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O08524

- TECTB_MOUSE

UniProt

O08524 - TECTB_MOUSE

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Protein

Beta-tectorin

Gene
Tectb
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

One of the major non-collagenous components of the tectorial membrane By similarity. The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.

GO - Molecular functioni

  1. extracellular matrix structural constituent Source: MGI

GO - Biological processi

  1. sensory perception of sound Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-tectorin
Gene namesi
Name:Tectb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:109574. Tectb.

Subcellular locationi

Cell membrane; Lipid-anchorGPI-anchor; Extracellular side Inferred. Secretedextracellular spaceextracellular matrix
Note: Found in the non-collagenous matrix of the tectorial membrane By similarity.

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
  3. proteinaceous extracellular matrix Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Extracellular matrix, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed predictionAdd
BLAST
Chaini18 – 305288Beta-tectorinPRO_0000041743Add
BLAST
Propeptidei306 – 32924Removed in mature form Reviewed predictionPRO_0000041744Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi80 – 801N-linked (GlcNAc...) Reviewed prediction
Glycosylationi104 – 1041N-linked (GlcNAc...) Reviewed prediction
Glycosylationi116 – 1161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi145 – 1451N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi204 ↔ 264 By similarity
Lipidationi305 – 3051GPI-anchor amidated alanine Reviewed prediction

Post-translational modificationi

The presence of a hydrophobic C-terminus preceded by a potential cleavage site strongly suggests that tectorins are synthesized as glycosylphosphatidylinositol-linked, membrane-bound precursors. Tectorins are targeted to the apical surface of the inner ear epithelia by the lipid and proteolytically released into the extracellular compartment.

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PRIDEiO08524.

Expressioni

Gene expression databases

BgeeiO08524.
CleanExiMM_TECTB.
GenevestigatoriO08524.

Interactioni

Subunit structurei

May form homomeric filament after self-association or heteromeric filament after association with alpha-tectorin.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113805.

Structurei

3D structure databases

ProteinModelPortaliO08524.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 283265ZPAdd
BLAST

Domaini

Zona pellucida domain may enable to form filaments.

Sequence similaritiesi

Contains 1 ZP domain.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG44475.
HOGENOMiHOG000124070.
HOVERGENiHBG056825.
PhylomeDBiO08524.
TreeFamiTF330284.

Family and domain databases

InterProiIPR001507. ZP_dom.
IPR017977. ZP_dom_CS.
[Graphical view]
PfamiPF00100. Zona_pellucida. 1 hit.
[Graphical view]
PRINTSiPR00023. ZPELLUCIDA.
SMARTiSM00241. ZP. 1 hit.
[Graphical view]
PROSITEiPS00682. ZP_1. 1 hit.
PS51034. ZP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O08524-1 [UniParc]FASTAAdd to Basket

« Hide

MVVRAFVLLA LFAEASAKSC TPNKADVILV FCYPKTIITK IPECPYGWEV    50
HQLALGGLCY NGVHEGGYYQ FVIPDLSPKN KSYCGTQSEY KPPIYHFYSH 100
IVSNDSTVIV KNQPVNYSFS CTYHSTYLVN QAAFDQRVAT VHVKNGSMGT 150
FESQLSLNFY TNAKFSTKKE APFVLETSEI GSDLFAGVEA KGLSVRFKVV 200
LNSCWATPSA DFMYPLQWQL INKGCPTDET VLVHENGKDH RATFQFNAFR 250
FQNIPKLSKV WLHCETFICD SEKLSCPVNC DKRKRMLRDQ TGGVLVVELS 300
LRSRAFSGLC DFSDVLLHLI LMLGTWAVL 329
Length:329
Mass (Da):36,986
Last modified:October 1, 2000 - v2
Checksum:iCC69A33EBC270AB3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X99806 mRNA. Translation: CAA68139.2.
CCDSiCCDS29907.1.
RefSeqiNP_033374.2. NM_009348.3.
XP_006526966.1. XM_006526903.1.
UniGeneiMm.42139.

Genome annotation databases

EnsembliENSMUST00000025936; ENSMUSP00000025936; ENSMUSG00000024979.
GeneIDi21684.
KEGGimmu:21684.
UCSCiuc008hxm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X99806 mRNA. Translation: CAA68139.2 .
CCDSi CCDS29907.1.
RefSeqi NP_033374.2. NM_009348.3.
XP_006526966.1. XM_006526903.1.
UniGenei Mm.42139.

3D structure databases

ProteinModelPortali O08524.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000113805.

Proteomic databases

PRIDEi O08524.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025936 ; ENSMUSP00000025936 ; ENSMUSG00000024979 .
GeneIDi 21684.
KEGGi mmu:21684.
UCSCi uc008hxm.1. mouse.

Organism-specific databases

CTDi 6975.
MGIi MGI:109574. Tectb.

Phylogenomic databases

eggNOGi NOG44475.
HOGENOMi HOG000124070.
HOVERGENi HBG056825.
PhylomeDBi O08524.
TreeFami TF330284.

Miscellaneous databases

NextBioi 301000.
PROi O08524.
SOURCEi Search...

Gene expression databases

Bgeei O08524.
CleanExi MM_TECTB.
Genevestigatori O08524.

Family and domain databases

InterProi IPR001507. ZP_dom.
IPR017977. ZP_dom_CS.
[Graphical view ]
Pfami PF00100. Zona_pellucida. 1 hit.
[Graphical view ]
PRINTSi PR00023. ZPELLUCIDA.
SMARTi SM00241. ZP. 1 hit.
[Graphical view ]
PROSITEi PS00682. ZP_1. 1 hit.
PS51034. ZP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The mouse tectorins. Modular matrix proteins of the inner ear homologous to components of the sperm-egg adhesion system."
    Legan P.K., Rau A., Keene J.N., Richardson G.P.
    J. Biol. Chem. 272:8791-8801(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CD-1.
    Tissue: Cochlea.

Entry informationi

Entry nameiTECTB_MOUSE
AccessioniPrimary (citable) accession number: O08524
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi