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O08584 (KLF6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Krueppel-like factor 6
Alternative name(s):
Core promoter element-binding protein
Gene names
Name:Klf6
Synonyms:Copeb, Cpbp
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length283 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcriptional activator. Binds a GC box motif. Could play a role in B-cell growth and development By similarity.

Subcellular location

Nucleus By similarity.

Tissue specificity

Highly expressed in placenta.

Developmental stage

Expression is lower in total embryos and in adult tissues.

Domain

The acidic N-terminal part may favor interaction with the basic domain of transcription factors.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 3 C2H2-type zinc fingers.

Sequence caution

The sequence AAC99478.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 283283Krueppel-like factor 6
PRO_0000047172

Regions

Zinc finger200 – 22425C2H2-type 1
Zinc finger230 – 25425C2H2-type 2
Zinc finger260 – 28223C2H2-type 3

Sequences

Sequence LengthMass (Da)Tools
O08584 [UniParc].

Last modified May 30, 2000. Version 3.
Checksum: 8ACF664A9C6697FC

FASTA28331,877
        10         20         30         40         50         60 
MDVLPMCSIF QELQIVHETG YFSALPSLEE YWQQTCLELE RYLQSEPCYV SASEIKFDSQ 

        70         80         90        100        110        120 
EDLWTKFILA REKKEESELK ISSSPPEDSL ISSSFNYNLE TNSLNSDVSS ESSDSSEELS 

       130        140        150        160        170        180 
PTTKFTSDPI GEVLVNSGNL SSSVISTPPS SPEVNRESSQ LWGCGPGDLP SPGKVRSGTS 

       190        200        210        220        230        240 
GKSGDKGNGD ASPDGRRRVH RCHFNGCRKV YTKSSHLKAH QRTHTGEKPY RCSWEGCEWR 

       250        260        270        280 
FARSDELTRH FRKHTGAKPF KCSHCDRCFS RSDHLALHMK RHL 

« Hide

References

[1]"The Kruppel-like core promoter binding protein gene is primarily expressed in placenta during mouse development."
Slavin D., Sapin V., Lopez-Diaz F., Jacquemin P., Koritschoner N., Dastugue B., Davidson I., Chatton B., Bocco J.L.
Biol. Reprod. 61:1586-1591(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Rockefeller.
Tissue: Placenta.
[2]"Klf6 is a zinc finger protein expressed in a cell-specific manner during kidney development."
Fischer E.A., Verpont M.C., Garrett-Sinha L.A., Ronco P.M., Rossert J.A.
J. Am. Soc. Nephrol. 12:726-735(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Swiss Webster / NIH.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF072403 mRNA. Translation: AAC99478.1. Different initiation.
AY027436 mRNA. Translation: AAK11733.1.
UniGeneMm.275036.

3D structure databases

ProteinModelPortalO08584.
SMRO08584. Positions 200-283.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteO08584.

Proteomic databases

PRIDEO08584.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:1346318. Klf6.

Phylogenomic databases

eggNOGCOG5048.
HOVERGENHBG000836.
InParanoidO08584.
PhylomeDBO08584.

Gene expression databases

ArrayExpressO08584.
BgeeO08584.
CleanExMM_KLF6.
GenevestigatorO08584.

Family and domain databases

Gene3D3.30.160.60. 3 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSKLF6. mouse.
PROO08584.
SOURCESearch...

Entry information

Entry nameKLF6_MOUSE
AccessionPrimary (citable) accession number: O08584
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: July 9, 2014
This is version 112 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot