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Protein

Syntaxin-binding protein 1

Gene

Stxbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • axon target recognition Source: MGI
  • developmental process involved in reproduction Source: Ensembl
  • exocytosis Source: MGI
  • long term synaptic depression Source: MGI
  • negative regulation of neuron apoptotic process Source: MGI
  • negative regulation of protein complex assembly Source: Ensembl
  • negative regulation of synaptic transmission, GABAergic Source: MGI
  • neuromuscular synaptic transmission Source: MGI
  • neurotransmitter secretion Source: MGI
  • platelet aggregation Source: MGI
  • platelet degranulation Source: MGI
  • positive regulation of calcium ion-dependent exocytosis Source: MGI
  • positive regulation of glutamate secretion, neurotransmission Source: Ensembl
  • positive regulation of mast cell degranulation Source: Ensembl
  • positive regulation of vesicle docking Source: Ensembl
  • presynaptic dense core vesicle exocytosis Source: SynGO
  • protein localization to plasma membrane Source: MGI
  • protein stabilization Source: MGI
  • protein transport Source: UniProtKB-KW
  • regulation of insulin secretion Source: Reactome
  • regulation of synaptic vesicle priming Source: Ensembl
  • regulation of vesicle fusion Source: Ensembl
  • response to estradiol Source: Ensembl
  • synaptic vesicle fusion to presynaptic active zone membrane Source: ParkinsonsUK-UCL
  • synaptic vesicle maturation Source: MGI
  • vesicle docking involved in exocytosis Source: ParkinsonsUK-UCL

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-181430. Norepinephrine Neurotransmitter Release Cycle.
R-MMU-210500. Glutamate Neurotransmitter Release Cycle.
R-MMU-264642. Acetylcholine Neurotransmitter Release Cycle.
R-MMU-422356. Regulation of insulin secretion.
R-MMU-888590. GABA synthesis, release, reuptake and degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-binding protein 1
Alternative name(s):
Protein unc-18 homolog 1
Short name:
Unc18-1
Protein unc-18 homolog A
Short name:
Unc-18A
Gene namesi
Name:Stxbp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:107363. Stxbp1.

Subcellular locationi

GO - Cellular componenti

  • cytoskeleton Source: Ensembl
  • cytosol Source: MGI
  • extracellular exosome Source: MGI
  • mitochondrion Source: MGI
  • myelin sheath Source: UniProtKB
  • nucleoplasm Source: MGI
  • perinuclear region of cytoplasm Source: Ensembl
  • plasma membrane Source: MGI
  • platelet alpha granule Source: MGI
  • postsynapse Source: Ensembl
  • presynaptic active zone membrane Source: SynGO
  • protein complex Source: Ensembl
  • terminal bouton Source: Ensembl

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002062781 – 594Syntaxin-binding protein 1Add BLAST594

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei476PhosphoserineBy similarity1
Modified residuei509PhosphoserineCombined sources1
Modified residuei511PhosphoserineCombined sources1
Modified residuei516PhosphoserineCombined sources1
Modified residuei593PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO08599.
MaxQBiO08599.
PaxDbiO08599.
PeptideAtlasiO08599.
PRIDEiO08599.

PTM databases

iPTMnetiO08599.
PhosphoSitePlusiO08599.
SwissPalmiO08599.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026797.
CleanExiMM_STXBP1.
ExpressionAtlasiO08599. baseline and differential.
GenevisibleiO08599. MM.

Interactioni

Subunit structurei

Binds SYTL4. Interacts with STX1A.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203564. 9 interactors.
DIPiDIP-31951N.
IntActiO08599. 15 interactors.
MINTiMINT-4136044.
STRINGi10090.ENSMUSP00000089051.

Structurei

3D structure databases

ProteinModelPortaliO08599.
SMRiO08599.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the STXBP/unc-18/SEC1 family.Curated

Phylogenomic databases

eggNOGiKOG1300. Eukaryota.
COG5158. LUCA.
GeneTreeiENSGT00390000005206.
HOGENOMiHOG000232146.
HOVERGENiHBG052710.
InParanoidiO08599.
KOiK15292.
OMAiHMREAID.
OrthoDBiEOG091G0WUI.
PhylomeDBiO08599.
TreeFamiTF313242.

Family and domain databases

InterProiView protein in InterPro
IPR001619. Sec1-like.
PANTHERiPTHR11679. PTHR11679. 1 hit.
PfamiView protein in Pfam
PF00995. Sec1. 1 hit.
PIRSFiPIRSF005715. VPS45_Sec1. 1 hit.
SUPFAMiSSF56815. SSF56815. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O08599-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPIGLKAVV GEKIMHDVIK KVKKKGEWKV LVVDQLSMRM LSSCCKMTDI
60 70 80 90 100
MTEGITIVED INKRREPLPS LEAVYLITPS EKSVHSLISD FKDPPTAKYR
110 120 130 140 150
AAHVFFTDSC PDALFNELVK SRAAKVIKTL TEINIAFLPY ESQVYSLDSA
160 170 180 190 200
DSFQSFYSPH KAQMKNPILE RLAEQIATLC ATLKEYPAVR YRGEYKDNAL
210 220 230 240 250
LAQLIQDKLD AYKADDPTMG EGPDKARSQL LILDRGFDPS SPVLHELTFQ
260 270 280 290 300
AMSYDLLPIE NDVYKYETSG IGEARVKEVL LDEDDDLWIA LRHKHIAEVS
310 320 330 340 350
QEVTRSLKDF SSSKRMNTGE KTTMRDLSQM LKKMPQYQKE LSKYSTHLHL
360 370 380 390 400
AEDCMKHYQG TVDKLCRVEQ DLAMGTDAEG EKIKDPMRAI VPILLDANVS
410 420 430 440 450
TYDKIRIILL YIFLKNGITE ENLNKLIQHA QIPPEDSEII TNMAHLGVPI
460 470 480 490 500
VTDSTLRRRS KPERKERISE QTYQLSRWTP IIKDIMEDTI EDKLDTKHYP
510 520 530 540 550
YISTRSSASF STTAVSARYG HWHKNKAPGE YRSGPRLIIF ILGGVSLNEM
560 570 580 590
RCAYEVTQAN GKWEVLIGST HILTPQKLLD TLKKLNKTDE EISS
Length:594
Mass (Da):67,569
Last modified:June 7, 2004 - v2
Checksum:i2DD0715F875CE0F3
GO
Isoform 2 (identifier: O08599-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     576-594: QKLLDTLKKLNKTDEEISS → TKFLMDLRHPDFRESSRVSFEDQAPTME

Show »
Length:603
Mass (Da):68,736
Checksum:i73D8337768259493
GO

Sequence cautioni

The sequence CAM20726 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti101A → R in BAA19479 (PubMed:8824310).Curated1
Sequence conflicti367R → H in BAA32486 (PubMed:9705297).Curated1
Sequence conflicti537L → F in BAA19479 (PubMed:8824310).Curated1
Sequence conflicti561G → A in BAA19479 (PubMed:8824310).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti216D → N in strain: DBA/2J. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010496576 – 594QKLLD…EEISS → TKFLMDLRHPDFRESSRVSF EDQAPTME in isoform 2. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D45903 mRNA. Translation: BAA19479.1.
AB012697 Genomic DNA. Translation: BAA32486.1.
AF326545 mRNA. Translation: AAL37391.1.
AF326563 mRNA. Translation: AAL37409.1.
AL845471 Genomic DNA. Translation: CAM20726.1. Sequence problems.
AL845471 Genomic DNA. Translation: CAM20727.1.
AL845471 Genomic DNA. Translation: CAM20728.1.
BC031728 mRNA. Translation: AAH31728.1.
CCDSiCCDS15933.1. [O08599-1]
CCDS50572.1. [O08599-2]
RefSeqiNP_001107041.1. NM_001113569.1. [O08599-2]
NP_033321.2. NM_009295.2. [O08599-1]
UniGeneiMm.278865.

Genome annotation databases

EnsembliENSMUST00000050000; ENSMUSP00000052440; ENSMUSG00000026797. [O08599-1]
ENSMUST00000077458; ENSMUSP00000089051; ENSMUSG00000026797. [O08599-2]
GeneIDi20910.
KEGGimmu:20910.
UCSCiuc008jha.2. mouse. [O08599-1]
uc008jhb.2. mouse. [O08599-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSTXB1_MOUSE
AccessioniPrimary (citable) accession number: O08599
Secondary accession number(s): A2ARS2
, A2ARS3, A2ARS4, Q5WAC6, Q8VD51
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 7, 2004
Last modified: August 30, 2017
This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families