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O08322

- OTC_LACPL

UniProt

O08322 - OTC_LACPL

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Protein

Ornithine carbamoyltransferase

Gene

argF

Organism
Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.By similarity

Catalytic activityi

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111Carbamoyl phosphateBy similarity
Sitei32 – 321Important for structural integrityBy similarity
Binding sitei73 – 731Carbamoyl phosphateBy similarity
Binding sitei84 – 841Carbamoyl phosphateBy similarity
Binding sitei108 – 1081Carbamoyl phosphateBy similarity
Sitei148 – 1481Important for structural integrityBy similarity
Binding sitei167 – 1671OrnithineBy similarity
Binding sitei231 – 2311OrnithineBy similarity
Binding sitei299 – 2991Carbamoyl phosphateBy similarity
Binding sitei317 – 3171Carbamoyl phosphateBy similarity

GO - Molecular functioni

  1. amino acid binding Source: InterPro
  2. ornithine carbamoyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

BioCyciLPLA220668-WGS:GSPK-443-MONOMER.
UniPathwayiUPA00068; UER00112.

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine carbamoyltransferase (EC:2.1.3.3)
Short name:
OTCase
Gene namesi
Name:argF
Ordered Locus Names:lp_0532
OrganismiLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Taxonomic identifieri220668 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000000432: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 340340Ornithine carbamoyltransferasePRO_0000112937Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi220668.lp_0532.

Structurei

3D structure databases

ProteinModelPortaliO08322.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni57 – 615Carbamoyl phosphate bindingBy similarity
Regioni135 – 1384Carbamoyl phosphate bindingBy similarity
Regioni235 – 2362Ornithine bindingBy similarity
Regioni271 – 2744Carbamoyl phosphate bindingBy similarity

Sequence similaritiesi

Belongs to the ATCase/OTCase family.Curated

Phylogenomic databases

eggNOGiCOG0078.
HOGENOMiHOG000022686.
KOiK00611.
OMAiVNIHIVA.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
HAMAPiMF_01109. OTCase.
InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
IPR024904. Orn_carbamltrans.
[Graphical view]
PfamiPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSiPR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00658. orni_carb_tr. 1 hit.
PROSITEiPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08322-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNNQFEGRSF LKEIDYTPTE LAYLIDFASH LKTLKAHHIP HPYLQGKNIA
60 70 80 90 100
LLFEKTSTRT RSAFTVAAND LGANPEFLCK DDIQFGTKES VVDTAKVLGS
110 120 130 140 150
MYDGIEFRGF KQSTVEDLAT YSGVPVWNGL TDEWHPTQIL ADFLTLKEHF
160 170 180 190 200
GHLKGLTLAY VGDGRNNMAN SLLVAGAMLG INIAIGSPVA LQPAPAVVAL
210 220 230 240 250
AQQYAQAAGS TVVITADPQQ AVTQADALYT DVWVSMGEQV DYGERIKQLL
260 270 280 290 300
PFQINTALLA ATGKSSTIVM HCLPALHDLK TQLGAKLGEQ YGMTAFEITD
310 320 330 340
DVFQSKQEVV FEEAGNRMPA IKAVMAATLG NLFIPTSIFN
Length:340
Mass (Da):36,974
Last modified:March 25, 2003 - v2
Checksum:i59BF46086D5620E9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti79 – 791C → G in CAA68243. (PubMed:9098069)Curated
Sequence conflicti187 – 1871S → A in CAA68243. (PubMed:9098069)Curated
Sequence conflicti257 – 2571A → T in CAA68243. (PubMed:9098069)Curated
Sequence conflicti308 – 3081E → A in CAA68243. (PubMed:9098069)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99978 Genomic DNA. Translation: CAA68243.1.
AL935263 Genomic DNA. Translation: CCC78022.1.
RefSeqiWP_011101046.1. NC_004567.2.
YP_004888536.1. NC_004567.2.

Genome annotation databases

EnsemblBacteriaiCCC78022; CCC78022; lp_0532.
GeneIDi1061878.
KEGGilpl:lp_0532.
PATRICi22247507. VBILacPla27411_0440.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99978 Genomic DNA. Translation: CAA68243.1 .
AL935263 Genomic DNA. Translation: CCC78022.1 .
RefSeqi WP_011101046.1. NC_004567.2.
YP_004888536.1. NC_004567.2.

3D structure databases

ProteinModelPortali O08322.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 220668.lp_0532.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCC78022 ; CCC78022 ; lp_0532 .
GeneIDi 1061878.
KEGGi lpl:lp_0532.
PATRICi 22247507. VBILacPla27411_0440.

Phylogenomic databases

eggNOGi COG0078.
HOGENOMi HOG000022686.
KOi K00611.
OMAi VNIHIVA.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00112 .
BioCyci LPLA220668-WGS:GSPK-443-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1370. 2 hits.
HAMAPi MF_01109. OTCase.
InterProi IPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
IPR024904. Orn_carbamltrans.
[Graphical view ]
Pfami PF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view ]
PRINTSi PR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMi SSF53671. SSF53671. 1 hit.
TIGRFAMsi TIGR00658. orni_carb_tr. 1 hit.
PROSITEi PS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Arginine biosynthesis and regulation in Lactobacillus plantarum: the carA gene and the argCJBDF cluster are divergently transcribed."
    Bringel F., Frey L., Boivin S., Hubert J.-C.
    J. Bacteriol. 179:2697-2706(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 8014 / CCM 1904 / DSM 20205 / NCDO 82 / NCIB 6376.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-793 / NCIMB 8826 / WCFS1.

Entry informationi

Entry nameiOTC_LACPL
AccessioniPrimary (citable) accession number: O08322
Secondary accession number(s): F9UL07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: March 25, 2003
Last modified: October 29, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3