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Protein

Chitosanase

Gene

csn

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Aids in the defense against invading fungal pathogens by degrading their cell wall chitosan.By similarity

Catalytic activityi

Endohydrolysis of beta-(1->4)-linkages between D-glucosamine residues in a partly acetylated chitosan.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei54 – 541Proton donorPROSITE-ProRule annotation
Active sitei70 – 701NucleophileBy similarity

GO - Molecular functioni

  • chitosanase activity Source: CACAO

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BioCyciBSUB:BSU26890-MONOMER.
MetaCyc:MONOMER-17651.

Protein family/group databases

CAZyiGH46. Glycoside Hydrolase Family 46.

Names & Taxonomyi

Protein namesi
Recommended name:
Chitosanase (EC:3.2.1.132)
Gene namesi
Name:csn
Ordered Locus Names:BSU26890
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

  • Secreted 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 35351 PublicationAdd
BLAST
Chaini36 – 277242ChitosanasePRO_0000012207Add
BLAST

Proteomic databases

PaxDbiO07921.

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100014701.

Structurei

3D structure databases

ProteinModelPortaliO07921.
SMRiO07921. Positions 35-277.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 46 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG41083Q9. Bacteria.
ENOG410ZJYK. LUCA.
HOGENOMiHOG000292583.
InParanoidiO07921.
KOiK01233.
OMAiTCGRAGF.
PhylomeDBiO07921.

Family and domain databases

CDDicd00978. chitosanase_glyco_hydro_46. 1 hit.
Gene3Di3.30.386.10. 1 hit.
InterProiIPR000400. Glyco_hydro_46.
IPR023099. Glyco_hydro_46_N.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PfamiPF01374. Glyco_hydro_46. 1 hit.
[Graphical view]
PIRSFiPIRSF036551. Chitosanase. 1 hit.
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS60000. CHITOSANASE_46_80. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O07921-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKISMQKADF WKKAAISLLV FTMFFTLMMS ETVFAAGLNK DQKRRAEQLT
60 70 80 90 100
SIFENGTTEI QYGYVERLDD GRGYTCGRAG FTTATGDALE VVEVYTKAVP
110 120 130 140 150
NNKLKKYLPE LRRLAKEESD DTSNLKGFAS AWKSLANDKE FRAAQDKVND
160 170 180 190 200
HLYYQPAMKR SDNAGLKTAL ARAVMYDTVI QHGDGDDPDS FYALIKRTNK
210 220 230 240 250
KAGGSPKDGI DEKKWLNKFL DVRYDDLMNP ANHDTRDEWR ESVARVDVLR
260 270
SIAKENNYNL NGPIHVRSNE YGNFVIK
Length:277
Mass (Da):31,497
Last modified:July 1, 1997 - v1
Checksum:i8C17C156AF27F781
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92868 Genomic DNA. Translation: CAA63455.1.
U93875 Genomic DNA. Translation: AAB80882.1.
AL009126 Genomic DNA. Translation: CAB14630.1.
PIRiC69608.
RefSeqiNP_390566.1. NC_000964.3.
WP_003229851.1. NZ_JNCM01000036.1.

Genome annotation databases

EnsemblBacteriaiCAB14630; CAB14630; BSU26890.
GeneIDi936802.
KEGGibsu:BSU26890.
PATRICi18977230. VBIBacSub10457_2804.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92868 Genomic DNA. Translation: CAA63455.1.
U93875 Genomic DNA. Translation: AAB80882.1.
AL009126 Genomic DNA. Translation: CAB14630.1.
PIRiC69608.
RefSeqiNP_390566.1. NC_000964.3.
WP_003229851.1. NZ_JNCM01000036.1.

3D structure databases

ProteinModelPortaliO07921.
SMRiO07921. Positions 35-277.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100014701.

Protein family/group databases

CAZyiGH46. Glycoside Hydrolase Family 46.

Proteomic databases

PaxDbiO07921.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB14630; CAB14630; BSU26890.
GeneIDi936802.
KEGGibsu:BSU26890.
PATRICi18977230. VBIBacSub10457_2804.

Phylogenomic databases

eggNOGiENOG41083Q9. Bacteria.
ENOG410ZJYK. LUCA.
HOGENOMiHOG000292583.
InParanoidiO07921.
KOiK01233.
OMAiTCGRAGF.
PhylomeDBiO07921.

Enzyme and pathway databases

BioCyciBSUB:BSU26890-MONOMER.
MetaCyc:MONOMER-17651.

Family and domain databases

CDDicd00978. chitosanase_glyco_hydro_46. 1 hit.
Gene3Di3.30.386.10. 1 hit.
InterProiIPR000400. Glyco_hydro_46.
IPR023099. Glyco_hydro_46_N.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PfamiPF01374. Glyco_hydro_46. 1 hit.
[Graphical view]
PIRSFiPIRSF036551. Chitosanase. 1 hit.
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS60000. CHITOSANASE_46_80. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCHIS_BACSU
AccessioniPrimary (citable) accession number: O07921
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: September 7, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.