Voltage-dependent calcium channel subunit alpha-2/delta-1 precursor

Preferred order of sections

Names and origin

Protein names

Recommended name:
Voltage-dependent calcium channel subunit alpha-2/delta-1

Alternative name(s):
Voltage-gated calcium channel subunit alpha-2/delta-1

Cleaved into the following 2 chains:

Voltage-dependent calcium channel subunit alpha-2-1
Voltage-dependent calcium channel subunit delta-1

Gene names

Name:	Cacna2d1
Synonyms:	Cacna2

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1103 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling By similarity.
Subunit structure	Dimer formed of alpha-2-1 and delta-1 chains; disulfide-linked. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) and delta (CACNA2D) subunits in a 1:1:1:1 ratio By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Tissue specificity	Isoform 2A is expressed in skeletal muscle and aorta. Isoform 2B is expressed in brain. Isoform 2C is expressed in heart. Isoform 2D is expressed in heart and smooth muscle. Isoform 2E is expressed in smooth muscle. All five isoforms are expressed in the cardiovascular system.
Domain	The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch By similarity.
Post-translational modification	Proteolytically processed into subunits alpha-2-1 and delta-1 that are disulfide-linked By similarity.
Miscellaneous	Binds gabapentin, an antiepileptic drug By similarity.
Sequence similarities	Belongs to the calcium channel subunit alpha-2/delta family. Contains 1 cache domain. Contains 1 VWFA domain.

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Signal Transmembrane Transmembrane helix
Ligand	Calcium Metal-binding
Molecular function	Calcium channel Ion channel Voltage-gated channel
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of calcium ion transport Inferred from mutant phenotype PubMed 15536090. Source: MGI
Cellular_component	T-tubule Inferred from direct assay PubMed 15536090. Source: MGI sarcoplasmic reticulum Inferred from direct assay PubMed 15536090. Source: MGI voltage-gated calcium channel complex Inferred from electronic annotation. Source: Compara
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW voltage-gated calcium channel activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 2A (identifier: O08532-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2B (identifier: O08532-2) The sequence of this isoform differs from the canonical sequence as follows: 531-549: Missing.

Isoform 2C (identifier: O08532-3) The sequence of this isoform differs from the canonical sequence as follows: 531-554: Missing.

Isoform 2D (identifier: O08532-4) The sequence of this isoform differs from the canonical sequence as follows: 531-554: Missing. 644-644: Y → SKKGKMKD

Isoform 2E (identifier: O08532-5) The sequence of this isoform differs from the canonical sequence as follows: 531-549: Missing. 644-644: Y → SKKGKMKD

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 24

24

By similarity

Chain

25 – 1103

1079

Voltage-dependent calcium channel subunit alpha-2/delta-1

PRO_0000304634

Chain

25 – 957

933

Voltage-dependent calcium channel subunit alpha-2-1

PRO_0000005003

Chain

958 – 1103

146

Voltage-dependent calcium channel subunit delta-1

PRO_0000005004

Regions

Topological domain

25 – 1073

1049

Extracellular Potential

Transmembrane

1074 – 1094

21

Helical; Potential

Topological domain

1095 – 1103

9

Cytoplasmic Potential

Domain

253 – 430

178

VWFA

Domain

446 – 537

92

Cache

Motif

259 – 263

5

MIDAS-like motif

Sites

Metal binding

259

1

Divalent metal cation By similarity

Metal binding

261

1

Divalent metal cation By similarity

Metal binding

263

1

Divalent metal cation By similarity

Amino acid modifications

Glycosylation

92

1

N-linked (GlcNAc...) Potential

Glycosylation

136

1

N-linked (GlcNAc...) Ref.2 Ref.3

Glycosylation

184

1

N-linked (GlcNAc...) Potential

Glycosylation

323

1

N-linked (GlcNAc...) Ref.2

Glycosylation

324

1

N-linked (GlcNAc...) Ref.2

Glycosylation

348

1

N-linked (GlcNAc...) Potential

Glycosylation

613

1

N-linked (GlcNAc...) Potential

Glycosylation

772

1

N-linked (GlcNAc...) Ref.2

Glycosylation

781

1

N-linked (GlcNAc...) Ref.2 Ref.3

Glycosylation

888

1

N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence

531 – 554

24

Missing in isoform 2C and isoform 2D.

VSP_050445

Alternative sequence

531 – 549

19

Missing in isoform 2B and isoform 2E.

VSP_050444

Alternative sequence

644

1

Y → SKKGKMKD in isoform 2D and isoform 2E.

VSP_050446

Sequences

Sequence		Length	Mass (Da)
Isoform 2A [UniParc]. Last modified July 1, 1997. Version 1. Checksum: 103773B4735120D4 Show »	FASTA	1,103	124,630
10 20 30 40 50 60 MAAGCLLALT LTLFQSGLIG PSSEEPFPSP VTIKSWVDKM QEDLVTLAKT ASGVTQLADI 70 80 90 100 110 120 YEKYQDLYTV EPNNARQLVE IAARDIEKLL SNRSKALVRL AMEAEKVQAA HQWREDFASN 130 140 150 160 170 180 EVVYYNAKDD LDPERNESEP GSQRIKPVFI EDANFGRQIS YQHAAVHIPT DIYEGSTIVL 190 200 210 220 230 240 NELNWTSALD EVFKRNRDED PTLLWQVFGS ATGLARYYPA SPWVDNSRTP NKIDLYDVRR 250 260 270 280 290 300 RPWYIQGAAS PKDMLILVDV SGSVSGLTLK LIRTSVSEML ETLSDDDFVN VASFNSNAQD 310 320 330 340 350 360 VSCFQHLVQA NVRNKKVLKD AVNNITAKGI TDYKKGFSFA FEQLLNYNVS RANCNKIIML 370 380 390 400 410 420 FTDGGEERAQ EIFAKYNKDK KVRVFTFSVG QHNYDRGPIQ WMACENKGYY YEIPSIGAIR 430 440 450 460 470 480 INTQEYLDVL GRPMVLAGDK AKQVQWTNVY LDALELGLVI TGTLPVFNVT GQSENKTNLK 490 500 510 520 530 540 NQLILGVMGV DVSLEDIKRL TPRFTLCPNG YYFAIDPNGY VLLHPNLQPK PIGVGIPTIN 550 560 570 580 590 600 LRKRRPNVQN PKSQEPVTLD FLDAELENEI KVEIRNKMID GESGEKTFRT LVKSQDERYI 610 620 630 640 650 660 DKGNRTYTWT PVNGTDYSLA LVLPTYSFYY IKAKLEETIT QARYSETLKP DNFEESGYTF 670 680 690 700 710 720 IAPREYCNDL KPSDNNTEFL LNFNEFIDRK TPNNPSCNTD LINRILLDAG FTNELVQNYW 730 740 750 760 770 780 SKQKNIKGVK ARFVVTDGGI TRVYPKEAGE NWQENPETYE DSFYKRSLDN DNYVFTAPYF 790 800 810 820 830 840 NKSGPGAYES GIMVSKAVEL YIQGKLLKPA VVGIKIDVNS WIENFTKTSI RDPCAGPVCD 850 860 870 880 890 900 CKRNSDVMDC VILDDGGFLL MANHDDYTNQ IGRFFGEIDP SMMRHLVNIS LYAFNKSYDY 910 920 930 940 950 960 QSVCDPGAAP KQGAGHRSAY VPSIADILQI GWWATAAAWS ILQQLLLSLT FPRLLEAVEM 970 980 990 1000 1010 1020 EEDDFTASLS KQSCITEQTQ YFFKNDTKSF SGLLDCGNCS RIFHVEKLMN TNLVFIMVES 1030 1040 1050 1060 1070 1080 KGTCPCDTRL LMQAEQTSDG PDPCDMVKQP RYRKGPDVCF DNNVLEDYTD CGGVSGLNPS 1090 1100 LWSIFGLQFI LLWLVSGSRH YLL « Hide
Isoform 2B [UniParc]. Checksum: 5B9D89AB98F7BD1D Show »	FASTA	1,084	122,520
10 20 30 40 50 60 MAAGCLLALT LTLFQSGLIG PSSEEPFPSP VTIKSWVDKM QEDLVTLAKT ASGVTQLADI 70 80 90 100 110 120 YEKYQDLYTV EPNNARQLVE IAARDIEKLL SNRSKALVRL AMEAEKVQAA HQWREDFASN 130 140 150 160 170 180 EVVYYNAKDD LDPERNESEP GSQRIKPVFI EDANFGRQIS YQHAAVHIPT DIYEGSTIVL 190 200 210 220 230 240 NELNWTSALD EVFKRNRDED PTLLWQVFGS ATGLARYYPA SPWVDNSRTP NKIDLYDVRR 250 260 270 280 290 300 RPWYIQGAAS PKDMLILVDV SGSVSGLTLK LIRTSVSEML ETLSDDDFVN VASFNSNAQD 310 320 330 340 350 360 VSCFQHLVQA NVRNKKVLKD AVNNITAKGI TDYKKGFSFA FEQLLNYNVS RANCNKIIML 370 380 390 400 410 420 FTDGGEERAQ EIFAKYNKDK KVRVFTFSVG QHNYDRGPIQ WMACENKGYY YEIPSIGAIR 430 440 450 460 470 480 INTQEYLDVL GRPMVLAGDK AKQVQWTNVY LDALELGLVI TGTLPVFNVT GQSENKTNLK 490 500 510 520 530 540 NQLILGVMGV DVSLEDIKRL TPRFTLCPNG YYFAIDPNGY VLLHPNLQPK NPKSQEPVTL 550 560 570 580 590 600 DFLDAELENE IKVEIRNKMI DGESGEKTFR TLVKSQDERY IDKGNRTYTW TPVNGTDYSL 610 620 630 640 650 660 ALVLPTYSFY YIKAKLEETI TQARYSETLK PDNFEESGYT FIAPREYCND LKPSDNNTEF 670 680 690 700 710 720 LLNFNEFIDR KTPNNPSCNT DLINRILLDA GFTNELVQNY WSKQKNIKGV KARFVVTDGG 730 740 750 760 770 780 ITRVYPKEAG ENWQENPETY EDSFYKRSLD NDNYVFTAPY FNKSGPGAYE SGIMVSKAVE 790 800 810 820 830 840 LYIQGKLLKP AVVGIKIDVN SWIENFTKTS IRDPCAGPVC DCKRNSDVMD CVILDDGGFL 850 860 870 880 890 900 LMANHDDYTN QIGRFFGEID PSMMRHLVNI SLYAFNKSYD YQSVCDPGAA PKQGAGHRSA 910 920 930 940 950 960 YVPSIADILQ IGWWATAAAW SILQQLLLSL TFPRLLEAVE MEEDDFTASL SKQSCITEQT 970 980 990 1000 1010 1020 QYFFKNDTKS FSGLLDCGNC SRIFHVEKLM NTNLVFIMVE SKGTCPCDTR LLMQAEQTSD 1030 1040 1050 1060 1070 1080 GPDPCDMVKQ PRYRKGPDVC FDNNVLEDYT DCGGVSGLNP SLWSIFGLQF ILLWLVSGSR HYLL « Hide
Isoform 2C [UniParc]. Checksum: 2A19773E55B31828 Show »	FASTA	1,079	121,965
10 20 30 40 50 60 MAAGCLLALT LTLFQSGLIG PSSEEPFPSP VTIKSWVDKM QEDLVTLAKT ASGVTQLADI 70 80 90 100 110 120 YEKYQDLYTV EPNNARQLVE IAARDIEKLL SNRSKALVRL AMEAEKVQAA HQWREDFASN 130 140 150 160 170 180 EVVYYNAKDD LDPERNESEP GSQRIKPVFI EDANFGRQIS YQHAAVHIPT DIYEGSTIVL 190 200 210 220 230 240 NELNWTSALD EVFKRNRDED PTLLWQVFGS ATGLARYYPA SPWVDNSRTP NKIDLYDVRR 250 260 270 280 290 300 RPWYIQGAAS PKDMLILVDV SGSVSGLTLK LIRTSVSEML ETLSDDDFVN VASFNSNAQD 310 320 330 340 350 360 VSCFQHLVQA NVRNKKVLKD AVNNITAKGI TDYKKGFSFA FEQLLNYNVS RANCNKIIML 370 380 390 400 410 420 FTDGGEERAQ EIFAKYNKDK KVRVFTFSVG QHNYDRGPIQ WMACENKGYY YEIPSIGAIR 430 440 450 460 470 480 INTQEYLDVL GRPMVLAGDK AKQVQWTNVY LDALELGLVI TGTLPVFNVT GQSENKTNLK 490 500 510 520 530 540 NQLILGVMGV DVSLEDIKRL TPRFTLCPNG YYFAIDPNGY VLLHPNLQPK EPVTLDFLDA 550 560 570 580 590 600 ELENEIKVEI RNKMIDGESG EKTFRTLVKS QDERYIDKGN RTYTWTPVNG TDYSLALVLP 610 620 630 640 650 660 TYSFYYIKAK LEETITQARY SETLKPDNFE ESGYTFIAPR EYCNDLKPSD NNTEFLLNFN 670 680 690 700 710 720 EFIDRKTPNN PSCNTDLINR ILLDAGFTNE LVQNYWSKQK NIKGVKARFV VTDGGITRVY 730 740 750 760 770 780 PKEAGENWQE NPETYEDSFY KRSLDNDNYV FTAPYFNKSG PGAYESGIMV SKAVELYIQG 790 800 810 820 830 840 KLLKPAVVGI KIDVNSWIEN FTKTSIRDPC AGPVCDCKRN SDVMDCVILD DGGFLLMANH 850 860 870 880 890 900 DDYTNQIGRF FGEIDPSMMR HLVNISLYAF NKSYDYQSVC DPGAAPKQGA GHRSAYVPSI 910 920 930 940 950 960 ADILQIGWWA TAAAWSILQQ LLLSLTFPRL LEAVEMEEDD FTASLSKQSC ITEQTQYFFK 970 980 990 1000 1010 1020 NDTKSFSGLL DCGNCSRIFH VEKLMNTNLV FIMVESKGTC PCDTRLLMQA EQTSDGPDPC 1030 1040 1050 1060 1070 DMVKQPRYRK GPDVCFDNNV LEDYTDCGGV SGLNPSLWSI FGLQFILLWL VSGSRHYLL « Hide
Isoform 2D [UniParc]. Checksum: 1576CB411BB1754A Show »	FASTA	1,086	122,705
10 20 30 40 50 60 MAAGCLLALT LTLFQSGLIG PSSEEPFPSP VTIKSWVDKM QEDLVTLAKT ASGVTQLADI 70 80 90 100 110 120 YEKYQDLYTV EPNNARQLVE IAARDIEKLL SNRSKALVRL AMEAEKVQAA HQWREDFASN 130 140 150 160 170 180 EVVYYNAKDD LDPERNESEP GSQRIKPVFI EDANFGRQIS YQHAAVHIPT DIYEGSTIVL 190 200 210 220 230 240 NELNWTSALD EVFKRNRDED PTLLWQVFGS ATGLARYYPA SPWVDNSRTP NKIDLYDVRR 250 260 270 280 290 300 RPWYIQGAAS PKDMLILVDV SGSVSGLTLK LIRTSVSEML ETLSDDDFVN VASFNSNAQD 310 320 330 340 350 360 VSCFQHLVQA NVRNKKVLKD AVNNITAKGI TDYKKGFSFA FEQLLNYNVS RANCNKIIML 370 380 390 400 410 420 FTDGGEERAQ EIFAKYNKDK KVRVFTFSVG QHNYDRGPIQ WMACENKGYY YEIPSIGAIR 430 440 450 460 470 480 INTQEYLDVL GRPMVLAGDK AKQVQWTNVY LDALELGLVI TGTLPVFNVT GQSENKTNLK 490 500 510 520 530 540 NQLILGVMGV DVSLEDIKRL TPRFTLCPNG YYFAIDPNGY VLLHPNLQPK EPVTLDFLDA 550 560 570 580 590 600 ELENEIKVEI RNKMIDGESG EKTFRTLVKS QDERYIDKGN RTYTWTPVNG TDYSLALVLP 610 620 630 640 650 660 TYSFYYIKAK LEETITQARS KKGKMKDSET LKPDNFEESG YTFIAPREYC NDLKPSDNNT 670 680 690 700 710 720 EFLLNFNEFI DRKTPNNPSC NTDLINRILL DAGFTNELVQ NYWSKQKNIK GVKARFVVTD 730 740 750 760 770 780 GGITRVYPKE AGENWQENPE TYEDSFYKRS LDNDNYVFTA PYFNKSGPGA YESGIMVSKA 790 800 810 820 830 840 VELYIQGKLL KPAVVGIKID VNSWIENFTK TSIRDPCAGP VCDCKRNSDV MDCVILDDGG 850 860 870 880 890 900 FLLMANHDDY TNQIGRFFGE IDPSMMRHLV NISLYAFNKS YDYQSVCDPG AAPKQGAGHR 910 920 930 940 950 960 SAYVPSIADI LQIGWWATAA AWSILQQLLL SLTFPRLLEA VEMEEDDFTA SLSKQSCITE 970 980 990 1000 1010 1020 QTQYFFKNDT KSFSGLLDCG NCSRIFHVEK LMNTNLVFIM VESKGTCPCD TRLLMQAEQT 1030 1040 1050 1060 1070 1080 SDGPDPCDMV KQPRYRKGPD VCFDNNVLED YTDCGGVSGL NPSLWSIFGL QFILLWLVSG SRHYLL « Hide
Isoform 2E [UniParc]. Checksum: CB272F8F81982F4B Show »	FASTA	1,091	123,260
10 20 30 40 50 60 MAAGCLLALT LTLFQSGLIG PSSEEPFPSP VTIKSWVDKM QEDLVTLAKT ASGVTQLADI 70 80 90 100 110 120 YEKYQDLYTV EPNNARQLVE IAARDIEKLL SNRSKALVRL AMEAEKVQAA HQWREDFASN 130 140 150 160 170 180 EVVYYNAKDD LDPERNESEP GSQRIKPVFI EDANFGRQIS YQHAAVHIPT DIYEGSTIVL 190 200 210 220 230 240 NELNWTSALD EVFKRNRDED PTLLWQVFGS ATGLARYYPA SPWVDNSRTP NKIDLYDVRR 250 260 270 280 290 300 RPWYIQGAAS PKDMLILVDV SGSVSGLTLK LIRTSVSEML ETLSDDDFVN VASFNSNAQD 310 320 330 340 350 360 VSCFQHLVQA NVRNKKVLKD AVNNITAKGI TDYKKGFSFA FEQLLNYNVS RANCNKIIML 370 380 390 400 410 420 FTDGGEERAQ EIFAKYNKDK KVRVFTFSVG QHNYDRGPIQ WMACENKGYY YEIPSIGAIR 430 440 450 460 470 480 INTQEYLDVL GRPMVLAGDK AKQVQWTNVY LDALELGLVI TGTLPVFNVT GQSENKTNLK 490 500 510 520 530 540 NQLILGVMGV DVSLEDIKRL TPRFTLCPNG YYFAIDPNGY VLLHPNLQPK NPKSQEPVTL 550 560 570 580 590 600 DFLDAELENE IKVEIRNKMI DGESGEKTFR TLVKSQDERY IDKGNRTYTW TPVNGTDYSL 610 620 630 640 650 660 ALVLPTYSFY YIKAKLEETI TQARSKKGKM KDSETLKPDN FEESGYTFIA PREYCNDLKP 670 680 690 700 710 720 SDNNTEFLLN FNEFIDRKTP NNPSCNTDLI NRILLDAGFT NELVQNYWSK QKNIKGVKAR 730 740 750 760 770 780 FVVTDGGITR VYPKEAGENW QENPETYEDS FYKRSLDNDN YVFTAPYFNK SGPGAYESGI 790 800 810 820 830 840 MVSKAVELYI QGKLLKPAVV GIKIDVNSWI ENFTKTSIRD PCAGPVCDCK RNSDVMDCVI 850 860 870 880 890 900 LDDGGFLLMA NHDDYTNQIG RFFGEIDPSM MRHLVNISLY AFNKSYDYQS VCDPGAAPKQ 910 920 930 940 950 960 GAGHRSAYVP SIADILQIGW WATAAAWSIL QQLLLSLTFP RLLEAVEMEE DDFTASLSKQ 970 980 990 1000 1010 1020 SCITEQTQYF FKNDTKSFSG LLDCGNCSRI FHVEKLMNTN LVFIMVESKG TCPCDTRLLM 1030 1040 1050 1060 1070 1080 QAEQTSDGPD PCDMVKQPRY RKGPDVCFDN NVLEDYTDCG GVSGLNPSLW SIFGLQFILL 1090 WLVSGSRHYL L « Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Tissue-specific expression of splice variants of the mouse voltage-gated calcium channel alpha2/delta subunit." Angelotti T., Hofmann F. FEBS Lett. 397:331-337(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation." Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B. Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-136; ASN-323; ASN-324; ASN-772 AND ASN-781, MASS SPECTROMETRY. Tissue: Myoblast.
[3]	"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins." Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D. Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-136 AND ASN-781, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U73484 mRNA. Translation: AAB50139.1. U73485 mRNA. Translation: AAB50140.1. U73483 mRNA. Translation: AAB50138.1. U73486 mRNA. Translation: AAB50141.1. U73487 mRNA. Translation: AAB50142.1.
IPI	IPI00230013. IPI00319970. IPI00407868. IPI00410982. IPI00626793.
RefSeq	NP_001104313.1. NM_001110843.1. NP_001104314.1. NM_001110844.1. NP_001104315.1. NM_001110845.1. NP_001104316.1. NM_001110846.1. NP_033914.1. NM_009784.2.
UniGene	Mm.159842.
3D structure databases
ProteinModelPortal	O08532.
ModBase	Search...
Protein-protein interaction databases
IntAct	O08532. 2 interactions.
PTM databases
PhosphoSite	O08532.
Proteomic databases
PaxDb	O08532.
PRIDE	O08532.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000039370; ENSMUSP00000049457; ENSMUSG00000040118. ENSMUST00000078272; ENSMUSP00000077391; ENSMUSG00000040118. ENSMUST00000101581; ENSMUSP00000099117; ENSMUSG00000040118. ENSMUST00000115281; ENSMUSP00000110936; ENSMUSG00000040118. ENSMUST00000180204; ENSMUSP00000136260; ENSMUSG00000040118.
GeneID	12293.
KEGG	mmu:12293.
UCSC	uc008wmx.2. mouse. uc008wmy.2. mouse. uc008wna.2. mouse. uc008wnb.2. mouse.
Organism-specific databases
CTD	781.
MGI	MGI:88295. Cacna2d1.
Phylogenomic databases
eggNOG	NOG307080.
GeneTree	ENSGT00530000062904.
HOGENOM	HOG000004860.
HOVERGEN	HBG057779.
InParanoid	O08532.
KO	K04858.
OMA	DYTNQIG.
OrthoDB	EOG4CVG65.
Gene expression databases
ArrayExpress	O08532.
Bgee	O08532.
Genevestigator	O08532.
GermOnline	ENSMUSG00000040118. Mus musculus.
Family and domain databases
InterPro	IPR004010. Cache_domain. IPR013680. VDCC_a2/dsu. IPR013608. VWA_N. IPR002035. VWF_A. [Graphical view]
Pfam	PF02743. Cache_1. 1 hit. PF08473. VGCC_alpha2. 1 hit. PF00092. VWA. 1 hit. PF08399. VWA_N. 1 hit. [Graphical view]
SMART	SM00327. VWA. 1 hit. [Graphical view]
PROSITE	PS50234. VWFA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	O08532.
ChEMBL	CHEMBL4676.
ChiTaRS	CACNA2D1. mouse.
NextBio	280788.
SOURCE	Search...

Entry information

Entry name

CA2D1_MOUSE

Accession

Primary (citable) accession number: O08532
Secondary accession number(s): O08533

O08536

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	July 1, 1997
Last modified:	April 3, 2013
This is version 102 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Cleaved into the following 2 chains:

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents