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Protein

C-C chemokine receptor type 5

Gene

Ccr5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity).By similarity

GO - Molecular functioni

  • C-C chemokine receptor activity Source: RGD
  • chemokine (C-C motif) ligand 5 binding Source: RGD
  • protein kinase binding Source: RGD

GO - Biological processi

  • aging Source: RGD
  • chemotaxis Source: InterPro
  • defense response to bacterium Source: RGD
  • fat cell differentiation Source: RGD
  • forebrain development Source: RGD
  • inflammatory response Source: RGD
  • inflammatory response to antigenic stimulus Source: RGD
  • leukocyte migration Source: RGD
  • negative regulation of axon extension Source: RGD
  • negative regulation of cell migration Source: RGD
  • negative regulation of neural precursor cell proliferation Source: RGD
  • neuron death Source: RGD
  • positive regulation of apoptotic process by virus Source: RGD
  • positive regulation of cell-cell adhesion Source: RGD
  • positive regulation of cell migration involved in sprouting angiogenesis Source: RGD
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • positive regulation of fever generation Source: RGD
  • positive regulation of gene expression Source: RGD
  • positive regulation of inflammatory response Source: RGD
  • positive regulation of interleukin-1 beta secretion Source: RGD
  • positive regulation of interleukin-6 production Source: RGD
  • positive regulation of neuron differentiation Source: RGD
  • positive regulation of tumor necrosis factor production Source: RGD
  • response to ionizing radiation Source: RGD
  • response to lipopolysaccharide Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 5
Short name:
C-C CKR-5
Short name:
CC-CKR-5
Short name:
CCR-5
Alternative name(s):
MIP-1 alpha receptor
CD_antigen: CD195
Gene namesi
Name:Ccr5
Synonyms:Cmkbr5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620596. Ccr5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32ExtracellularSequence analysisAdd BLAST32
Transmembranei33 – 60Helical; Name=1Sequence analysisAdd BLAST28
Topological domaini61 – 70CytoplasmicSequence analysis10
Transmembranei71 – 91Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini92 – 104ExtracellularSequence analysisAdd BLAST13
Transmembranei105 – 126Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini127 – 143CytoplasmicSequence analysisAdd BLAST17
Transmembranei144 – 168Helical; Name=4Sequence analysisAdd BLAST25
Topological domaini169 – 200ExtracellularSequence analysisAdd BLAST32
Transmembranei201 – 220Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini221 – 237CytoplasmicSequence analysisAdd BLAST17
Transmembranei238 – 262Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini263 – 279ExtracellularSequence analysisAdd BLAST17
Transmembranei280 – 303Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini304 – 354CytoplasmicSequence analysisAdd BLAST51

GO - Cellular componenti

  • cell surface Source: RGD
  • cytoplasm Source: RGD
  • endosome Source: RGD
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1795146.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000692801 – 354C-C chemokine receptor type 5Add BLAST354

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6O-linked (GalNAc...)By similarity1
Modified residuei10SulfotyrosineSequence analysis1
Modified residuei16SulfotyrosineSequence analysis1
Glycosylationi19O-linked (GalNAc...)Sequence analysis1
Disulfide bondi103 ↔ 180PROSITE-ProRule annotation
Lipidationi323S-palmitoyl cysteineBy similarity1
Lipidationi326S-palmitoyl cysteineBy similarity1
Modified residuei338Phosphoserine; by BARK1By similarity1
Modified residuei339Phosphoserine; by BARK1By similarity1
Modified residuei344Phosphoserine; by BARK1By similarity1
Modified residuei351Phosphoserine; by BARK1By similarity1

Post-translational modificationi

Sulfated on at least 2 of the N-terminal tyrosines. Sulfation is required for efficient binding of the chemokines, CCL3 and CCL4 (By similarity).By similarity
O-glycosylated, but not N-glycosylated. Ser-6 appears to be the major site. Also sialylated glycans present which contribute to chemokine binding. Ser-17 may also be glycosylated and, if so, with small moieties such as a T-antigen (By similarity).By similarity
Palmitoylation in the C-terminal is important for cell surface expression.By similarity
Phosphorylation on serine residues in the C-terminal is stimulated by binding CC chemokines especially by APO-RANTES.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein, Sulfation

Proteomic databases

PaxDbiO08556.

PTM databases

iPTMnetiO08556.
PhosphoSitePlusiO08556.
SwissPalmiO08556.

Interactioni

Subunit structurei

Interacts with PRAF2. Efficient ligand binding to CCL3/MIP-1alpha and CCL4/MIP-1beta requires sulfation, O-glycosylation and sialic acid modifications. Glycosylation on Ser-6 is required for efficient binding of CCL4. Interacts with GRK2. Interacts with ARRB1 and ARRB2. Interacts with CNIH4.By similarity

GO - Molecular functioni

  • chemokine (C-C motif) ligand 5 binding Source: RGD
  • protein kinase binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066146.

Chemistry databases

BindingDBiO08556.

Structurei

3D structure databases

ProteinModelPortaliO08556.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiO08556.
KOiK04180.
PhylomeDBiO08556.

Family and domain databases

InterProiIPR002240. Chemokine_CCR5.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01110. CHEMOKINER5.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08556-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFQGSIPTY IYDIDYSMSA PCQKVNVKQI AAQLLPPLYS LVFIFGFVGN
60 70 80 90 100
MMVFLILISC KKLKSMTDIY LFNLAISDLL FLLTLPFWAH YAANEWVFGN
110 120 130 140 150
IMCKLFTGIY HIGYFGGIFF IILLTIDRYL AIVHAVFAIK ARTVNFGVIT
160 170 180 190 200
SVVTWVVAVF VSLPEIIFMR SQKEGSHYTC SPHFLHIQYR FWKHFQTLKM
210 220 230 240 250
VILSLILPLL VMVICYSGIL NTLFRCRNEK KRHRAVRLIF AIMIVYFLFW
260 270 280 290 300
TPYNIVLLLT TFQEYFGLNN CSSSNRLDQA MQVTETLGMT HCCLNPVIYA
310 320 330 340 350
FVGEKFRNYL SVFFRKHIVK RFCKHCSIFQ QVNPDRVSSV YTRSTGEQEV

STGL
Length:354
Mass (Da):41,031
Last modified:July 1, 1997 - v1
Checksum:i77EDB368AA4C868D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12009 mRNA. Translation: CAA72737.1.
U77350 Genomic DNA. Translation: AAC03243.1.
RefSeqiNP_446412.2. NM_053960.3.
UniGeneiRn.10736.

Genome annotation databases

GeneIDi117029.
KEGGirno:117029.
UCSCiRGD:620596. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12009 mRNA. Translation: CAA72737.1.
U77350 Genomic DNA. Translation: AAC03243.1.
RefSeqiNP_446412.2. NM_053960.3.
UniGeneiRn.10736.

3D structure databases

ProteinModelPortaliO08556.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066146.

Chemistry databases

BindingDBiO08556.
ChEMBLiCHEMBL1795146.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO08556.
PhosphoSitePlusiO08556.
SwissPalmiO08556.

Proteomic databases

PaxDbiO08556.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi117029.
KEGGirno:117029.
UCSCiRGD:620596. rat.

Organism-specific databases

CTDi1234.
RGDi620596. Ccr5.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiO08556.
KOiK04180.
PhylomeDBiO08556.

Miscellaneous databases

PROiO08556.

Family and domain databases

InterProiIPR002240. Chemokine_CCR5.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01110. CHEMOKINER5.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCR5_RAT
AccessioniPrimary (citable) accession number: O08556
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: November 2, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.