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Protein

Krueppel-like factor 6

Gene

Klf6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional activator. Binds a GC box motif. Could play a role in B-cell growth and development (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri200 – 22425C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri230 – 25425C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri260 – 28223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: MGI
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 6
Alternative name(s):
Core promoter element-binding protein
Gene namesi
Name:Klf6
Synonyms:Copeb, Cpbp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1346318. Klf6.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 283283Krueppel-like factor 6PRO_0000047172Add
BLAST

Proteomic databases

PRIDEiO08584.

PTM databases

PhosphoSiteiO08584.

Expressioni

Tissue specificityi

Highly expressed in placenta.

Developmental stagei

Expression is lower in total embryos and in adult tissues.

Gene expression databases

BgeeiO08584.
CleanExiMM_KLF6.
ExpressionAtlasiO08584. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000080.

Structurei

3D structure databases

ProteinModelPortaliO08584.
SMRiO08584. Positions 200-283.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The acidic N-terminal part may favor interaction with the basic domain of transcription factors.

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri200 – 22425C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri230 – 25425C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri260 – 28223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOVERGENiHBG000836.
InParanoidiO08584.
PhylomeDBiO08584.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08584-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVLPMCSIF QELQIVHETG YFSALPSLEE YWQQTCLELE RYLQSEPCYV
60 70 80 90 100
SASEIKFDSQ EDLWTKFILA REKKEESELK ISSSPPEDSL ISSSFNYNLE
110 120 130 140 150
TNSLNSDVSS ESSDSSEELS PTTKFTSDPI GEVLVNSGNL SSSVISTPPS
160 170 180 190 200
SPEVNRESSQ LWGCGPGDLP SPGKVRSGTS GKSGDKGNGD ASPDGRRRVH
210 220 230 240 250
RCHFNGCRKV YTKSSHLKAH QRTHTGEKPY RCSWEGCEWR FARSDELTRH
260 270 280
FRKHTGAKPF KCSHCDRCFS RSDHLALHMK RHL
Length:283
Mass (Da):31,877
Last modified:May 30, 2000 - v3
Checksum:i8ACF664A9C6697FC
GO

Sequence cautioni

The sequence AAC99478.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072403 mRNA. Translation: AAC99478.1. Different initiation.
AY027436 mRNA. Translation: AAK11733.1.
UniGeneiMm.275036.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072403 mRNA. Translation: AAC99478.1. Different initiation.
AY027436 mRNA. Translation: AAK11733.1.
UniGeneiMm.275036.

3D structure databases

ProteinModelPortaliO08584.
SMRiO08584. Positions 200-283.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000080.

PTM databases

PhosphoSiteiO08584.

Proteomic databases

PRIDEiO08584.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1346318. Klf6.

Phylogenomic databases

eggNOGiCOG5048.
HOVERGENiHBG000836.
InParanoidiO08584.
PhylomeDBiO08584.

Miscellaneous databases

ChiTaRSiKlf6. mouse.
PROiO08584.
SOURCEiSearch...

Gene expression databases

BgeeiO08584.
CleanExiMM_KLF6.
ExpressionAtlasiO08584. baseline and differential.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The Kruppel-like core promoter binding protein gene is primarily expressed in placenta during mouse development."
    Slavin D., Sapin V., Lopez-Diaz F., Jacquemin P., Koritschoner N., Dastugue B., Davidson I., Chatton B., Bocco J.L.
    Biol. Reprod. 61:1586-1591(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Rockefeller.
    Tissue: Placenta.
  2. "Klf6 is a zinc finger protein expressed in a cell-specific manner during kidney development."
    Fischer E.A., Verpont M.C., Garrett-Sinha L.A., Ronco P.M., Rossert J.A.
    J. Am. Soc. Nephrol. 12:726-735(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Swiss Webster / NIH.

Entry informationi

Entry nameiKLF6_MOUSE
AccessioniPrimary (citable) accession number: O08584
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: June 24, 2015
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.