O08325 (XYLA_BACMD) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 73.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Xylose isomerase EC=5.3.1.5 | ||||
| Gene names |
| ||||
| Organism | Bacillus megaterium (strain DSM 319) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 592022 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus |
Protein attributes
| Sequence length | 445 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | D-xylose = D-xylulose. HAMAP MF_00455 |
| Cofactor | Binds 2 magnesium ions per subunit By similarity. HAMAP MF_00455 |
| Subunit structure | Homotetramer By similarity. HAMAP MF_00455 |
| Subcellular location | |
| Sequence similarities | Belongs to the xylose isomerase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Carbohydrate metabolism Pentose shunt Xylose metabolism |
| Cellular component | Cytoplasm |
| Ligand | Magnesium Metal-binding |
| Molecular function | Isomerase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | D-xylose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW pentose-phosphate shuntInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW xylose isomerase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 445 | 445 | Xylose isomerase HAMAP MF_00455 | PRO_0000195764 | |||||
Sites | |||||||||
| Active site | 107 | 1 | By similarity | ||||||
| Active site | 110 | 1 | By similarity | ||||||
| Metal binding | 238 | 1 | Magnesium 1 By similarity | ||||||
| Metal binding | 274 | 1 | Magnesium 1 By similarity | ||||||
| Metal binding | 274 | 1 | Magnesium 2 By similarity | ||||||
| Metal binding | 277 | 1 | Magnesium 2 By similarity | ||||||
| Metal binding | 302 | 1 | Magnesium 1 By similarity | ||||||
| Metal binding | 313 | 1 | Magnesium 2 By similarity | ||||||
| Metal binding | 315 | 1 | Magnesium 2 By similarity | ||||||
| Metal binding | 345 | 1 | Magnesium 1 By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 58 | 1 | T → Q in CAA40821. Ref.1 | ||||||
| Sequence conflict | 58 | 1 | T → Q in CAA96094. Ref.2 | ||||||
| Sequence conflict | 170 | 1 | A → R in CAA40821. Ref.1 | ||||||
| Sequence conflict | 170 | 1 | A → R in CAA96094. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Molecular cloning, structure, promoters and regulatory elements for transcription of the Bacillus megaterium encoded regulon for xylose utilization." Rygus T., Scheler A., Allmansberger R., Hillen W. Arch. Microbiol. 155:535-542(1991) [PubMed: 1719948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "Regulation of expression, genetic organization and substrate specificity of xylose uptake in Bacillus megaterium." Schmiedel D., Kintrup M., Kuster E., Hillen W. Mol. Microbiol. 23:1053-1062(1997) [PubMed: 9076741] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | "Genome sequences of the industrial vitamin B12-producers B. megaterium QM B1551 and DSM319 reveal new insights into the Bacillus genome evolution and pan-genome structure." Eppinger M., Bunk B., Johns M.A., Edirisinghe J.N., Kutumbaka K.K., Riley D.R., Creasy H.H., Koenig S.S.K., Galens K., Orvis J., Creasy T., Biedendieck R., Braun C., Grayburn S., Jahn D., Ravel J., Vary P.S. Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 319. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | X57598 Genomic DNA. Translation: CAA40821.1. Z71474 Genomic DNA. Translation: CAA96094.1. CP001982 Genomic DNA. Translation: ADF38711.1. |
| RefSeq | YP_003597061.1. NC_014103.1. |
3D structure databases | |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBBACT00000421601; EBBACP00000415988; EBBACG00000419779. |
| GeneID | 9117249. |
| GenomeReviews | Gene locus BMD_1858 in contig CP001982_GR. |
| KEGG | bmd:BMD_1858. |
| PATRIC | 37253748. VBIBacMeg104484_1800. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| GeneTree | EBGT00050000002648. |
| ProtClustDB | PRK05474. |
Family and domain databases | |
| HAMAP | MF_00455. Xylose_isom_A. [Tree] |
| InterPro | IPR013022. Xyl_isomerase-like_TIM-brl. IPR012307. Xyl_isomerase_TIM-brl. IPR013452. Xylose_isom_bac. IPR001998. Xylose_isomerase. [Graphical view] |
| Gene3D | G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit. |
| KO | K01805. |
| Pfam | PF01261. AP_endonuc_2. 1 hit. [Graphical view] |
| PRINTS | PR00688. XYLOSISMRASE. |
| SUPFAM | SSF51658. Xyl_isomerase-like_TIM-brl. 1 hit. |
| TIGRFAMs | TIGR02630. Xylose_isom_A. 1 hit. |
| PROSITE | PS51415. XYLOSE_ISOMERASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | XYLA_BACMD | ||||||||
| Accession | Primary (citable) accession number: O08325 Secondary accession number(s): D5DF38 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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