O08368 (GPWA_PSEWI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutathione peroxidase
EC=1.11.1.9

Gene names

Name:

gpwA

Organism

Pseudomonas wisconsinensis

Taxonomic identifier

57038 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	222 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2 glutathione + H2O2 = glutathione disulfide + 2 H2O.
Subcellular location	Periplasm.
Sequence similarities	Belongs to the glutathione peroxidase family.

Ontologies

Keywords
Cellular component	Periplasm
Domain	Signal
Molecular function	Oxidoreductase Peroxidase
Gene Ontology (GO)
Biological process	response to oxidative stress Inferred from electronic annotation. Source: InterPro
Cellular component	periplasmic space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glutathione peroxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 222	200	Glutathione peroxidase		PRO_0000013095
Sites
	Active site	61	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	O08368 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: 04A89ABC21E777CB	FASTA	222	24,742
	10 20 30 40 50 60 MSIRRLACSL LLSSLALPVL AAECPAMLQG ELPKLRAKGE NIELCQYAGK PLVVVNTASF 70 80 90 100 110 120 CGFTPQFKGL EALYQRYKDQ ELEVLGVPSD DFRQESADSK ETATVCYVNY GVTFAMTEPQ 130 140 150 160 170 180 PVSGANAIPL FKGLAEQSRQ PRWNFFKYVV DRQGKVVASF SSLTKPDDPE LIAARREGDR 190 200 210 220 LATLIPSRFT ALHPSGRWAL SVCLPRLARR RTQFTRRALQ EQ

References

[1]

"Molecular characterization of an operon from Pseudomonas wisconsinensis responsible for the production of an extracellular lipase." Hazbon M.H., Dufel H., Cornelis P., Jaeger K.-E. Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: LMG P-15151.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U88907 Genomic DNA. Translation: AAB53646.1.
3D structure databases
ProteinModelPortal	O08368.
ModBase	Search...
Protein family/group databases
PeroxiBase	3743. PwGPx01.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR000889. Glutathione_peroxidase. IPR012336. Thioredoxin-like_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHER	PTHR11592. Glut_peroxidase. 1 hit.
Pfam	PF00255. GSHPx. 1 hit. [Graphical view]
PIRSF	PIRSF000303. Glutathion_perox. 1 hit.
PRINTS	PR01011. GLUTPROXDASE.
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS00460. GLUTATHIONE_PEROXID_1. 1 hit. PS00763. GLUTATHIONE_PEROXID_2. False negative. PS51355. GLUTATHIONE_PEROXID_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPWA_PSEWI

Accession

Primary (citable) accession number: O08368

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	July 1, 1997
Last modified:	September 21, 2011
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program