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O08581

- KCNK1_MOUSE

UniProt

O08581 - KCNK1_MOUSE

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Protein

Potassium channel subfamily K member 1

Gene

Kcnk1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Weak inwardly rectifying potassium channel.

GO - Molecular functioni

  1. potassium channel activity Source: MGI
  2. voltage-gated ion channel activity Source: UniProtKB-KW

GO - Biological processi

  1. potassium ion transport Source: MGI
  2. response to nicotine Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_199065. Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK).

Protein family/group databases

TCDBi1.A.1.8.1. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily K member 1
Alternative name(s):
Inward rectifying potassium channel protein TWIK-1
Gene namesi
Name:Kcnk1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:109322. Kcnk1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei21 – 4121HelicalSequence AnalysisAdd
BLAST
Intramembranei104 – 13027Pore-forming; Name=Pore-forming 1Sequence AnalysisAdd
BLAST
Transmembranei133 – 15321HelicalSequence AnalysisAdd
BLAST
Topological domaini154 – 17724CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei178 – 19821HelicalSequence AnalysisAdd
BLAST
Intramembranei212 – 23827Pore-forming; Name=Pore-forming 2Sequence AnalysisAdd
BLAST
Transmembranei247 – 26721HelicalSequence AnalysisAdd
BLAST
Topological domaini268 – 33669CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. brush border membrane Source: Ensembl
  3. endosome Source: MGI
  4. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 336336Potassium channel subfamily K member 1PRO_0000101741Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi69 – 69InterchainBy similarity
Glycosylationi95 – 951N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO08581.
PRIDEiO08581.

PTM databases

PhosphoSiteiO08581.

Expressioni

Tissue specificityi

Widely expressed. Highest expression in brain, kidney, thyroid, salivary gland, adrenal gland, prostate, epididymis, uterus, placenta, colon and jejunum. Moderate expression in eyes, pituitary, pancreas, smooth muscle, testis and ovary. Very low levels in lung, aorta, liver, heart, skeletal muscle, thymus and spleen. In the brain, highest expression in cerebellar granule cells, brainstem, hippocampus and cerebral cortex.

Developmental stagei

Expression detected as early as 7 days post conception. Expression increases from 2-8 days after birth and stabilizes after day 8.

Gene expression databases

BgeeiO08581.
CleanExiMM_KCNK1.
GenevestigatoriO08581.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

BioGridi200907. 2 interactions.
STRINGi10090.ENSMUSP00000046103.

Structurei

3D structure databases

ProteinModelPortaliO08581.
SMRiO08581. Positions 19-281.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG290832.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000286014.
HOVERGENiHBG052237.
InParanoidiO08581.
KOiK04912.
OMAiKQLRKMF.
OrthoDBiEOG7TTQ85.
TreeFamiTF313947.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR013099. 2pore_dom_K_chnl_dom.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR005408. 2pore_dom_K_chnl_TWIK.
IPR001779. 2pore_dom_K_chnl_TWIK1.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSiPR01333. 2POREKCHANEL.
PR01096. TWIK1CHANNEL.
PR01586. TWIKCHANNEL.

Sequencei

Sequence statusi: Complete.

O08581-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLQSLAGSSC VRLVERHRSA WCFGFLVLGY LLYLVFGAVV FSSVELPYED
60 70 80 90 100
LLRQELRKLK RRFLEEHECL SEPQLEQFLG RVLEASNYGV SVLSNASGNW
110 120 130 140 150
NWDFTSALFF ASTVLSTTGY GHTVPLSDGG KAFCIIYSVI GIPFTLLFLT
160 170 180 190 200
AVVQRVTVHV TRRPVLYFHI RWGFSKQVVA IVHAVLLGFV TVSCFFFIPA
210 220 230 240 250
AVFSVLEDDW NFLESFYFCF ISLSTIGLGD YVPGEGYNQK FRELYKIGIT
260 270 280 290 300
CYLLLGLIAM LVVLETFCEL HELKKFRKMF YVKKDKDEDL VHIMEHDQLS
310 320 330
FSSVTEQVAG LKEEQKQSEP FVASQSPPYE DGSADH
Length:336
Mass (Da):38,201
Last modified:July 27, 2011 - v2
Checksum:i76B7FD5361A6216C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti44 – 441V → E in AAC16973. (PubMed:9013852)Curated
Sequence conflicti152 – 1521V → L in AAC16973. (PubMed:9013852)Curated
Sequence conflicti259 – 2591A → T in AAC16973. (PubMed:9013852)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF033017 mRNA. Translation: AAC16973.1.
CH466525 Genomic DNA. Translation: EDL11808.1.
BC003729 mRNA. Translation: AAH03729.1.
CCDSiCCDS22783.1.
RefSeqiNP_032456.2. NM_008430.2.
UniGeneiMm.10800.

Genome annotation databases

EnsembliENSMUST00000046765; ENSMUSP00000046103; ENSMUSG00000033998.
GeneIDi16525.
KEGGimmu:16525.
UCSCiuc009nyr.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF033017 mRNA. Translation: AAC16973.1 .
CH466525 Genomic DNA. Translation: EDL11808.1 .
BC003729 mRNA. Translation: AAH03729.1 .
CCDSi CCDS22783.1.
RefSeqi NP_032456.2. NM_008430.2.
UniGenei Mm.10800.

3D structure databases

ProteinModelPortali O08581.
SMRi O08581. Positions 19-281.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200907. 2 interactions.
STRINGi 10090.ENSMUSP00000046103.

Protein family/group databases

TCDBi 1.A.1.8.1. the voltage-gated ion channel (vic) superfamily.

PTM databases

PhosphoSitei O08581.

Proteomic databases

MaxQBi O08581.
PRIDEi O08581.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000046765 ; ENSMUSP00000046103 ; ENSMUSG00000033998 .
GeneIDi 16525.
KEGGi mmu:16525.
UCSCi uc009nyr.3. mouse.

Organism-specific databases

CTDi 3775.
MGIi MGI:109322. Kcnk1.

Phylogenomic databases

eggNOGi NOG290832.
GeneTreei ENSGT00760000118858.
HOGENOMi HOG000286014.
HOVERGENi HBG052237.
InParanoidi O08581.
KOi K04912.
OMAi KQLRKMF.
OrthoDBi EOG7TTQ85.
TreeFami TF313947.

Enzyme and pathway databases

Reactomei REACT_199065. Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK).

Miscellaneous databases

ChiTaRSi Kcnk1. mouse.
NextBioi 289919.
PROi O08581.
SOURCEi Search...

Gene expression databases

Bgeei O08581.
CleanExi MM_KCNK1.
Genevestigatori O08581.

Family and domain databases

InterProi IPR003280. 2pore_dom_K_chnl.
IPR013099. 2pore_dom_K_chnl_dom.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR005408. 2pore_dom_K_chnl_TWIK.
IPR001779. 2pore_dom_K_chnl_TWIK1.
[Graphical view ]
Pfami PF07885. Ion_trans_2. 2 hits.
[Graphical view ]
PIRSFi PIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSi PR01333. 2POREKCHANEL.
PR01096. TWIK1CHANNEL.
PR01586. TWIKCHANNEL.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The structure, function and distribution of the mouse TWIK-1 K+ channel."
    Lesage F., Lauritzen I., Duprat F., Reyes R., Fink M., Heurteaux C., Lazdunski M.
    FEBS Lett. 402:28-32(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Structure, chromosome localization, and tissue distribution of the mouse twik K+ channel gene."
    Arrighi I., Lesage F., Scimeca J.-C., Carle G.F., Barhanin J.
    FEBS Lett. 425:310-316(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129/SvJ.
    Tissue: Liver.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiKCNK1_MOUSE
AccessioniPrimary (citable) accession number: O08581
Secondary accession number(s): Q99L99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Inhibited by quinine, barium, and internal acidification. Activated by protein kinase C.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3