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O08524

- TECTB_MOUSE

UniProt

O08524 - TECTB_MOUSE

Protein

Beta-tectorin

Gene

Tectb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 2 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    One of the major non-collagenous components of the tectorial membrane By similarity. The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.By similarity

    GO - Molecular functioni

    1. extracellular matrix structural constituent Source: MGI

    GO - Biological processi

    1. sensory perception of sound Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-tectorin
    Gene namesi
    Name:Tectb
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:109574. Tectb.

    Subcellular locationi

    Cell membrane Curated; Lipid-anchorGPI-anchor Curated; Extracellular side Curated. Secretedextracellular spaceextracellular matrix
    Note: Found in the non-collagenous matrix of the tectorial membrane.By similarity

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    3. proteinaceous extracellular matrix Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Extracellular matrix, Membrane, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 305288Beta-tectorinPRO_0000041743Add
    BLAST
    Propeptidei306 – 32924Removed in mature formSequence AnalysisPRO_0000041744Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi80 – 801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi116 – 1161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi145 – 1451N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi204 ↔ 264By similarity
    Lipidationi305 – 3051GPI-anchor amidated alanineSequence Analysis

    Post-translational modificationi

    The presence of a hydrophobic C-terminus preceded by a potential cleavage site strongly suggests that tectorins are synthesized as glycosylphosphatidylinositol-linked, membrane-bound precursors. Tectorins are targeted to the apical surface of the inner ear epithelia by the lipid and proteolytically released into the extracellular compartment.

    Keywords - PTMi

    Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    PRIDEiO08524.

    Expressioni

    Gene expression databases

    BgeeiO08524.
    CleanExiMM_TECTB.
    GenevestigatoriO08524.

    Interactioni

    Subunit structurei

    May form homomeric filament after self-association or heteromeric filament after association with alpha-tectorin.

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000113805.

    Structurei

    3D structure databases

    ProteinModelPortaliO08524.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini19 – 283265ZPPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    Zona pellucida domain may enable to form filaments.

    Sequence similaritiesi

    Contains 1 ZP domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG44475.
    HOGENOMiHOG000124070.
    HOVERGENiHBG056825.
    PhylomeDBiO08524.
    TreeFamiTF330284.

    Family and domain databases

    InterProiIPR001507. ZP_dom.
    IPR017977. ZP_dom_CS.
    [Graphical view]
    PfamiPF00100. Zona_pellucida. 1 hit.
    [Graphical view]
    PRINTSiPR00023. ZPELLUCIDA.
    SMARTiSM00241. ZP. 1 hit.
    [Graphical view]
    PROSITEiPS00682. ZP_1. 1 hit.
    PS51034. ZP_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O08524-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVVRAFVLLA LFAEASAKSC TPNKADVILV FCYPKTIITK IPECPYGWEV    50
    HQLALGGLCY NGVHEGGYYQ FVIPDLSPKN KSYCGTQSEY KPPIYHFYSH 100
    IVSNDSTVIV KNQPVNYSFS CTYHSTYLVN QAAFDQRVAT VHVKNGSMGT 150
    FESQLSLNFY TNAKFSTKKE APFVLETSEI GSDLFAGVEA KGLSVRFKVV 200
    LNSCWATPSA DFMYPLQWQL INKGCPTDET VLVHENGKDH RATFQFNAFR 250
    FQNIPKLSKV WLHCETFICD SEKLSCPVNC DKRKRMLRDQ TGGVLVVELS 300
    LRSRAFSGLC DFSDVLLHLI LMLGTWAVL 329
    Length:329
    Mass (Da):36,986
    Last modified:October 1, 2000 - v2
    Checksum:iCC69A33EBC270AB3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X99806 mRNA. Translation: CAA68139.2.
    CCDSiCCDS29907.1.
    RefSeqiNP_033374.2. NM_009348.3.
    XP_006526966.1. XM_006526903.1.
    UniGeneiMm.42139.

    Genome annotation databases

    EnsembliENSMUST00000025936; ENSMUSP00000025936; ENSMUSG00000024979.
    GeneIDi21684.
    KEGGimmu:21684.
    UCSCiuc008hxm.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X99806 mRNA. Translation: CAA68139.2 .
    CCDSi CCDS29907.1.
    RefSeqi NP_033374.2. NM_009348.3.
    XP_006526966.1. XM_006526903.1.
    UniGenei Mm.42139.

    3D structure databases

    ProteinModelPortali O08524.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000113805.

    Proteomic databases

    PRIDEi O08524.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025936 ; ENSMUSP00000025936 ; ENSMUSG00000024979 .
    GeneIDi 21684.
    KEGGi mmu:21684.
    UCSCi uc008hxm.1. mouse.

    Organism-specific databases

    CTDi 6975.
    MGIi MGI:109574. Tectb.

    Phylogenomic databases

    eggNOGi NOG44475.
    HOGENOMi HOG000124070.
    HOVERGENi HBG056825.
    PhylomeDBi O08524.
    TreeFami TF330284.

    Miscellaneous databases

    NextBioi 301000.
    PROi O08524.
    SOURCEi Search...

    Gene expression databases

    Bgeei O08524.
    CleanExi MM_TECTB.
    Genevestigatori O08524.

    Family and domain databases

    InterProi IPR001507. ZP_dom.
    IPR017977. ZP_dom_CS.
    [Graphical view ]
    Pfami PF00100. Zona_pellucida. 1 hit.
    [Graphical view ]
    PRINTSi PR00023. ZPELLUCIDA.
    SMARTi SM00241. ZP. 1 hit.
    [Graphical view ]
    PROSITEi PS00682. ZP_1. 1 hit.
    PS51034. ZP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The mouse tectorins. Modular matrix proteins of the inner ear homologous to components of the sperm-egg adhesion system."
      Legan P.K., Rau A., Keene J.N., Richardson G.P.
      J. Biol. Chem. 272:8791-8801(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: CD-1.
      Tissue: Cochlea.

    Entry informationi

    Entry nameiTECTB_MOUSE
    AccessioniPrimary (citable) accession number: O08524
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 98 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3