O08350 (O08350_BURCE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Class A beta-lactamase EMBL AAB53622.1
EC=3.5.2.6 EMBL AAB53622.1

Gene names

Name:

penA EMBL AAB53622.1

Organism

Burkholderia cepacia (Pseudomonas cepacia) EMBL AAB53622.1

Taxonomic identifier

292 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	302 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Predicted

General annotation (Comments)

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid. SAAS SAAS000871

Ontologies

Keywords
Biological process	Antibiotic resistance SAAS SAAS000871
Domain	Signal EMBL AAB53622.1
Molecular function	Hydrolase SAAS SAAS000871 EMBL AAB53622.1
Gene Ontology (GO)
Biological_process	beta-lactam antibiotic catabolic process Inferred from electronic annotation. Source: InterPro response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	beta-lactamase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 27	27	Potential EMBL AAB53622.1
	Chain	28 – 302	275	class A beta-lactamase EMBL AAB53622.1		PRO_5000145213

Sequences

	Sequence		Length	Mass (Da)
	O08350 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: D7B6D354C097C5FA	FASTA	302	31,726
	10 20 30 40 50 60 MTHSSQRRIL LLAAATAPLA LSLGACAARD ATVSDAASPV GAAPASFAAL ERAAGGRLGV 70 80 90 100 110 120 CAIDTATGRR ALHRADERFP FCSTFKAMLG AAVLAQSVAH PGLLQQRVTY GRSDLVNYSP 130 140 150 160 170 180 VTERHVDTGM TVAELCAATI QYSDNTAANE LMKRIGGPAA VTAYARSIGD DTFRLDRWET 190 200 210 220 230 240 ELNTALPGDL RDTTTPAAMA ANLRVLVLGD ALPPAQRAQL IEWLRGNKVG DKRIRAGVPT 250 260 270 280 290 300 GWRVGDKTGT GDYGTTNDVG VLWPPSRAPI VLAVYYTQTR ADAKAKDDVI AAATRIASAT LA

References

[1]

"Characterization of the penA and penR genes of Burkholderia cepacia 249 which encode the chromosomal class A penicillinase and its LysR-type transcriptional regulator." Trepanier S., Prince A., Huletsky A. Antimicrob. Agents Chemother. 41:2399-2405(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: 249 EMBL AAB53622.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U85041 Genomic DNA. Translation: AAB53622.1.
3D structure databases
HSSP	HSSP built from PDB template 1IYS based on UniProtKB Q47066.
ProteinModelPortal	O08350.
SMR	O08350. Positions 47-298.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.40.710.10. 1 hit.
InterPro	IPR012338. Beta-lactam/transpept-like. IPR000871. Beta-lactam_class-A/D. IPR023650. Beta-lactam_class-A_AS. IPR006311. TAT_signal. [Graphical view]
PRINTS	PR00118. BLACTAMASEA.
SUPFAM	SSF56601. PBP_transp_fold. 1 hit.
PROSITE	PS00146. BETA_LACTAMASE_A. 1 hit. PS51318. TAT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

O08350_BURCE

Accession

Primary (citable) accession number: O08350

Entry history

Integrated into UniProtKB/TrEMBL:	July 1, 1997
Last sequence update:	July 1, 1997
Last modified:	April 3, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)