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Protein

Xylose isomerase

Gene

xylA

Organism
Bacillus megaterium (strain DSM 319)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.

Cofactori

Mg2+By similarityNote: Binds 2 magnesium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei107By similarity1
Active sitei110By similarity1
Metal bindingi238Magnesium 1By similarity1
Metal bindingi274Magnesium 1By similarity1
Metal bindingi274Magnesium 2By similarity1
Metal bindingi277Magnesium 2By similarity1
Metal bindingi302Magnesium 1By similarity1
Metal bindingi313Magnesium 2By similarity1
Metal bindingi315Magnesium 2By similarity1
Metal bindingi345Magnesium 1By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Pentose shunt, Xylose metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomerase (EC:5.3.1.5)
Gene namesi
Name:xylA
Ordered Locus Names:BMD_1858
OrganismiBacillus megaterium (strain DSM 319)
Taxonomic identifieri592022 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000002365 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001957641 – 445Xylose isomeraseAdd BLAST445

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliO08325.
SMRiO08325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.Curated

Phylogenomic databases

HOGENOMiHOG000252293.
KOiK01805.
OMAiHTFQHEL.
OrthoDBiPOG091H07LC.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A. 1 hit.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08325-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQTSTNKIN HFESANKVLY EGKDSKNPLA FKYYNPEEVV GGKTMKDQLR
60 70 80 90 100
FSVAYWHTFT ADGTDPFGAA TMQRSWDRYD GMDLAKARVE AAFQLFETLN
110 120 130 140 150
VPFFAFHDRD IAPEGSTLQE TNKNLDVIVT MIKEYMQTSN VKLLWNTANM
160 170 180 190 200
FTNPRFVHGA ATSCNADVFA YAAAQVKKGL ETAKELGAEN YVFWGGREGY
210 220 230 240 250
ETLLNTNLQL ELDNLARFMH MAVDYATEIG YTGQFLIEPK PKEPTTHQYD
260 270 280 290 300
TDAATTISFL RQYGLDKYFK LNLEANHATL AGHTFEHELR VARVQGLLGS
310 320 330 340 350
VDANQGDPLL GWDTDEFPTD LYSTTLAMYE ILQNGGLGSG GLNFDAKVRR
360 370 380 390 400
GSFEQDDLLY AHVAGMDAFA RGLKVAHKLV EDRVFENVIN ERYSSFKEGI
410 420 430 440
GLEIVEGKAN FHTLEQYAFK NPNIANKSGR QERLKSILNQ YILEV
Length:445
Mass (Da):50,167
Last modified:August 10, 2010 - v2
Checksum:i39CB7340E7403622
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58T → Q in CAA40821 (PubMed:1719948).Curated1
Sequence conflicti58T → Q in CAA96094 (PubMed:9076741).Curated1
Sequence conflicti170A → R in CAA40821 (PubMed:1719948).Curated1
Sequence conflicti170A → R in CAA96094 (PubMed:9076741).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57598 Genomic DNA. Translation: CAA40821.1.
Z71474 Genomic DNA. Translation: CAA96094.1.
CP001982 Genomic DNA. Translation: ADF38711.1.
RefSeqiWP_013082761.1. NC_014103.1.

Genome annotation databases

EnsemblBacteriaiADF38711; ADF38711; BMD_1858.
GeneIDi9117249.
KEGGibmd:BMD_1858.
PATRICi37253748. VBIBacMeg104484_1800.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57598 Genomic DNA. Translation: CAA40821.1.
Z71474 Genomic DNA. Translation: CAA96094.1.
CP001982 Genomic DNA. Translation: ADF38711.1.
RefSeqiWP_013082761.1. NC_014103.1.

3D structure databases

ProteinModelPortaliO08325.
SMRiO08325.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADF38711; ADF38711; BMD_1858.
GeneIDi9117249.
KEGGibmd:BMD_1858.
PATRICi37253748. VBIBacMeg104484_1800.

Phylogenomic databases

HOGENOMiHOG000252293.
KOiK01805.
OMAiHTFQHEL.
OrthoDBiPOG091H07LC.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A. 1 hit.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiXYLA_BACMD
AccessioniPrimary (citable) accession number: O08325
Secondary accession number(s): D5DF38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 10, 2010
Last modified: November 2, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.