ID   KATG1_MYCFO             Reviewed;         752 AA.
AC   O08404;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   05-MAY-2009, entry version 58.
DE   RecName: Full=Catalase-peroxidase 1;
DE            Short=CP 1;
DE            EC=1.11.1.6;
DE            EC=1.11.1.7;
DE   AltName: Full=Peroxidase/catalase 1;
GN   Name=katG1; Synonyms=katGI;
OS   Mycobacterium fortuitum.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium.
OX   NCBI_TaxID=1766;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 6841 / DSM 46621 / IFO 13159 / NBRC 13159 / NCTC 10394;
RX   MEDLINE=98037481; PubMed=9371430;
RA   Menendez M.C., Ainsa J.A., Martin C., Garcia M.J.;
RT   "katGI and katGII encode two different catalases-peroxidases in
RT   Mycobacterium fortuitum.";
RL   J. Bacteriol. 179:6880-6886(1997).
CC   -!- FUNCTION: Bifunctional enzyme with both catalase and broad-
CC       spectrum peroxidase activity. May play a role in the intracellular
CC       survival of mycobacteria (By similarity).
CC   -!- CATALYTIC ACTIVITY: 2 H(2)O(2) = O(2) + 2 H(2)O.
CC   -!- CATALYTIC ACTIVITY: Donor + H(2)O(2) = oxidized donor + 2 H(2)O.
CC   -!- COFACTOR: Binds 1 heme B (iron-protoporphyrin IX) group per dimer.
CC   -!- SUBUNIT: Homodimer or homotetramer (By similarity).
CC   -!- PTM: The covalent Trp-Tyr-Met adduct is important for the
CC       catalase, but not the peroxidase activity of the enzyme (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the peroxidase family. Peroxidase/catalase
CC       subfamily.
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DR   EMBL; Y07865; CAA69192.1; -; Genomic_DNA.
DR   HSSP; Q939D2; 1MWV.
DR   PeroxiBase; 2396; MfoCP01.
DR   BRENDA; 1.11.1.6; 141585.
DR   GO; GO:0004096; F:catalase activity; IEA:HAMAP.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0042744; P:hydrogen peroxide catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_01961; -; 1.
DR   InterPro; IPR000763; Catalase_proxase.
DR   InterPro; IPR002016; Haem_peroxidase_pln/fun/bac.
DR   InterPro; IPR019794; Peroxidases_AS.
DR   InterPro; IPR019793; Peroxidases_heam-ligand_BS.
DR   Pfam; PF00141; peroxidase; 2.
DR   PRINTS; PR00460; BPEROXIDASE.
DR   PRINTS; PR00458; PEROXIDASE.
DR   TIGRFAMs; TIGR00198; cat_per_HPI; 1.
DR   PROSITE; PS00435; PEROXIDASE_1; 1.
DR   PROSITE; PS00436; PEROXIDASE_2; 1.
DR   PROSITE; PS50873; PEROXIDASE_4; 1.
PE   3: Inferred from homology;
KW   Heme; Hydrogen peroxide; Iron; Metal-binding; Oxidoreductase;
KW   Peroxidase.
FT   CHAIN         1    752       Catalase-peroxidase 1.
FT                                /FTId=PRO_0000055572.
FT   ACT_SITE    117    117       Proton acceptor (By similarity).
FT   METAL       285    285       Iron (heme axial ligand) (By similarity).
FT   SITE        113    113       Transition state stabilizer (By
FT                                similarity).
FT   CROSSLNK    116    244       Tryptophyl-tyrosyl-methioninium (Trp-Tyr)
FT                                (with M-270) (By similarity).
FT   CROSSLNK    244    270       Tryptophyl-tyrosyl-methioninium (Tyr-Met)
FT                                (with W-116) (By similarity).
SQ   SEQUENCE   752 AA;  83101 MW;  B66BAD53DD26E70D CRC64;
     MPPNTPDASD ARPPQADTET HSHSESENPV IESPKPKAHA PLTNQDWWPD QVDVSRLHKQ
     PIEGNPLGAG FNYAEEFQKL DVEALRADML ELMTSSQDWW PRDYGTYAGL FIRMSWHAAG
     TYRIFDGRGG AGQGAQRFAP INSWPDNVSL DKARRLLWPI KQKYGNKISW ADLIIFAGNV
     ALESAGFKTF GFAFGRQDIW EPEEILWGQE DTWLGTDKRY GGTNDSTNRE LANPYGATTM
     GLIYVNPEGP EGKPDPLAAA HDIRETFGRM AMNDEETAAL IVGGHTLGKT HGPGPGDLVG
     PEPEAAPIEQ QGLGWKCAFG SGKGSDTITS GLEVVWTTTP TKWSNSYLEI LYGYEWELTK
     SPGDAWQFEA KDAEAIIPDP FGGPPRKPTM LVTDISMRVD PIYGPITRRW LEHPEELNEA
     FAKAWYKLLH RDMGPISRYL GPWIPEPQLW QDPVPDVDHP LVDEQDIAAL KEKLLDSGLS
     VQQLVKTAWS AAASFRGTDK RGGANGGRLR LQPQRNWEVN EPSELDKALP VLERIAQDFN
     ASASDGKKIS LADLIVLGGS AAIEKAARDG GYEVKVHFVA GRTDASQENT DVDSFAVLEP
     RADGFRNFVR PGDKAPLEQL LVDKAYFLNL TAPEMTVLVG GLRALNTNHG GSKHGVFTAN
     PGALSNDFFV NLLDMSTEWK PSETAENVYE GRDRRTGQTR WTATANDLVF GSNSVLRAVA
     EVYAQEDNKA KMIEDFVAAW VKVMNNDRFD LD
//