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Protein

Pyrrolidone-carboxylate peptidase

Gene

pcp

Organism
Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Removes 5-oxoproline from various penultimate amino acid residues except L-proline.

Catalytic activityi

Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei801
Active sitei1431
Active sitei1671

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Enzyme and pathway databases

BRENDAi3.4.19.3 6302

Protein family/group databases

MEROPSiC15.001

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrrolidone-carboxylate peptidase (EC:3.4.19.3)
Alternative name(s):
5-oxoprolyl-peptidase
Pyroglutamyl-peptidase I
Short name:
PGP-I
Gene namesi
Name:pcp
ORF Names:OCC_03923
OrganismiThermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C)
Taxonomic identifieri523849 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000015502 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001847601 – 220Pyrrolidone-carboxylate peptidaseAdd BLAST220

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi190Interchain

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Homotetramer.

Structurei

Secondary structure

1220
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 9Combined sources8
Helixi19 – 27Combined sources9
Beta strandi35 – 42Combined sources8
Helixi46 – 60Combined sources15
Beta strandi63 – 70Combined sources8
Beta strandi75 – 80Combined sources6
Beta strandi82 – 85Combined sources4
Beta strandi100 – 102Combined sources3
Beta strandi110 – 113Combined sources4
Helixi118 – 127Combined sources10
Beta strandi132 – 136Combined sources5
Helixi142 – 157Combined sources16
Beta strandi161 – 168Combined sources8
Helixi172 – 175Combined sources4
Beta strandi179 – 181Combined sources3
Helixi191 – 210Combined sources20

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A2ZX-ray1.73A/B/C/D1-220[»]
ProteinModelPortaliO07883
SMRiO07883
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO07883

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C15 family.Curated

Phylogenomic databases

KOiK01304
OMAiHHIATRA
OrthoDBiPOG093Z0BJN

Family and domain databases

CDDicd00501 Peptidase_C15, 1 hit
Gene3Di3.40.630.20, 1 hit
HAMAPiMF_00417 Pyrrolid_peptidase, 1 hit
InterProiView protein in InterPro
IPR000816 Peptidase_C15
IPR016125 Peptidase_C15-like
IPR036440 Peptidase_C15-like_sf
IPR029762 PGP-I_bact-type
IPR033694 PGPEP1_Cys_AS
IPR033693 PGPEP1_Glu_AS
PANTHERiPTHR23402 PTHR23402, 1 hit
PfamiView protein in Pfam
PF01470 Peptidase_C15, 1 hit
PIRSFiPIRSF015592 Prld-crbxl_pptds, 1 hit
PRINTSiPR00706 PYROGLUPTASE
SUPFAMiSSF53182 SSF53182, 1 hit
TIGRFAMsiTIGR00504 pyro_pdase, 1 hit
PROSITEiView protein in PROSITE
PS01334 PYRASE_CYS, 1 hit
PS01333 PYRASE_GLU, 1 hit

Sequencei

Sequence statusi: Complete.

O07883-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKVLITGFE PFGGDSKNPT EQIAKYFDRK QIGNAMVYGR VLPVSVKRAT
60 70 80 90 100
IELKRYLEEI KPEIVINLGL APTYSNITVE RIAVNIIDAR IPDNDGYQPI
110 120 130 140 150
DEKIEEDAPL AYMATLPVRA ITKTLRDNGI PATISYSAGT YLCNYVMFKT
160 170 180 190 200
LHFSKIEGYP LKAGFIHVPY TPDQVVNKFF LLGKNTPSMC LEAEIKAIEL
210 220
AVKVSLDYLE KDRDDIKIPL
Length:220
Mass (Da):24,747
Last modified:July 1, 1997 - v1
Checksum:i58B9774015D07ADC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13966 Genomic DNA Translation: CAA74299.1
CP006670 Genomic DNA Translation: EHR78169.1
RefSeqiWP_004068885.1, NC_022084.1

Genome annotation databases

EnsemblBacteriaiEHR78169; EHR78169; OCC_03923
GeneIDi16550208
KEGGitlt:OCC_03923

Similar proteinsi

Entry informationi

Entry nameiPCP_THELN
AccessioniPrimary (citable) accession number: O07883
Secondary accession number(s): H3ZQF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 1, 1997
Last modified: May 23, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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