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O08560

- DGKZ_RAT

UniProt

O08560 - DGKZ_RAT

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Protein

Diacylglycerol kinase zeta

Gene
Dgkz, Dagk6
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Regulates RASGRP1 activity By similarity.

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri98 – 15356Phorbol-ester/DAG-type 1Add
BLAST
Zinc fingeri173 – 23159Phorbol-ester/DAG-type 2Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. diacylglycerol kinase activity Source: RGD
  3. enzyme inhibitor activity Source: Ensembl
  4. lipid kinase activity Source: Ensembl
  5. metal ion binding Source: UniProtKB-KW
  6. NAD+ kinase activity Source: InterPro
  7. protein binding Source: IntAct

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. mitotic G1 DNA damage checkpoint Source: Ensembl
  3. negative regulation of mitotic cell cycle Source: Ensembl
  4. negative regulation of Ras protein signal transduction Source: Ensembl
  5. protein kinase C-activating G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BRENDAi2.7.1.107. 5301.

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinase zeta (EC:2.7.1.107)
Short name:
DAG kinase zeta
Alternative name(s):
104 kDa diacylglycerol kinase
DGK-IV
Diglyceride kinase zeta
Short name:
DGK-zeta
Gene namesi
Name:Dgkz
Synonyms:Dagk6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 3

Organism-specific databases

RGDi70929. Dgkz.

Subcellular locationi

Cytoplasm By similarity. Nucleus. Cell membrane By similarity 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. lamellipodium Source: Ensembl
  3. nucleus Source: RGD
  4. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 929929Diacylglycerol kinase zetaPRO_0000218470Add
BLAST

Proteomic databases

PaxDbiO08560.
PRIDEiO08560.

PTM databases

PhosphoSiteiO08560.

Expressioni

Gene expression databases

GenevestigatoriO08560.

Interactioni

Subunit structurei

Interacts with the PDZ domain of the syntrophin SNTG1 and that of SNX27. Forms a signaling complex with RASGRP1 and HRAS By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
Dlg1Q626964EBI-8570505,EBI-389325
Dlg2Q636224EBI-8570505,EBI-396947
Dlg3Q629364EBI-8570505,EBI-349596
Dlg4P310166EBI-8570505,EBI-375655

Protein-protein interaction databases

BioGridi249679. 3 interactions.
IntActiO08560. 6 interactions.
STRINGi10116.ENSRNOP00000060930.

Structurei

3D structure databases

ProteinModelPortaliO08560.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini292 – 426135DAGKcAdd
BLAST
Repeati823 – 85331ANK 1Add
BLAST
Repeati858 – 88730ANK 2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni279 – 417139Mediates interaction with RASGRP1 By similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi362 – 3709Nuclear export signal By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi67 – 726Poly-Pro
Compositional biasi260 – 2634Poly-Lys
Compositional biasi372 – 3754Poly-Pro

Sequence similaritiesi

Contains 2 ANK repeats.
Contains 1 DAGKc domain.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri98 – 15356Phorbol-ester/DAG-type 1Add
BLAST
Zinc fingeri173 – 23159Phorbol-ester/DAG-type 2Add
BLAST

Keywords - Domaini

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG47311.
GeneTreeiENSGT00740000115137.
HOGENOMiHOG000231472.
HOVERGENiHBG067303.
InParanoidiO08560.
KOiK00901.
OMAiQQEPDGA.
OrthoDBiEOG76HQ0Q.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
[Graphical view]
PfamiPF00130. C1_1. 1 hit.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
SM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS50146. DAGK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08560-1 [UniParc]FASTAAdd to Basket

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MEPRDPSPEA RSSDSESASA SSSGSERDAD PEPDKAPRRL TKRRFPGLRL    50
FGHRKAITKS GLQHLAPPPP TPGAPCGESE RQIRSTVDWS ESAAYGEHIW 100
FETNVSGDFC YVGEQYCVAK MLPKSAPRRK CAACKIVVHT PCIGQLEKIN 150
FRCKPSFRES GSRNVREPTF VRHHWVHRRR QDGKCRHCGK GFQQKFTFHS 200
KEIVAISCSW CKQAYHSKVS CFMLQQIEEP CSLGVHAAVV IPPTWILRAR 250
RPQNTLKASK KKKRASFKRR SSKKGPEEGR WRPFIIRPTP SPLMKPLLVF 300
VNPKSGGNQG AKIIQSFLWY LNPRQVFDLS QGGPREALEM YRKVHNLRIL 350
ACGGDGTVGW ILSTLDQLRL KPPPPVAILP LGTGNDLART LNWGGGYTDE 400
PVSKILSHVE EGNVVQLDRW DLRAEPNPEA GPEERDDGAT DRLPLDVFNN 450
YFSLGFDAHV TLEFHESREA NPEKFNSRFR NKMFYAGTAF SDFLMGSSKD 500
LAKHIRVVCD GMDLTPKIQD LKPQCIVFLN IPRYCAGTMP WGHPGEHHDF 550
EPQRHDDGYL EVIGFTMTSL AALQVGGHGE RLTQCREVLL TTAKAIPVQV 600
DGEPCKLAAS RIRIALRNQA TMVQKAKRRS TAPLHSDQQP VPEQLRIQVS 650
RVSMHDYEAL HYDKEQLKEA SVPLGTVVVP GDSDLELCRA HIERLQQEPD 700
GAGAKSPMCH PLSSKWCFLD ATTASRFYRI DRAQEHLNYV TEIAQDEIYI 750
LDPELLGASA RPDLPTPTSP LPASPCSPTP GSLQGDAALP QGEELIEAAK 800
RNDFCKLQEL HRAGGDLMHR DHQSRTLLHH AVSTGSKEVV RYLLDHAPPE 850
ILDAVEENGE TCLHQAAALG QRTICHYIVE AGASLMKTDQ QGDTPRQRAE 900
KAQDTELAAY LENRQHYQMI QREDQETAV 929
Length:929
Mass (Da):104,009
Last modified:July 1, 1997 - v1
Checksum:i6279872004F5F38D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D78588 mRNA. Translation: BAA18942.1.
PIRiJC6124.
RefSeqiNP_112405.1. NM_031143.1.
UniGeneiRn.11208.

Genome annotation databases

EnsembliENSRNOT00000024280; ENSRNOP00000024280; ENSRNOG00000017737.
GeneIDi81821.
KEGGirno:81821.
UCSCiRGD:70929. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D78588 mRNA. Translation: BAA18942.1 .
PIRi JC6124.
RefSeqi NP_112405.1. NM_031143.1.
UniGenei Rn.11208.

3D structure databases

ProteinModelPortali O08560.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 249679. 3 interactions.
IntActi O08560. 6 interactions.
STRINGi 10116.ENSRNOP00000060930.

PTM databases

PhosphoSitei O08560.

Proteomic databases

PaxDbi O08560.
PRIDEi O08560.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000024280 ; ENSRNOP00000024280 ; ENSRNOG00000017737 .
GeneIDi 81821.
KEGGi rno:81821.
UCSCi RGD:70929. rat.

Organism-specific databases

CTDi 8525.
RGDi 70929. Dgkz.

Phylogenomic databases

eggNOGi NOG47311.
GeneTreei ENSGT00740000115137.
HOGENOMi HOG000231472.
HOVERGENi HBG067303.
InParanoidi O08560.
KOi K00901.
OMAi QQEPDGA.
OrthoDBi EOG76HQ0Q.

Enzyme and pathway databases

BRENDAi 2.7.1.107. 5301.

Miscellaneous databases

NextBioi 615743.
PROi O08560.

Gene expression databases

Genevestigatori O08560.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
[Graphical view ]
Pfami PF00130. C1_1. 1 hit.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
[Graphical view ]
SMARTi SM00248. ANK. 2 hits.
SM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS50146. DAGK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A 104-kDa diacylglycerol kinase containing ankyrin-like repeats localizes in the cell nucleus."
    Goto K., Kondo H.
    Proc. Natl. Acad. Sci. U.S.A. 93:11196-11201(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
    Strain: Wistar.

Entry informationi

Entry nameiDGKZ_RAT
AccessioniPrimary (citable) accession number: O08560
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: June 11, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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