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Protein
Submitted name:

Pristinamycin I synthase 3 and 4

Gene

snbDE

Organism
Streptomyces pristinaespiralis
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Protein family/group databases

ESTHERistrpr-SNBDE. Thioesterase.

Names & Taxonomyi

Protein namesi
Submitted name:
Pristinamycin I synthase 3 and 4Imported
Gene namesi
Name:snbDEImported
OrganismiStreptomyces pristinaespiralisImported
Taxonomic identifieri38300 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini968 – 103568Acyl carrierInterPro annotationAdd
BLAST
Domaini2401 – 246868Acyl carrierInterPro annotationAdd
BLAST
Domaini3443 – 351068Acyl carrierInterPro annotationAdd
BLAST
Domaini4509 – 457668Acyl carrierInterPro annotationAdd
BLAST

Phylogenomic databases

KOiK16118.

Family and domain databases

Gene3Di1.10.1200.10. 4 hits.
3.40.50.150. 1 hit.
3.40.50.1820. 2 hits.
InterProiIPR010071. AA_adenyl_domain.
IPR029058. AB_hydrolase.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR001242. Condensatn.
IPR013217. Methyltransf_12.
IPR020806. PKS_PP-bd.
IPR020802. PKS_thioesterase.
IPR009081. PP-bd_ACP.
IPR006162. Ppantetheine_attach_site.
IPR029063. SAM-dependent_MTases.
IPR001031. Thioesterase.
[Graphical view]
PfamiPF00501. AMP-binding. 4 hits.
PF13193. AMP-binding_C. 3 hits.
PF00668. Condensation. 4 hits.
PF08242. Methyltransf_12. 1 hit.
PF00550. PP-binding. 4 hits.
PF00975. Thioesterase. 1 hit.
[Graphical view]
SMARTiSM00823. PKS_PP. 4 hits.
SM00824. PKS_TE. 1 hit.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 4 hits.
SSF53335. SSF53335. 1 hit.
SSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR01733. AA-adenyl-dom. 4 hits.
PROSITEiPS50075. ACP_DOMAIN. 4 hits.
PS00455. AMP_BINDING. 4 hits.
PS00012. PHOSPHOPANTETHEINE. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O07944-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRSGLADVL PLSPLQEGLL FQVTYGAETH GPDVYTVQMV FELRGPLDED
60 70 80 90 100
GLRAAAAALL RRHPNLRAGF WQQGVERPVQ FVPNEVPLPW HTRDFTALGE
110 120 130 140 150
SDRERAVEAY VTADRAERFD PGAPPLIRFA LLGLAADHHK LVLTTHHLLL
160 170 180 190 200
DGWSMPLLVR ELFTLYGQRG DDAGMPPVTP YRAYLAHLAG RDDDAARAAW
210 220 230 240 250
RTALADLEEP SLVAGAGAGR GAADGSALPG QIWHEIDAAT TAGLTALARS
260 270 280 290 300
CNITLQHPGA KRLGTAARPQ LGRDDVVFGA TVAHRPPEIP GIESTIGMFI
310 320 330 340 350
NTLPVRVRVR PAETLGDLLG RVQREQAALI EHRHLSLTDI RSTTGTGELF
360 370 380 390 400
DTVVVFENYP LDPAVLRAEA RGLRLAGFEV SDATHYPLSL LAIPGESLRF
410 420 430 440 450
RLDHRGDVLD EAGARLLLER LDTLLTDIAE HGADLPVGRL DLLSAAERHQ
460 470 480 490 500
VLEEFNDTGL PAEDATLAAL FEAQAARTPD TTALLVGGRS LTYAELNARA
510 520 530 540 550
NRLARHLVTL GAGPEQIVAV KLERSLDLYV ALLAVLKTGA AYLPVDTAYP
560 570 580 590 600
AERIAFMMDD ARPAVVLTGE DTGQDLSGYD DTDLTDADRT APLLPAHPAY
610 620 630 640 650
VIYTSGSTGT PKAVVMPGAA LVNLLAWHRR EIPGEAGAPV AQFTTIGFDV
660 670 680 690 700
AAQEILATWL HGKTLAVPSQ EVRRSAEQLA AWLDEQHVSE LYAPNLVIEA
710 720 730 740 750
LAEAAAEAGR TLPALRHIAQ AGEALTLTRT VREFAAAVPG RQLHNHYGPA
760 770 780 790 800
ETHVMTGTAL PEDPAAWSEH APLGRPVSGA RVYVLDSALR PVAPGVTGEL
810 820 830 840 850
YLAGAGVSRG YLNRPVLTAE RFVADPYAPS PGARMYRTGD LGRWNTRGEL
860 870 880 890 900
EFAGRADHQV KIRGFRIEPG EIEAALTDLP AVARAAVVVR EDRPGDKRLV
910 920 930 940 950
AYAVPAGEGL DAAAVRSRLA RTLPDFMVPA AIVALDALPL TPNGKLDRAA
960 970 980 990 1000
LPAPQSTTAV QRTPRSPREE ILTTLFAAVL KLPRVGIDDN FFDLGGHSLL
1010 1020 1030 1040 1050
ATRLISRIRT VLGAEITLRD LFEAPTVAGL GERLDQASGA RPALTPAERP
1060 1070 1080 1090 1100
ERLPLSHAQR RLWFLGRLDG PNSTYNIPLA LRLSGTLDTA ALRAALADLV
1110 1120 1130 1140 1150
ARHETLRTRY PSHDGEPYQH IVAPADATPA LTVVHTEEHR LAEQLAEATA
1160 1170 1180 1190 1200
RPYDLTTELP LRATLFRLGE DEHVLLLLLH HIAGDGWSLA PLTRDLAAAY
1210 1220 1230 1240 1250
AARRDGHAPG FAPLPVQYAD YTLWQRGLLG DADDPTSLQA AQLAHWRQAL
1260 1270 1280 1290 1300
EGRPAHLELP CDHPRPAVAT HRGATVPFHI DAGLHEKLTA LAKACDSSLF
1310 1320 1330 1340 1350
MVLQAAFAAL LTRHGAGTDI PVGSPVAGRT DDALDDLVGF FVNTLVLRTD
1360 1370 1380 1390 1400
TSGDPTFREL VARVRQFDLA AYTHQDMPFE KLVEEVNPER SLARNPLFQV
1410 1420 1430 1440 1450
VLALQSMPAA DLALPGLDVA AEPVRVGFAK FDLGLAVIEE HTADGTRAGI
1460 1470 1480 1490 1500
RGDWEYSTEL FERGTVEALG SRLVRLLDAV ADDPERTIGS VDLLDATERH
1510 1520 1530 1540 1550
RLLVGLNTTD GPLPEERTLT ALFEQQAAAT PDATALVMGD RSLTYAELDA
1560 1570 1580 1590 1600
RANRLARHLV ALGAGPEQIV ALQLPRSLDL VTAVLAVWKS GAAYLPVDPD
1610 1620 1630 1640 1650
YPPERIAHMR ADARPALVVD AIPDDTTLAA YADSRLTDAD RSAPLLPAHP
1660 1670 1680 1690 1700
AYVIYTSGST GAPKGVVVAH RSLAATVPAQ AAAFGLGTHS RVLNFASISF
1710 1720 1730 1740 1750
DAAVWELTSA LFTGAGLVLA DADDLLPGPS LARLVHDRHI TLIALPPSAL
1760 1770 1780 1790 1800
PALPDGALPP GTDLIVAGDA TAPDQAARFA PGRRMVNAYG LTETTVCATM
1810 1820 1830 1840 1850
SEPATGDGAP PIGRPVAHAR VYVLDERLRP VPPGVTGEMY VSGAGVARGY
1860 1870 1880 1890 1900
LHRPALTAQR FVPDPYALLF GETGTRMYRT GDLARLDADG RLHFAGRADQ
1910 1920 1930 1940 1950
QVKIRGFRIE PGEIETVLTA HPAVAAGAVI AREDTPGDKQ LVAYLTRDTT
1960 1970 1980 1990 2000
HHAAPDQDLG TGQVDRWQQT YDSLYEAEPG RAFGEDFSGW NSSYTAEEIP
2010 2020 2030 2040 2050
LEEMREWRAA TVDRVLALRP RRVLEIGCGT GLILSQVAPH TEEYRGTDLS
2060 2070 2080 2090 2100
RSVVARLAAH LAGRPDLADK VTVDARAAHE TDDLPKGRFD TIVLNSVAQY
2110 2120 2130 2140 2150
FPDARYLAGI LHRAAELLAP GGTIFLGDIR NLRTLHAFRT AVELRRAGPF
2160 2170 2180 2190 2200
ADPAAVRRAV EQSLATEKEL LLDPDFFTDL VDRDPHLTRA DITLRTAAHH
2210 2220 2230 2240 2250
NEMSRHRYDV TLHRGGDSPA PAETVLRWGT DLDTAGELAR VLSGPRPVRV
2260 2270 2280 2290 2300
TGIPNARLTG ETRAAQALER GSAADACARL EAPAPAGALD PHDVYALGAV
2310 2320 2330 2340 2350
CTWGHDDDTF DAYAGDGTAY RPRTGRQGPL ANDPARAEQD AALVGELRDL
2360 2370 2380 2390 2400
VAQRLPAHMA PAAYVLLDRL PLSANGKLDR DALPAPDRGE DAAGQAPRTR
2410 2420 2430 2440 2450
REEILSTLFA EVLGLPAVGI DRSFFDLGGH SLLATRLLSR IRSVLGAELA
2460 2470 2480 2490 2500
VRDLFQAPTV AALAERVDGA QEARPPLTAR TRPAEVPLSF AQYRLWFLHR
2510 2520 2530 2540 2550
MEGPGPTYNI PMSLRLTGTL DTAALRAALA DVTARHEALR TVYPESGGVP
2560 2570 2580 2590 2600
RQHVLHDVRP HFETADTTAQ TLEADLTRAA RRGFDLAREL PLRATLFRLA
2610 2620 2630 2640 2650
EDEHVLLLLM HHIAGDGWSW PPLARDLGDA YAARLAGRAP DLPPLPVQYA
2660 2670 2680 2690 2700
DYALWQRDLL GDEDDPTSRH ARQLAYWAGA LDDLPEELQL PCDRPRPAVA
2710 2720 2730 2740 2750
THRGDTVPFA VDPDLHQRLN ALATEGRASL FMVLQAAFAA LLTRHGAGTD
2760 2770 2780 2790 2800
IPLGSPIAGR TDDALEDLVG FFVNTLVLRT DTSGDPTFRE LLQRVRESDL
2810 2820 2830 2840 2850
AAYAHQDVPF EKLVEKLRPE RSLSRHPLFQ VMLAFQNSGE ARLALPGLDA
2860 2870 2880 2890 2900
RALPVGVGVA KFDLHLSMVE LRTGDGRPGG IQAALEYATD LFDRTTAQAL
2910 2920 2930 2940 2950
VDRLLRLLAA VADDPGLTVG RVELLDPAER HRVLQDWNTT PGGDGAARTP
2960 2970 2980 2990 3000
VTELLERQAA RTPDAVALVH DDGRLTYAEL HARANRLARH LITLGAGPEQ
3010 3020 3030 3040 3050
IVALRMPRSL DLYVALLAVL KTGAAYLPVD ISYPAERIAF MIEDARPVTV
3060 3070 3080 3090 3100
LDRLPDDLGA YRDTDLTDAD RTAPLRPEHP AYVIHTSGST GTPKAVVMPH
3110 3120 3130 3140 3150
AGLANLLTWH ARRFPGGTGV RTAQFTAIGF DFSVQEILSP LVMGKTLAVP
3160 3170 3180 3190 3200
SEEVRHSAEL LAGWLETQQI NELFAPNLVI EALAEAAAEA GRTLPDLTDI
3210 3220 3230 3240 3250
LQGGEALAPT ERVRAFTAAV PGRRLHNVYG PAETHAVTTH TLAADPAHWP
3260 3270 3280 3290 3300
PSAPIGRPVD HDRVYVLDSA LRPVPPGVTG ELYLAGAGVA RGYLHRPRTT
3310 3320 3330 3340 3350
AERFVADPYA PRPGARMYRT GDLGRWNTRG ELEFAGRADH QVKIRGFRVE
3360 3370 3380 3390 3400
PGEVEAALTA HPRITQAAVL AHGDRLVAYV VTTADRDLTG VREHLAARLP
3410 3420 3430 3440 3450
DFMVPTAYVR LEALPLTVNG KLDRAALPAP DAPAAGRAPR TVREEILCGL
3460 3470 3480 3490 3500
FAEVLGTERA GIDDNFFDLG GHSLLATRLI SRIRTALGAE ITLRDLFEAP
3510 3520 3530 3540 3550
TVAGLGERLD QASGARPALT PAERPERLPL SYAQRRLWFL GRLTGGDPGY
3560 3570 3580 3590 3600
NMPVGLRLSG TLDTAALTAA LADLVARHET LRTVFPEGDD GSPHQLVLDP
3610 3620 3630 3640 3650
GAARPALHPR DTTQDDLATE LAAAARHCFD LTTELPLRAT LFRLAEDEHV
3660 3670 3680 3690 3700
LLLLLHHIAG DGWSLAPLAR DLVTAYAARR DGHAPDFAPL PVQYADYTLW
3710 3720 3730 3740 3750
QHALLGDEND PDSTISRQSA HWKDALAGLP EEIQLPADRP RPATPAHRGE
3760 3770 3780 3790 3800
AVFRTLDADL HRELLHLART GGASLFMVLQ AAVAAVLTRH GAGTDIPLGS
3810 3820 3830 3840 3850
PIAGRTDDAL DDLVGFFVNT LVLRTDTSGN PTFRELLDRV REFDLAAYAH
3860 3870 3880 3890 3900
QDVPFEKLVE DAAPGRSLSR HPLFQVLLAL QNTPEAVLEL PGLTARPEVV
3910 3920 3930 3940 3950
TLGAAKFDLT FNLAERHGPD GEPHGIDAVL EYSTDLFDRT TAEALTDRLI
3960 3970 3980 3990 4000
TFLRAVAADP GRTVADVPIL DADDHARVLT GWNDTDHPRG RRTADACLPR
4010 4020 4030 4040 4050
RIAEQAARTP HAVAVTEAGG TLITYSELDA RANRLARHLI RRGVTAETRV
4060 4070 4080 4090 4100
AVLAERSAQL VVTTLAILKA GGVYVPLHTG YPVDRMRHVL ADTEAALLLT
4110 4120 4130 4140 4150
DTHHAATAAR LDTPALTVDE DTTAGEQDTT APDVTVRPDQ LAYIMFTSGS
4160 4170 4180 4190 4200
TGTPKGIGIT HRDAIALAAD RCWDLDTGSR VLMHSPYAFD ISTFELFAPL
4210 4220 4230 4240 4250
LAGGRIVVAP RGDIDAAVLQ RTLAAHGVTS LLLTAGLLGV IADEAPEVFT
4260 4270 4280 4290 4300
GVKDVWTGGD VVSPTAVRRV LEACPGTVVK TLYGPTETTL GCTWLPFTDP
4310 4320 4330 4340 4350
RRIPPAVPIG RPLDNTRAYV LDERLRPVPP GVTGELYIAG AGLARGYWDQ
4360 4370 4380 4390 4400
SARTAERFTA DPHAHLFGDT GGRMYRTGDL ARRDADGVLH FCGRADQQVK
4410 4420 4430 4440 4450
IRGFRIEPGE IETALAAHPD VTRAAVVARP GRAGDKVLVA YLVTAPDAGD
4460 4470 4480 4490 4500
TTAEQLRAGL ETQLPDYMVP AAFVALPALP VTPNGKLDRD ALPEPDWGGG
4510 4520 4530 4540 4550
AGRPPRGPRE EILCGLFAEV LGAPRVGTDD NFFELGGHSM LATRLVGRVK
4560 4570 4580 4590 4600
TVLGADIGVR TLFEAPTVAA LAARIDGADT GHDPFGVVLP LRTGGSRAPL
4610 4620 4630 4640 4650
FCVHPAGGFG WVYSALLRHT DREQPLYALQ ARGLARPEPL PDDIDAMARD
4660 4670 4680 4690 4700
YAEQIRKTVP EGPYEILGWS FGGLVAHAVA ARLQAEGAEV SLLAVLDGYP
4710 4720 4730 4740 4750
DAYDGTEHEV GEEQVLAILL NAAGVDRAQA FGDAPLQRAA VLEKLRDSGS
4760 4770 4780 4790 4800
ALGNLDDDAV GRMVTVFLNN TRLIQNFRPR RFTGDMVFFA AAAGHHDPAL
4810 4820 4830 4840
TPGNWRPYVT GRIEEHHLDT DHAGLARPEA LGAVARTLAQ RDTPQAGH
Length:4,848
Mass (Da):522,087
Last modified:July 1, 1997 - v1
Checksum:iE17591617A2B9A0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98690 Genomic DNA. Translation: CAA67249.1.
Y11548 Genomic DNA. Translation: CAA72312.1.
PIRiT30289.

Genome annotation databases

KEGGiag:CAA67249.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98690 Genomic DNA. Translation: CAA67249.1.
Y11548 Genomic DNA. Translation: CAA72312.1.
PIRiT30289.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

ESTHERistrpr-SNBDE. Thioesterase.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGiag:CAA67249.

Phylogenomic databases

KOiK16118.

Family and domain databases

Gene3Di1.10.1200.10. 4 hits.
3.40.50.150. 1 hit.
3.40.50.1820. 2 hits.
InterProiIPR010071. AA_adenyl_domain.
IPR029058. AB_hydrolase.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR001242. Condensatn.
IPR013217. Methyltransf_12.
IPR020806. PKS_PP-bd.
IPR020802. PKS_thioesterase.
IPR009081. PP-bd_ACP.
IPR006162. Ppantetheine_attach_site.
IPR029063. SAM-dependent_MTases.
IPR001031. Thioesterase.
[Graphical view]
PfamiPF00501. AMP-binding. 4 hits.
PF13193. AMP-binding_C. 3 hits.
PF00668. Condensation. 4 hits.
PF08242. Methyltransf_12. 1 hit.
PF00550. PP-binding. 4 hits.
PF00975. Thioesterase. 1 hit.
[Graphical view]
SMARTiSM00823. PKS_PP. 4 hits.
SM00824. PKS_TE. 1 hit.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 4 hits.
SSF53335. SSF53335. 1 hit.
SSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR01733. AA-adenyl-dom. 4 hits.
PROSITEiPS50075. ACP_DOMAIN. 4 hits.
PS00455. AMP_BINDING. 4 hits.
PS00012. PHOSPHOPANTETHEINE. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Pristinamycin I biosynthesis in Streptomyces pristinaespiralis: molecular characterization of the first two structural peptide synthetase genes."
    de Crecy-Lagard V., Blanc V., Gil P., Naudin L., Lorenzon S., Famechon A., Bamas-Jacques N., Crouzet J., Thibaut D.
    J. Bacteriol. 179:705-713(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SP92Imported.
  2. "Streptogramin B biosynthesis in Streptomyces pristinaespiralis and Streptomyces virginiae: molecular characterization of the last structural peptide synthase gene."
    de Crecy-Lagard V.A., Saurin W., Thibaut D., Gil P., Naudin L., Crouzet J., Blanc V.
    Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SP92Imported.

Entry informationi

Entry nameiO07944_STRPR
AccessioniPrimary (citable) accession number: O07944
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: July 1, 1997
Last modified: July 6, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.