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O08545

- EFNA3_MOUSE

UniProt

O08545 - EFNA3_MOUSE

Protein

Ephrin-A3

Gene

Efna3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 4 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.1 Publication

    GO - Molecular functioni

    1. ephrin receptor binding Source: UniProtKB

    GO - Biological processi

    1. axon guidance Source: RefGenome
    2. ephrin receptor signaling pathway Source: UniProtKB
    3. regulation of neuron differentiation Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ephrin-A3
    Alternative name(s):
    EHK1 ligand
    Short name:
    EHK1-L
    EPH-related receptor tyrosine kinase ligand 3
    Short name:
    LERK-3
    Gene namesi
    Name:Efna3
    Synonyms:Epl3, Eplg3, Lerk3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:106644. Efna3.

    Subcellular locationi

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: RefGenome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 206184Ephrin-A3PRO_0000008371Add
    BLAST
    Propeptidei207 – 23024Removed in mature formSequence AnalysisPRO_0000008372Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi38 – 381N-linked (GlcNAc...)1 Publication
    Disulfide bondi63 ↔ 102PROSITE-ProRule annotation
    Glycosylationi67 – 671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi84 – 841N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi91 ↔ 150PROSITE-ProRule annotation
    Glycosylationi92 – 921N-linked (GlcNAc...)Sequence Analysis
    Lipidationi206 – 2061GPI-anchor amidated glycineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    PRIDEiO08545.

    Expressioni

    Gene expression databases

    ArrayExpressiO08545.
    BgeeiO08545.
    CleanExiMM_EFNA3.
    GenevestigatoriO08545.

    Interactioni

    Subunit structurei

    Interacts with EPHA8; activates EPHA8.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliO08545.
    SMRiO08545. Positions 31-157.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 161132Ephrin RBDPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ephrin family.PROSITE-ProRule annotation
    Contains 1 ephrin RBD (ephrin receptor-binding) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG295575.
    GeneTreeiENSGT00390000015107.
    HOGENOMiHOG000234373.
    HOVERGENiHBG051447.
    InParanoidiO08545.
    KOiK05462.
    OMAiGPHVKIN.
    OrthoDBiEOG70W3FD.
    PhylomeDBiO08545.

    Family and domain databases

    Gene3Di2.60.40.420. 1 hit.
    InterProiIPR008972. Cupredoxin.
    IPR001799. Ephrin.
    IPR019765. Ephrin_CS.
    [Graphical view]
    PANTHERiPTHR11304. PTHR11304. 1 hit.
    PfamiPF00812. Ephrin. 1 hit.
    [Graphical view]
    PRINTSiPR01347. EPHRIN.
    ProDomiPD002533. Ephrin. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF49503. SSF49503. 1 hit.
    PROSITEiPS01299. EPHRIN_RBD_1. 1 hit.
    PS51551. EPHRIN_RBD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O08545-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAAPLLLLL LLVPVPLLPL LAQGPGGALG NRHAVYWNSS NQHLRREGYT    50
    VQVNVNDYLD IYCPHYNSSG PGGGAEQYVL YMVNLSGYRT CNASQGSKRW 100
    ECNRQHASHS PIKFSEKFQR YSAFSLGYEF HAGQEYYYIS TPTHNLHWKC 150
    LRMKVFVCCA STSHSGEKPV PTLPQFTMGP NVKINVLEDF EGENPQVPKL 200
    EKSISGTSPK REHLPLAVGI AFFLMTLLAS 230
    Length:230
    Mass (Da):25,632
    Last modified:January 9, 2007 - v4
    Checksum:iC08AAA0D84B0D795
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti62 – 621Y → I in AAB50241. (PubMed:8903354)Curated
    Sequence conflicti76 – 772EQ → DR in AAB50241. (PubMed:8903354)Curated
    Sequence conflicti89 – 902RT → QP in AAB50241. (PubMed:8903354)Curated
    Sequence conflicti121 – 1211Y → W in AAB50241. (PubMed:8903354)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC107002 mRNA. Translation: AAI07003.1.
    BC125003 mRNA. Translation: AAI25004.1.
    U92885 Genomic DNA. Translation: AAC39961.1.
    U90666 mRNA. Translation: AAB50241.1.
    CCDSiCCDS38488.1.
    RefSeqiNP_034238.1. NM_010108.1.
    UniGeneiMm.331159.

    Genome annotation databases

    EnsembliENSMUST00000029673; ENSMUSP00000029673; ENSMUSG00000028039.
    GeneIDi13638.
    KEGGimmu:13638.
    UCSCiuc008pyq.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC107002 mRNA. Translation: AAI07003.1 .
    BC125003 mRNA. Translation: AAI25004.1 .
    U92885 Genomic DNA. Translation: AAC39961.1 .
    U90666 mRNA. Translation: AAB50241.1 .
    CCDSi CCDS38488.1.
    RefSeqi NP_034238.1. NM_010108.1.
    UniGenei Mm.331159.

    3D structure databases

    ProteinModelPortali O08545.
    SMRi O08545. Positions 31-157.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi O08545.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029673 ; ENSMUSP00000029673 ; ENSMUSG00000028039 .
    GeneIDi 13638.
    KEGGi mmu:13638.
    UCSCi uc008pyq.1. mouse.

    Organism-specific databases

    CTDi 1944.
    MGIi MGI:106644. Efna3.

    Phylogenomic databases

    eggNOGi NOG295575.
    GeneTreei ENSGT00390000015107.
    HOGENOMi HOG000234373.
    HOVERGENi HBG051447.
    InParanoidi O08545.
    KOi K05462.
    OMAi GPHVKIN.
    OrthoDBi EOG70W3FD.
    PhylomeDBi O08545.

    Miscellaneous databases

    NextBioi 284328.
    PROi O08545.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O08545.
    Bgeei O08545.
    CleanExi MM_EFNA3.
    Genevestigatori O08545.

    Family and domain databases

    Gene3Di 2.60.40.420. 1 hit.
    InterProi IPR008972. Cupredoxin.
    IPR001799. Ephrin.
    IPR019765. Ephrin_CS.
    [Graphical view ]
    PANTHERi PTHR11304. PTHR11304. 1 hit.
    Pfami PF00812. Ephrin. 1 hit.
    [Graphical view ]
    PRINTSi PR01347. EPHRIN.
    ProDomi PD002533. Ephrin. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF49503. SSF49503. 1 hit.
    PROSITEi PS01299. EPHRIN_RBD_1. 1 hit.
    PS51551. EPHRIN_RBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "Characterization of the genes for mouse LERK-3/Ephrin-A3 (Epl3), mouse LERK-4/Ephrin-A4 (Epl4), and human LERK-6/Ephrin-A2 (EPLG6): conservation of intron/exon structure."
      Cerretti D.P., Nelson N.
      Genomics 47:131-135(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 44-230.
      Strain: 129.
    3. "Distinct and overlapping expression patterns of ligands for Eph-related receptor tyrosine kinases during mouse embryogenesis."
      Flenniken A.M., Gale N.W., Yancopoulos G.D., Wilkinson D.G.
      Dev. Biol. 179:382-401(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 60-121.
    4. "The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands."
      Park S., Sanchez M.P.
      Oncogene 14:533-542(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN EPHA8 ACTIVATION, INTERACTION WITH EPHA8.
    5. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-38.

    Entry informationi

    Entry nameiEFNA3_MOUSE
    AccessioniPrimary (citable) accession number: O08545
    Secondary accession number(s): O55217, Q08AV0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 104 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3