O08371 (SUCD_RICPR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Succinyl-CoA ligase [ADP-forming] subunit alpha
EC=6.2.1.5

Alternative name(s):
Succinyl-CoA synthetase subunit alpha
Short name=SCS-alpha

Gene names

Name:	sucD
Ordered Locus Names:	RP432

Organism

Rickettsia prowazekii (strain Madrid E)

Taxonomic identifier

272947 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	292 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.
Subunit structure	Heterotetramer of two alpha and two beta subunits By similarity.
Sequence similarities	Belongs to the succinate/malate CoA ligase alpha subunit family.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATP citrate synthase activity Inferred from electronic annotation. Source: InterPro succinate-CoA ligase (ADP-forming) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 292	292	Succinyl-CoA ligase [ADP-forming] subunit alpha		PRO_0000102798
Sites
	Active site	248	1	Tele-phosphohistidine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	O08371 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: 134D5AC87DC1D510	FASTA	292	30,176
	10 20 30 40 50 60 MAILINKKTK VICQGFTGSQ GTFHSEQAIA YGTNMVGGVT PGKGGHTHLN LPVYNTVHEA 70 80 90 100 110 120 KAKTGANASV IYVPPGFAAD SILEAIDAKI EVVVCITEGI PVLDMIKVKR ALIGSKTRLI 130 140 150 160 170 180 GPNCPGVITP GECKIGIMPG HIHKIGDIGI VSRSGTLTYE AVAQTTAAGL GQSTCVGIGG 190 200 210 220 230 240 DPVNGTSFVD CIEMFLQDDE TKAIIMIGEI GGSAEEDAAD FIKQSKIKKP IVSFIAGITA 250 260 270 280 290 PADKRMGHAG AIISGGKGSA EDKVEVLQSA GVIITRSPAD IGKTMLDLLN KI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genomic rearrangements during evolution of the obligate intracellular parasite Rickettsia prowazekii as inferred from an analysis of 52015 bp nucleotide sequence." Andersson J.O., Andersson S.G.E. Microbiology 143:2783-2795(1997) [PubMed: 9274032] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Madrid E.
[2]	"The genome sequence of Rickettsia prowazekii and the origin of mitochondria." Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G. Nature 396:133-140(1998) [PubMed: 9823893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Madrid E.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y11777 Genomic DNA. Translation: CAA72446.1. AJ235271 Genomic DNA. Translation: CAA14889.1.
PIR	G71701.
RefSeq	NP_220813.1. NC_000963.1.
3D structure databases
ProteinModelPortal	O08371.
SMR	O08371. Positions 2-289.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	883308.
GenomeReviews	Gene locus RP432 in contig AJ235269_GR.
KEGG	rpr:RP432.
PATRIC	17901645. VBIRicPro72556_0445.
Phylogenomic databases
HOGENOM	HBG615372.
OMA	APPGRTM.
ProtClustDB	PRK05678.
Enzyme and pathway databases
BioCyc	RPRO272947:RP432-MONOMER.
Family and domain databases
InterPro	IPR017440. Cit_synth/succinyl-CoA_lig_AS. IPR003781. CoA-bd. IPR005810. CoA_lig_alpha. IPR005811. CoA_ligase. IPR016040. NAD(P)-bd_dom. IPR016102. Succinyl-CoA_synth-like. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:3.40.50.261. Succinyl-CoA_synth-like. 1 hit.
KO	K01902.
Pfam	PF02629. CoA_binding. 1 hit. PF00549. Ligase_CoA. 1 hit. [Graphical view]
PIRSF	PIRSF001553. SucCS_alpha. 1 hit.
PRINTS	PR01798. SCOASYNTHASE.
SMART	SM00881. CoA_binding. 1 hit. [Graphical view]
SUPFAM	SSF52210. CoA_ligase. 1 hit.
TIGRFAMs	TIGR01019. SucCoAalpha. 1 hit.
PROSITE	PS01216. SUCCINYL_COA_LIG_1. 1 hit. PS00399. SUCCINYL_COA_LIG_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SUCD_RICPR

Accession

Primary (citable) accession number: O08371

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	July 1, 1997
Last modified:	January 25, 2012
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program