Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O08445

- ALR_LACPL

UniProt

O08445 - ALR_LACPL

Protein

Alanine racemase

Gene

alr

Organism
Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei41 – 411Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei141 – 1411SubstrateUniRule annotation
    Active sitei270 – 2701Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei317 – 3171Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciLPLA220668-WGS:GSPK-434-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Name:alr
    Ordered Locus Names:lp_0523
    OrganismiLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
    Taxonomic identifieri220668 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000000432: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 375375Alanine racemasePRO_0000114528Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei41 – 411N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi220668.lp_0523.

    Structurei

    3D structure databases

    ProteinModelPortaliO08445.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0787.
    HOGENOMiHOG000031444.
    KOiK01775.
    OMAiYGHGLER.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O08445-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVVIGEHRHT QVTVDLQAIK TNISNEMAQK DELTELWAVV KANGYGHGII    50
    QVAQAAKEAG ATGFCVAILD EALALRAAGF AEPILVLGIT EPEYAPLVAE 100
    KDISLAVGTQ DWLTTAAAIL AANQVTTPLH VHLALDTGMG RIGFQTPEEL 150
    ATAVTTLRQP QSPFDFEGIF THFATADQAD DTYFTHQLNN WKHLIAVVDE 200
    LPRYVHVSNS ATSLWHQACN GNMVRFGVAL YGLNPSGREL SAPYPLQPAL 250
    SLTARLTFVK RLARGKSVSY GATYTAAQDE WIGTVPIGYA DGYERRLQGF 300
    HVLVDGEFCE IVGRVCMDQL MVRLPHEVPV GAKVTLVGTD GARTISLQDI 350
    ADYCGTIHYE IACGLAPRVP RVYID 375
    Length:375
    Mass (Da):40,710
    Last modified:July 1, 1997 - v1
    Checksum:i844E9BAC5FF3463B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y08941 Genomic DNA. Translation: CAA70140.1.
    AL935263 Genomic DNA. Translation: CCC78013.1.
    RefSeqiWP_003642062.1. NC_004567.2.
    YP_004888527.1. NC_004567.2.

    Genome annotation databases

    EnsemblBacteriaiCCC78013; CCC78013; lp_0523.
    GeneIDi1061815.
    KEGGilpl:lp_0523.
    PATRICi22247489. VBILacPla27411_0431.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y08941 Genomic DNA. Translation: CAA70140.1 .
    AL935263 Genomic DNA. Translation: CCC78013.1 .
    RefSeqi WP_003642062.1. NC_004567.2.
    YP_004888527.1. NC_004567.2.

    3D structure databases

    ProteinModelPortali O08445.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 220668.lp_0523.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CCC78013 ; CCC78013 ; lp_0523 .
    GeneIDi 1061815.
    KEGGi lpl:lp_0523.
    PATRICi 22247489. VBILacPla27411_0431.

    Phylogenomic databases

    eggNOGi COG0787.
    HOGENOMi HOG000031444.
    KOi K01775.
    OMAi YGHGLER.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci LPLA220668-WGS:GSPK-434-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The alanine racemase gene is essential for growth of Lactobacillus plantarum."
      Hols P., Defrenne C., Ferain T., Derzelle S., Delplace B., Delcour J.
      J. Bacteriol. 179:3804-3807(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC BAA-793 / NCIMB 8826 / WCFS1.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-793 / NCIMB 8826 / WCFS1.

    Entry informationi

    Entry nameiALR_LACPL
    AccessioniPrimary (citable) accession number: O08445
    Secondary accession number(s): F9UKZ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3