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O08593

- PDE7A_RAT

UniProt

O08593 - PDE7A_RAT

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Protein

High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A

Gene
Pde7a
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction By similarity.

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.

Cofactori

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.

Enzyme regulationi

Insensitive to all selective PDE inhibitors By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei156 – 1561Proton donor By similarity
Metal bindingi160 – 1601Divalent metal cation 1 By similarity
Metal bindingi196 – 1961Divalent metal cation 1 By similarity
Metal bindingi197 – 1971Divalent metal cation 1 By similarity
Metal bindingi197 – 1971Divalent metal cation 2 By similarity
Metal bindingi306 – 3061Divalent metal cation 1 By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-AMP phosphodiesterase activity Source: RGD
  2. cyclic-nucleotide phosphodiesterase activity Source: RGD
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cAMP catabolic process Source: UniProtKB-UniPathway
  2. cAMP-mediated signaling Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00762; UER00747.

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC:3.1.4.53)
Alternative name(s):
Rolipram-insensitive phosphodiesterase type 7
Gene namesi
Name:Pde7a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi68391. Pde7a.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 426›426High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7APRO_0000198835Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriO08593.

Interactioni

Subunit structurei

Interacts with CBFA2T3 By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000040981.

Structurei

3D structure databases

ProteinModelPortaliO08593.
SMRiO08593. Positions 83-399.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni131 – 395265Catalytic By similarityAdd
BLAST

Domaini

Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain.

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG300643.
HOGENOMiHOG000220881.
HOVERGENiHBG053543.
InParanoidiO08593.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
InterProiIPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00471. HDc. 1 hit.
[Graphical view]
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

O08593-1 [UniParc]FASTAAdd to Basket

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DQTALYIRML GDVRVRSRAG FETERRGSHP YIDFRIFHAQ SEIEASVSAR    50
NIRRLLSFQR YLRSSRFFRG ATVCRSLNIL DEDYNGQAKC MLEKVGNWNF 100
DIFLFDRLTN GNSLVSLTFH LFSLHGLIEY FHLDMVKLRR FLVMIQEDYH 150
SQNPYHNAVH AADVTQAMHC YLKEPKLANS VTPWDILLSL IAAATHDLDH 200
PGVNQPFLIK TNHYLATLYK NTSVLENHHW RSAVGLLRES GLFSHLPLES 250
RHEMEAQIGA LILATDISRQ NEYLSLFRSH LDKGDLHLDD GRHRHLVLQM 300
ALKCADICNP CRNWELSKQW SEKVTEEFFH QGDIEKKYHL GVSPLCDRQT 350
ESIANIQIGF MTYLQEPLFT EWARFSDTRL SQTMLGHVGL NKASWKGLQR 400
QQPSSEDASA AFELNSQLLT QENRLS 426
Length:426
Mass (Da):49,274
Last modified:July 1, 1997 - v1
Checksum:i129BDC01C9351D26
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U77880 mRNA. Translation: AAB51234.1.
UniGeneiRn.39142.

Genome annotation databases

UCSCiRGD:68391. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U77880 mRNA. Translation: AAB51234.1 .
UniGenei Rn.39142.

3D structure databases

ProteinModelPortali O08593.
SMRi O08593. Positions 83-399.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000040981.

Chemistry

BindingDBi O08593.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:68391. rat.

Organism-specific databases

RGDi 68391. Pde7a.

Phylogenomic databases

eggNOGi NOG300643.
HOGENOMi HOG000220881.
HOVERGENi HBG053543.
InParanoidi O08593.

Enzyme and pathway databases

UniPathwayi UPA00762 ; UER00747 .

Miscellaneous databases

PROi O08593.

Gene expression databases

Genevestigatori O08593.

Family and domain databases

Gene3Di 1.10.1300.10. 1 hit.
InterProi IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view ]
Pfami PF00233. PDEase_I. 1 hit.
[Graphical view ]
PRINTSi PR00387. PDIESTERASE1.
SMARTi SM00471. HDc. 1 hit.
[Graphical view ]
PROSITEi PS00126. PDEASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Differential distribution of rat PDE-7 mRNA in embryonic and adult rat brain."
    Hoffmann R., Abdel'Al S., Engels P.
    Cell Biochem. Biophys. 28:103-113(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiPDE7A_RAT
AccessioniPrimary (citable) accession number: O08593
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: June 11, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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