Reviewed, UniProtKB/Swiss-Prot O08447 (C135A_MYCTU)

Names and origin

Protein names

Recommended name:
    Putative cytochrome P450 135A1
    EC=1.14.-.-

Gene names

Name:	CYP135A1
Ordered Locus Names:	Rv0327c, MT0342
ORF Names:	MTCY63.32c

Organism

Mycobacterium tuberculosis [Complete proteome] [HAMAP]

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	449 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Cofactor	Heme group By similarity.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro monooxygenase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 449	449	Putative cytochrome P450 135A1		PRO_0000052292
Sites
	Metal binding	383	1	Iron (heme axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	O08447-1 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: 192E3CF1855EDCF5	FASTA	449	50,011
	10 20 30 40 50 60 MASTLTTGLP PGPRLPRYLQ SVLYLRFREW FLPAMHRKYG DVFSLRVPPY ADNLVVYTRP 70 80 90 100 110 120 EHIKEIFAAD PRSLHAGEGN HILGFVMGEH SVLMTDEAEH ARMRSLLMPA FTRAALRGYR 130 140 150 160 170 180 DMIASVAREH ITRWRPHATI NSLDHMNALT LDIILRVVFG VTDPKVKAEL TSRLQQIINI 190 200 210 220 230 240 HPAILAGVPY PSLKRMNPWK RFFHNQTKID EILYREIASR RIDSDLTART DVLSRLLQTK 250 260 270 280 290 300 DTPTKPLTDA ELRDQLITLL LAGHETTAAA LSWTLWELAH APEIQSQVVW AAVGGDDGFL 310 320 330 340 350 360 EAVLKEGMRR HTVIASTARK VTAPAEIGGW RLPAGTVVNT SILLAHASEV SHPKPTEFRP 370 380 390 400 410 420 SRFLDGSVAP NTWLPFGGGV RRCLGFGFAL TEGAVILQEI FRRFTITAAG PSKGETPLVR 430 440 NITTVPKHGA HLRLIPQRRL GGLGDSDPP

References

[1]

"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Nature 393:537-544(1998) [PubMed: 9634230] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv.

[2]

"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. , Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M. J. Bacteriol. 184:5479-5490(2002) [PubMed: 12218036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX842573 Genomic DNA. Translation: CAB09576.1. AE000516 Genomic DNA. Translation: AAK44565.1.
PIR	H70526.
RefSeq	NP_214841.1. NP_334751.1.
3D structure databases
HSSP	HSSP built from PDB template 1JME based on UniProtKB P14779.
ModBase	Search...
Genome annotation databases
GeneID	886538. 923443.
GenomeReviews	Gene locus MT0342 in contig AE000516_GR. Gene locus Rv0327c in contig AL123456_GR.
KEGG	mtc:MT0342. mtu:Rv0327c.
TIGR	MT0342.
Organism-specific databases
TubercuList	Rv0327c.
Phylogenomic databases
HOGENOM	O08447.
OMA	O08447. QLMEASA.
Family and domain databases
InterPro	IPR001128. Cyt_P450. IPR017973. Cyt_P450_C. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. [Graphical view]
Gene3D	G3DSA:1.10.630.10. Cyt_P450. 1 hit.
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR00385. P450.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

C135A_MYCTU

Accession

Primary (citable) accession number: O08447

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	July 1, 1997
Last modified:	June 16, 2009
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)