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O08445

- ALR_LACPL

UniProt

O08445 - ALR_LACPL

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Protein

Alanine racemase

Gene

alr

Organism
Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei41 – 411Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei141 – 1411SubstrateUniRule annotation
Active sitei270 – 2701Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei317 – 3171Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciLPLA220668-WGS:GSPK-434-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alr
Ordered Locus Names:lp_0523
OrganismiLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Taxonomic identifieri220668 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000000432: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375Alanine racemasePRO_0000114528Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei41 – 411N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi220668.lp_0523.

Structurei

3D structure databases

ProteinModelPortaliO08445.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031444.
KOiK01775.
OMAiYGHGLER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08445 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVVIGEHRHT QVTVDLQAIK TNISNEMAQK DELTELWAVV KANGYGHGII
60 70 80 90 100
QVAQAAKEAG ATGFCVAILD EALALRAAGF AEPILVLGIT EPEYAPLVAE
110 120 130 140 150
KDISLAVGTQ DWLTTAAAIL AANQVTTPLH VHLALDTGMG RIGFQTPEEL
160 170 180 190 200
ATAVTTLRQP QSPFDFEGIF THFATADQAD DTYFTHQLNN WKHLIAVVDE
210 220 230 240 250
LPRYVHVSNS ATSLWHQACN GNMVRFGVAL YGLNPSGREL SAPYPLQPAL
260 270 280 290 300
SLTARLTFVK RLARGKSVSY GATYTAAQDE WIGTVPIGYA DGYERRLQGF
310 320 330 340 350
HVLVDGEFCE IVGRVCMDQL MVRLPHEVPV GAKVTLVGTD GARTISLQDI
360 370
ADYCGTIHYE IACGLAPRVP RVYID
Length:375
Mass (Da):40,710
Last modified:July 1, 1997 - v1
Checksum:i844E9BAC5FF3463B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y08941 Genomic DNA. Translation: CAA70140.1.
AL935263 Genomic DNA. Translation: CCC78013.1.
RefSeqiWP_003642062.1. NC_004567.2.
YP_004888527.1. NC_004567.2.

Genome annotation databases

EnsemblBacteriaiCCC78013; CCC78013; lp_0523.
GeneIDi1061815.
KEGGilpl:lp_0523.
PATRICi22247489. VBILacPla27411_0431.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y08941 Genomic DNA. Translation: CAA70140.1 .
AL935263 Genomic DNA. Translation: CCC78013.1 .
RefSeqi WP_003642062.1. NC_004567.2.
YP_004888527.1. NC_004567.2.

3D structure databases

ProteinModelPortali O08445.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 220668.lp_0523.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCC78013 ; CCC78013 ; lp_0523 .
GeneIDi 1061815.
KEGGi lpl:lp_0523.
PATRICi 22247489. VBILacPla27411_0431.

Phylogenomic databases

eggNOGi COG0787.
HOGENOMi HOG000031444.
KOi K01775.
OMAi YGHGLER.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci LPLA220668-WGS:GSPK-434-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The alanine racemase gene is essential for growth of Lactobacillus plantarum."
    Hols P., Defrenne C., Ferain T., Derzelle S., Delplace B., Delcour J.
    J. Bacteriol. 179:3804-3807(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC BAA-793 / NCIMB 8826 / WCFS1.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-793 / NCIMB 8826 / WCFS1.

Entry informationi

Entry nameiALR_LACPL
AccessioniPrimary (citable) accession number: O08445
Secondary accession number(s): F9UKZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 1, 1997
Last modified: October 1, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3