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O08523

- TECTA_MOUSE

UniProt

O08523 - TECTA_MOUSE

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Protein
Alpha-tectorin
Gene
Tecta
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

One of the major non-collagenous components of the tectorial membrane By similarity. The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.

GO - Molecular functioni

  1. extracellular matrix structural constituent Source: MGI
  2. protein binding Source: MGI

GO - Biological processi

  1. cell-matrix adhesion Source: InterPro
  2. sensory perception of sound Source: MGI
Complete GO annotation...

Keywords - Biological processi

Hearing

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-tectorin
Gene namesi
Name:Tecta
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:109575. Tecta.

Subcellular locationi

Cell membrane; Lipid-anchorGPI-anchor; Extracellular side Inferred. Secretedextracellular spaceextracellular matrix
Note: Found in the non-collagenous matrix of the tectorial membrane.1 Publication

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
  3. proteinaceous extracellular matrix Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Extracellular matrix, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 24241 Publication
Add
BLAST
Chaini25 – 20912067Alpha-tectorin
PRO_0000041737Add
BLAST
Propeptidei2092 – 215564Removed in mature form Reviewed prediction
PRO_0000041738Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi34 – 341N-linked (GlcNAc...) Reviewed prediction
Glycosylationi187 – 1871N-linked (GlcNAc...) Reviewed prediction
Glycosylationi215 – 2151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi278 – 2781N-linked (GlcNAc...) Reviewed prediction
Glycosylationi455 – 4551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi506 – 5061N-linked (GlcNAc...) Reviewed prediction
Glycosylationi528 – 5281N-linked (GlcNAc...) Reviewed prediction
Glycosylationi560 – 5601N-linked (GlcNAc...) Reviewed prediction
Glycosylationi670 – 6701N-linked (GlcNAc...) Reviewed prediction
Glycosylationi687 – 6871N-linked (GlcNAc...) Reviewed prediction
Glycosylationi813 – 8131N-linked (GlcNAc...) Reviewed prediction
Glycosylationi843 – 8431N-linked (GlcNAc...) Reviewed prediction
Glycosylationi855 – 8551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi898 – 8981N-linked (GlcNAc...) Reviewed prediction
Glycosylationi920 – 9201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi931 – 9311N-linked (GlcNAc...) Reviewed prediction
Glycosylationi949 – 9491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1048 – 10481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1064 – 10641N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1235 – 12351N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1364 – 13641N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1538 – 15381N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1565 – 15651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1756 – 17561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1772 – 17721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1794 – 17941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1851 – 18511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1864 – 18641N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1880 – 18801N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1920 – 19201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1939 – 19391N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1980 ↔ 2040 By similarity
Lipidationi2091 – 20911GPI-anchor amidated asparagine Reviewed prediction

Post-translational modificationi

3 products of tectorin seem to exist: HMM, MMM and LMM. They may be generated by active processing or the result of proteolysis occurring between intrachain disulfide bonds.
The presence of a hydrophobic C-terminus preceded by a potential cleavage site strongly suggests that tectorins are synthesized as glycosylphosphatidylinositol-linked, membrane-bound precursors. Tectorins are targeted to the apical surface of the inner ear epithelia by the lipid and proteolytically released into the extracellular compartment.

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiO08523.
PRIDEiO08523.

PTM databases

PhosphoSiteiO08523.

Expressioni

Tissue specificityi

Cochlea-specific.1 Publication

Gene expression databases

BgeeiO08523.
CleanExiMM_TECTA.
GenevestigatoriO08523.

Interactioni

Subunit structurei

May form homomeric filament after self-association or heteromeric filament after association with beta-tectorin. Interacts with CEACAM16 By similarity.1 Publication

Protein-protein interaction databases

IntActiO08523. 1 interaction.
MINTiMINT-4137390.

Structurei

3D structure databases

ProteinModelPortaliO08523.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini98 – 252155NIDO
Add
BLAST
Domaini260 – 31455VWFC
Add
BLAST
Domaini321 – 540220VWFD 1
Add
BLAST
Domaini597 – 65054TIL 1
Add
BLAST
Domaini712 – 929218VWFD 2
Add
BLAST
Domaini984 – 103653TIL 2
Add
BLAST
Domaini1099 – 1317219VWFD 3
Add
BLAST
Domaini1372 – 142554TIL 3
Add
BLAST
Domaini1486 – 1694209VWFD 4
Add
BLAST
Domaini1805 – 2059255ZP
Add
BLAST

Domaini

Zona pellucida domain may enable to form filaments.

Sequence similaritiesi

Contains 1 NIDO domain.
Contains 1 VWFC domain.
Contains 4 VWFD domains.
Contains 1 ZP domain.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG317991.
GeneTreeiENSGT00730000110288.
HOGENOMiHOG000168220.
HOVERGENiHBG079244.
InParanoidiO08523.
KOiK18273.
OMAiYLTFDGY.
OrthoDBiEOG7SJD3N.
TreeFamiTF300299.

Family and domain databases

InterProiIPR000742. EG-like_dom.
IPR003886. Nidogen_extracell_dom.
IPR002919. TIL_dom.
IPR025615. TILa_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR006552. VWC_out.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
IPR001507. ZP_dom.
IPR017977. ZP_dom_CS.
[Graphical view]
PfamiPF08742. C8. 4 hits.
PF06119. NIDO. 1 hit.
PF01826. TIL. 3 hits.
PF12714. TILa. 2 hits.
PF00094. VWD. 4 hits.
PF00100. Zona_pellucida. 1 hit.
[Graphical view]
SMARTiSM00832. C8. 4 hits.
SM00181. EGF. 1 hit.
SM00539. NIDO. 1 hit.
SM00214. VWC. 1 hit.
SM00215. VWC_out. 1 hit.
SM00216. VWD. 4 hits.
SM00241. ZP. 1 hit.
[Graphical view]
SUPFAMiSSF57567. SSF57567. 3 hits.
PROSITEiPS51220. NIDO. 1 hit.
PS51233. VWFD. 4 hits.
PS00682. ZP_1. 1 hit.
PS51034. ZP_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O08523-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MNYSSLLRIW VSFIFALVRH QAQPRELMYP FWQNDTRTPK VDDGSSSEIK     50
LAIPVFFFGV PYRTVYVNNN GVVSFNVLVS QFTPESFPLT DGRAFIAPFW 100
ADVHNGIRGE IYYRETMDPA ILRRATKDIR KYFKDMTTFS ATWVFIVTWE 150
EVTFYGGSST TPVNTFQAVL VSDGSYTFTL FNYYEINWTT GTASGGDPLT 200
GLGGVMAQAG FNGGNLTNFF SLPGSRTPEI VNIQETTNVN VPGRWAFKVD 250
GKEIDPANGC TSRGQFLRRG EVFWDDLNCT IKCRCLDFNN EIYCQEASCS 300
PYEVCEPKGR FFYCSPVETS TCVVFGEPHY HTFDGFLFHF QGSCAYLLAR 350
QCLQTSSLPF FSVEAKNEHR GGSAVSWVKE LSVEVNGYKI LIPKGSYGKV 400
KVNDLVTSLP VTLELGAVKI YQSGMSTAVE TDFGLLVTFD GQHYASISIP 450
GSYINSTCGL CGNYNKNPLD DFLRPDGRPA MSVLDLGESW RVYHADWKCG 500
SGCVDNCTQC DAATEALYFG SDYCGFLNKT DGPLWECGTV VDATAFVHSC 550
VYDLCSVRDN GTLLCQAIQA YALVCQALGI PIGDWRIQTG CVSTVRCPSF 600
SHYSVCTSSC PDTCSDLTAS QNCATPCTEG CECNEGFVLS TSQCVPLHKC 650
GCDFDGHYYT MGEFFWATAN CTVQCLCEEG GDVYCFNKTC RSGEVCAVED 700
GYQGCFPKRE TVCLLSQNQV LHTFDGAAYA FPSELSYTLL KTCPERPEYL 750
EIDINKKKPD AGPAWLRGVR ILVADQEVKI GGVGALEVKL NGQDVELPFF 800
HPSGRLEIHR NKNSTTVESK GVVSVQYSDV GLLYIRLSTM YFNCTGGLCG 850
FFNANASDEF CLPNGKCTDN LAVFLESWTT FEEICNGECG DLLKACNNDS 900
ELLKFYRSRS RCGIINDPSN SSFLECHGVV NVTAYYRTCL FRLCQSGGNE 950
SELCDSVARY ASACKNADVE VGPWRTYDFC PLECPENSHF EECMTCTETC 1000
ETLALGPICV DSCSEGCQCD EGYALQGSQC VPRSECGCNF EGHQLATNET 1050
FWVDQDCQIF CYCNGTDNSV HCETIPCRDD EYCMEESGLY YCQPRTDASC 1100
IVSGYGHYLT FDGYPFDFQT SCPLILCTTG SRPISDSFPK FIVTAKNEDR 1150
DPSLALWVKQ VDVNVFGYSI VIHRAYKHTV LVNNERLYLP LKLGQGKINI 1200
FSFGFHVVVE TDFGLKVVYD WKTFLSITVP RSMQNGTYGL CGRYNGNPDD 1250
DLEMPMGLPA LSINEFGQSW VKRDTFCQVG CGDRCPSCAK VEGFSKVQQL 1300
CSLIPNQNAG FAKCHSKVNP TFFYKNCLFD SCIDGGAVQT ACSWLQNYAS 1350
TCQTQGIAVT GWRNYTSCSV TCPPNSHYES CVSVCQPRCA AIRLKSDCNH 1400
YCVEGCQCDA GYVLNGKSCI LPHNCGCYSD GKYYEPKQLF WNGDCTRRCR 1450
CFRRNLIQCD PRQCKSDEEC ALRSGVRGCF STKTSYCLAA GGGVFRTFDG 1500
AFLRFPANCA FVLSTICQKL PDISFQLIIN FDKWSSPNLT IISPVYFYIN 1550
EEQILINDRN TVKVNGTQVN VPFITGLATK IYSSEGFLVI DTSPDIQIYY 1600
NGFNVIKISI SERLQNKVCG LCGNFNGDMT DDYVTLRGKP VVSSVVLAQS 1650
WKTNGMQKRP LAPSCNELQF SQYAATCDNV HIQAMQGDGY CLKLTDMKGF 1700
FQPCYGLLDP LPFYESCYLD GCYNHKKFQL CGSLAAYGEA CRSFGILSTE 1750
WIEKENCSGV VEDPCVGADC PNRTCELDNG GELCGCIEPP PYGNNSHDII 1800
DAEVTCKAAQ MEVSISKCKL FQLGFEREGV RINDRQCSGI EGEDFISFQI 1850
NNTKGNCGNI VQSNGTHIMY KNTIWIESAN NTGNIITRDR TINVEFSCAY 1900
ELDIKISLDS VVKPMLSVIN LTVPTQEGSF TTKMALYKNA SYKHPYRQGE 1950
VVLTTRDVLY VGVFVVGADS THLILTLNKC YATPSRDSND KLRYFIIEGG 2000
CQNIKDNTIG IEENGVSLTC RFHVTVFKFI GDYDEVHLHC AVSLCDSEKY 2050
SCKINCPQNS RIATDYSKEH KEQIISVGPI RRKRLDWCED NGGCEQICTS 2100
RVDGPLCSCV TGSLQEDGRS CRASNSSVEL QVWTLLLIMT QISLWHLIYK 2150
SGATS 2155
Length:2,155
Mass (Da):239,433
Last modified:July 27, 2011 - v2
Checksum:i1F93E76E0FFB2C23
GO
Isoform 2 (identifier: O08523-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1659-1663: Missing.

Show »
Length:2,150
Mass (Da):238,898
Checksum:iB80D56156F66FA75
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1659 – 16635Missing in isoform 2.
VSP_010557

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti803 – 8031S → T in CAA68138. 1 Publication
Sequence conflicti1024 – 10241A → R in CAA68138. 1 Publication
Sequence conflicti1032 – 10321P → T in CAA68138. 1 Publication
Sequence conflicti1229 – 12291V → I in CAA68138. 1 Publication
Sequence conflicti2148 – 21481I → V in CAA68138. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X99805 mRNA. Translation: CAA68138.1.
AC156631 Genomic DNA. No translation available.
CCDSiCCDS23087.1. [O08523-1]
PIRiT30197.
RefSeqiNP_033373.2. NM_009347.2. [O08523-1]
XP_006510211.1. XM_006510148.1. [O08523-1]
XP_006510212.1. XM_006510149.1. [O08523-1]
XP_006510213.1. XM_006510150.1. [O08523-2]
UniGeneiMm.42209.

Genome annotation databases

EnsembliENSMUST00000042190; ENSMUSP00000040262; ENSMUSG00000037705. [O08523-1]
ENSMUST00000160940; ENSMUSP00000125370; ENSMUSG00000037705. [O08523-2]
GeneIDi21683.
KEGGimmu:21683.
UCSCiuc009pau.1. mouse. [O08523-1]
uc012grn.1. mouse. [O08523-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X99805 mRNA. Translation: CAA68138.1 .
AC156631 Genomic DNA. No translation available.
CCDSi CCDS23087.1. [O08523-1 ]
PIRi T30197.
RefSeqi NP_033373.2. NM_009347.2. [O08523-1 ]
XP_006510211.1. XM_006510148.1. [O08523-1 ]
XP_006510212.1. XM_006510149.1. [O08523-1 ]
XP_006510213.1. XM_006510150.1. [O08523-2 ]
UniGenei Mm.42209.

3D structure databases

ProteinModelPortali O08523.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O08523. 1 interaction.
MINTi MINT-4137390.

PTM databases

PhosphoSitei O08523.

Proteomic databases

PaxDbi O08523.
PRIDEi O08523.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000042190 ; ENSMUSP00000040262 ; ENSMUSG00000037705 . [O08523-1 ]
ENSMUST00000160940 ; ENSMUSP00000125370 ; ENSMUSG00000037705 . [O08523-2 ]
GeneIDi 21683.
KEGGi mmu:21683.
UCSCi uc009pau.1. mouse. [O08523-1 ]
uc012grn.1. mouse. [O08523-2 ]

Organism-specific databases

CTDi 7007.
MGIi MGI:109575. Tecta.

Phylogenomic databases

eggNOGi NOG317991.
GeneTreei ENSGT00730000110288.
HOGENOMi HOG000168220.
HOVERGENi HBG079244.
InParanoidi O08523.
KOi K18273.
OMAi YLTFDGY.
OrthoDBi EOG7SJD3N.
TreeFami TF300299.

Miscellaneous databases

NextBioi 300996.
PROi O08523.
SOURCEi Search...

Gene expression databases

Bgeei O08523.
CleanExi MM_TECTA.
Genevestigatori O08523.

Family and domain databases

InterProi IPR000742. EG-like_dom.
IPR003886. Nidogen_extracell_dom.
IPR002919. TIL_dom.
IPR025615. TILa_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR006552. VWC_out.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
IPR001507. ZP_dom.
IPR017977. ZP_dom_CS.
[Graphical view ]
Pfami PF08742. C8. 4 hits.
PF06119. NIDO. 1 hit.
PF01826. TIL. 3 hits.
PF12714. TILa. 2 hits.
PF00094. VWD. 4 hits.
PF00100. Zona_pellucida. 1 hit.
[Graphical view ]
SMARTi SM00832. C8. 4 hits.
SM00181. EGF. 1 hit.
SM00539. NIDO. 1 hit.
SM00214. VWC. 1 hit.
SM00215. VWC_out. 1 hit.
SM00216. VWD. 4 hits.
SM00241. ZP. 1 hit.
[Graphical view ]
SUPFAMi SSF57567. SSF57567. 3 hits.
PROSITEi PS51220. NIDO. 1 hit.
PS51233. VWFD. 4 hits.
PS00682. ZP_1. 1 hit.
PS51034. ZP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The mouse tectorins. Modular matrix proteins of the inner ear homologous to components of the sperm-egg adhesion system."
    Legan P.K., Rau A., Keene J.N., Richardson G.P.
    J. Biol. Chem. 272:8791-8801(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), PROTEIN SEQUENCE OF 25-34, SUBUNIT, SUBCELLULAR LOCATION, POST-TRANSLATIONAL MODIFICATIONS, TISSUE SPECIFICITY.
    Strain: CD-1.
    Tissue: Cochlea.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiTECTA_MOUSE
AccessioniPrimary (citable) accession number: O08523
Secondary accession number(s): E9QNR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi