQRWSTLVAE VEALQPRLKG ESQQVLGYKR RLDEVTCWLT
2110 2120 2130 2140 2150
KVESAVQKRS TPDPEESPQE LTDLAQETEV QAENIKWLNR AELEMLSDKN
2160 2170 2180 2190 2200
LSLREREKLS ESLKNVNTTW TKVCREVPSL LKTRTQDPCS APQMRMAAHP
2210 2220 2230 2240 2250
NVQKVVLVSS ASDAPLRGGL EISVPADLDK TITELADWLV LIDQMLKSNI
2260 2270 2280 2290 2300
VTVGDVKEIN KTVSRMKITK ADLEQRHPQL DCVFTLAQNL KNKASSSDVR
2310 2320 2330 2340 2350
TAITEKLEKL KTQWESTQHG VELRRQQLED MVVDSLQWDD HREETEELMR
2360 2370 2380 2390 2400
KYEARFYMLQ QARRDPLSKQ VSDNQLLLQE LGSGDGVIMA FDNVLQKLLE
2410 2420 2430 2440 2450
EYSGDDTRNV EETTEYLKTS WVNLKQSIAD RQSALEAELQ TVQTSRRDLE
2460 2470 2480 2490 2500
NFVKWLQEAE TTANVLADAS QRENALQDSV LARQLRQQML DIQAEIDAHN
2510 2520 2530 2540 2550
DIFKSIDGNR QKMVKALGNS EEATMLQHRL DDMNQRWNDL KAKSASIRAH
2560 2570 2580 2590 2600
LEASAEKWNR LLASLEELIK WLNMKDEELK KQMPIGGDVP ALQLQYDHCK
2610 2620 2630 2640 2650
VLRRELKEKE YSVLNAVDQA RVFLADQPIE APEEPRRNPQ SKTELTPEER
2660 2670 2680 2690 2700
AQKIAKAMRK QSSEVREKWE NLNAVTSNWQ KQVGKALEKL RDLQGAMDDL
2710 2720 2730 2740 2750
DADMKEVEAV RNGWKPVGDL LIDSLQDHIE KTLAFREEIA PINLKVKTMN
2760 2770 2780 2790 2800
DLSSQLSPLD LHPSLKMSRQ LDDLNMRWKL LQVSVDDRLK QLQEAHRDFG
2810 2820 2830 2840 2850
PSSQHFLSTS VQLPWQRSIS HNKVPYYINH QTQTTCWDHP KMTELFQSLA
2860 2870 2880 2890 2900
DLNNVRFSAY RTAIKIRRLQ KALCLDLLEL NTTNEVFKQH KLNQNDQLLS
2910 2920 2930 2940 2950
VPDVINCLTT TYDGLEQLHK DLVNVPLCVD MCLNWLLNVY DTGRTGKIRV
2960 2970 2980 2990 3000
QSLKIGLMSL SKGLLEEKYR CLFKEVAGPT EMCDQRQLGL LLHDAIQIPR
3010 3020 3030 3040 3050
QLGEVAAFGG SNIEPSVRSC FQQNNNKPEI SVKEFIDWMH LEPQSMVWLP
3060 3070 3080 3090 3100
VLHRVAAAET AKHQAKCNIC KECPIVGFRY RSLKHFNYDV CQSCFFSGRT
3110 3120 3130 3140 3150
AKGHKLHYPM VEYCIPTTSG EDVRDFTKVL KNKFRSKKYF AKHPRLGYLP
3160 3170 3180 3190 3200
VQTVLEGDNL ETPITLISMW PEHYDPSQSP QLFHDDTHSR IEQYATRLAQ
3210 3220 3230 3240 3250
MERTNGSFLT DSSSTTGSVE DEHALIQQYC QTLGGESPVS QPQSPAQILK
3260 3270 3280 3290 3300
SVEREERGEL ERIIADLEEE QRNLQVEYEQ LKEQHLRRGL PVGSPPDSIV
3310 3320 3330 3340 3350
SPHHTSEDSE LIAEAKLLRQ HKGRLEARMQ ILEDHNKQLE SQLHRLRQLL
3360 3370 3380 3390 3400
EQPDSDSRIN GVSPWASPQH SALSYSLDTD PGPQFHQAAS EDLLAPPHDT
3410 3420
STDLTDVMEQ INSTFPSCSS NVPSRPQAM
Length:3,429
Mass (Da):392,506
Last modified:July 1, 1997 - v1
Checksum:iF51DFA5BC35CFFCE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12229 mRNA Translation: CAA72912.1
UniGeneiMm.331784
Mm.418026

Similar proteinsi

Entry informationi

Entry nameiO08614_MOUSE
AccessioniPrimary (citable) accession number: O08614
Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: July 1, 1997
Last modified: May 23, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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