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Protein

Xylose isomerase

Gene

xylA

Organism
Bacillus megaterium (strain DSM 319)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.

Cofactori

Mg2+By similarityNote: Binds 2 magnesium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei107By similarity1
Active sitei110By similarity1
Metal bindingi238Magnesium 1By similarity1
Metal bindingi274Magnesium 1By similarity1
Metal bindingi274Magnesium 2By similarity1
Metal bindingi277Magnesium 2By similarity1
Metal bindingi302Magnesium 1By similarity1
Metal bindingi313Magnesium 2By similarity1
Metal bindingi315Magnesium 2By similarity1
Metal bindingi345Magnesium 1By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism, Xylose metabolism
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciBMEG592022:G1GHR-1856-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomerase (EC:5.3.1.5)
Gene namesi
Name:xylA
Ordered Locus Names:BMD_1858
OrganismiBacillus megaterium (strain DSM 319)
Taxonomic identifieri592022 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000002365 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001957641 – 445Xylose isomeraseAdd BLAST445

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliO08325
SMRiO08325
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.Curated

Phylogenomic databases

HOGENOMiHOG000252293
KOiK01805
OMAiHTFQHEL
OrthoDBiPOG091H07LC

Family and domain databases

HAMAPiMF_00455 Xylose_isom_A, 1 hit
InterProiView protein in InterPro
IPR036237 Xyl_isomerase-like_sf
IPR013022 Xyl_isomerase-like_TIM-brl
IPR013452 Xylose_isom_bac
IPR001998 Xylose_isomerase
PANTHERiPTHR32176:SF0 PTHR32176:SF0, 1 hit
PfamiView protein in Pfam
PF01261 AP_endonuc_2, 1 hit
PRINTSiPR00688 XYLOSISMRASE
SUPFAMiSSF51658 SSF51658, 1 hit
TIGRFAMsiTIGR02630 xylose_isom_A, 1 hit
PROSITEiView protein in PROSITE
PS51415 XYLOSE_ISOMERASE, 1 hit

Sequencei

Sequence statusi: Complete.

O08325-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQTSTNKIN HFESANKVLY EGKDSKNPLA FKYYNPEEVV GGKTMKDQLR
60 70 80 90 100
FSVAYWHTFT ADGTDPFGAA TMQRSWDRYD GMDLAKARVE AAFQLFETLN
110 120 130 140 150
VPFFAFHDRD IAPEGSTLQE TNKNLDVIVT MIKEYMQTSN VKLLWNTANM
160 170 180 190 200
FTNPRFVHGA ATSCNADVFA YAAAQVKKGL ETAKELGAEN YVFWGGREGY
210 220 230 240 250
ETLLNTNLQL ELDNLARFMH MAVDYATEIG YTGQFLIEPK PKEPTTHQYD
260 270 280 290 300
TDAATTISFL RQYGLDKYFK LNLEANHATL AGHTFEHELR VARVQGLLGS
310 320 330 340 350
VDANQGDPLL GWDTDEFPTD LYSTTLAMYE ILQNGGLGSG GLNFDAKVRR
360 370 380 390 400
GSFEQDDLLY AHVAGMDAFA RGLKVAHKLV EDRVFENVIN ERYSSFKEGI
410 420 430 440
GLEIVEGKAN FHTLEQYAFK NPNIANKSGR QERLKSILNQ YILEV
Length:445
Mass (Da):50,167
Last modified:August 10, 2010 - v2
Checksum:i39CB7340E7403622
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58T → Q in CAA40821 (PubMed:1719948).Curated1
Sequence conflicti58T → Q in CAA96094 (PubMed:9076741).Curated1
Sequence conflicti170A → R in CAA40821 (PubMed:1719948).Curated1
Sequence conflicti170A → R in CAA96094 (PubMed:9076741).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57598 Genomic DNA Translation: CAA40821.1
Z71474 Genomic DNA Translation: CAA96094.1
CP001982 Genomic DNA Translation: ADF38711.1
RefSeqiWP_013082761.1, NC_014103.1

Genome annotation databases

EnsemblBacteriaiADF38711; ADF38711; BMD_1858
KEGGibmd:BMD_1858
PATRICifig|592022.4.peg.1800

Similar proteinsi

Entry informationi

Entry nameiXYLA_BACMD
AccessioniPrimary (citable) accession number: O08325
Secondary accession number(s): D5DF38
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 10, 2010
Last modified: April 25, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health