O07898 (VIBC_VIBCH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Vibriobactin-specific isochorismate synthase
EC=5.4.4.2

Alternative name(s):
Isochorismate mutase

Gene names

Name:	vibC
Ordered Locus Names:	VC_0773

Organism

Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) [Reference proteome] [HAMAP]

Taxonomic identifier

243277 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio › Vibrio cholerae › Vibrio cholerae O1 › Vibrio cholerae O1 biovar El Tor

Protein attributes

Sequence length	395 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Chorismate = isochorismate.
Pathway	Siderophore biosynthesis; vibriobactin biosynthesis.
Sequence similarities	Belongs to the isochorismate synthase family.
Caution	It is uncertain whether Met-1 or Met-3 is the initiator.

Ontologies

Keywords
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	siderophore biosynthetic process Inferred from sequence or structural similarity Ref.2. Source: TIGR vibriobactin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	isochorismate synthase activity Inferred from sequence or structural similarity Ref.2. Source: TIGR
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 395	395	Vibriobactin-specific isochorismate synthase		PRO_0000154152

Sequences

	Sequence		Length	Mass (Da)
	O07898 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: 2FFAF87DD948C78B	FASTA	395	43,594
	10 20 30 40 50 60 MVMKREVVGY TTMSEHLIDT QLTRSPFFFA SANQSMLGCG VAHAFQQAIP FAELANQAKQ 70 80 90 100 110 120 LLQQAKRDEC DNPLLFGIVP FDPKTPTRFM IPRTLYVSSS PRLNRPAHLT RQVAKLISSP 130 140 150 160 170 180 SGEQYKQGVS HLLNMFHHSG LSKVVLSRAI EIATEQEIAL PTLLRSLLAI NHHGYTFAAS 190 200 210 220 230 240 LDEQRKLIGA SPELLVAKRG NYLISNPLAG SRPRSQDAQE NAQRRASLLN TAKDLHEHGL 250 260 270 280 290 300 VVEEVERIMS RYCRNLYTPM VPSVIETETM LHLSTLLEGQ VSDPEVCALQ VAADLHPTPA 310 320 330 340 350 360 VCGFPRESAY QAIRELEEFD RGYFTGMVGW CDARGNGEWV VTIRCAEVGS HQMKLFAGAG 370 380 390 IVDESLPQSE LEETGAKMKT ILAAAGIELN DVLTA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of a Vibrio cholerae vibriobactin gene cluster: identification of genes required for early steps in siderophore biosynthesis." Wyckoff E.E., Stoebner J.A., Reed K.E., Payne S.M. J. Bacteriol. 179:7055-7062(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: El Tor Lou15.
[2]	"DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae." Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R., Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D., Vamathevan J.J., Bass S. , Qin H., Dragoi I., Sellers P., McDonald L.A., Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L., Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M. Nature 406:477-483(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 39315 / El Tor Inaba N16961.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U52150 Genomic DNA. Translation: AAC45925.1. AE003852 Genomic DNA. Translation: AAF93938.1.
PIR	A82283.
RefSeq	NP_230422.1. NC_002505.1.
3D structure databases
ProteinModelPortal	O07898.
ModBase	Search...
Protein-protein interaction databases
STRING	243277.VC0773.
Protocols and materials databases
DNASU	2615316.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAF93938; AAF93938; VC_0773.
GeneID	2615316.
KEGG	vch:VC0773.
PATRIC	20080657. VBIVibCho83274_0737.
Phylogenomic databases
eggNOG	COG1169.
KO	K02361.
OMA	NAQGDGE.
ProtClustDB	CLSK793765.
Enzyme and pathway databases
BioCyc	MetaCyc:VC0773-MONOMER.
UniPathway	UPA00022.
Family and domain databases
Gene3D	3.60.120.10. 1 hit.
InterPro	IPR005801. ADC_synthase. IPR015890. Chorismate-bd_C. IPR004561. IsoChor_synthase. [Graphical view]
PANTHER	PTHR11236:SF3. PTHR11236:SF3. 1 hit.
Pfam	PF00425. Chorismate_bind. 1 hit. [Graphical view]
SUPFAM	SSF56322. TRPE_1_chor_bd. 1 hit.
TIGRFAMs	TIGR00543. isochor_syn. 1 hit.
ProtoNet	Search...

Entry information

Entry name

VIBC_VIBCH

Accession

Primary (citable) accession number: O07898
Secondary accession number(s): Q9JQ09

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	July 1, 1997
Last modified:	May 1, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program