Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Clathrin light chain A

Gene

Clta

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Clathrin light chain A
Short name:
Lca
Gene namesi
Name:Clta
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:894297. Clta.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Coated pit, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 235235Clathrin light chain APRO_0000205768Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei104 – 1041PhosphoserineBy similarity
Modified residuei193 – 1931PhosphoserineCombined sources
Modified residuei210 – 2101N6-acetyllysineBy similarity
Modified residuei223 – 2231PhosphoserineCombined sources
Modified residuei229 – 2291N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO08585.
MaxQBiO08585.
PRIDEiO08585.

PTM databases

iPTMnetiO08585.
PhosphoSiteiO08585.

Expressioni

Gene expression databases

CleanExiMM_CLTA.

Interactioni

Subunit structurei

Clathrin coats are formed from molecules containing 3 heavy chains and 3 light chains. Interacts with CALY; the interaction stimulates clathrin self-assembly and clathrin-mediated endocytosis (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiO08585. 1 interaction.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni99 – 16163Involved in binding clathrin heavy chainAdd
BLAST

Sequence similaritiesi

Belongs to the clathrin light chain family.Curated

Phylogenomic databases

HOGENOMiHOG000008147.
HOVERGENiHBG003386.
InParanoidiO08585.

Family and domain databases

InterProiIPR000996. Clathrin_L-chain.
[Graphical view]
PANTHERiPTHR10639. PTHR10639. 1 hit.
PfamiPF01086. Clathrin_lg_ch. 1 hit.
[Graphical view]
PROSITEiPS00224. CLATHRIN_LIGHT_CHN_1. 1 hit.
PS00581. CLATHRIN_LIGHT_CHN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08585-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAELDPFGAP AGAPGGPALG NGVAGAGEED PAAAFLAQQE SEIAGIENDE
60 70 80 90 100
AFAILDGGAP GRATRRAAGG PDAVDGVMNG EYYQESNGPT DSYAAISEVD
110 120 130 140 150
RLQSEPESIR KWREEQTERL EALDANSRKQ EAEWKEKAIK ELEEWYARQD
160 170 180 190 200
EQLQKTKANN RVADEAFYKQ PFADLIGYVA AEEAFVNDID ESSPGTEWER
210 220 230
VARLCDFNPK SSKQAKDVSR MRSVLISLKQ APLVH
Length:235
Mass (Da):25,604
Last modified:October 3, 2012 - v2
Checksum:i1594B3F3F204C221
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91A → D in AAB51286 (Ref. 1) Curated
Sequence conflicti38 – 392QQ → HE in AAB51286 (Ref. 1) Curated
Sequence conflicti68 – 681A → G in AAB51286 (Ref. 1) Curated
Sequence conflicti162 – 1643VAD → AAE in AAB51286 (Ref. 1) Curated
Sequence conflicti175 – 1751L → V in AAB51286 (Ref. 1) Curated
Sequence conflicti203 – 2031R → P in AAB51286 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91848 mRNA. Translation: AAB51286.1.
AL732563 Genomic DNA. No translation available.
UniGeneiMm.298875.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91848 mRNA. Translation: AAB51286.1.
AL732563 Genomic DNA. No translation available.
UniGeneiMm.298875.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO08585. 1 interaction.

PTM databases

iPTMnetiO08585.
PhosphoSiteiO08585.

Proteomic databases

EPDiO08585.
MaxQBiO08585.
PRIDEiO08585.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:894297. Clta.

Phylogenomic databases

HOGENOMiHOG000008147.
HOVERGENiHBG003386.
InParanoidiO08585.

Miscellaneous databases

PROiO08585.
SOURCEiSearch...

Gene expression databases

CleanExiMM_CLTA.

Family and domain databases

InterProiIPR000996. Clathrin_L-chain.
[Graphical view]
PANTHERiPTHR10639. PTHR10639. 1 hit.
PfamiPF01086. Clathrin_lg_ch. 1 hit.
[Graphical view]
PROSITEiPS00224. CLATHRIN_LIGHT_CHN_1. 1 hit.
PS00581. CLATHRIN_LIGHT_CHN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLCA_MOUSE
AccessioniPrimary (citable) accession number: O08585
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 3, 2012
Last modified: July 6, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.