Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Xylose isomerase

Gene

xylA

Organism
Bacillus megaterium (strain DSM 319)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.

Cofactori

Mg2+By similarityNote: Binds 2 magnesium ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei107 – 1071By similarity
Active sitei110 – 1101By similarity
Metal bindingi238 – 2381Magnesium 1By similarity
Metal bindingi274 – 2741Magnesium 1By similarity
Metal bindingi274 – 2741Magnesium 2By similarity
Metal bindingi277 – 2771Magnesium 2By similarity
Metal bindingi302 – 3021Magnesium 1By similarity
Metal bindingi313 – 3131Magnesium 2By similarity
Metal bindingi315 – 3151Magnesium 2By similarity
Metal bindingi345 – 3451Magnesium 1By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Pentose shunt, Xylose metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciBMEG592022:GIVX-1858-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomerase (EC:5.3.1.5)
Gene namesi
Name:xylA
Ordered Locus Names:BMD_1858
OrganismiBacillus megaterium (strain DSM 319)
Taxonomic identifieri592022 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000002365 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445Xylose isomerasePRO_0000195764Add
BLAST

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliO08325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.Curated

Phylogenomic databases

HOGENOMiHOG000252293.
KOiK01805.
OMAiHTFQHEL.
OrthoDBiPOG091H07LC.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A. 1 hit.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08325-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQTSTNKIN HFESANKVLY EGKDSKNPLA FKYYNPEEVV GGKTMKDQLR
60 70 80 90 100
FSVAYWHTFT ADGTDPFGAA TMQRSWDRYD GMDLAKARVE AAFQLFETLN
110 120 130 140 150
VPFFAFHDRD IAPEGSTLQE TNKNLDVIVT MIKEYMQTSN VKLLWNTANM
160 170 180 190 200
FTNPRFVHGA ATSCNADVFA YAAAQVKKGL ETAKELGAEN YVFWGGREGY
210 220 230 240 250
ETLLNTNLQL ELDNLARFMH MAVDYATEIG YTGQFLIEPK PKEPTTHQYD
260 270 280 290 300
TDAATTISFL RQYGLDKYFK LNLEANHATL AGHTFEHELR VARVQGLLGS
310 320 330 340 350
VDANQGDPLL GWDTDEFPTD LYSTTLAMYE ILQNGGLGSG GLNFDAKVRR
360 370 380 390 400
GSFEQDDLLY AHVAGMDAFA RGLKVAHKLV EDRVFENVIN ERYSSFKEGI
410 420 430 440
GLEIVEGKAN FHTLEQYAFK NPNIANKSGR QERLKSILNQ YILEV
Length:445
Mass (Da):50,167
Last modified:August 10, 2010 - v2
Checksum:i39CB7340E7403622
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti58 – 581T → Q in CAA40821 (PubMed:1719948).Curated
Sequence conflicti58 – 581T → Q in CAA96094 (PubMed:9076741).Curated
Sequence conflicti170 – 1701A → R in CAA40821 (PubMed:1719948).Curated
Sequence conflicti170 – 1701A → R in CAA96094 (PubMed:9076741).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57598 Genomic DNA. Translation: CAA40821.1.
Z71474 Genomic DNA. Translation: CAA96094.1.
CP001982 Genomic DNA. Translation: ADF38711.1.
RefSeqiWP_013082761.1. NC_014103.1.

Genome annotation databases

EnsemblBacteriaiADF38711; ADF38711; BMD_1858.
GeneIDi9117249.
KEGGibmd:BMD_1858.
PATRICi37253748. VBIBacMeg104484_1800.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57598 Genomic DNA. Translation: CAA40821.1.
Z71474 Genomic DNA. Translation: CAA96094.1.
CP001982 Genomic DNA. Translation: ADF38711.1.
RefSeqiWP_013082761.1. NC_014103.1.

3D structure databases

ProteinModelPortaliO08325.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADF38711; ADF38711; BMD_1858.
GeneIDi9117249.
KEGGibmd:BMD_1858.
PATRICi37253748. VBIBacMeg104484_1800.

Phylogenomic databases

HOGENOMiHOG000252293.
KOiK01805.
OMAiHTFQHEL.
OrthoDBiPOG091H07LC.

Enzyme and pathway databases

BioCyciBMEG592022:GIVX-1858-MONOMER.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A. 1 hit.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiXYLA_BACMD
AccessioniPrimary (citable) accession number: O08325
Secondary accession number(s): D5DF38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 10, 2010
Last modified: September 7, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.