ID   GPWA_PSEWI              Reviewed;         222 AA.
AC   O08368;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   16-JUN-2009, entry version 46.
DE   RecName: Full=Glutathione peroxidase;
DE            EC=1.11.1.9;
DE   Flags: Precursor;
GN   Name=gpwA;
OS   Pseudomonas wisconsinensis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=57038;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=LMG P-15151;
RA   Hazbon M.H., Dufel H., Cornelis P., Jaeger K.-E.;
RT   "Molecular characterization of an operon from Pseudomonas
RT   wisconsinensis responsible for the production of an extracellular
RT   lipase.";
RL   Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: 2 glutathione + H(2)O(2) = glutathione
CC       disulfide + 2 H(2)O.
CC   -!- SUBCELLULAR LOCATION: Periplasm.
CC   -!- SIMILARITY: Belongs to the glutathione peroxidase family.
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DR   EMBL; U88907; AAB53646.1; -; Genomic_DNA.
DR   PeroxiBase; 3743; PwGPx01.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0004602; F:glutathione peroxidase activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   InterPro; IPR000889; Glutathione_peroxidase.
DR   InterPro; IPR012335; Thioredoxin_fold.
DR   Gene3D; G3DSA:3.40.30.10; Thioredoxin_fold; 1.
DR   PANTHER; PTHR11592; Glut_peroxidase; 1.
DR   Pfam; PF00255; GSHPx; 1.
DR   PIRSF; PIRSF000303; Glutathion_perox; 1.
DR   PRINTS; PR01011; GLUTPROXDASE.
DR   PROSITE; PS00460; GLUTATHIONE_PEROXID_1; 1.
DR   PROSITE; PS00763; GLUTATHIONE_PEROXID_2; FALSE_NEG.
DR   PROSITE; PS51355; GLUTATHIONE_PEROXID_3; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase; Periplasm; Peroxidase; Signal.
FT   SIGNAL        1     22       Potential.
FT   CHAIN        23    222       Glutathione peroxidase.
FT                                /FTId=PRO_0000013095.
FT   ACT_SITE     61     61       By similarity.
SQ   SEQUENCE   222 AA;  24742 MW;  04A89ABC21E777CB CRC64;
     MSIRRLACSL LLSSLALPVL AAECPAMLQG ELPKLRAKGE NIELCQYAGK PLVVVNTASF
     CGFTPQFKGL EALYQRYKDQ ELEVLGVPSD DFRQESADSK ETATVCYVNY GVTFAMTEPQ
     PVSGANAIPL FKGLAEQSRQ PRWNFFKYVV DRQGKVVASF SSLTKPDDPE LIAARREGDR
     LATLIPSRFT ALHPSGRWAL SVCLPRLARR RTQFTRRALQ EQ
//