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O08322

- OTC_LACPL

UniProt

O08322 - OTC_LACPL

Protein

Ornithine carbamoyltransferase

Gene

argF

Organism
Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 2 (25 Mar 2003)
      Previous versions | rss
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    Functioni

    Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.By similarity

    Catalytic activityi

    Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei11 – 111Carbamoyl phosphateBy similarity
    Sitei32 – 321Important for structural integrityBy similarity
    Binding sitei73 – 731Carbamoyl phosphateBy similarity
    Binding sitei84 – 841Carbamoyl phosphateBy similarity
    Binding sitei108 – 1081Carbamoyl phosphateBy similarity
    Sitei148 – 1481Important for structural integrityBy similarity
    Binding sitei167 – 1671OrnithineBy similarity
    Binding sitei231 – 2311OrnithineBy similarity
    Binding sitei299 – 2991Carbamoyl phosphateBy similarity
    Binding sitei317 – 3171Carbamoyl phosphateBy similarity

    GO - Molecular functioni

    1. amino acid binding Source: InterPro
    2. ornithine carbamoyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Enzyme and pathway databases

    BioCyciLPLA220668-WGS:GSPK-443-MONOMER.
    UniPathwayiUPA00068; UER00112.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ornithine carbamoyltransferase (EC:2.1.3.3)
    Short name:
    OTCase
    Gene namesi
    Name:argF
    Ordered Locus Names:lp_0532
    OrganismiLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
    Taxonomic identifieri220668 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000000432: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 340340Ornithine carbamoyltransferasePRO_0000112937Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi220668.lp_0532.

    Structurei

    3D structure databases

    ProteinModelPortaliO08322.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni57 – 615Carbamoyl phosphate bindingBy similarity
    Regioni135 – 1384Carbamoyl phosphate bindingBy similarity
    Regioni235 – 2362Ornithine bindingBy similarity
    Regioni271 – 2744Carbamoyl phosphate bindingBy similarity

    Sequence similaritiesi

    Belongs to the ATCase/OTCase family.Curated

    Phylogenomic databases

    eggNOGiCOG0078.
    HOGENOMiHOG000022686.
    KOiK00611.
    OMAiVNIHIVA.

    Family and domain databases

    Gene3Di3.40.50.1370. 2 hits.
    HAMAPiMF_01109. OTCase.
    InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
    IPR006130. Asp/Orn_carbamoylTrfase.
    IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
    IPR002292. Orn/put_carbamltrans.
    IPR024904. Orn_carbamltrans.
    [Graphical view]
    PfamiPF00185. OTCace. 1 hit.
    PF02729. OTCace_N. 1 hit.
    [Graphical view]
    PRINTSiPR00100. AOTCASE.
    PR00102. OTCASE.
    SUPFAMiSSF53671. SSF53671. 1 hit.
    TIGRFAMsiTIGR00658. orni_carb_tr. 1 hit.
    PROSITEiPS00097. CARBAMOYLTRANSFERASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O08322-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNNQFEGRSF LKEIDYTPTE LAYLIDFASH LKTLKAHHIP HPYLQGKNIA    50
    LLFEKTSTRT RSAFTVAAND LGANPEFLCK DDIQFGTKES VVDTAKVLGS 100
    MYDGIEFRGF KQSTVEDLAT YSGVPVWNGL TDEWHPTQIL ADFLTLKEHF 150
    GHLKGLTLAY VGDGRNNMAN SLLVAGAMLG INIAIGSPVA LQPAPAVVAL 200
    AQQYAQAAGS TVVITADPQQ AVTQADALYT DVWVSMGEQV DYGERIKQLL 250
    PFQINTALLA ATGKSSTIVM HCLPALHDLK TQLGAKLGEQ YGMTAFEITD 300
    DVFQSKQEVV FEEAGNRMPA IKAVMAATLG NLFIPTSIFN 340
    Length:340
    Mass (Da):36,974
    Last modified:March 25, 2003 - v2
    Checksum:i59BF46086D5620E9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti79 – 791C → G in CAA68243. (PubMed:9098069)Curated
    Sequence conflicti187 – 1871S → A in CAA68243. (PubMed:9098069)Curated
    Sequence conflicti257 – 2571A → T in CAA68243. (PubMed:9098069)Curated
    Sequence conflicti308 – 3081E → A in CAA68243. (PubMed:9098069)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X99978 Genomic DNA. Translation: CAA68243.1.
    AL935263 Genomic DNA. Translation: CCC78022.1.
    RefSeqiYP_004888536.1. NC_004567.2.

    Genome annotation databases

    EnsemblBacteriaiCCC78022; CCC78022; lp_0532.
    GeneIDi1061878.
    KEGGilpl:lp_0532.
    PATRICi22247507. VBILacPla27411_0440.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X99978 Genomic DNA. Translation: CAA68243.1 .
    AL935263 Genomic DNA. Translation: CCC78022.1 .
    RefSeqi YP_004888536.1. NC_004567.2.

    3D structure databases

    ProteinModelPortali O08322.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 220668.lp_0532.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CCC78022 ; CCC78022 ; lp_0532 .
    GeneIDi 1061878.
    KEGGi lpl:lp_0532.
    PATRICi 22247507. VBILacPla27411_0440.

    Phylogenomic databases

    eggNOGi COG0078.
    HOGENOMi HOG000022686.
    KOi K00611.
    OMAi VNIHIVA.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00112 .
    BioCyci LPLA220668-WGS:GSPK-443-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1370. 2 hits.
    HAMAPi MF_01109. OTCase.
    InterProi IPR006132. Asp/Orn_carbamoyltranf_P-bd.
    IPR006130. Asp/Orn_carbamoylTrfase.
    IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
    IPR002292. Orn/put_carbamltrans.
    IPR024904. Orn_carbamltrans.
    [Graphical view ]
    Pfami PF00185. OTCace. 1 hit.
    PF02729. OTCace_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00100. AOTCASE.
    PR00102. OTCASE.
    SUPFAMi SSF53671. SSF53671. 1 hit.
    TIGRFAMsi TIGR00658. orni_carb_tr. 1 hit.
    PROSITEi PS00097. CARBAMOYLTRANSFERASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Arginine biosynthesis and regulation in Lactobacillus plantarum: the carA gene and the argCJBDF cluster are divergently transcribed."
      Bringel F., Frey L., Boivin S., Hubert J.-C.
      J. Bacteriol. 179:2697-2706(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 8014 / CCM 1904 / DSM 20205 / NCDO 82 / NCIB 6376.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-793 / NCIMB 8826 / WCFS1.

    Entry informationi

    Entry nameiOTC_LACPL
    AccessioniPrimary (citable) accession number: O08322
    Secondary accession number(s): F9UL07
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: March 25, 2003
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3