ID   KLF6_MOUSE              Reviewed;         283 AA.
AC   O08584;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 3.
DT   27-MAR-2024, entry version 155.
DE   RecName: Full=Krueppel-like factor 6;
DE   AltName: Full=Core promoter element-binding protein;
GN   Name=Klf6; Synonyms=Copeb, Cpbp;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Rockefeller; TISSUE=Placenta;
RX   PubMed=10570007; DOI=10.1095/biolreprod61.6.1586;
RA   Slavin D., Sapin V., Lopez-Diaz F., Jacquemin P., Koritschoner N.,
RA   Dastugue B., Davidson I., Chatton B., Bocco J.L.;
RT   "The Kruppel-like core promoter binding protein gene is primarily expressed
RT   in placenta during mouse development.";
RL   Biol. Reprod. 61:1586-1591(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Swiss Webster / NIH;
RX   PubMed=11274234; DOI=10.1681/asn.v124726;
RA   Fischer E.A., Verpont M.C., Garrett-Sinha L.A., Ronco P.M., Rossert J.A.;
RT   "Klf6 is a zinc finger protein expressed in a cell-specific manner during
RT   kidney development.";
RL   J. Am. Soc. Nephrol. 12:726-735(2001).
CC   -!- FUNCTION: Transcriptional activator. Binds a GC box motif. Could play a
CC       role in B-cell growth and development (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with ZZEF1. {ECO:0000250|UniProtKB:Q99612}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in placenta.
CC   -!- DEVELOPMENTAL STAGE: Expression is lower in total embryos and in adult
CC       tissues.
CC   -!- DOMAIN: The acidic N-terminal part may favor interaction with the basic
CC       domain of transcription factors.
CC   -!- DOMAIN: The 9aaTAD motif is a transactivation domain present in a large
CC       number of yeast and animal transcription factors. In KLF6, the motif is
CC       inactive. {ECO:0000250|UniProtKB:Q99612}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC99478.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AF072403; AAC99478.1; ALT_INIT; mRNA.
DR   EMBL; AY027436; AAK11733.1; -; mRNA.
DR   AlphaFoldDB; O08584; -.
DR   SMR; O08584; -.
DR   STRING; 10090.ENSMUSP00000000080; -.
DR   iPTMnet; O08584; -.
DR   PhosphoSitePlus; O08584; -.
DR   EPD; O08584; -.
DR   MaxQB; O08584; -.
DR   PaxDb; 10090-ENSMUSP00000000080; -.
DR   ProteomicsDB; 263620; -.
DR   AGR; MGI:1346318; -.
DR   MGI; MGI:1346318; Klf6.
DR   eggNOG; KOG1721; Eukaryota.
DR   InParanoid; O08584; -.
DR   PhylomeDB; O08584; -.
DR   ChiTaRS; Klf6; mouse.
DR   PRO; PR:O08584; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; O08584; Protein.
DR   GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR   GO; GO:0005829; C:cytosol; ISO:MGI.
DR   GO; GO:0001650; C:fibrillar center; ISO:MGI.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR   GO; GO:0005730; C:nucleolus; ISO:MGI.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:0003677; F:DNA binding; ISS:MGI.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISO:MGI.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0003690; F:double-stranded DNA binding; ISO:MGI.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:MGI.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IDA:MGI.
DR   GO; GO:1905205; P:positive regulation of connective tissue replacement; IMP:BHF-UCL.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd21586; KLF6_N; 1.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 3.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR23235:SF41; KRUEPPEL-LIKE FACTOR 6; 1.
DR   PANTHER; PTHR23235; KRUEPPEL-LIKE TRANSCRIPTION FACTOR; 1.
DR   Pfam; PF00096; zf-C2H2; 3.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..283
FT                   /note="Krueppel-like factor 6"
FT                   /id="PRO_0000047172"
FT   ZN_FING         200..224
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         230..254
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         260..282
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          104..198
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           62..70
FT                   /note="9aaTAD; inactive"
FT                   /evidence="ECO:0000250|UniProtKB:Q99612"
FT   COMPBIAS        104..158
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   283 AA;  31877 MW;  8ACF664A9C6697FC CRC64;
     MDVLPMCSIF QELQIVHETG YFSALPSLEE YWQQTCLELE RYLQSEPCYV SASEIKFDSQ
     EDLWTKFILA REKKEESELK ISSSPPEDSL ISSSFNYNLE TNSLNSDVSS ESSDSSEELS
     PTTKFTSDPI GEVLVNSGNL SSSVISTPPS SPEVNRESSQ LWGCGPGDLP SPGKVRSGTS
     GKSGDKGNGD ASPDGRRRVH RCHFNGCRKV YTKSSHLKAH QRTHTGEKPY RCSWEGCEWR
     FARSDELTRH FRKHTGAKPF KCSHCDRCFS RSDHLALHMK RHL
//