O08584 (KLF6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Krueppel-like factor 6

Alternative name(s):
Core promoter element-binding protein

Gene names

Name:	Klf6
Synonyms:	Copeb, Cpbp

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	283 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Transcriptional activator. Binds a GC box motif. Could play a role in B-cell growth and development By similarity.
Subcellular location	Nucleus By similarity.
Tissue specificity	Highly expressed in placenta.
Developmental stage	Expression is lower in total embryos and in adult tissues.
Domain	The acidic N-terminal part may favor interaction with the basic domain of transcription factors.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 3 C2H2-type zinc fingers.
Sequence caution	The sequence AAC99478.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 283	283	Krueppel-like factor 6		PRO_0000047172
Regions
	Zinc finger	200 – 224	25	C2H2-type 1
	Zinc finger	230 – 254	25	C2H2-type 2
	Zinc finger	260 – 282	23	C2H2-type 3

Sequences

	Sequence		Length	Mass (Da)
	O08584 [UniParc]. Last modified May 30, 2000. Version 3. Checksum: 8ACF664A9C6697FC	FASTA	283	31,877
	10 20 30 40 50 60 MDVLPMCSIF QELQIVHETG YFSALPSLEE YWQQTCLELE RYLQSEPCYV SASEIKFDSQ 70 80 90 100 110 120 EDLWTKFILA REKKEESELK ISSSPPEDSL ISSSFNYNLE TNSLNSDVSS ESSDSSEELS 130 140 150 160 170 180 PTTKFTSDPI GEVLVNSGNL SSSVISTPPS SPEVNRESSQ LWGCGPGDLP SPGKVRSGTS 190 200 210 220 230 240 GKSGDKGNGD ASPDGRRRVH RCHFNGCRKV YTKSSHLKAH QRTHTGEKPY RCSWEGCEWR 250 260 270 280 FARSDELTRH FRKHTGAKPF KCSHCDRCFS RSDHLALHMK RHL

References

[1]	"The Kruppel-like core promoter binding protein gene is primarily expressed in placenta during mouse development." Slavin D., Sapin V., Lopez-Diaz F., Jacquemin P., Koritschoner N., Dastugue B., Davidson I., Chatton B., Bocco J.L. Biol. Reprod. 61:1586-1591(1999) [PubMed: 10570007] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Rockefeller. Tissue: Placenta.
[2]	"Klf6 is a zinc finger protein expressed in a cell-specific manner during kidney development." Fischer E.A., Verpont M.C., Garrett-Sinha L.A., Ronco P.M., Rossert J.A. J. Am. Soc. Nephrol. 12:726-735(2001) [PubMed: 11274234] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Swiss Webster / NIH.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF072403 mRNA. Translation: AAC99478.1. Different initiation. AY027436 mRNA. Translation: AAK11733.1.
IPI	IPI00223531.
UniGene	Mm.275036.
3D structure databases
ProteinModelPortal	O08584.
SMR	O08584. Positions 200-283.
ModBase	Search...
Protein-protein interaction databases
STRING	O08584.
PTM databases
PhosphoSite	O08584.
Proteomic databases
PRIDE	O08584.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:1346318. Klf6.
Phylogenomic databases
eggNOG	roNOG13952.
HOVERGEN	HBG000836.
InParanoid	O08584.
OrthoDB	EOG49079R.
Gene expression databases
ArrayExpress	O08584.
Bgee	O08584.
CleanEx	MM_KLF6.
Genevestigator	O08584.
GermOnline	ENSMUSG00000000078. Mus musculus.
Family and domain databases
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Gene3D	G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 3 hits.
Pfam	PF00096. zf-C2H2. 3 hits. [Graphical view]
SMART	SM00355. ZnF_C2H2. 3 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 3 hits. PS50157. ZINC_FINGER_C2H2_2. 3 hits. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

KLF6_MOUSE

Accession

Primary (citable) accession number: O08584

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 30, 2000
Last modified:	December 14, 2011
This is version 95 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program