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O08556

- CCR5_RAT

UniProt

O08556 - CCR5_RAT

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Protein

C-C chemokine receptor type 5

Gene

Ccr5

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity).By similarity

GO - Molecular functioni

  1. C-C chemokine receptor activity Source: RGD
  2. chemokine (C-C motif) ligand 5 binding Source: RGD
  3. protein kinase binding Source: RGD

GO - Biological processi

  1. aging Source: RGD
  2. chemokine-mediated signaling pathway Source: GOC
  3. chemotaxis Source: InterPro
  4. defense response to bacterium Source: RGD
  5. fat cell differentiation Source: RGD
  6. forebrain development Source: RGD
  7. inflammatory response Source: RGD
  8. inflammatory response to antigenic stimulus Source: RGD
  9. leukocyte migration Source: RGD
  10. negative regulation of axon extension Source: RGD
  11. negative regulation of cell migration Source: RGD
  12. negative regulation of neural precursor cell proliferation Source: RGD
  13. neuron death Source: RGD
  14. positive regulation of apoptotic process by virus Source: RGD
  15. positive regulation of cell-cell adhesion Source: RGD
  16. positive regulation of cell migration involved in sprouting angiogenesis Source: RGD
  17. positive regulation of cytosolic calcium ion concentration Source: RGD
  18. positive regulation of fever generation Source: RGD
  19. positive regulation of gene expression Source: RGD
  20. positive regulation of inflammatory response Source: RGD
  21. positive regulation of interleukin-1 beta secretion Source: RGD
  22. positive regulation of interleukin-6 production Source: RGD
  23. positive regulation of neuron differentiation Source: RGD
  24. positive regulation of tumor necrosis factor production Source: RGD
  25. response to ionizing radiation Source: RGD
  26. response to lipopolysaccharide Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 5
Short name:
C-C CKR-5
Short name:
CC-CKR-5
Short name:
CCR-5
Alternative name(s):
MIP-1 alpha receptor
CD_antigen: CD195
Gene namesi
Name:Ccr5
Synonyms:Cmkbr5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi620596. Ccr5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232ExtracellularSequence AnalysisAdd
BLAST
Transmembranei33 – 6028Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini61 – 7010CytoplasmicSequence Analysis
Transmembranei71 – 9121Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini92 – 10413ExtracellularSequence AnalysisAdd
BLAST
Transmembranei105 – 12622Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini127 – 14317CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei144 – 16825Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini169 – 20032ExtracellularSequence AnalysisAdd
BLAST
Transmembranei201 – 22020Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini221 – 23717CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei238 – 26225Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini263 – 27917ExtracellularSequence AnalysisAdd
BLAST
Transmembranei280 – 30324Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini304 – 35451CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: RGD
  2. cytoplasm Source: RGD
  3. endosome Source: RGD
  4. integral component of membrane Source: UniProtKB-KW
  5. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354C-C chemokine receptor type 5PRO_0000069280Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61O-linked (GalNAc...)By similarity
Modified residuei10 – 101SulfotyrosineSequence Analysis
Modified residuei16 – 161SulfotyrosineSequence Analysis
Glycosylationi19 – 191O-linked (GalNAc...)Sequence Analysis
Disulfide bondi103 ↔ 180PROSITE-ProRule annotation
Lipidationi323 – 3231S-palmitoyl cysteineBy similarity
Lipidationi326 – 3261S-palmitoyl cysteineBy similarity
Modified residuei338 – 3381Phosphoserine; by BARK1By similarity
Modified residuei339 – 3391Phosphoserine; by BARK1By similarity
Modified residuei344 – 3441Phosphoserine; by BARK1By similarity
Modified residuei351 – 3511Phosphoserine; by BARK1By similarity

Post-translational modificationi

Sulfated on at least 2 of the N-terminal tyrosines. Sulfation is required for efficient binding of the chemokines, CCL3 and CCL4 (By similarity).By similarity
O-glycosylated, but not N-glycosylated. Ser-6 appears to be the major site. Also sialylated glycans present which contribute to chemokine binding. Ser-17 may also be glycosylated and, if so, with small moieties such as a T-antigen (By similarity).By similarity
Palmitoylation in the C-terminal is important for cell surface expression.By similarity
Phosphorylation on serine residues in the C-terminal is stimulated by binding CC chemokines especially by APO-RANTES.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein, Sulfation

PTM databases

PhosphoSiteiO08556.

Expressioni

Gene expression databases

GenevestigatoriO08556.

Interactioni

Subunit structurei

Interacts with PRAF2. Efficient ligand binding to CCL3/MIP-1alpha and CCL4/MIP-1beta requires sulfation, O-glycosylation and sialic acid modifications. Glycosylation on Ser-6 is required for efficient binding of CCL4. Interacts with ADRBK1. Interacts with ARRB1 and ARRB2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008871.

Structurei

3D structure databases

ProteinModelPortaliO08556.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148353.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiO08556.
KOiK04180.
PhylomeDBiO08556.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR002240. Chemokine_CCR5.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01110. CHEMOKINER5.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08556-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDFQGSIPTY IYDIDYSMSA PCQKVNVKQI AAQLLPPLYS LVFIFGFVGN
60 70 80 90 100
MMVFLILISC KKLKSMTDIY LFNLAISDLL FLLTLPFWAH YAANEWVFGN
110 120 130 140 150
IMCKLFTGIY HIGYFGGIFF IILLTIDRYL AIVHAVFAIK ARTVNFGVIT
160 170 180 190 200
SVVTWVVAVF VSLPEIIFMR SQKEGSHYTC SPHFLHIQYR FWKHFQTLKM
210 220 230 240 250
VILSLILPLL VMVICYSGIL NTLFRCRNEK KRHRAVRLIF AIMIVYFLFW
260 270 280 290 300
TPYNIVLLLT TFQEYFGLNN CSSSNRLDQA MQVTETLGMT HCCLNPVIYA
310 320 330 340 350
FVGEKFRNYL SVFFRKHIVK RFCKHCSIFQ QVNPDRVSSV YTRSTGEQEV

STGL
Length:354
Mass (Da):41,031
Last modified:July 1, 1997 - v1
Checksum:i77EDB368AA4C868D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12009 mRNA. Translation: CAA72737.1.
U77350 Genomic DNA. Translation: AAC03243.1.
RefSeqiNP_446412.2. NM_053960.3.
UniGeneiRn.10736.

Genome annotation databases

GeneIDi117029.
KEGGirno:117029.
UCSCiRGD:620596. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12009 mRNA. Translation: CAA72737.1 .
U77350 Genomic DNA. Translation: AAC03243.1 .
RefSeqi NP_446412.2. NM_053960.3.
UniGenei Rn.10736.

3D structure databases

ProteinModelPortali O08556.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000008871.

Chemistry

BindingDBi O08556.
ChEMBLi CHEMBL1795146.
GuidetoPHARMACOLOGYi 62.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei O08556.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 117029.
KEGGi rno:117029.
UCSCi RGD:620596. rat.

Organism-specific databases

CTDi 1234.
RGDi 620596. Ccr5.

Phylogenomic databases

eggNOGi NOG148353.
HOGENOMi HOG000234122.
HOVERGENi HBG106917.
InParanoidi O08556.
KOi K04180.
PhylomeDBi O08556.

Miscellaneous databases

NextBioi 619809.
PROi O08556.

Gene expression databases

Genevestigatori O08556.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR002240. Chemokine_CCR5.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24227. PTHR24227. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00657. CCCHEMOKINER.
PR01110. CHEMOKINER5.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of rat HIV-1-chemokine coreceptor CKR5 from microglia and upregulation of its mRNA in ischemic and endotoxinemic rat brain."
    Spleiss O., Gourmala N., Boddeke H.W.G.M., Sauter A., Fiebich B.L., Berger M., Gebicke-Haerter P.J.
    J. Neurosci. Res. 53:16-28(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Brain.
  2. "Chemokine receptor expression in cultured glia and rat experimental allergic encephalomyelitis."
    Jiang Y., Salafranca M.N., Adhikari S., Xia Y., Feng L., Sonntag M.K., deFiebre C.M., Pennell N.A., Streit W.J., Harrison J.K.
    J. Neuroimmunol. 86:1-12(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiCCR5_RAT
AccessioniPrimary (citable) accession number: O08556
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: October 29, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3