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Protein

Ephrin-A3

Gene

Efna3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.1 Publication

GO - Molecular functioni

  • ephrin receptor binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-2682334. EPH-Ephrin signaling.
R-MMU-3928663. EPHA-mediated growth cone collapse.
R-MMU-3928665. EPH-ephrin mediated repulsion of cells.

Names & Taxonomyi

Protein namesi
Recommended name:
Ephrin-A3
Alternative name(s):
EHK1 ligand
Short name:
EHK1-L
EPH-related receptor tyrosine kinase ligand 3
Short name:
LERK-3
Gene namesi
Name:Efna3
Synonyms:Epl3, Eplg3, Lerk3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:106644. Efna3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000837123 – 206Ephrin-A3Add BLAST184
PropeptideiPRO_0000008372207 – 230Removed in mature formSequence analysisAdd BLAST24

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...)1 Publication1
Disulfide bondi63 ↔ 102PROSITE-ProRule annotation
Glycosylationi67N-linked (GlcNAc...)Sequence analysis1
Glycosylationi84N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi91 ↔ 150PROSITE-ProRule annotation
Glycosylationi92N-linked (GlcNAc...)Sequence analysis1
Lipidationi206GPI-anchor amidated glycineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiO08545.
PaxDbiO08545.
PRIDEiO08545.

PTM databases

iPTMnetiO08545.
PhosphoSitePlusiO08545.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028039.
CleanExiMM_EFNA3.
ExpressionAtlasiO08545. baseline and differential.
GenevisibleiO08545. MM.

Interactioni

Subunit structurei

Interacts with EPHA8; activates EPHA8.1 Publication

GO - Molecular functioni

  • ephrin receptor binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029673.

Structurei

3D structure databases

ProteinModelPortaliO08545.
SMRiO08545.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 161Ephrin RBDPROSITE-ProRule annotationAdd BLAST132

Sequence similaritiesi

Belongs to the ephrin family.PROSITE-ProRule annotation
Contains 1 ephrin RBD (ephrin receptor-binding) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3858. Eukaryota.
ENOG4111FMJ. LUCA.
GeneTreeiENSGT00390000015107.
HOGENOMiHOG000234373.
HOVERGENiHBG051447.
InParanoidiO08545.
KOiK05462.
OMAiQGSKRWE.
OrthoDBiEOG091G0XCP.
PhylomeDBiO08545.

Family and domain databases

Gene3Di2.60.40.420. 1 hit.
InterProiIPR008972. Cupredoxin.
IPR031328. Ephrin.
IPR019765. Ephrin_CS.
IPR001799. Ephrin_RBD.
[Graphical view]
PANTHERiPTHR11304. PTHR11304. 1 hit.
PfamiPF00812. Ephrin. 1 hit.
[Graphical view]
PRINTSiPR01347. EPHRIN.
ProDomiPD002533. Ephrin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF49503. SSF49503. 1 hit.
PROSITEiPS01299. EPHRIN_RBD_1. 1 hit.
PS51551. EPHRIN_RBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O08545-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAPLLLLL LLVPVPLLPL LAQGPGGALG NRHAVYWNSS NQHLRREGYT
60 70 80 90 100
VQVNVNDYLD IYCPHYNSSG PGGGAEQYVL YMVNLSGYRT CNASQGSKRW
110 120 130 140 150
ECNRQHASHS PIKFSEKFQR YSAFSLGYEF HAGQEYYYIS TPTHNLHWKC
160 170 180 190 200
LRMKVFVCCA STSHSGEKPV PTLPQFTMGP NVKINVLEDF EGENPQVPKL
210 220 230
EKSISGTSPK REHLPLAVGI AFFLMTLLAS
Length:230
Mass (Da):25,632
Last modified:January 9, 2007 - v4
Checksum:iC08AAA0D84B0D795
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti62Y → I in AAB50241 (PubMed:8903354).Curated1
Sequence conflicti76 – 77EQ → DR in AAB50241 (PubMed:8903354).Curated2
Sequence conflicti89 – 90RT → QP in AAB50241 (PubMed:8903354).Curated2
Sequence conflicti121Y → W in AAB50241 (PubMed:8903354).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC107002 mRNA. Translation: AAI07003.1.
BC125003 mRNA. Translation: AAI25004.1.
U92885 Genomic DNA. Translation: AAC39961.1.
U90666 mRNA. Translation: AAB50241.1.
CCDSiCCDS38488.1.
RefSeqiNP_034238.1. NM_010108.1.
UniGeneiMm.331159.

Genome annotation databases

EnsembliENSMUST00000029673; ENSMUSP00000029673; ENSMUSG00000028039.
GeneIDi13638.
KEGGimmu:13638.
UCSCiuc008pyq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC107002 mRNA. Translation: AAI07003.1.
BC125003 mRNA. Translation: AAI25004.1.
U92885 Genomic DNA. Translation: AAC39961.1.
U90666 mRNA. Translation: AAB50241.1.
CCDSiCCDS38488.1.
RefSeqiNP_034238.1. NM_010108.1.
UniGeneiMm.331159.

3D structure databases

ProteinModelPortaliO08545.
SMRiO08545.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029673.

PTM databases

iPTMnetiO08545.
PhosphoSitePlusiO08545.

Proteomic databases

MaxQBiO08545.
PaxDbiO08545.
PRIDEiO08545.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029673; ENSMUSP00000029673; ENSMUSG00000028039.
GeneIDi13638.
KEGGimmu:13638.
UCSCiuc008pyq.1. mouse.

Organism-specific databases

CTDi1944.
MGIiMGI:106644. Efna3.

Phylogenomic databases

eggNOGiKOG3858. Eukaryota.
ENOG4111FMJ. LUCA.
GeneTreeiENSGT00390000015107.
HOGENOMiHOG000234373.
HOVERGENiHBG051447.
InParanoidiO08545.
KOiK05462.
OMAiQGSKRWE.
OrthoDBiEOG091G0XCP.
PhylomeDBiO08545.

Enzyme and pathway databases

ReactomeiR-MMU-2682334. EPH-Ephrin signaling.
R-MMU-3928663. EPHA-mediated growth cone collapse.
R-MMU-3928665. EPH-ephrin mediated repulsion of cells.

Miscellaneous databases

PROiO08545.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028039.
CleanExiMM_EFNA3.
ExpressionAtlasiO08545. baseline and differential.
GenevisibleiO08545. MM.

Family and domain databases

Gene3Di2.60.40.420. 1 hit.
InterProiIPR008972. Cupredoxin.
IPR031328. Ephrin.
IPR019765. Ephrin_CS.
IPR001799. Ephrin_RBD.
[Graphical view]
PANTHERiPTHR11304. PTHR11304. 1 hit.
PfamiPF00812. Ephrin. 1 hit.
[Graphical view]
PRINTSiPR01347. EPHRIN.
ProDomiPD002533. Ephrin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF49503. SSF49503. 1 hit.
PROSITEiPS01299. EPHRIN_RBD_1. 1 hit.
PS51551. EPHRIN_RBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEFNA3_MOUSE
AccessioniPrimary (citable) accession number: O08545
Secondary accession number(s): O55217, Q08AV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 9, 2007
Last modified: November 2, 2016
This is version 120 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.