Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O08537

- ESR2_MOUSE

UniProt

O08537 - ESR2_MOUSE

Protein

Estrogen receptor beta

Gene

Esr2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 145 (01 Oct 2014)
      Sequence version 3 (21 Mar 2012)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1 (ER-alpha), and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. May play a role in ovarian follicular growth and maturation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi149 – 21466Nuclear receptorPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri149 – 16921NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri185 – 20925NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. core promoter sequence-specific DNA binding Source: Ensembl
    2. DNA binding Source: MGI
    3. estrogen receptor activity Source: InterPro
    4. estrogen response element binding Source: Ensembl
    5. protein binding Source: IntAct
    6. sequence-specific DNA binding transcription factor activity Source: InterPro
    7. steroid binding Source: UniProtKB
    8. zinc ion binding Source: InterPro

    GO - Biological processi

    1. brain development Source: MGI
    2. epithelial cell maturation involved in prostate gland development Source: MGI
    3. hormone-mediated apoptotic signaling pathway Source: MGI
    4. intracellular estrogen receptor signaling pathway Source: MGI
    5. negative regulation of androgen receptor signaling pathway Source: MGI
    6. negative regulation of cell proliferation Source: MGI
    7. negative regulation of epithelial cell proliferation Source: MGI
    8. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    9. neuron migration Source: MGI
    10. ovarian follicle development Source: MGI
    11. positive regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
    12. prostate gland epithelium morphogenesis Source: MGI
    13. regulation of cell proliferation Source: MGI
    14. transcription, DNA-templated Source: UniProtKB-KW
    15. uterus development Source: MGI
    16. vagina development Source: MGI

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Lipid-binding, Metal-binding, Steroid-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Estrogen receptor beta
    Short name:
    ER-beta
    Alternative name(s):
    Nuclear receptor subfamily 3 group A member 2
    Gene namesi
    Name:Esr2
    Synonyms:Estrb, Nr3a2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:109392. Esr2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. mitochondrion Source: Ensembl
    3. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi105 – 1051S → A: Abolishes stimulatory effect of Ras. 1 Publication
    Mutagenesisi139 – 1391S → A: No loss of the stimulatory effect of Ras. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 530530Estrogen receptor betaPRO_0000053644Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei61 – 611Phosphoserine; alternate1 Publication
    Glycosylationi61 – 611O-linked (GlcNAc); alternate1 PublicationCAR_000201
    Modified residuei87 – 871Phosphoserine; by MAPK1 Publication
    Modified residuei105 – 1051Phosphoserine; by MAPK1 Publication

    Post-translational modificationi

    Phosphorylation at Ser-87 and Ser-105 recruits NCOA1.2 Publications

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PRIDEiO08537.

    PTM databases

    PhosphoSiteiO08537.
    UniCarbKBiO08537.

    Expressioni

    Tissue specificityi

    Expressed in prostate, ovary, Leydig cells and in epithelium of the efferent ductules and of the initial segment of the epididymis.1 Publication

    Inductioni

    Isoforms 1 and 2 are down-regulated by 17-beta-estradiol.1 Publication

    Gene expression databases

    ArrayExpressiO08537.
    BgeeiO08537.
    CleanExiMM_ESR2.
    GenevestigatoriO08537.

    Interactioni

    Subunit structurei

    Binds DNA as a homodimer. Can form a heterodimer with ESR1. Interacts with NCOA1, NCOA3, NCOA5 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with PELP1, UBE1C and AKAP13. Interacts with DNTTIP2 By similarity. Interacts with CCDC62 in the presence of estradiol/E2; this interaction seems to enhance the transcription of target genes. Interacts with DYX1C1. Interacts with PRMT2 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    FosP011012EBI-2526214,EBI-4288185

    Protein-protein interaction databases

    IntActiO08537. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliO08537.
    SMRiO08537. Positions 147-498.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 148148ModulatingAdd
    BLAST
    Regioni215 – 530316Steroid-bindingAdd
    BLAST

    Domaini

    Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

    Sequence similaritiesi

    Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri149 – 16921NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri185 – 20925NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG271979.
    GeneTreeiENSGT00730000110346.
    HOGENOMiHOG000233468.
    HOVERGENiHBG108344.
    KOiK08551.
    OrthoDBiEOG7288S1.
    TreeFamiTF323751.

    Family and domain databases

    Gene3Di1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProiIPR028355. ER-beta/gamma.
    IPR021064. Estrogen_rcpt_beta_N.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR024178. Oest_rcpt/oest-rel_rcp.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF12497. ERbeta_N. 1 hit.
    PF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view]
    PIRSFiPIRSF500102. ER-b. 1 hit.
    PIRSF002527. ER-like_NR. 1 hit.
    PRINTSiPR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTiSM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 2 hits.
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform 1 (identifier: O08537-1) [UniParc]FASTAAdd to Basket

    Also known as: Beta-1

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEIKNSPSSL TSPASYNCSQ SILPLEHGPI YIPSSYVESR HEYSAMTFYS    50
    PAVMNYSVPS STGNLEGGPV RQTASPNVLW PTSGHLSPLA THCQSSLLYA 100
    EPQKSPWCEA RSLEHTLPVN RETLKRKLGG SGCASPVTSP SAKRDAHFCA 150
    VCSDYASGYH YGVWSCEGCK AFFKRSIQGH NDYICPATNQ CTIDKNRRKS 200
    CQACRLRKCY EVGMVKCGSR RERCGYRIVR RQRSASEQVH CLNKAKRTSG 250
    HTPRVKELLL NSLSPEQLVL TLLEAEPPNV LVSRPSMPFT EASMMMSLTK 300
    LADKELVHMI GWAKKIPGFV ELSLLDQVRL LESCWMEVLM VGLMWRSIDH 350
    PGKLIFAPDL VLDRDEGKCV EGILEIFDML LATTARFREL KLQHKEYLCV 400
    KAMILLNSSM YPLATASQEA ESSRKLTHLL NAVTDALVWV ISKSGISSQQ 450
    QSVRLANLLM LLSHVRHISN KGMEHLLSMK CKNVVPVYDL LLEMLNAHTL 500
    RGYKSSISGS ECCSTEDSKS KEGSQNLQSQ 530
    Length:530
    Mass (Da):59,070
    Last modified:March 21, 2012 - v3
    Checksum:iBEFA25F62650A8D4
    GO
    Isoform 2 (identifier: O08537-2) [UniParc]FASTAAdd to Basket

    Also known as: Beta-2

    The sequence of this isoform differs from the canonical sequence as follows:
         364-364: R → RSSEDPHWHVAQTKSAVPR

    Show »
    Length:548
    Mass (Da):61,084
    Checksum:i5A3BFF5FCD158E7C
    GO
    Isoform 3 (identifier: O08537-4) [UniParc]FASTAAdd to Basket

    Also known as: Beta-5A

    The sequence of this isoform differs from the canonical sequence as follows:
         319-409: Missing.

    Note: Corresponds to exons 5 and 6 deletion.1 Publication

    Show »
    Length:439
    Mass (Da):48,550
    Checksum:iFCA85E5235E368D2
    GO
    Isoform 4 (identifier: O08537-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         319-343: FVELSLLDQVRLLESCWMEVLMVGL → MRGSAWKGFWKSLTCSWRRRHGSVS
         344-530: Missing.

    Note: Corresponds to exon 5 deletion (PubMed:9685228). May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.1 Publication

    Show »
    Length:343
    Mass (Da):38,185
    Checksum:i0073C2E153F493D3
    GO
    Isoform 5 (identifier: O08537-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         365-377: DEGKCVEGILEIF → YVPLGYRKPGSRE
         378-530: Missing.

    Note: Corresponds to exon 6 deletion (PubMed:9685228). May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.1 Publication

    Show »
    Length:377
    Mass (Da):42,107
    Checksum:i59314206E084E413
    GO

    Sequence cautioni

    The sequence AAC17919.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence AAI41076.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence AAI45330.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence AAL15175.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence BAC35719.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence BAC35770.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti47 – 471T → A in CAA03949. (PubMed:9280064)Curated
    Sequence conflicti142 – 1421A → T in CAA03949. (PubMed:9280064)Curated
    Sequence conflicti200 – 2001S → N in CAA03949. (PubMed:9280064)Curated
    Sequence conflicti378 – 3781D → G in AAB51132. (PubMed:16141072)Curated
    Sequence conflicti378 – 3781D → G in AAL15175. (PubMed:11878304)Curated
    Sequence conflicti412 – 4121P → H in CAA03949. (PubMed:9280064)Curated
    Sequence conflicti445 – 4451G → R in CAA03949. (PubMed:9280064)Curated
    Sequence conflicti511 – 5111E → G in CAA03949. (PubMed:9280064)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei319 – 40991Missing in isoform 3. CuratedVSP_003696Add
    BLAST
    Alternative sequencei319 – 34325FVELS…LMVGL → MRGSAWKGFWKSLTCSWRRR HGSVS in isoform 4. CuratedVSP_042429Add
    BLAST
    Alternative sequencei344 – 530187Missing in isoform 4. CuratedVSP_042430Add
    BLAST
    Alternative sequencei364 – 3641R → RSSEDPHWHVAQTKSAVPR in isoform 2. 2 PublicationsVSP_003693
    Alternative sequencei365 – 37713DEGKC…ILEIF → YVPLGYRKPGSRE in isoform 5. CuratedVSP_042431Add
    BLAST
    Alternative sequencei378 – 530153Missing in isoform 5. CuratedVSP_042432Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK054290 mRNA. Translation: BAC35719.1. Different initiation.
    AK054413 mRNA. Translation: BAC35770.1. Different initiation.
    AC164121 Genomic DNA. No translation available.
    BC141075 mRNA. Translation: AAI41076.1. Different initiation.
    BC145329 mRNA. Translation: AAI45330.1. Different initiation.
    U81451 mRNA. Translation: AAB51132.1.
    AJ000220 Genomic DNA. Translation: CAA03949.1.
    AY054413 mRNA. Translation: AAL15175.1. Different initiation.
    AF067422 mRNA. Translation: AAC17919.1. Different initiation.
    AF063853 mRNA. Translation: AAC16656.1.
    RefSeqiNP_034287.3. NM_010157.3.
    NP_997590.1. NM_207707.1.
    UniGeneiMm.2561.

    Genome annotation databases

    EnsembliENSMUST00000076634; ENSMUSP00000075932; ENSMUSG00000021055.
    ENSMUST00000101291; ENSMUSP00000098849; ENSMUSG00000021055.
    ENSMUST00000110421; ENSMUSP00000106051; ENSMUSG00000021055.
    GeneIDi13983.
    KEGGimmu:13983.
    UCSCiuc007nxu.1. mouse. [O08537-2]
    uc007nxv.1. mouse. [O08537-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK054290 mRNA. Translation: BAC35719.1 . Different initiation.
    AK054413 mRNA. Translation: BAC35770.1 . Different initiation.
    AC164121 Genomic DNA. No translation available.
    BC141075 mRNA. Translation: AAI41076.1 . Different initiation.
    BC145329 mRNA. Translation: AAI45330.1 . Different initiation.
    U81451 mRNA. Translation: AAB51132.1 .
    AJ000220 Genomic DNA. Translation: CAA03949.1 .
    AY054413 mRNA. Translation: AAL15175.1 . Different initiation.
    AF067422 mRNA. Translation: AAC17919.1 . Different initiation.
    AF063853 mRNA. Translation: AAC16656.1 .
    RefSeqi NP_034287.3. NM_010157.3.
    NP_997590.1. NM_207707.1.
    UniGenei Mm.2561.

    3D structure databases

    ProteinModelPortali O08537.
    SMRi O08537. Positions 147-498.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O08537. 2 interactions.

    Chemistry

    BindingDBi O08537.
    ChEMBLi CHEMBL2995.
    GuidetoPHARMACOLOGYi 621.

    PTM databases

    PhosphoSitei O08537.
    UniCarbKBi O08537.

    Proteomic databases

    PRIDEi O08537.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000076634 ; ENSMUSP00000075932 ; ENSMUSG00000021055 .
    ENSMUST00000101291 ; ENSMUSP00000098849 ; ENSMUSG00000021055 .
    ENSMUST00000110421 ; ENSMUSP00000106051 ; ENSMUSG00000021055 .
    GeneIDi 13983.
    KEGGi mmu:13983.
    UCSCi uc007nxu.1. mouse. [O08537-2 ]
    uc007nxv.1. mouse. [O08537-1 ]

    Organism-specific databases

    CTDi 2100.
    MGIi MGI:109392. Esr2.

    Phylogenomic databases

    eggNOGi NOG271979.
    GeneTreei ENSGT00730000110346.
    HOGENOMi HOG000233468.
    HOVERGENi HBG108344.
    KOi K08551.
    OrthoDBi EOG7288S1.
    TreeFami TF323751.

    Miscellaneous databases

    NextBioi 284858.
    PROi O08537.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O08537.
    Bgeei O08537.
    CleanExi MM_ESR2.
    Genevestigatori O08537.

    Family and domain databases

    Gene3Di 1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProi IPR028355. ER-beta/gamma.
    IPR021064. Estrogen_rcpt_beta_N.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR024178. Oest_rcpt/oest-rel_rcp.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF12497. ERbeta_N. 1 hit.
    PF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF500102. ER-b. 1 hit.
    PIRSF002527. ER-like_NR. 1 hit.
    PRINTSi PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTi SM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 2 hits.
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6J.
      Tissue: Ovary.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    4. "Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor beta."
      Tremblay G.B., Tremblay A., Copeland N.G., Gilbert D.J., Jenkins N.A., Labrie F., Giguere V.
      Mol. Endocrinol. 11:353-365(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 46-530, MUTAGENESIS.
      Strain: 129/Sv.
      Tissue: Ovary.
    5. "Mouse estrogen receptor beta forms estrogen response element-binding heterodimers with estrogen receptor alpha."
      Pettersson K., Grandien K., Kuiper G.G.J.M., Gustafsson J.-A.
      Mol. Endocrinol. 11:1486-1496(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 46-530, CHARACTERIZATION.
      Tissue: Ovary.
    6. "Exposure of KS483 cells to estrogen enhances osteogenesis and inhibits adipogenesis."
      Dang Z.C., van Bezooijen R.L., Karperien M., Papapoulos S.E., Lowik C.W.
      J. Bone Miner. Res. 17:394-405(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 46-530 (ISOFORM 2), INDUCTION.
      Strain: ddY.
      Tissue: Calvaria.
    7. Leygue E., Lu B., Dotzlaw H., Glor C., Watson P.H., Murphy L.C.
      Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-60.
      Tissue: Ovary.
    8. Rosenfeld C.S., Lubahn D.B.
      Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-60.
      Tissue: Ovary.
    9. "The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function."
      Torchia J., Rose D.W., Inostroza J., Kamei Y., Westin S., Glass C.K., Rosenfeld M.G.
      Nature 387:677-684(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NCOA3.
    10. "Transcription and translation of estrogen receptor-beta in the male reproductive tract of estrogen receptor-alpha knock-out and wild-type mice."
      Rosenfeld C.S., Ganjam V.K., Taylor J.A., Yuan X., Stiehr J.R., Hardy M.P., Lubahn D.B.
      Endocrinology 139:2982-2987(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    11. "Estrogen receptor-beta mRNA variants in human and murine tissues."
      Lu B., Leygue E., Dotzlaw H., Murphy L.J., Murphy L.C., Watson P.H.
      Mol. Cell. Endocrinol. 138:199-203(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING (ISOFORMS 1; 2; 3; 4 AND 5).
      Tissue: Ovary.
    12. "Ligand-independent recruitment of SRC-1 to estrogen receptor beta through phosphorylation of activation function AF-1."
      Tremblay A., Tremblay G.B., Labrie F., Giguere V.
      Mol. Cell 3:513-519(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-87 AND SER-105.
    13. "Alternative O-glycosylation/O-phosphorylation of the murine estrogen receptor beta."
      Cheng X., Cole R.N., Zaia J., Hart G.W.
      Biochemistry 39:11609-11620(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION AT SER-61, PHOSPHORYLATION AT SER-61.
    14. "Isolation and characterization of peroxisome proliferator-activated receptor (PPAR) interacting protein (PRIP) as a coactivator for PPAR."
      Zhu Y.-J., Kan L., Qi C., Kanwar Y.S., Yeldandi A.V., Rao M.S., Reddy J.K.
      J. Biol. Chem. 275:13510-13516(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NCOA6.

    Entry informationi

    Entry nameiESR2_MOUSE
    AccessioniPrimary (citable) accession number: O08537
    Secondary accession number(s): B2RUC6
    , E9QKX7, O35635, O70519, Q8BG65, Q91Z86
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: March 21, 2012
    Last modified: October 1, 2014
    This is version 145 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3