Heat resistant RNA dependent ATPase

Preferred order of sections

Names and origin

Protein names

Submitted name:
Heat resistant RNA dependent ATPase EMBL CAA65745.1

Gene names

Name:

HERA EMBL CAA65745.1

Organism

Thermus thermophilus EMBL CAA65745.1

Taxonomic identifier

274 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus

Protein attributes

Sequence length	510 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the DEAD box helicase family. RuleBase RU000492

Ontologies

Keywords
Ligand	ATP-binding Calcium PDB 2GXS Metal-binding PDB 2GXS Nucleotide-binding
Molecular function	Helicase RuleBase RU000452 Hydrolase
Technical term	3D-structure PDB 2GXQ PDB 2GXS PDB 2GXU
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATP-dependent helicase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Regions

Nucleotide binding

47 – 52

6

AMP PDB 2GXQ PDB 2GXS

Sites

Metal binding

127

1

Calcium 1 PDB 2GXS

Metal binding

129

1

Calcium 1; via amide nitrogen PDB 2GXS

Metal binding

160

1

Calcium 2; via carbonyl oxygen PDB 2GXS

Metal binding

163

1

Calcium 2 PDB 2GXS

Metal binding

164

1

Calcium 2 PDB 2GXS

Binding site

23

1

AMP; via carbonyl oxygen PDB 2GXQ PDB 2GXS

Binding site

28

1

AMP PDB 2GXQ PDB 2GXS

Sequences

Sequence

Length

Mass (Da)

Tools

O07897 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 9784D18D31F7E39C
Show »

FASTA

510

55,953

        10         20         30         40         50         60 
MEFKDFPLKP EILEALHGRG LTTPTPIQAA ALPLALEGKD LIGQARTGTG KTLAFALPIA 

        70         80         90        100        110        120 
ERLAPSQERG RKPRALVLTP TRELALQVAS ELTAVAPHLK VVAVYGGTGY GKQKEALLRG 

       130        140        150        160        170        180 
ADAVVATPGR ALDYLRQGVL DLSRVEVAVL DEADEMLSMG FEEEVEALLS ATPPSRQTLL 

       190        200        210        220        230        240 
FSATLPSWAK RLAERYMKNP VLINVIKDEP VTYEEEAVPA PVRGRLEVLS DLLYVASPDR 

       250        260        270        280        290        300 
AMVFTRTKAE TEEIAQGLLR LGHLAQALHG DLSQGERERV LGAFRQGEVR VLVATDVAAR 

       310        320        330        340        350        360 
GLDIPQVDLV VHYRLPDRAE AYQHRSGRTG RAGRGGRVVL LYGPRERRDV EALERAVGRR 

       370        380        390        400        410        420 
FKRVNPPTPE EVLEAKWRHL LARLARVPEK DYRLHLDFAG RLFSEGRVEV VAALLALLLG 

       430        440        450        460        470        480 
GAPKEKSLLT GEEGWRTYKA TGPRLSLPRL VALLKGQGLE VGKIAEAEGG LYVDLRPEAR 

       490        500        510 
PEVAGLRLEP ARRVEGLLEI PSRTRRPARA

« Hide

References

[1]	"Hera from Thermus thermophilus: the first thermostable DEAD-box helicase with an RNase P protein motif." Morlang S., Weglohner W., Franceschi F. J. Mol. Biol. 294:795-805(1999) [PubMed: 10610797] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: HB-8 EMBL CAA65745.1.
[2]	"Crystal structure and nucleotide binding of the Thermus thermophilus RNA helicase Hera N-terminal domain." Rudolph M.G., Heissmann R., Wittmann J.G., Klostermeier D. J. Mol. Biol. 361:731-743(2006) [PubMed: 16890241] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.20 ANGSTROMS) OF 1-207 IN COMPLEX WITH AMP AND CALCIUM.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X97017 Genomic DNA. Translation: CAA65745.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2GXQ	X-ray	1.20	A	1-207	[»]
2GXS	X-ray	1.66	A/B	1-207	[»]
2GXU	X-ray	1.67	A	1-207	[»]

ProteinModelPortal

O07897.

SMR

O07897. Positions 1-207.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

InterPro

IPR014001. DEAD-like_helicase.
IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR001650. Helicase_C.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]

Pfam

PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]

SMART

SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]

PROSITE

PS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

O07897_THETH

Accession

Primary (citable) accession number: O07897

Entry history

Integrated into UniProtKB/TrEMBL:	July 1, 1997
Last sequence update:	July 1, 1997
Last modified:	July 27, 2011
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)