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Protein

GTP-binding protein 1

Gene

Gtpbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi167 – 174GTPSequence analysis8
Nucleotide bindingi252 – 256GTPSequence analysis5
Nucleotide bindingi308 – 311GTPSequence analysis4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein 1
Short name:
G-protein 1
Short name:
GP-1
Short name:
GP1
Gene namesi
Name:Gtpbp1
Synonyms:Gtpbp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:109443. Gtpbp1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

No visible phenotype. Mice are born at the expected Mendelian ratio, develop normally and are fertile. They exhibit increased stability of some mRNA species.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001224701 – 668GTP-binding protein 1Add BLAST668

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6PhosphoserineCombined sources1
Modified residuei8PhosphoserineCombined sources1
Modified residuei12PhosphoserineCombined sources1
Modified residuei24PhosphoserineCombined sources1
Modified residuei25PhosphoserineCombined sources1
Modified residuei44PhosphoserineCombined sources1
Modified residuei47PhosphoserineCombined sources1
Modified residuei69PhosphoserineBy similarity1
Modified residuei580PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO08582.
MaxQBiO08582.
PaxDbiO08582.
PeptideAtlasiO08582.
PRIDEiO08582.

PTM databases

iPTMnetiO08582.
PhosphoSitePlusiO08582.

Expressioni

Tissue specificityi

Detected in some neurons in the brain cortex. Detected in small arteries, dendritic cells and macrophages in the thymus. Detected in lung bronchi, in bronchial epithelial cells and in bronchial smooth muscle cells. Detected in smooth muscle cells in a broad range of organs (at protein level). Expressed in brain, thymus, lung, and kidney.2 Publications

Gene expression databases

BgeeiENSMUSG00000042535.
CleanExiMM_GTPBP1.
GenevisibleiO08582. MM.

Interactioni

Subunit structurei

Interacts with EXOSC2/RRP4, EXOSC3/RRP40, EXOSC5/RRP46, HNRNPD, HNRNPR and SYNCRIP. Identified in a complex with AANAT mRNA, but does not bind mRNA by itself (By similarity).By similarity

Protein-protein interaction databases

IntActiO08582. 1 interactor.
MINTiMINT-8178484.
STRINGi10090.ENSMUSP00000043575.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KJ2X-ray2.71P/Q246-253[»]
1KJ3X-ray2.30P/Q246-253[»]
ProteinModelPortaliO08582.
SMRiO08582.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO08582.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini158 – 389tr-type GPROSITE-ProRule annotationAdd BLAST232

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni167 – 174G1PROSITE-ProRule annotation8
Regioni206 – 210G2PROSITE-ProRule annotation5
Regioni252 – 255G3PROSITE-ProRule annotation4
Regioni308 – 311G4PROSITE-ProRule annotation4
Regioni366 – 368G5PROSITE-ProRule annotation3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi28 – 36Poly-Ala9

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. GTPBP1 subfamily.PROSITE-ProRule annotation
Contains 1 tr-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0463. Eukaryota.
COG5258. LUCA.
GeneTreeiENSGT00730000110829.
HOGENOMiHOG000176635.
HOVERGENiHBG004471.
InParanoidiO08582.
OMAiPPGDEAC.
OrthoDBiEOG091G06LY.
PhylomeDBiO08582.
TreeFamiTF350446.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08582-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAERSRSPV DSPVPASMFA PEPSSPGAAR AAAAAARLHG GFDSDCSEDG
60 70 80 90 100
EALNGEPELD LTSKLVLVSP TSEQYDSLLR QMWERMDEGC GETIYVIGQG
110 120 130 140 150
SDGTEYGLSE ADMEASYATV KSMAEQIEAD VILLRERQEA GGRVRDYLVR
160 170 180 190 200
KRVGDNDFLE VRVAVVGNVD AGKSTLLGVL THGELDNGRG FARQKLFRHK
210 220 230 240 250
HEIESGRTSS VGNDILGFDS EGNVVNKPDS HGGSLEWTKI CEKSSKVITF
260 270 280 290 300
IDLAGHEKYL KTTVFGMTGH LPDFCMLMVG SNAGIVGMTK EHLGLALALN
310 320 330 340 350
VPVFVVVTKI DMCPANILQE TLKLLQRLLK SPGCRKIPVL VQSKDDVIVT
360 370 380 390 400
ASNFSSERMC PIFQISNVTG ENLDLLKMFL NLLSPRTSYR EEEPAEFQID
410 420 430 440 450
DTYSVPGVGT VVSGTTLRGL IKLNDTLLLG PDPLGNFLSI AVKSIHRKRM
460 470 480 490 500
PVKEVRGGQT ASFALKKIKR SSIRKGMVMV SPRLNPQASW EFEAEILVLH
510 520 530 540 550
HPTTISPRYQ AMVHCGSIRQ TATILSMDKD CLRTGDKATV HFRFIKTPEY
560 570 580 590 600
LHIDQRLVFR EGRTKAVGTI TKLLQTTNNS PMNSKPQQIK MQSTKKGPLS
610 620 630 640 650
KREEGGPCGV PAAGGPPTGD EASSLGTAQA ASTSGLQPQP KPSSGGRRRG
660
GQRHKVKSGA CVTPASGC
Length:668
Mass (Da):72,301
Last modified:September 5, 2006 - v2
Checksum:iE77C2148D6B237F8
GO

Sequence cautioni

The sequence AAB51274 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB23409 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE28091 differs from that shown. Reason: Frameshift at position 631.Curated
The sequence BAE29280 differs from that shown. Reason: Frameshift at position 666.Curated
The sequence BAE29365 differs from that shown. Reason: Frameshift at position 666.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti121K → E in BAE28091 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004612 mRNA. Translation: BAB23409.1. Different initiation.
AK147717 mRNA. Translation: BAE28091.1. Frameshift.
AK150068 mRNA. Translation: BAE29280.1. Frameshift.
AK150185 mRNA. Translation: BAE29365.1. Frameshift.
AK170091 mRNA. Translation: BAE41557.1.
BC046228 mRNA. Translation: AAH46228.1.
U87965 mRNA. Translation: AAB51274.1. Different initiation.
CCDSiCCDS27648.1.
PIRiJC5292.
RefSeqiNP_038846.2. NM_013818.2.
UniGeneiMm.19080.

Genome annotation databases

EnsembliENSMUST00000046463; ENSMUSP00000043575; ENSMUSG00000042535.
GeneIDi14904.
KEGGimmu:14904.
UCSCiuc007wuf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004612 mRNA. Translation: BAB23409.1. Different initiation.
AK147717 mRNA. Translation: BAE28091.1. Frameshift.
AK150068 mRNA. Translation: BAE29280.1. Frameshift.
AK150185 mRNA. Translation: BAE29365.1. Frameshift.
AK170091 mRNA. Translation: BAE41557.1.
BC046228 mRNA. Translation: AAH46228.1.
U87965 mRNA. Translation: AAB51274.1. Different initiation.
CCDSiCCDS27648.1.
PIRiJC5292.
RefSeqiNP_038846.2. NM_013818.2.
UniGeneiMm.19080.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KJ2X-ray2.71P/Q246-253[»]
1KJ3X-ray2.30P/Q246-253[»]
ProteinModelPortaliO08582.
SMRiO08582.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO08582. 1 interactor.
MINTiMINT-8178484.
STRINGi10090.ENSMUSP00000043575.

PTM databases

iPTMnetiO08582.
PhosphoSitePlusiO08582.

Proteomic databases

EPDiO08582.
MaxQBiO08582.
PaxDbiO08582.
PeptideAtlasiO08582.
PRIDEiO08582.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046463; ENSMUSP00000043575; ENSMUSG00000042535.
GeneIDi14904.
KEGGimmu:14904.
UCSCiuc007wuf.1. mouse.

Organism-specific databases

CTDi9567.
MGIiMGI:109443. Gtpbp1.

Phylogenomic databases

eggNOGiKOG0463. Eukaryota.
COG5258. LUCA.
GeneTreeiENSGT00730000110829.
HOGENOMiHOG000176635.
HOVERGENiHBG004471.
InParanoidiO08582.
OMAiPPGDEAC.
OrthoDBiEOG091G06LY.
PhylomeDBiO08582.
TreeFamiTF350446.

Miscellaneous databases

ChiTaRSiGtpbp1. mouse.
EvolutionaryTraceiO08582.
PROiO08582.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042535.
CleanExiMM_GTPBP1.
GenevisibleiO08582. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGTPB1_MOUSE
AccessioniPrimary (citable) accession number: O08582
Secondary accession number(s): Q3UD96
, Q3UGW6, Q545R1, Q80ZY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: September 5, 2006
Last modified: November 2, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.