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Protein

Beta-tectorin

Gene

Tectb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.By similarity

GO - Molecular functioni

  1. extracellular matrix structural constituent Source: MGI

GO - Biological processi

  1. sensory perception of sound Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-tectorin
Gene namesi
Name:Tectb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:109574. Tectb.

Subcellular locationi

Cell membrane Curated; Lipid-anchorGPI-anchor Curated; Extracellular side Curated. Secretedextracellular spaceextracellular matrix
Note: Found in the non-collagenous matrix of the tectorial membrane.By similarity

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
  3. proteinaceous extracellular matrix Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Extracellular matrix, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 305288Beta-tectorinPRO_0000041743Add
BLAST
Propeptidei306 – 32924Removed in mature formSequence AnalysisPRO_0000041744Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi80 – 801N-linked (GlcNAc...)Sequence Analysis
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi116 – 1161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi145 – 1451N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi204 ↔ 264By similarity
Lipidationi305 – 3051GPI-anchor amidated alanineSequence Analysis

Post-translational modificationi

The presence of a hydrophobic C-terminus preceded by a potential cleavage site strongly suggests that tectorins are synthesized as glycosylphosphatidylinositol-linked, membrane-bound precursors. Tectorins are targeted to the apical surface of the inner ear epithelia by the lipid and proteolytically released into the extracellular compartment.

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PRIDEiO08524.

Expressioni

Gene expression databases

BgeeiO08524.
CleanExiMM_TECTB.
ExpressionAtlasiO08524. baseline and differential.
GenevestigatoriO08524.

Interactioni

Subunit structurei

May form homomeric filament after self-association or heteromeric filament after association with alpha-tectorin.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113805.

Structurei

3D structure databases

ProteinModelPortaliO08524.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 283265ZPPROSITE-ProRule annotationAdd
BLAST

Domaini

Zona pellucida domain may enable to form filaments.

Sequence similaritiesi

Contains 1 ZP domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG44475.
HOGENOMiHOG000124070.
HOVERGENiHBG056825.
InParanoidiO08524.
PhylomeDBiO08524.
TreeFamiTF330284.

Family and domain databases

InterProiIPR001507. ZP_dom.
IPR017977. ZP_dom_CS.
[Graphical view]
PfamiPF00100. Zona_pellucida. 1 hit.
[Graphical view]
PRINTSiPR00023. ZPELLUCIDA.
SMARTiSM00241. ZP. 1 hit.
[Graphical view]
PROSITEiPS00682. ZP_1. 1 hit.
PS51034. ZP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O08524-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVRAFVLLA LFAEASAKSC TPNKADVILV FCYPKTIITK IPECPYGWEV
60 70 80 90 100
HQLALGGLCY NGVHEGGYYQ FVIPDLSPKN KSYCGTQSEY KPPIYHFYSH
110 120 130 140 150
IVSNDSTVIV KNQPVNYSFS CTYHSTYLVN QAAFDQRVAT VHVKNGSMGT
160 170 180 190 200
FESQLSLNFY TNAKFSTKKE APFVLETSEI GSDLFAGVEA KGLSVRFKVV
210 220 230 240 250
LNSCWATPSA DFMYPLQWQL INKGCPTDET VLVHENGKDH RATFQFNAFR
260 270 280 290 300
FQNIPKLSKV WLHCETFICD SEKLSCPVNC DKRKRMLRDQ TGGVLVVELS
310 320
LRSRAFSGLC DFSDVLLHLI LMLGTWAVL
Length:329
Mass (Da):36,986
Last modified:October 1, 2000 - v2
Checksum:iCC69A33EBC270AB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99806 mRNA. Translation: CAA68139.2.
CCDSiCCDS29907.1.
RefSeqiNP_033374.2. NM_009348.3.
XP_006526966.1. XM_006526903.1.
UniGeneiMm.42139.

Genome annotation databases

EnsembliENSMUST00000025936; ENSMUSP00000025936; ENSMUSG00000024979.
GeneIDi21684.
KEGGimmu:21684.
UCSCiuc008hxm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99806 mRNA. Translation: CAA68139.2.
CCDSiCCDS29907.1.
RefSeqiNP_033374.2. NM_009348.3.
XP_006526966.1. XM_006526903.1.
UniGeneiMm.42139.

3D structure databases

ProteinModelPortaliO08524.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113805.

Proteomic databases

PRIDEiO08524.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025936; ENSMUSP00000025936; ENSMUSG00000024979.
GeneIDi21684.
KEGGimmu:21684.
UCSCiuc008hxm.1. mouse.

Organism-specific databases

CTDi6975.
MGIiMGI:109574. Tectb.

Phylogenomic databases

eggNOGiNOG44475.
HOGENOMiHOG000124070.
HOVERGENiHBG056825.
InParanoidiO08524.
PhylomeDBiO08524.
TreeFamiTF330284.

Miscellaneous databases

NextBioi301000.
PROiO08524.
SOURCEiSearch...

Gene expression databases

BgeeiO08524.
CleanExiMM_TECTB.
ExpressionAtlasiO08524. baseline and differential.
GenevestigatoriO08524.

Family and domain databases

InterProiIPR001507. ZP_dom.
IPR017977. ZP_dom_CS.
[Graphical view]
PfamiPF00100. Zona_pellucida. 1 hit.
[Graphical view]
PRINTSiPR00023. ZPELLUCIDA.
SMARTiSM00241. ZP. 1 hit.
[Graphical view]
PROSITEiPS00682. ZP_1. 1 hit.
PS51034. ZP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The mouse tectorins. Modular matrix proteins of the inner ear homologous to components of the sperm-egg adhesion system."
    Legan P.K., Rau A., Keene J.N., Richardson G.P.
    J. Biol. Chem. 272:8791-8801(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CD-1.
    Tissue: Cochlea.

Entry informationi

Entry nameiTECTB_MOUSE
AccessioniPrimary (citable) accession number: O08524
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2000
Last modified: March 4, 2015
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.