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Protein

Catalase-peroxidase 2

Gene

katG2

Organism
Mycobacterium fortuitum
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. May play a role in the intracellular survival of mycobacteria (By similarity).UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei103Transition state stabilizerUniRule annotation1
Active sitei107Proton acceptorUniRule annotation1
Metal bindingi275Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei3128. MfoCP02.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidase 2UniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CP 2UniRule annotation
Alternative name(s):
Peroxidase/catalase 2UniRule annotation
Gene namesi
Name:katG2UniRule annotation
Synonyms:katGII
OrganismiMycobacterium fortuitum
Taxonomic identifieri1766 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003450931 – 733Catalase-peroxidase 2Add BLAST733

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki106 ↔ 234Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-260)UniRule annotation
Cross-linki234 ↔ 260Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-106)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiO08405.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08405-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEAETHPPI GESQTEPAES GCPMRIKPPV EGGSNRDWWP NAVNLKILQK
60 70 80 90 100
NPPAIDPSDE GYDSEAVKSL DVEAFQRDFD ELLTNSQDWW PADFGHYGPL
110 120 130 140 150
FVRMSWHAAG TYRVEDGRGG GGRGMQPFAP LNSWPDNVSL DKARRLLWPL
160 170 180 190 200
KKKYGKQISW SDLIVYSGNR AMEHMGFKTA GFAFGRPDYW EPEEDIYWGA
210 220 230 240 250
EAEWLGSQDR YAGANGDRTK LENPPXXPHM GLIYVNPEGP EGNPDYLAAA
260 270 280 290 300
IDIRETFGRM AMNDIETAAL IVGGHTFGKT HGATDIENGV EPEXXPLEQM
310 320 330 340 350
GLGWANPGLG NDTVSSGLEV TWTQHPTKWD NSFLEILYSN EWELTKSPAG
360 370 380 390 400
ANQWKPKDNG WANSWPMAQG TGKTHPSMLT TDLSMRFDPI YGEITRRWLD
410 420 430 440 450
HPEELAEEYA KAWFKLIHRD MGPVTRYLGP LVPKQTWLWQ DIIPAGKQLS
460 470 480 490 500
DADVATLKAA IADSGLSIQQ LVNTAWKAAA SYRSSDMRGG NGGRIRLQPQ
510 520 530 540 550
LGWEVNEPEE LAPVIAKLEE IQAASDSGVS FADLVVLGGV VGLEKAIKAA
560 570 580 590 600
GFDVAVPFTS GPRDALQEQT DVDSFAYLEP KGDGFRNFVA KGDSVPAEYR
610 620 630 640 650
LIDRANLLGL SAPQMTVLIG GLRVLGANHG GSELGVLTDK VGQLTNDYFV
660 670 680 690 700
NLTDMGTKWA PAPADDGTYV GTDRATGSPK WTASRVDLLF GSNSQLRALA
710 720 730
EVYAEDDSKE KFVKDFVAAW TKVMNADRFD LEA
Length:733
Mass (Da):80,596
Last modified:July 1, 1997 - v1
Checksum:i20C8BCB076F9E58F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07866 Genomic DNA. Translation: CAA69193.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07866 Genomic DNA. Translation: CAA69193.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

PeroxiBasei3128. MfoCP02.

Proteomic databases

PRIDEiO08405.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG2_MYCFO
AccessioniPrimary (citable) accession number: O08405
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 1, 1997
Last modified: October 5, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.