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Protein
Submitted name:

Mannitol dehydrogenase

Gene

mtlD

Organism
Pseudomonas fluorescens
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei373 – 3731NADCombined sources

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi34 – 374NADCombined sources
Nucleotide bindingi66 – 694NADCombined sources
Nucleotide bindingi130 – 1334NADCombined sources
Nucleotide bindingi190 – 1912NADCombined sources
Nucleotide bindingi231 – 2333NADCombined sources

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseSAAS annotationImported

Keywords - Ligandi

NADCombined sourcesSAAS annotation, Nucleotide-bindingCombined sources

Enzyme and pathway databases

BRENDAi1.1.1.67. 5121.
SABIO-RKO08355.

Names & Taxonomyi

Protein namesi
Submitted name:
Mannitol dehydrogenaseImported (EC:1.1.1.67Imported)
Gene namesi
Name:mtlDImported
OrganismiPseudomonas fluorescensImported
Taxonomic identifieri294 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Pathology & Biotechi

Chemistry

DrugBankiDB00742. Mannitol.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LJ8X-ray1.70A2-331[»]
A335-493[»]
1M2WX-ray1.80A/B2-331[»]
A/B335-493[»]
ProteinModelPortaliO08355.
SMRiO08355. Positions 1-492.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO08355.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 192165Mannitol_dhInterPro annotationAdd
BLAST
Domaini221 – 465245Mannitol_dh_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the mannitol dehydrogenase family.SAAS annotation

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR023027. Mannitol_DH_CS.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSiPR00084. MTLDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00974. MANNITOL_DHGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08355-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLNKQNLTQ LAPEVKLPAY TLADTRQGIA HIGVGGFHRA HQAYYTDALM
60 70 80 90 100
NTGEGLDWSI CGVGLRSEDR KARDDLAGQD YLFTLYELGD TDDTEVRVIG
110 120 130 140 150
SISDMLLAED SAQALIDKLA SPEIRIVSLT ITEGGYCIDD SNGEFMAHLP
160 170 180 190 200
QIQHDLAHPS SPKTVFGFIC AALTQRRAAG IPAFTVMSCD NLPHNGAVTR
210 220 230 240 250
KALLAFAALH NAELHDWIKA HVSFPNAMVD RITPMTSTAH RLQLHDEHGI
260 270 280 290 300
DDAWPVVCEP FVQWVLEDKF VNGRPAWEKV GVQFTDDVTP YEEMKIGLLN
310 320 330 340 350
GSHLALTYLG FLKGYRFVHE TMNDPLFVAY MRAYMDLDVT PNLAPVPGID
360 370 380 390 400
LTDYKQTLVD RFSNQAIADQ LERVCSDGSS KFPKFTVPTI NRLIADGRET
410 420 430 440 450
ERAALVVAAW ALYLKGVDEN GVSYTIPDPR AEFCQGLVSD DALISQRLLA
460 470 480 490
VEEIFGTAIP NSPEFVAAFE RCYGSLRDNG VTTTLKHLLK KPV
Length:493
Mass (Da):54,498
Last modified:July 1, 1997 - v1
Checksum:i7C12DFA443CEA443
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007800 Genomic DNA. Translation: AAC04472.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007800 Genomic DNA. Translation: AAC04472.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LJ8X-ray1.70A2-331[»]
A335-493[»]
1M2WX-ray1.80A/B2-331[»]
A/B335-493[»]
ProteinModelPortaliO08355.
SMRiO08355. Positions 1-492.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

DrugBankiDB00742. Mannitol.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi1.1.1.67. 5121.
SABIO-RKO08355.

Miscellaneous databases

EvolutionaryTraceiO08355.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR023027. Mannitol_DH_CS.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSiPR00084. MTLDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00974. MANNITOL_DHGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO08355_PSEFL
AccessioniPrimary (citable) accession number: O08355
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: July 1, 1997
Last modified: May 11, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.