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O08593

- PDE7A_RAT

UniProt

O08593 - PDE7A_RAT

Protein

High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A

Gene

Pde7a

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction By similarity.By similarity

    Catalytic activityi

    Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.

    Cofactori

    Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.By similarity

    Enzyme regulationi

    Insensitive to all selective PDE inhibitors.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei156 – 1561Proton donorBy similarity
    Metal bindingi160 – 1601Divalent metal cation 1By similarity
    Metal bindingi196 – 1961Divalent metal cation 1By similarity
    Metal bindingi197 – 1971Divalent metal cation 1By similarity
    Metal bindingi197 – 1971Divalent metal cation 2By similarity
    Metal bindingi306 – 3061Divalent metal cation 1By similarity

    GO - Molecular functioni

    1. 3',5'-cyclic-AMP phosphodiesterase activity Source: RGD
    2. cyclic-nucleotide phosphodiesterase activity Source: RGD
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cAMP catabolic process Source: UniProtKB-UniPathway
    2. cAMP-mediated signaling Source: RGD

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    cAMP, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00762; UER00747.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC:3.1.4.53)
    Alternative name(s):
    Rolipram-insensitive phosphodiesterase type 7
    Gene namesi
    Name:Pde7a
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi68391. Pde7a.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 426›426High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7APRO_0000198835Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriO08593.

    Interactioni

    Subunit structurei

    Interacts with CBFA2T3.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000040981.

    Structurei

    3D structure databases

    ProteinModelPortaliO08593.
    SMRiO08593. Positions 83-399.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni131 – 395265CatalyticBy similarityAdd
    BLAST

    Domaini

    Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain.

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG300643.
    HOGENOMiHOG000220881.
    HOVERGENiHBG053543.
    InParanoidiO08593.

    Family and domain databases

    Gene3Di1.10.1300.10. 1 hit.
    InterProiIPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    [Graphical view]
    PfamiPF00233. PDEase_I. 1 hit.
    [Graphical view]
    PRINTSiPR00387. PDIESTERASE1.
    SMARTiSM00471. HDc. 1 hit.
    [Graphical view]
    PROSITEiPS00126. PDEASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    O08593-1 [UniParc]FASTAAdd to Basket

    « Hide

    DQTALYIRML GDVRVRSRAG FETERRGSHP YIDFRIFHAQ SEIEASVSAR    50
    NIRRLLSFQR YLRSSRFFRG ATVCRSLNIL DEDYNGQAKC MLEKVGNWNF 100
    DIFLFDRLTN GNSLVSLTFH LFSLHGLIEY FHLDMVKLRR FLVMIQEDYH 150
    SQNPYHNAVH AADVTQAMHC YLKEPKLANS VTPWDILLSL IAAATHDLDH 200
    PGVNQPFLIK TNHYLATLYK NTSVLENHHW RSAVGLLRES GLFSHLPLES 250
    RHEMEAQIGA LILATDISRQ NEYLSLFRSH LDKGDLHLDD GRHRHLVLQM 300
    ALKCADICNP CRNWELSKQW SEKVTEEFFH QGDIEKKYHL GVSPLCDRQT 350
    ESIANIQIGF MTYLQEPLFT EWARFSDTRL SQTMLGHVGL NKASWKGLQR 400
    QQPSSEDASA AFELNSQLLT QENRLS 426
    Length:426
    Mass (Da):49,274
    Last modified:July 1, 1997 - v1
    Checksum:i129BDC01C9351D26
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U77880 mRNA. Translation: AAB51234.1.
    UniGeneiRn.39142.

    Genome annotation databases

    UCSCiRGD:68391. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U77880 mRNA. Translation: AAB51234.1 .
    UniGenei Rn.39142.

    3D structure databases

    ProteinModelPortali O08593.
    SMRi O08593. Positions 83-399.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000040981.

    Chemistry

    BindingDBi O08593.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:68391. rat.

    Organism-specific databases

    RGDi 68391. Pde7a.

    Phylogenomic databases

    eggNOGi NOG300643.
    HOGENOMi HOG000220881.
    HOVERGENi HBG053543.
    InParanoidi O08593.

    Enzyme and pathway databases

    UniPathwayi UPA00762 ; UER00747 .

    Miscellaneous databases

    PROi O08593.

    Gene expression databases

    Genevestigatori O08593.

    Family and domain databases

    Gene3Di 1.10.1300.10. 1 hit.
    InterProi IPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    [Graphical view ]
    Pfami PF00233. PDEase_I. 1 hit.
    [Graphical view ]
    PRINTSi PR00387. PDIESTERASE1.
    SMARTi SM00471. HDc. 1 hit.
    [Graphical view ]
    PROSITEi PS00126. PDEASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Differential distribution of rat PDE-7 mRNA in embryonic and adult rat brain."
      Hoffmann R., Abdel'Al S., Engels P.
      Cell Biochem. Biophys. 28:103-113(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiPDE7A_RAT
    AccessioniPrimary (citable) accession number: O08593
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3