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Protein

Diacylglycerol kinase zeta

Gene

Dgkz

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Regulates RASGRP1 activity (By similarity).By similarity

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri98 – 153Phorbol-ester/DAG-type 1Add BLAST56
Zinc fingeri173 – 231Phorbol-ester/DAG-type 2Add BLAST59

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • diacylglycerol kinase activity Source: RGD
  • metal ion binding Source: UniProtKB-KW
  • NAD+ kinase activity Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BRENDAi2.7.1.107 5301
ReactomeiR-RNO-114508 Effects of PIP2 hydrolysis

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinase zeta (EC:2.7.1.107)
Short name:
DAG kinase zeta
Alternative name(s):
104 kDa diacylglycerol kinase
DGK-IV
Diglyceride kinase zeta
Short name:
DGK-zeta
Gene namesi
Name:Dgkz
Synonyms:Dagk6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi70929 Dgkz

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002184701 – 929Diacylglycerol kinase zetaAdd BLAST929

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei706PhosphoserineBy similarity1
Modified residuei782PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO08560
PRIDEiO08560

PTM databases

iPTMnetiO08560
PhosphoSitePlusiO08560

Expressioni

Gene expression databases

BgeeiENSRNOG00000017737
ExpressionAtlasiO08560 baseline and differential
GenevisibleiO08560 RN

Interactioni

Subunit structurei

Interacts with the PDZ domain of the syntrophin SNTG1 and that of SNX27. Forms a signaling complex with RASGRP1 and HRAS (By similarity).By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi249679, 3 interactors
IntActiO08560, 6 interactors
MINTiO08560
STRINGi10116.ENSRNOP00000024280

Structurei

3D structure databases

ProteinModelPortaliO08560
SMRiO08560
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini292 – 426DAGKcPROSITE-ProRule annotationAdd BLAST135
Repeati823 – 853ANK 1Add BLAST31
Repeati858 – 887ANK 2Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni279 – 417Mediates interaction with RASGRP1By similarityAdd BLAST139

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi362 – 370Nuclear export signalBy similarity9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi67 – 72Poly-Pro6
Compositional biasi260 – 263Poly-Lys4
Compositional biasi372 – 375Poly-Pro4

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri98 – 153Phorbol-ester/DAG-type 1Add BLAST56
Zinc fingeri173 – 231Phorbol-ester/DAG-type 2Add BLAST59

Keywords - Domaini

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0782 Eukaryota
ENOG410XSCB LUCA
GeneTreeiENSGT00760000119050
HOGENOMiHOG000231472
HOVERGENiHBG067303
InParanoidiO08560
KOiK00901
OMAiAGGDLMH
OrthoDBiEOG091G13Z8

Family and domain databases

CDDicd00204 ANK, 1 hit
cd00029 C1, 1 hit
Gene3Di1.25.40.20, 1 hit
3.40.50.10330, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR017438 ATP-NAD_kinase_N
IPR037607 DGK
IPR000756 Diacylglycerol_kin_accessory
IPR001206 Diacylglycerol_kinase_cat_dom
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002219 PE/DAG-bd
PANTHERiPTHR11255 PTHR11255, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00130 C1_1, 1 hit
PF00609 DAGK_acc, 1 hit
PF00781 DAGK_cat, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SM00109 C1, 2 hits
SM00045 DAGKa, 1 hit
SM00046 DAGKc, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit
SSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
PS50146 DAGK, 1 hit

Sequencei

Sequence statusi: Complete.

O08560-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPRDPSPEA RSSDSESASA SSSGSERDAD PEPDKAPRRL TKRRFPGLRL
60 70 80 90 100
FGHRKAITKS GLQHLAPPPP TPGAPCGESE RQIRSTVDWS ESAAYGEHIW
110 120 130 140 150
FETNVSGDFC YVGEQYCVAK MLPKSAPRRK CAACKIVVHT PCIGQLEKIN
160 170 180 190 200
FRCKPSFRES GSRNVREPTF VRHHWVHRRR QDGKCRHCGK GFQQKFTFHS
210 220 230 240 250
KEIVAISCSW CKQAYHSKVS CFMLQQIEEP CSLGVHAAVV IPPTWILRAR
260 270 280 290 300
RPQNTLKASK KKKRASFKRR SSKKGPEEGR WRPFIIRPTP SPLMKPLLVF
310 320 330 340 350
VNPKSGGNQG AKIIQSFLWY LNPRQVFDLS QGGPREALEM YRKVHNLRIL
360 370 380 390 400
ACGGDGTVGW ILSTLDQLRL KPPPPVAILP LGTGNDLART LNWGGGYTDE
410 420 430 440 450
PVSKILSHVE EGNVVQLDRW DLRAEPNPEA GPEERDDGAT DRLPLDVFNN
460 470 480 490 500
YFSLGFDAHV TLEFHESREA NPEKFNSRFR NKMFYAGTAF SDFLMGSSKD
510 520 530 540 550
LAKHIRVVCD GMDLTPKIQD LKPQCIVFLN IPRYCAGTMP WGHPGEHHDF
560 570 580 590 600
EPQRHDDGYL EVIGFTMTSL AALQVGGHGE RLTQCREVLL TTAKAIPVQV
610 620 630 640 650
DGEPCKLAAS RIRIALRNQA TMVQKAKRRS TAPLHSDQQP VPEQLRIQVS
660 670 680 690 700
RVSMHDYEAL HYDKEQLKEA SVPLGTVVVP GDSDLELCRA HIERLQQEPD
710 720 730 740 750
GAGAKSPMCH PLSSKWCFLD ATTASRFYRI DRAQEHLNYV TEIAQDEIYI
760 770 780 790 800
LDPELLGASA RPDLPTPTSP LPASPCSPTP GSLQGDAALP QGEELIEAAK
810 820 830 840 850
RNDFCKLQEL HRAGGDLMHR DHQSRTLLHH AVSTGSKEVV RYLLDHAPPE
860 870 880 890 900
ILDAVEENGE TCLHQAAALG QRTICHYIVE AGASLMKTDQ QGDTPRQRAE
910 920
KAQDTELAAY LENRQHYQMI QREDQETAV
Length:929
Mass (Da):104,009
Last modified:July 1, 1997 - v1
Checksum:i6279872004F5F38D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78588 mRNA Translation: BAA18942.1
PIRiJC6124
RefSeqiNP_112405.1, NM_031143.1
UniGeneiRn.11208

Genome annotation databases

EnsembliENSRNOT00000024280; ENSRNOP00000024280; ENSRNOG00000017737
GeneIDi81821
KEGGirno:81821
UCSCiRGD:70929 rat

Similar proteinsi

Entry informationi

Entry nameiDGKZ_RAT
AccessioniPrimary (citable) accession number: O08560
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: May 23, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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