Reviewed,
UniProtKB/Swiss-Prot O08538 (ANGP1_MOUSE)
Last modified
June 16, 2009.
Version 65.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Angiopoietin-1 Short name=ANG-1 | ||||
| Gene names |
| ||||
| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 498 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development. |
| Subcellular location | |
| Developmental stage | Early in development, at E9 to E11, it is found most prominently in the heart myocardium surrounding the endocardium. Later, it becomes more widely distributed, most often in the mesenchyme surrounding developing vessels, in close association with endothelial cells. |
| Sequence similarities | Contains 1 fibrinogen C-terminal domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Angiogenesis Differentiation |
| Cellular component | Secreted |
| Domain | Coiled coil Signal |
| Molecular function | Developmental protein |
| PTM | Disulfide bond Glycoprotein |
| Gene Ontology (GO) | |
| Biological process | angiogenesis Inferred from electronic annotation. Source: UniProtKB-KW cell differentiationInferred from electronic annotation. Source: UniProtKB-KW endoderm developmentTraceable author statement. Source: MGI transmembrane receptor protein tyrosine kinase signaling pathwayInferred from direct assay. Source: MGI |
| Cellular component | extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | vascular endothelial growth factor receptor binding Traceable author statement. Source: MGI |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 19 | 19 | Potential | ||||||||
| Chain | 20 – 498 | 479 | Angiopoietin-1 | PRO_0000009111 | |||||||
Regions | |||||||||||
| Domain | 277 – 497 | 221 | Fibrinogen C-terminal | ||||||||
| Coiled coil | 81 – 119 | 39 | Potential | ||||||||
| Coiled coil | 153 – 261 | 109 | Potential | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 92 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 122 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 154 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 243 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 295 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 286 ↔ 315 | By similarity | |||||||||
| Disulfide bond | 439 ↔ 452 | By similarity | |||||||||
Sequences
| ||||||||||||||||||
References
| [1] | "Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning." Davis S., Aldrich T.H., Jones P.F., Acheson A., Compton D.L., Jain V., Ryan T.E., Bruno J., Radziejewski C., Maisonpierre P.C., Yancopoulos G.D. Cell 87:1161-1169(1996) [PubMed: 8980223] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U83509 mRNA. Translation: AAB50558.1. | |
| IPI | IPI00114350. |
| UniGene | Mm.309336 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1FZD based on UniProtKB P02671. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:6051N. |
PTM databases | |
| PhosphoSite | O08538. |
Proteomic databases | |
| PRIDE | O08538. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000022309. Mus musculus. [Contig view] |
Organism-specific databases | |
| MGI | MGI:108448. Angpt1. |
Phylogenomic databases | |
| HOVERGEN | O08538. |
Gene expression databases | |
| ArrayExpress | O08538. |
| Bgee | O08538. |
| CleanEx | MM_ANGPT1. |
| GermOnline | ENSMUSG00000022309. Mus musculus. |
Family and domain databases | |
| InterPro | IPR002181. Fibrinogen_a/b/g_C. IPR014716. Fibrinogen_a/b/g_C_1. [Graphical view] |
| Gene3D | G3DSA:3.90.215.10. Fibrinogen_a/b/g_C_1. 1 hit. |
| Pfam | PF00147. Fibrinogen_C. 1 hit. [Graphical view] |
| SMART | SM00186. FBG. 1 hit. [Graphical view] |
| PROSITE | PS00514. FIBRINOGEN_C_1. 1 hit. PS51406. FIBRINOGEN_C_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| SOURCE | Search... |
Entry information
| Entry name | ANGP1_MOUSE | ||||||||
| Accession | Primary (citable) accession number: O08538 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


