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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes UMP from orotate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Orotate phosphoribosyltransferase (pyrE), Orotate phosphoribosyltransferase (pyrE)
  2. Orotidine 5'-phosphate decarboxylase (pyrF)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei95Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Gene namesi
Name:pyrF
Ordered Locus Names:MSMEG_3048, MSMEI_2974
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001346291 – 276Orotidine 5'-phosphate decarboxylaseAdd BLAST276

Interactioni

Protein-protein interaction databases

STRINGi246196.MSMEG_3048

Structurei

3D structure databases

ProteinModelPortaliO08323
SMRiO08323
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105SKN Bacteria
COG0284 LUCA
HOGENOMiHOG000245748
KOiK01591
OMAiQSAFFER
OrthoDBiPOG091H09O1

Family and domain databases

Gene3Di3.20.20.70, 1 hit
HAMAPiMF_01215 OMPdecase_type2, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR018089 OMPdecase_AS
IPR011995 OMPdecase_type-2
IPR001754 OMPdeCOase_dom
IPR011060 RibuloseP-bd_barrel
PANTHERiPTHR43375 PTHR43375, 1 hit
PfamiView protein in Pfam
PF00215 OMPdecase, 1 hit
SMARTiView protein in SMART
SM00934 OMPdecase, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
TIGRFAMsiTIGR02127 pyrF_sub2, 1 hit
PROSITEiView protein in PROSITE
PS00156 OMPDECASE, 1 hit

Sequencei

Sequence statusi: Complete.

O08323-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGFGQRLDA AVSARGPLCP GIDPHPELLN AWGLTVDAEG LRAFCDICVA
60 70 80 90 100
AFAGFAIVKP QVAFFEAYGS AGFAVLEDTI AALRAEGVLV LADAKRGDIG
110 120 130 140 150
STMAAYAAAW AGDSPLAADA VTASPYLGFG SLRPLLDTAV ANGRGVFVLA
160 170 180 190 200
ATSNPEGVGL QRAVAGDVTV AQSIVDAVAQ ANREADPAAR DGDPVGPFGV
210 220 230 240 250
VVGATVADPP DLHMLGGPVL VPGVGAQGGR PEALGGLGNA RRLLPAVSRE
260 270
VLRAGPAVDD VRAAAERLRD QVAYLA
Length:276
Mass (Da):27,816
Last modified:July 1, 1997 - v1
Checksum:i41437843A3E2A896
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91572 Genomic DNA Translation: AAB50157.1
CP000480 Genomic DNA Translation: ABK73017.1
CP001663 Genomic DNA Translation: AFP39438.1
RefSeqiWP_003894432.1, NZ_CP009494.1
YP_887364.1, NC_008596.1

Genome annotation databases

EnsemblBacteriaiABK73017; ABK73017; MSMEG_3048
AFP39438; AFP39438; MSMEI_2974
GeneIDi4532520
KEGGimsb:LJ00_15170
msg:MSMEI_2974
msm:MSMEG_3048
PATRICifig|246196.19.peg.3010

Similar proteinsi

Entry informationi

Entry nameiPYRF_MYCS2
AccessioniPrimary (citable) accession number: O08323
Secondary accession number(s): A0QWS6, I7FL41
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 1, 1997
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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