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O08556

- CCR5_RAT

UniProt

O08556 - CCR5_RAT

Protein

C-C chemokine receptor type 5

Gene

Ccr5

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation By similarity.By similarity

    GO - Molecular functioni

    1. C-C chemokine receptor activity Source: RGD
    2. chemokine (C-C motif) ligand 5 binding Source: RGD
    3. protein binding Source: RGD
    4. protein kinase binding Source: RGD

    GO - Biological processi

    1. aging Source: RGD
    2. chemokine-mediated signaling pathway Source: GOC
    3. chemotaxis Source: InterPro
    4. defense response to bacterium Source: RGD
    5. fat cell differentiation Source: RGD
    6. forebrain development Source: RGD
    7. inflammatory response Source: RGD
    8. inflammatory response to antigenic stimulus Source: RGD
    9. leukocyte migration Source: RGD
    10. negative regulation of axon extension Source: RGD
    11. negative regulation of cell migration Source: RGD
    12. negative regulation of neural precursor cell proliferation Source: RGD
    13. neuron death Source: RGD
    14. positive regulation of apoptotic process by virus Source: RGD
    15. positive regulation of cell-cell adhesion Source: RGD
    16. positive regulation of cell migration involved in sprouting angiogenesis Source: RGD
    17. positive regulation of cytosolic calcium ion concentration Source: RGD
    18. positive regulation of fever generation Source: RGD
    19. positive regulation of gene expression Source: RGD
    20. positive regulation of inflammatory response Source: RGD
    21. positive regulation of interleukin-1 beta secretion Source: RGD
    22. positive regulation of interleukin-6 production Source: RGD
    23. positive regulation of neuron differentiation Source: RGD
    24. positive regulation of tumor necrosis factor production Source: RGD
    25. response to ionizing radiation Source: RGD
    26. response to lipopolysaccharide Source: RGD

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C chemokine receptor type 5
    Short name:
    C-C CKR-5
    Short name:
    CC-CKR-5
    Short name:
    CCR-5
    Alternative name(s):
    MIP-1 alpha receptor
    CD_antigen: CD195
    Gene namesi
    Name:Ccr5
    Synonyms:Cmkbr5
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi620596. Ccr5.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: RGD
    2. cytoplasm Source: RGD
    3. endosome Source: RGD
    4. integral component of membrane Source: UniProtKB-KW
    5. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 354354C-C chemokine receptor type 5PRO_0000069280Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi6 – 61O-linked (GalNAc...)By similarity
    Modified residuei10 – 101SulfotyrosineSequence Analysis
    Modified residuei16 – 161SulfotyrosineSequence Analysis
    Glycosylationi19 – 191O-linked (GalNAc...)Sequence Analysis
    Disulfide bondi103 ↔ 180PROSITE-ProRule annotation
    Lipidationi323 – 3231S-palmitoyl cysteineBy similarity
    Lipidationi326 – 3261S-palmitoyl cysteineBy similarity
    Modified residuei338 – 3381Phosphoserine; by BARK1By similarity
    Modified residuei339 – 3391Phosphoserine; by BARK1By similarity
    Modified residuei344 – 3441Phosphoserine; by BARK1By similarity
    Modified residuei351 – 3511Phosphoserine; by BARK1By similarity

    Post-translational modificationi

    Sulfated on at least 2 of the N-terminal tyrosines. Sulfation is required for efficient binding of the chemokines, CCL3 and CCL4 By similarity.By similarity
    O-glycosylated, but not N-glycosylated. Ser-6 appears to be the major site. Also sialylated glycans present which contribute to chemokine binding. Ser-17 may also be glycosylated and, if so, with small moieties such as a T-antigen By similarity.By similarity
    Palmitoylation in the C-terminal is important for cell surface expression.By similarity
    Phosphorylation on serine residues in the C-terminal is stimulated by binding CC chemokines especially by APO-RANTES.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein, Sulfation

    PTM databases

    PhosphoSiteiO08556.

    Expressioni

    Gene expression databases

    GenevestigatoriO08556.

    Interactioni

    Subunit structurei

    Interacts with PRAF2. Efficient ligand binding to CCL3/MIP-1alpha and CCL4/MIP-1beta requires sulfation, O-glycosylation and sialic acid modifications. Glycosylation on Ser-6 is required for efficient binding of CCL4. Interacts with ADRBK1. Interacts with ARRB1 and ARRB2 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000008871.

    Structurei

    3D structure databases

    ProteinModelPortaliO08556.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3232ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini61 – 7010CytoplasmicSequence Analysis
    Topological domaini92 – 10413ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini127 – 14317CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini169 – 20032ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini221 – 23717CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini263 – 27917ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini304 – 35451CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei33 – 6028Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei71 – 9121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei105 – 12622Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei144 – 16825Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei201 – 22020Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei238 – 26225Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei280 – 30324Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG148353.
    HOGENOMiHOG000234122.
    HOVERGENiHBG106917.
    InParanoidiO08556.
    KOiK04180.
    PhylomeDBiO08556.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR002240. Chemokine_CCR5.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24227. PTHR24227. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00657. CCCHEMOKINER.
    PR01110. CHEMOKINER5.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O08556-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDFQGSIPTY IYDIDYSMSA PCQKVNVKQI AAQLLPPLYS LVFIFGFVGN    50
    MMVFLILISC KKLKSMTDIY LFNLAISDLL FLLTLPFWAH YAANEWVFGN 100
    IMCKLFTGIY HIGYFGGIFF IILLTIDRYL AIVHAVFAIK ARTVNFGVIT 150
    SVVTWVVAVF VSLPEIIFMR SQKEGSHYTC SPHFLHIQYR FWKHFQTLKM 200
    VILSLILPLL VMVICYSGIL NTLFRCRNEK KRHRAVRLIF AIMIVYFLFW 250
    TPYNIVLLLT TFQEYFGLNN CSSSNRLDQA MQVTETLGMT HCCLNPVIYA 300
    FVGEKFRNYL SVFFRKHIVK RFCKHCSIFQ QVNPDRVSSV YTRSTGEQEV 350
    STGL 354
    Length:354
    Mass (Da):41,031
    Last modified:July 1, 1997 - v1
    Checksum:i77EDB368AA4C868D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y12009 mRNA. Translation: CAA72737.1.
    U77350 Genomic DNA. Translation: AAC03243.1.
    RefSeqiNP_446412.2. NM_053960.3.
    UniGeneiRn.10736.

    Genome annotation databases

    GeneIDi117029.
    KEGGirno:117029.
    UCSCiRGD:620596. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y12009 mRNA. Translation: CAA72737.1 .
    U77350 Genomic DNA. Translation: AAC03243.1 .
    RefSeqi NP_446412.2. NM_053960.3.
    UniGenei Rn.10736.

    3D structure databases

    ProteinModelPortali O08556.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000008871.

    Chemistry

    BindingDBi O08556.
    ChEMBLi CHEMBL1795146.
    GuidetoPHARMACOLOGYi 62.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei O08556.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 117029.
    KEGGi rno:117029.
    UCSCi RGD:620596. rat.

    Organism-specific databases

    CTDi 1234.
    RGDi 620596. Ccr5.

    Phylogenomic databases

    eggNOGi NOG148353.
    HOGENOMi HOG000234122.
    HOVERGENi HBG106917.
    InParanoidi O08556.
    KOi K04180.
    PhylomeDBi O08556.

    Miscellaneous databases

    NextBioi 619809.
    PROi O08556.

    Gene expression databases

    Genevestigatori O08556.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR002240. Chemokine_CCR5.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24227. PTHR24227. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00657. CCCHEMOKINER.
    PR01110. CHEMOKINER5.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of rat HIV-1-chemokine coreceptor CKR5 from microglia and upregulation of its mRNA in ischemic and endotoxinemic rat brain."
      Spleiss O., Gourmala N., Boddeke H.W.G.M., Sauter A., Fiebich B.L., Berger M., Gebicke-Haerter P.J.
      J. Neurosci. Res. 53:16-28(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
      Tissue: Brain.
    2. "Chemokine receptor expression in cultured glia and rat experimental allergic encephalomyelitis."
      Jiang Y., Salafranca M.N., Adhikari S., Xia Y., Feng L., Sonntag M.K., deFiebre C.M., Pennell N.A., Streit W.J., Harrison J.K.
      J. Neuroimmunol. 86:1-12(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Sprague-Dawley.

    Entry informationi

    Entry nameiCCR5_RAT
    AccessioniPrimary (citable) accession number: O08556
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3