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O08530

- S1PR1_MOUSE

UniProt

O08530 - S1PR1_MOUSE

Protein

Sphingosine 1-phosphate receptor 1

Gene

S1pr1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis. Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.10 Publications

    GO - Molecular functioni

    1. sphingolipid binding Source: Ensembl
    2. sphingosine-1-phosphate receptor activity Source: UniProtKB

    GO - Biological processi

    1. actin cytoskeleton reorganization Source: UniProtKB
    2. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: MGI
    3. angiogenesis Source: MGI
    4. blood vessel maturation Source: UniProtKB
    5. brain development Source: MGI
    6. cardiac muscle tissue growth involved in heart morphogenesis Source: UniProtKB
    7. cell migration Source: UniProtKB
    8. chemotaxis Source: UniProtKB
    9. endothelial cell differentiation Source: Ensembl
    10. heart trabecula morphogenesis Source: UniProtKB
    11. lamellipodium assembly Source: UniProtKB
    12. negative regulation of stress fiber assembly Source: Ensembl
    13. neuron differentiation Source: Ensembl
    14. positive regulation of cell migration Source: Ensembl
    15. positive regulation of cell proliferation Source: MGI
    16. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: Ensembl
    17. positive regulation of positive chemotaxis Source: Ensembl
    18. positive regulation of Ras GTPase activity Source: Ensembl
    19. positive regulation of smooth muscle cell proliferation Source: Ensembl
    20. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    21. regulation of bone mineralization Source: UniProtKB
    22. regulation of bone resorption Source: UniProtKB
    23. regulation of cell adhesion Source: MGI
    24. sphingosine-1-phosphate signaling pathway Source: UniProtKB
    25. T cell migration Source: UniProtKB
    26. transmission of nerve impulse Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Angiogenesis, Chemotaxis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sphingosine 1-phosphate receptor 1
    Short name:
    S1P receptor 1
    Short name:
    S1P1
    Alternative name(s):
    Endothelial differentiation G-protein coupled receptor 1
    Lysophospholipid receptor B1
    Sphingosine 1-phosphate receptor Edg-1
    Short name:
    S1P receptor Edg-1
    CD_antigen: CD363
    Gene namesi
    Name:S1pr1
    Synonyms:Edg1, Lpb1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1096355. S1pr1.

    Subcellular locationi

    Cell membrane; Multi-pass membrane protein. Endosome By similarity. Membranecaveola By similarity
    Note: Recruited to caveolin-enriched plasma membrane microdomains in response to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine. Ligand binding leads to receptor internalization By similarity.By similarity

    GO - Cellular componenti

    1. caveola Source: UniProtKB-SubCell
    2. endosome Source: UniProtKB-SubCell
    3. external side of plasma membrane Source: MGI
    4. integral component of membrane Source: UniProtKB-KW
    5. intrinsic component of plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Endosome, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Embryonic lethality, due to impaired vascular maturation and defects in heart development. Embryos appear normal up to 11.5 dpc, but after that they display massive hemorrhage. They have a normally arborized vascular network, but present excessive sprouting angiogenesis and severe aberrations in vessel size. Their aorta and other arteries are not properly enveloped by vascular smooth muscle cells, causing hemorrhage. Likewise, small blood vessels show a marked reduction in the number of vascular pericytes. In addition, mutants display defects in heart morphogenesis, with reduced myocardial tissue and altered morphology of the heart wall and the trabeculae. Conditional knockout in endothelial cells leads to the same vascular maturation defect as that seen in homozygous knockout mice. Conditional knockout in fibroblasts leads to defects in chemotaxis, probably due to defects in the activation of SRC and PTK2/FAK1, resulting in defects in the reorganization of the actin cytoskeleton and lamellipodia formation. A T-cell-specific knockout leads to a defect in the egress of mature T-cells from the thymus into the periphery. Conditional knockout in osteoclast precursors leads to osteoporosis, due to impaired migration of osteoclast precursors and increased osteoclast attachment to the bone.8 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 382381Sphingosine 1-phosphate receptor 1PRO_0000069413Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylvaline1 Publication
    Modified residuei10 – 101N6-acetyllysine1 Publication
    Glycosylationi30 – 301N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi184 ↔ 191PROSITE-ProRule annotation
    Modified residuei236 – 2361PhosphothreonineBy similarity
    Disulfide bondi282 ↔ 287PROSITE-ProRule annotation
    Lipidationi328 – 3281S-palmitoyl cysteineBy similarity
    Modified residuei353 – 3531PhosphoserineSequence Analysis

    Keywords - PTMi

    Acetylation, Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

    Proteomic databases

    PaxDbiO08530.
    PRIDEiO08530.

    PTM databases

    PhosphoSiteiO08530.

    Expressioni

    Tissue specificityi

    Expressed in a wide variety of tissues with highest levels in brain, heart and spleen. Lower levels found in kidney, liver, lung, muscle, placenta, thymus, and uterus. Very low levels in intestine, stomach and testis. According to PubMed:9931453, expressed modestly in apparent endothelial cells surrounding some blood vessels (e.g. aortic trunk).2 Publications

    Gene expression databases

    ArrayExpressiO08530.
    BgeeiO08530.
    GenevestigatoriO08530.

    Interactioni

    Subunit structurei

    Interacts with GNAI1 and GNAI3.By similarity

    Protein-protein interaction databases

    BioGridi199373. 2 interactions.
    DIPiDIP-32248N.
    IntActiO08530. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliO08530.
    SMRiO08530. Positions 16-326.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 4645ExtracellularBy similarityAdd
    BLAST
    Topological domaini69 – 8214CytoplasmicBy similarityAdd
    BLAST
    Topological domaini105 – 11612ExtracellularBy similarityAdd
    BLAST
    Topological domaini139 – 16022CytoplasmicBy similarityAdd
    BLAST
    Topological domaini183 – 19614ExtracellularBy similarityAdd
    BLAST
    Topological domaini225 – 25733CytoplasmicBy similarityAdd
    BLAST
    Topological domaini279 – 28911ExtracellularBy similarityAdd
    BLAST
    Topological domaini311 – 38272CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei47 – 6822Helical; Name=1By similarityAdd
    BLAST
    Transmembranei83 – 10422Helical; Name=2By similarityAdd
    BLAST
    Transmembranei117 – 13822Helical; Name=3By similarityAdd
    BLAST
    Transmembranei161 – 18222Helical; Name=4By similarityAdd
    BLAST
    Transmembranei197 – 22428Helical; Name=5By similarityAdd
    BLAST
    Transmembranei258 – 27821Helical; Name=6By similarityAdd
    BLAST
    Transmembranei290 – 31021Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni120 – 1212Sphingosine 1-phosphate bindingBy similarity
    Regioni265 – 2695Sphingosine 1-phosphate bindingBy similarity

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG148018.
    GeneTreeiENSGT00750000117544.
    HOGENOMiHOG000233501.
    HOVERGENiHBG103071.
    InParanoidiQ9DC35.
    KOiK04288.
    OMAiSAFIACW.
    OrthoDBiEOG708W0B.
    TreeFamiTF330052.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000987. EDG1_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR004061. S1P_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00642. EDG1RECEPTOR.
    PR00237. GPCRRHODOPSN.
    PR01523. S1PRECEPTOR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O08530-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVSTSIPEVK ALRSSVSDYG NYDIIVRHYN YTGKLNIGAE KDHGIKLTSV    50
    VFILICCFII LENIFVLLTI WKTKKFHRPM YYFIGNLALS DLLAGVAYTA 100
    NLLLSGATTY KLTPAQWFLR EGSMFVALSA SVFSLLAIAI ERYITMLKMK 150
    LHNGSNSSRS FLLISACWVI SLILGGLPIM GWNCISSLSS CSTVLPLYHK 200
    HYILFCTTVF TLLLLSIVIL YCRIYSLVRT RSRRLTFRKN ISKASRSSEK 250
    SLALLKTVII VLSVFIACWA PLFILLLLDV GCKAKTCDIL YKAEYFLVLA 300
    VLNSGTNPII YTLTNKEMRR AFIRIVSCCK CPNGDSAGKF KRPIIPGMEF 350
    SRSKSDNSSH PQKDDGDNPE TIMSSGNVNS SS 382
    Length:382
    Mass (Da):42,639
    Last modified:July 27, 2011 - v3
    Checksum:i5FE4C9A2BD65CB2A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti179 – 1791I → S in AAC53294. (PubMed:9226368)Curated
    Sequence conflicti179 – 1791I → S in AAD16975. (PubMed:9931453)Curated
    Sequence conflicti218 – 2181V → A in AAC53294. (PubMed:9226368)Curated
    Sequence conflicti244 – 2441A → G in AAC53294. (PubMed:9226368)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U40811 Genomic DNA. Translation: AAC53294.1.
    AF108019 Genomic DNA. Translation: AAD16975.1.
    AK004591 mRNA. Translation: BAB23393.1.
    AK146501 mRNA. Translation: BAE27216.1.
    CH466532 Genomic DNA. Translation: EDL12402.1.
    BC049094 mRNA. Translation: AAH49094.1.
    BC051023 mRNA. Translation: AAH51023.1.
    CCDSiCCDS17781.1.
    RefSeqiNP_031927.2. NM_007901.5.
    UniGeneiMm.982.

    Genome annotation databases

    EnsembliENSMUST00000055676; ENSMUSP00000050897; ENSMUSG00000045092.
    GeneIDi13609.
    KEGGimmu:13609.
    UCSCiuc008rbo.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U40811 Genomic DNA. Translation: AAC53294.1 .
    AF108019 Genomic DNA. Translation: AAD16975.1 .
    AK004591 mRNA. Translation: BAB23393.1 .
    AK146501 mRNA. Translation: BAE27216.1 .
    CH466532 Genomic DNA. Translation: EDL12402.1 .
    BC049094 mRNA. Translation: AAH49094.1 .
    BC051023 mRNA. Translation: AAH51023.1 .
    CCDSi CCDS17781.1.
    RefSeqi NP_031927.2. NM_007901.5.
    UniGenei Mm.982.

    3D structure databases

    ProteinModelPortali O08530.
    SMRi O08530. Positions 16-326.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199373. 2 interactions.
    DIPi DIP-32248N.
    IntActi O08530. 1 interaction.

    Chemistry

    BindingDBi O08530.
    ChEMBLi CHEMBL1914262.
    GuidetoPHARMACOLOGYi 275.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei O08530.

    Proteomic databases

    PaxDbi O08530.
    PRIDEi O08530.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000055676 ; ENSMUSP00000050897 ; ENSMUSG00000045092 .
    GeneIDi 13609.
    KEGGi mmu:13609.
    UCSCi uc008rbo.2. mouse.

    Organism-specific databases

    CTDi 1901.
    MGIi MGI:1096355. S1pr1.

    Phylogenomic databases

    eggNOGi NOG148018.
    GeneTreei ENSGT00750000117544.
    HOGENOMi HOG000233501.
    HOVERGENi HBG103071.
    InParanoidi Q9DC35.
    KOi K04288.
    OMAi SAFIACW.
    OrthoDBi EOG708W0B.
    TreeFami TF330052.

    Miscellaneous databases

    NextBioi 284254.
    PROi O08530.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O08530.
    Bgeei O08530.
    Genevestigatori O08530.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000987. EDG1_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR004061. S1P_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00642. EDG1RECEPTOR.
    PR00237. GPCRRHODOPSN.
    PR01523. S1PRECEPTOR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The mouse gene for the inducible G-protein-coupled receptor edg-1."
      Liu C.H., Hla T.
      Genomics 43:15-24(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: BALB/c.
      Tissue: Liver.
    2. "Comparative analysis of three murine G-protein coupled receptors activated by sphingosine-1-phosphate."
      Zhang G., Contos J.J.A., Weiner J.A., Fukushima N., Chun J.
      Gene 227:89-99(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
      Strain: 129/SvJ.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Heart and Lung.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Eye.
    6. "Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation."
      Liu Y., Wada R., Yamashita T., Mi Y., Deng C.X., Hobson J.P., Rosenfeldt H.M., Nava V.E., Chae S.S., Lee M.J., Liu C.H., Hla T., Spiegel S., Proia R.L.
      J. Clin. Invest. 106:951-961(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE, FUNCTION IN VASCULAR MATURATION AND CHEMOTAXIS, TISSUE SPECIFICITY.
    7. "EDG-1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration."
      Rosenfeldt H.M., Hobson J.P., Maceyka M., Olivera A., Nava V.E., Milstien S., Spiegel S.
      FASEB J. 15:2649-2659(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN FIBROBLAST CHEMOTAXIS, DISRUPTION PHENOTYPE.
    8. "Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility."
      Hobson J.P., Rosenfeldt H.M., Barak L.S., Olivera A., Poulton S., Caron M.G., Milstien S., Spiegel S.
      Science 291:1800-1803(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. "G-protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation."
      Allende M.L., Yamashita T., Proia R.L.
      Blood 102:3665-3667(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE, FUNCTION IN VASCULAR MATURATION.
    10. "Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigration."
      Allende M.L., Dreier J.L., Mandala S., Proia R.L.
      J. Biol. Chem. 279:15396-15401(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE, FUNCTION IN T CELL MIGRATION.
    11. "Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1."
      Matloubian M., Lo C.G., Cinamon G., Lesneski M.J., Xu Y., Brinkmann V., Allende M.L., Proia R.L., Cyster J.G.
      Nature 427:355-360(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE, FUNCTION IN T CELL MIGRATION.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    13. "Akt-mediated transactivation of the S1P1 receptor in caveolin-enriched microdomains regulates endothelial barrier enhancement by oxidized phospholipids."
      Singleton P.A., Chatchavalvanich S., Fu P., Xing J., Birukova A.A., Fortune J.A., Klibanov A.M., Garcia J.G., Birukov K.G.
      Circ. Res. 104:978-986(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    14. "Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis."
      Ishii M., Egen J.G., Klauschen F., Meier-Schellersheim M., Saeki Y., Vacher J., Proia R.L., Germain R.N.
      Nature 458:524-528(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE, FUNCTION IN OSTEOCLAST MIGRATION AND BONE HOMEOSTASIS.
    15. "The Sphingosine-1-phospate receptor 1 mediates S1P action during cardiac development."
      Poulsen R.R., McClaskey C.M., Rivkees S.A., Wendler C.C.
      BMC Dev. Biol. 11:37-37(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE, FUNCTION IN HEART MORPHOGENESIS AND DEVELOPMENT.
    16. "S1P1 inhibits sprouting angiogenesis during vascular development."
      Ben Shoham A., Malkinson G., Krief S., Shwartz Y., Ely Y., Ferrara N., Yaniv K., Zelzer E.
      Development 139:3859-3869(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE, FUNCTION IN SPROUTING ANGIOGENESIS.
    17. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT VAL-2 AND LYS-10, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiS1PR1_MOUSE
    AccessioniPrimary (citable) accession number: O08530
    Secondary accession number(s): Q9DC35, Q9R235
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 126 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

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