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O08584

- KLF6_MOUSE

UniProt

O08584 - KLF6_MOUSE

Protein

Krueppel-like factor 6

Gene

Klf6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 3 (30 May 2000)
      Previous versions | rss
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    Functioni

    Transcriptional activator. Binds a GC box motif. Could play a role in B-cell growth and development By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri200 – 22425C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri230 – 25425C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri260 – 28223C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cytokine-mediated signaling pathway Source: MGI
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Krueppel-like factor 6
    Alternative name(s):
    Core promoter element-binding protein
    Gene namesi
    Name:Klf6
    Synonyms:Copeb, Cpbp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1346318. Klf6.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 283283Krueppel-like factor 6PRO_0000047172Add
    BLAST

    Proteomic databases

    PRIDEiO08584.

    PTM databases

    PhosphoSiteiO08584.

    Expressioni

    Tissue specificityi

    Highly expressed in placenta.

    Developmental stagei

    Expression is lower in total embryos and in adult tissues.

    Gene expression databases

    ArrayExpressiO08584.
    BgeeiO08584.
    CleanExiMM_KLF6.
    GenevestigatoriO08584.

    Structurei

    3D structure databases

    ProteinModelPortaliO08584.
    SMRiO08584. Positions 200-283.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The acidic N-terminal part may favor interaction with the basic domain of transcription factors.

    Sequence similaritiesi

    Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri200 – 22425C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri230 – 25425C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri260 – 28223C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOVERGENiHBG000836.
    InParanoidiO08584.
    PhylomeDBiO08584.

    Family and domain databases

    Gene3Di3.30.160.60. 3 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 3 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O08584-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDVLPMCSIF QELQIVHETG YFSALPSLEE YWQQTCLELE RYLQSEPCYV    50
    SASEIKFDSQ EDLWTKFILA REKKEESELK ISSSPPEDSL ISSSFNYNLE 100
    TNSLNSDVSS ESSDSSEELS PTTKFTSDPI GEVLVNSGNL SSSVISTPPS 150
    SPEVNRESSQ LWGCGPGDLP SPGKVRSGTS GKSGDKGNGD ASPDGRRRVH 200
    RCHFNGCRKV YTKSSHLKAH QRTHTGEKPY RCSWEGCEWR FARSDELTRH 250
    FRKHTGAKPF KCSHCDRCFS RSDHLALHMK RHL 283
    Length:283
    Mass (Da):31,877
    Last modified:May 30, 2000 - v3
    Checksum:i8ACF664A9C6697FC
    GO

    Sequence cautioni

    The sequence AAC99478.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF072403 mRNA. Translation: AAC99478.1. Different initiation.
    AY027436 mRNA. Translation: AAK11733.1.
    UniGeneiMm.275036.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF072403 mRNA. Translation: AAC99478.1 . Different initiation.
    AY027436 mRNA. Translation: AAK11733.1 .
    UniGenei Mm.275036.

    3D structure databases

    ProteinModelPortali O08584.
    SMRi O08584. Positions 200-283.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei O08584.

    Proteomic databases

    PRIDEi O08584.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:1346318. Klf6.

    Phylogenomic databases

    eggNOGi COG5048.
    HOVERGENi HBG000836.
    InParanoidi O08584.
    PhylomeDBi O08584.

    Miscellaneous databases

    ChiTaRSi KLF6. mouse.
    PROi O08584.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O08584.
    Bgeei O08584.
    CleanExi MM_KLF6.
    Genevestigatori O08584.

    Family and domain databases

    Gene3Di 3.30.160.60. 3 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 3 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Kruppel-like core promoter binding protein gene is primarily expressed in placenta during mouse development."
      Slavin D., Sapin V., Lopez-Diaz F., Jacquemin P., Koritschoner N., Dastugue B., Davidson I., Chatton B., Bocco J.L.
      Biol. Reprod. 61:1586-1591(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Rockefeller.
      Tissue: Placenta.
    2. "Klf6 is a zinc finger protein expressed in a cell-specific manner during kidney development."
      Fischer E.A., Verpont M.C., Garrett-Sinha L.A., Ronco P.M., Rossert J.A.
      J. Am. Soc. Nephrol. 12:726-735(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Swiss Webster / NIH.

    Entry informationi

    Entry nameiKLF6_MOUSE
    AccessioniPrimary (citable) accession number: O08584
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 113 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3