Copper-transporting ATPase - Helicobacter pylori

Preferred order of sections

Names and origin

Protein names

Recommended name:
Copper-transporting ATPase
EC=3.6.3.4

Gene names

Name:

copA

Organism

Helicobacter pylori (Campylobacter pylori)

Taxonomic identifier

210 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	745 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Probably involved in copper export.
Catalytic activity	ATP + H₂O + Cu²⁺(In) = ADP + phosphate + Cu²⁺(Out).
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. [View classification] Contains 1 HMA domain.

Ontologies

Keywords
Biological process	Copper transport Ion transport Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Copper Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW copper-exporting ATPase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 745

745

Copper-transporting ATPase

PRO_0000046173

Regions

Topological domain

1 – 83

83

Cytoplasmic Potential

Transmembrane

84 – 104

21

Helical; Potential

Topological domain

105 – 124

20

Extracellular Potential

Transmembrane

125 – 144

20

Helical; Potential

Topological domain

145 – 151

7

Cytoplasmic Potential

Transmembrane

152 – 172

21

Helical; Potential

Topological domain

173 – 194

22

Extracellular Potential

Transmembrane

195 – 215

21

Helical; Potential

Topological domain

216 – 343

128

Cytoplasmic Potential

Transmembrane

344 – 366

23

Helical; Potential

Topological domain

367 – 379

13

Extracellular Potential

Transmembrane

380 – 397

18

Helical; Potential

Topological domain

398 – 685

288

Cytoplasmic Potential

Transmembrane

686 – 705

20

Helical; Potential

Topological domain

706 – 716

11

Extracellular Potential

Transmembrane

717 – 735

19

Helical; Potential

Topological domain

736 – 745

10

Cytoplasmic Potential

Domain

2 – 68

67

HMA

Sites

Active site

435

1

4-aspartylphosphate intermediate By similarity

Metal binding

12

1

Copper Potential

Metal binding

15

1

Copper Potential

Metal binding

631

1

Magnesium By similarity

Metal binding

635

1

Magnesium By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

O08462 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 604CA6DC74B13480
Show »

FASTA

745

81,845

        10         20         30         40         50         60 
MKESFYIEGM TCTACSSGIE RSLGRKSFVK KIEVSLLNKS ANIEFNENET NLDEIFKLIE 

        70         80         90        100        110        120 
KLGYSPKKTL AEEKKEFFSP NVKLALAVIF TLFVVYLSMG AMLSPSLLPE SLLAINNHSN 

       130        140        150        160        170        180 
FLNACLQLIG ALIVMHLGRD FYIQGFKALW HRQPNMSSLI AIGTSAALIS SLWQLYLVYT 

       190        200        210        220        230        240 
NHYTDQWSYG HYYFESVCVI LMFVMVGKRI ENVSKDKALD AMQALMKNAP KTALKMQNNQ 

       250        260        270        280        290        300 
QIEVLVDSIV VGDILKVLPG SAIAVDGEII EGEGELDESM LSGEALPVYK KVGDKVFSGT 

       310        320        330        340        350        360 
LNSHTSFLMK ATQNNKNSTL SQIIEMIHNA QSSKAEISRL ADKVSSVFVP SVIAIAILAF 

       370        380        390        400        410        420 
VVWLIIAPKP DFWWNFGIAL EVFVSVLVIS CPCALGLATP MSILVANQKA SSLGLFFKDA 

       430        440        450        460        470        480 
KSLEKARLVN TIVFDKTGTL TNGKPVVKSV HSKIELLELL SLAGSIEKSS EHVIAKGIVE 

       490        500        510        520        530        540 
YAKERNAPLK EMSEVKVKTG FGISAKTDYQ GIKEIIKVGN SEFFNPINTL EIKENGILVF 

       550        560        570        580        590        600 
VGRAISEKED ELLGVFVLED LPKKGVKEHI AQIKNLGINT FLLSGDNREN VKKCALELGI 

       610        620        630        640        650        660 
DGYISNAKPQ DKLNKIKELK EQGQIVMMVG DGLNDAPSLA MNDVAVVMAK GSDVSVQAAD 

       670        680        690        700        710        720 
IVSFNNDIKS VYSAIKLSQA TIKNIKENLF WAFCYNSVFI PLACGVLYKA NIMLSPAIAG 

       730        740 
LAMSLSSVSV VLNSQRLRNF KIKDH

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References

[1]

"Identification and characterization of an operon of Helicobacter pylori that is involved in motility and stress adaptation."
Beier D., Spohn G., Rappuoli R., Scarlato V.
J. Bacteriol. 179:4676-4683(1997) [PubMed: 9244252] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: DSM 4867 / CCUG 17874 / NCTC 11638.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U97567 Genomic DNA. Translation: AAB66380.1.
3D structure databases
ProteinModelPortal	O08462.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR008250. ATPase_P-typ_ATPase-assoc-dom. IPR006403. ATPase_P-typ_cat/Cu-transptr. IPR023300. ATPase_P-typ_cyto_domA. IPR023299. ATPase_P-typ_cyto_domN. IPR006416. ATPase_P-typ_heavy-metal. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_P_site. IPR005834. Dehalogen-like_hydro. IPR023214. HAD-like_dom. IPR017969. Heavy-metal-associated_CS. IPR006121. HeavyMe-assoc_HMA. [Graphical view]
Gene3D	G3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 1 hit. G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 1 hit. G3DSA:3.40.50.1000. HAD-like_dom. 2 hits.
Pfam	PF00122. E1-E2_ATPase. 1 hit. PF00403. HMA. 1 hit. PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE. PR00943. CUATPASE.
SUPFAM	SSF56784. HAD-like_dom. 1 hit. SSF55008. HeavyMe_transpt. 1 hit.
TIGRFAMs	TIGR01511. ATPase-IB1_Cu. 1 hit. TIGR01525. ATPase-IB_hvy. 1 hit. TIGR01494. ATPase_P-type. 1 hit.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. PS01047. HMA_1. 1 hit. PS50846. HMA_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COPA3_HELPX

Accession

Primary (citable) accession number: O08462

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	July 1, 1997
Last modified:	December 14, 2011
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Family and domain databases

Entry information

Relevant documents