O07944 (O07944_STRPR) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Pristinamycin I synthase 3 and 4 EMBL CAA72312.1

Gene names

Name:

snbDE EMBL CAA72312.1

Organism

Streptomyces pristinaespiralis EMBL CAA72312.1

Taxonomic identifier

38300 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	4848 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Keywords
Ligand	Phosphopantetheine RuleBase RU000721
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	acyl carrier activity Inferred from electronic annotation. Source: InterPro cofactor binding Inferred from electronic annotation. Source: InterPro hydrolase activity, acting on ester bonds Inferred from electronic annotation. Source: InterPro ligase activity Inferred from electronic annotation. Source: InterPro phosphopantetheine binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	O07944 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: E17591617A2B9A0E	FASTA	4,848	522,087
	10 20 30 40 50 60 MTRSGLADVL PLSPLQEGLL FQVTYGAETH GPDVYTVQMV FELRGPLDED GLRAAAAALL 70 80 90 100 110 120 RRHPNLRAGF WQQGVERPVQ FVPNEVPLPW HTRDFTALGE SDRERAVEAY VTADRAERFD 130 140 150 160 170 180 PGAPPLIRFA LLGLAADHHK LVLTTHHLLL DGWSMPLLVR ELFTLYGQRG DDAGMPPVTP 190 200 210 220 230 240 YRAYLAHLAG RDDDAARAAW RTALADLEEP SLVAGAGAGR GAADGSALPG QIWHEIDAAT 250 260 270 280 290 300 TAGLTALARS CNITLQHPGA KRLGTAARPQ LGRDDVVFGA TVAHRPPEIP GIESTIGMFI 310 320 330 340 350 360 NTLPVRVRVR PAETLGDLLG RVQREQAALI EHRHLSLTDI RSTTGTGELF DTVVVFENYP 370 380 390 400 410 420 LDPAVLRAEA RGLRLAGFEV SDATHYPLSL LAIPGESLRF RLDHRGDVLD EAGARLLLER 430 440 450 460 470 480 LDTLLTDIAE HGADLPVGRL DLLSAAERHQ VLEEFNDTGL PAEDATLAAL FEAQAARTPD 490 500 510 520 530 540 TTALLVGGRS LTYAELNARA NRLARHLVTL GAGPEQIVAV KLERSLDLYV ALLAVLKTGA 550 560 570 580 590 600 AYLPVDTAYP AERIAFMMDD ARPAVVLTGE DTGQDLSGYD DTDLTDADRT APLLPAHPAY 610 620 630 640 650 660 VIYTSGSTGT PKAVVMPGAA LVNLLAWHRR EIPGEAGAPV AQFTTIGFDV AAQEILATWL 670 680 690 700 710 720 HGKTLAVPSQ EVRRSAEQLA AWLDEQHVSE LYAPNLVIEA LAEAAAEAGR TLPALRHIAQ 730 740 750 760 770 780 AGEALTLTRT VREFAAAVPG RQLHNHYGPA ETHVMTGTAL PEDPAAWSEH APLGRPVSGA 790 800 810 820 830 840 RVYVLDSALR PVAPGVTGEL YLAGAGVSRG YLNRPVLTAE RFVADPYAPS PGARMYRTGD 850 860 870 880 890 900 LGRWNTRGEL EFAGRADHQV KIRGFRIEPG EIEAALTDLP AVARAAVVVR EDRPGDKRLV 910 920 930 940 950 960 AYAVPAGEGL DAAAVRSRLA RTLPDFMVPA AIVALDALPL TPNGKLDRAA LPAPQSTTAV 970 980 990 1000 1010 1020 QRTPRSPREE ILTTLFAAVL KLPRVGIDDN FFDLGGHSLL ATRLISRIRT VLGAEITLRD 1030 1040 1050 1060 1070 1080 LFEAPTVAGL GERLDQASGA RPALTPAERP ERLPLSHAQR RLWFLGRLDG PNSTYNIPLA 1090 1100 1110 1120 1130 1140 LRLSGTLDTA ALRAALADLV ARHETLRTRY PSHDGEPYQH IVAPADATPA LTVVHTEEHR 1150 1160 1170 1180 1190 1200 LAEQLAEATA RPYDLTTELP LRATLFRLGE DEHVLLLLLH HIAGDGWSLA PLTRDLAAAY 1210 1220 1230 1240 1250 1260 AARRDGHAPG FAPLPVQYAD YTLWQRGLLG DADDPTSLQA AQLAHWRQAL EGRPAHLELP 1270 1280 1290 1300 1310 1320 CDHPRPAVAT HRGATVPFHI DAGLHEKLTA LAKACDSSLF MVLQAAFAAL LTRHGAGTDI 1330 1340 1350 1360 1370 1380 PVGSPVAGRT DDALDDLVGF FVNTLVLRTD TSGDPTFREL VARVRQFDLA AYTHQDMPFE 1390 1400 1410 1420 1430 1440 KLVEEVNPER SLARNPLFQV VLALQSMPAA DLALPGLDVA AEPVRVGFAK FDLGLAVIEE 1450 1460 1470 1480 1490 1500 HTADGTRAGI RGDWEYSTEL FERGTVEALG SRLVRLLDAV ADDPERTIGS VDLLDATERH 1510 1520 1530 1540 1550 1560 RLLVGLNTTD GPLPEERTLT ALFEQQAAAT PDATALVMGD RSLTYAELDA RANRLARHLV 1570 1580 1590 1600 1610 1620 ALGAGPEQIV ALQLPRSLDL VTAVLAVWKS GAAYLPVDPD YPPERIAHMR ADARPALVVD 1630 1640 1650 1660 1670 1680 AIPDDTTLAA YADSRLTDAD RSAPLLPAHP AYVIYTSGST GAPKGVVVAH RSLAATVPAQ 1690 1700 1710 1720 1730 1740 AAAFGLGTHS RVLNFASISF DAAVWELTSA LFTGAGLVLA DADDLLPGPS LARLVHDRHI 1750 1760 1770 1780 1790 1800 TLIALPPSAL PALPDGALPP GTDLIVAGDA TAPDQAARFA PGRRMVNAYG LTETTVCATM 1810 1820 1830 1840 1850 1860 SEPATGDGAP PIGRPVAHAR VYVLDERLRP VPPGVTGEMY VSGAGVARGY LHRPALTAQR 1870 1880 1890 1900 1910 1920 FVPDPYALLF GETGTRMYRT GDLARLDADG RLHFAGRADQ QVKIRGFRIE PGEIETVLTA 1930 1940 1950 1960 1970 1980 HPAVAAGAVI AREDTPGDKQ LVAYLTRDTT HHAAPDQDLG TGQVDRWQQT YDSLYEAEPG 1990 2000 2010 2020 2030 2040 RAFGEDFSGW NSSYTAEEIP LEEMREWRAA TVDRVLALRP RRVLEIGCGT GLILSQVAPH 2050 2060 2070 2080 2090 2100 TEEYRGTDLS RSVVARLAAH LAGRPDLADK VTVDARAAHE TDDLPKGRFD TIVLNSVAQY 2110 2120 2130 2140 2150 2160 FPDARYLAGI LHRAAELLAP GGTIFLGDIR NLRTLHAFRT AVELRRAGPF ADPAAVRRAV 2170 2180 2190 2200 2210 2220 EQSLATEKEL LLDPDFFTDL VDRDPHLTRA DITLRTAAHH NEMSRHRYDV TLHRGGDSPA 2230 2240 2250 2260 2270 2280 PAETVLRWGT DLDTAGELAR VLSGPRPVRV TGIPNARLTG ETRAAQALER GSAADACARL 2290 2300 2310 2320 2330 2340 EAPAPAGALD PHDVYALGAV CTWGHDDDTF DAYAGDGTAY RPRTGRQGPL ANDPARAEQD 2350 2360 2370 2380 2390 2400 AALVGELRDL VAQRLPAHMA PAAYVLLDRL PLSANGKLDR DALPAPDRGE DAAGQAPRTR 2410 2420 2430 2440 2450 2460 REEILSTLFA EVLGLPAVGI DRSFFDLGGH SLLATRLLSR IRSVLGAELA VRDLFQAPTV 2470 2480 2490 2500 2510 2520 AALAERVDGA QEARPPLTAR TRPAEVPLSF AQYRLWFLHR MEGPGPTYNI PMSLRLTGTL 2530 2540 2550 2560 2570 2580 DTAALRAALA DVTARHEALR TVYPESGGVP RQHVLHDVRP HFETADTTAQ TLEADLTRAA 2590 2600 2610 2620 2630 2640 RRGFDLAREL PLRATLFRLA EDEHVLLLLM HHIAGDGWSW PPLARDLGDA YAARLAGRAP 2650 2660 2670 2680 2690 2700 DLPPLPVQYA DYALWQRDLL GDEDDPTSRH ARQLAYWAGA LDDLPEELQL PCDRPRPAVA 2710 2720 2730 2740 2750 2760 THRGDTVPFA VDPDLHQRLN ALATEGRASL FMVLQAAFAA LLTRHGAGTD IPLGSPIAGR 2770 2780 2790 2800 2810 2820 TDDALEDLVG FFVNTLVLRT DTSGDPTFRE LLQRVRESDL AAYAHQDVPF EKLVEKLRPE 2830 2840 2850 2860 2870 2880 RSLSRHPLFQ VMLAFQNSGE ARLALPGLDA RALPVGVGVA KFDLHLSMVE LRTGDGRPGG 2890 2900 2910 2920 2930 2940 IQAALEYATD LFDRTTAQAL VDRLLRLLAA VADDPGLTVG RVELLDPAER HRVLQDWNTT 2950 2960 2970 2980 2990 3000 PGGDGAARTP VTELLERQAA RTPDAVALVH DDGRLTYAEL HARANRLARH LITLGAGPEQ 3010 3020 3030 3040 3050 3060 IVALRMPRSL DLYVALLAVL KTGAAYLPVD ISYPAERIAF MIEDARPVTV LDRLPDDLGA 3070 3080 3090 3100 3110 3120 YRDTDLTDAD RTAPLRPEHP AYVIHTSGST GTPKAVVMPH AGLANLLTWH ARRFPGGTGV 3130 3140 3150 3160 3170 3180 RTAQFTAIGF DFSVQEILSP LVMGKTLAVP SEEVRHSAEL LAGWLETQQI NELFAPNLVI 3190 3200 3210 3220 3230 3240 EALAEAAAEA GRTLPDLTDI LQGGEALAPT ERVRAFTAAV PGRRLHNVYG PAETHAVTTH 3250 3260 3270 3280 3290 3300 TLAADPAHWP PSAPIGRPVD HDRVYVLDSA LRPVPPGVTG ELYLAGAGVA RGYLHRPRTT 3310 3320 3330 3340 3350 3360 AERFVADPYA PRPGARMYRT GDLGRWNTRG ELEFAGRADH QVKIRGFRVE PGEVEAALTA 3370 3380 3390 3400 3410 3420 HPRITQAAVL AHGDRLVAYV VTTADRDLTG VREHLAARLP DFMVPTAYVR LEALPLTVNG 3430 3440 3450 3460 3470 3480 KLDRAALPAP DAPAAGRAPR TVREEILCGL FAEVLGTERA GIDDNFFDLG GHSLLATRLI 3490 3500 3510 3520 3530 3540 SRIRTALGAE ITLRDLFEAP TVAGLGERLD QASGARPALT PAERPERLPL SYAQRRLWFL 3550 3560 3570 3580 3590 3600 GRLTGGDPGY NMPVGLRLSG TLDTAALTAA LADLVARHET LRTVFPEGDD GSPHQLVLDP 3610 3620 3630 3640 3650 3660 GAARPALHPR DTTQDDLATE LAAAARHCFD LTTELPLRAT LFRLAEDEHV LLLLLHHIAG 3670 3680 3690 3700 3710 3720 DGWSLAPLAR DLVTAYAARR DGHAPDFAPL PVQYADYTLW QHALLGDEND PDSTISRQSA 3730 3740 3750 3760 3770 3780 HWKDALAGLP EEIQLPADRP RPATPAHRGE AVFRTLDADL HRELLHLART GGASLFMVLQ 3790 3800 3810 3820 3830 3840 AAVAAVLTRH GAGTDIPLGS PIAGRTDDAL DDLVGFFVNT LVLRTDTSGN PTFRELLDRV 3850 3860 3870 3880 3890 3900 REFDLAAYAH QDVPFEKLVE DAAPGRSLSR HPLFQVLLAL QNTPEAVLEL PGLTARPEVV 3910 3920 3930 3940 3950 3960 TLGAAKFDLT FNLAERHGPD GEPHGIDAVL EYSTDLFDRT TAEALTDRLI TFLRAVAADP 3970 3980 3990 4000 4010 4020 GRTVADVPIL DADDHARVLT GWNDTDHPRG RRTADACLPR RIAEQAARTP HAVAVTEAGG 4030 4040 4050 4060 4070 4080 TLITYSELDA RANRLARHLI RRGVTAETRV AVLAERSAQL VVTTLAILKA GGVYVPLHTG 4090 4100 4110 4120 4130 4140 YPVDRMRHVL ADTEAALLLT DTHHAATAAR LDTPALTVDE DTTAGEQDTT APDVTVRPDQ 4150 4160 4170 4180 4190 4200 LAYIMFTSGS TGTPKGIGIT HRDAIALAAD RCWDLDTGSR VLMHSPYAFD ISTFELFAPL 4210 4220 4230 4240 4250 4260 LAGGRIVVAP RGDIDAAVLQ RTLAAHGVTS LLLTAGLLGV IADEAPEVFT GVKDVWTGGD 4270 4280 4290 4300 4310 4320 VVSPTAVRRV LEACPGTVVK TLYGPTETTL GCTWLPFTDP RRIPPAVPIG RPLDNTRAYV 4330 4340 4350 4360 4370 4380 LDERLRPVPP GVTGELYIAG AGLARGYWDQ SARTAERFTA DPHAHLFGDT GGRMYRTGDL 4390 4400 4410 4420 4430 4440 ARRDADGVLH FCGRADQQVK IRGFRIEPGE IETALAAHPD VTRAAVVARP GRAGDKVLVA 4450 4460 4470 4480 4490 4500 YLVTAPDAGD TTAEQLRAGL ETQLPDYMVP AAFVALPALP VTPNGKLDRD ALPEPDWGGG 4510 4520 4530 4540 4550 4560 AGRPPRGPRE EILCGLFAEV LGAPRVGTDD NFFELGGHSM LATRLVGRVK TVLGADIGVR 4570 4580 4590 4600 4610 4620 TLFEAPTVAA LAARIDGADT GHDPFGVVLP LRTGGSRAPL FCVHPAGGFG WVYSALLRHT 4630 4640 4650 4660 4670 4680 DREQPLYALQ ARGLARPEPL PDDIDAMARD YAEQIRKTVP EGPYEILGWS FGGLVAHAVA 4690 4700 4710 4720 4730 4740 ARLQAEGAEV SLLAVLDGYP DAYDGTEHEV GEEQVLAILL NAAGVDRAQA FGDAPLQRAA 4750 4760 4770 4780 4790 4800 VLEKLRDSGS ALGNLDDDAV GRMVTVFLNN TRLIQNFRPR RFTGDMVFFA AAAGHHDPAL 4810 4820 4830 4840 TPGNWRPYVT GRIEEHHLDT DHAGLARPEA LGAVARTLAQ RDTPQAGH

References

[1]	"Pristinamycin I biosynthesis in Streptomyces pristinaespiralis: molecular characterization of the first two structural peptide synthetase genes." de Crecy-Lagard V., Blanc V., Gil P., Naudin L., Lorenzon S., Famechon A., Bamas-Jacques N., Crouzet J., Thibaut D. J. Bacteriol. 179:705-713(1997) [PubMed: 9006024] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: SP92 EMBL CAA67249.1.
[2]	"Streptogramin B biosynthesis in Streptomyces pristinaespiralis and Streptomyces virginiae: molecular characterization of the last structural peptide synthase gene." de Crecy-Lagard V.A., Saurin W., Thibaut D., Gil P., Naudin L., Crouzet J., Blanc V. Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: SP92 EMBL CAA72312.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X98690 Genomic DNA. Translation: CAA67249.1. Y11548 Genomic DNA. Translation: CAA72312.1.
PIR	T30289.
3D structure databases
HSSP	HSSP built from PDB template 1DNY based on UniProtKB O30409.
ProteinModelPortal	O07944.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR010071. AA_adenyl_domain. IPR009081. Acyl_carrier_prot-like. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. IPR001242. Condensatn. IPR013217. Methyltransf_12. IPR006163. Phsphopanteth-bd. IPR020806. PKS_PP-bd. IPR006162. PPantetheine_attach_site. IPR001031. Thioesterase. [Graphical view]
Gene3D	G3DSA:1.10.1200.10. ACP_like. 4 hits.
Pfam	PF00501. AMP-binding. 4 hits. PF00668. Condensation. 4 hits. PF08242. Methyltransf_12. 1 hit. PF00550. PP-binding. 4 hits. PF00975. Thioesterase. 1 hit. [Graphical view]
SMART	SM00823. PKS_PP. 4 hits. [Graphical view]
SUPFAM	SSF47336. ACP_like. 4 hits.
TIGRFAMs	TIGR01733. AA-adenyl-dom. 4 hits.
PROSITE	PS50075. ACP_DOMAIN. 4 hits. PS00455. AMP_BINDING. 4 hits. PS00012. PHOSPHOPANTETHEINE. 4 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

O07944_STRPR

Accession

Primary (citable) accession number: O07944

Entry history

Integrated into UniProtKB/TrEMBL:	July 1, 1997
Last sequence update:	July 1, 1997
Last modified:	November 16, 2011
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)