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O08530 (S1PR1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sphingosine 1-phosphate receptor 1
Short name=S1P receptor 1
Short name=S1P1
Alternative name(s):
Endothelial differentiation G-protein coupled receptor 1
Lysophospholipid receptor B1
Sphingosine 1-phosphate receptor Edg-1
Short name=S1P receptor Edg-1
CD_antigen=CD363
Gene names
Name:S1pr1
Synonyms:Edg1, Lpb1
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length382 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. This inducible epithelial cell G-protein-coupled receptor may be involved in the processes that regulate the differentiation of endothelial cells. Seems to be coupled to the G(i) subclass of heteromeric G proteins By similarity. Ref.6

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in a wide variety of tissues with highest levels in brain, heart and spleen. Lower levels found in kidney, liver, lung, muscle, placenta, thymus, and uterus. Very low levels in intestine, stomach and testis. According to Ref.2, expressed modestly in apparent endothelial cells surrounding some blood vessels (e.g. aortic trunk). Ref.2

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 382382Sphingosine 1-phosphate receptor 1
PRO_0000069413

Regions

Topological domain1 – 4646Extracellular By similarity
Transmembrane47 – 7125Helical; Name=1; By similarity
Topological domain72 – 787Cytoplasmic By similarity
Transmembrane79 – 10729Helical; Name=2; By similarity
Topological domain108 – 12114Extracellular By similarity
Transmembrane122 – 14019Helical; Name=3; By similarity
Topological domain141 – 15919Cytoplasmic By similarity
Transmembrane160 – 18526Helical; Name=4; By similarity
Topological domain186 – 20116Extracellular By similarity
Transmembrane202 – 22221Helical; Name=5; By similarity
Topological domain223 – 25634Cytoplasmic By similarity
Transmembrane257 – 27822Helical; Name=6; By similarity
Topological domain279 – 29416Extracellular By similarity
Transmembrane295 – 31521Helical; Name=7; By similarity
Topological domain316 – 38267Cytoplasmic By similarity

Amino acid modifications

Modified residue3531Phosphoserine Potential
Lipidation3281S-palmitoyl cysteine By similarity
Glycosylation301N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict1791I → S in AAC53294. Ref.1
Sequence conflict1791I → S in AAD16975. Ref.2
Sequence conflict2181V → A in AAC53294. Ref.1
Sequence conflict2441A → G in AAC53294. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O08530 [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: 5FE4C9A2BD65CB2A

FASTA38242,639
        10         20         30         40         50         60 
MVSTSIPEVK ALRSSVSDYG NYDIIVRHYN YTGKLNIGAE KDHGIKLTSV VFILICCFII 

        70         80         90        100        110        120 
LENIFVLLTI WKTKKFHRPM YYFIGNLALS DLLAGVAYTA NLLLSGATTY KLTPAQWFLR 

       130        140        150        160        170        180 
EGSMFVALSA SVFSLLAIAI ERYITMLKMK LHNGSNSSRS FLLISACWVI SLILGGLPIM 

       190        200        210        220        230        240 
GWNCISSLSS CSTVLPLYHK HYILFCTTVF TLLLLSIVIL YCRIYSLVRT RSRRLTFRKN 

       250        260        270        280        290        300 
ISKASRSSEK SLALLKTVII VLSVFIACWA PLFILLLLDV GCKAKTCDIL YKAEYFLVLA 

       310        320        330        340        350        360 
VLNSGTNPII YTLTNKEMRR AFIRIVSCCK CPNGDSAGKF KRPIIPGMEF SRSKSDNSSH 

       370        380 
PQKDDGDNPE TIMSSGNVNS SS

« Hide

References

« Hide 'large scale' references
[1]"The mouse gene for the inducible G-protein-coupled receptor edg-1."
Liu C.H., Hla T.
Genomics 43:15-24(1997) [PubMed: 9226368] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: BALB/c.
Tissue: Liver.
[2]"Comparative analysis of three murine G-protein coupled receptors activated by sphingosine-1-phosphate."
Zhang G., Contos J.J.A., Weiner J.A., Fukushima N., Chun J.
Gene 227:89-99(1999) [PubMed: 9931453] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
Strain: 129/SvJ.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Heart and Lung.
[4]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Eye.
[6]"Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility."
Hobson J.P., Rosenfeldt H.M., Barak L.S., Olivera A., Poulton S., Caron M.G., Milstien S., Spiegel S.
Science 291:1800-1803(2001) [PubMed: 11230698] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U40811 Genomic DNA. Translation: AAC53294.1.
AF108019 Genomic DNA. Translation: AAD16975.1.
AK004591 mRNA. Translation: BAB23393.1.
AK146501 mRNA. Translation: BAE27216.1.
CH466532 Genomic DNA. Translation: EDL12402.1.
BC049094 mRNA. Translation: AAH49094.1.
BC051023 mRNA. Translation: AAH51023.1.
IPIIPI00308940.
RefSeqNP_031927.2. NM_007901.5.
UniGeneMm.982.

3D structure databases

ProteinModelPortalO08530.
SMRO08530. Positions 44-336.
ModBaseSearch...

Protein-protein interaction databases

IntActO08530. 1 interaction.
STRINGO08530.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteO08530.

Proteomic databases

PRIDEO08530.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000055676; ENSMUSP00000050897; ENSMUSG00000045092.
GeneID13609.
KEGGmmu:13609.

Organism-specific databases

CTD1901.
MGIMGI:1096355. S1pr1.

Phylogenomic databases

GeneTreeENSGT00590000082727.
HOGENOMHBG714382.
HOVERGENHBG103071.
InParanoidO08530.
OrthoDBEOG418BNR.

Gene expression databases

ArrayExpressO08530.
BgeeO08530.
GenevestigatorO08530.
GermOnlineENSMUSG00000045092. Mus musculus.

Family and domain databases

InterProIPR000276. 7TM_GPCR_Rhodpsn.
IPR000987. EDG1_rcpt.
IPR017452. GPCR_Rhodpsn_supfam.
IPR004061. S1P_rcpt.
[Graphical view]
KOK04288.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00642. EDG1RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01523. S1PRECEPTOR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameS1PR1_MOUSE
AccessionPrimary (citable) accession number: O08530
Secondary accession number(s): Q9DC35, Q9R235
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: January 25, 2012
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents