Reviewed, UniProtKB/Swiss-Prot O07836 (IORB_PYRKO)

Names and origin

Protein names

Recommended name:
    Indolepyruvate oxidoreductase subunit iorB
      Short name=IOR
    EC=1.2.7.8
Alternative name(s):
    Indolepyruvate ferredoxin oxidoreductase subunit beta

Gene names

Name:	iorB
Ordered Locus Names:	TK0135

Organism

Pyrococcus kodakaraensis (Thermococcus kodakaraensis) [Complete proteome] [HAMAP]

Taxonomic identifier

69014 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Thermococcus

Protein attributes

Sequence length	202 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
Catalytic activity	(Indol-3-yl)pyruvate + CoA + 2 oxidized ferredoxin = S-2-(indol-3-yl)acetyl-CoA + CO2 + 2 reduced ferredoxin + H+.
Subunit structure	Heterodimer of the iorA and iorB subunits.
biophysicochemical properties	Temperature dependence: Optimum temperature is 70 degrees Celsius.
Sequence caution	The sequence BAA20529.1 differs from that shown. Reason: Frameshift at positions 132, 148, 167, 176 and 189.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro indolepyruvate ferredoxin oxidoreductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 202	202	Indolepyruvate oxidoreductase subunit iorB		PRO_0000099936
Experimental info
	Sequence conflict	158	1	Q → K in BAA20529. Ref.1
	Sequence conflict	188	1	A → S in BAA20529. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O07836-1 [UniParc]. Last modified March 29, 2005. Version 2. Checksum: 2BCB29E499855B43	FASTA	202	21,886
	10 20 30 40 50 60 MKEYNIVITG VGGQGILTAA NLLGWAALRA GYKVRVGEVH GMSQRFGSVI AYVRFGEDVY 70 80 90 100 110 120 GAMVPEGKAD VILSFEPVEA LRYINYLKKG GLVFTNARPI PPVQVSMGLA TYPTLDEMKK 130 140 150 160 170 180 IVEEDFGGKF MAFDAEKLAM EAGNIVTTNV VLIGALSQTP GFPLSEEQIK EVIRISVPPK 190 200 TIDVNMRAFE LGVKAAKEML GL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Indolepyruvate ferredoxin oxidoreductase from Pyrococcus sp. KOD1 possesses a mosaic structure showing features of various oxidoreductases." Siddiqui M.A., Fujiwara S., Imanaka T. Mol. Gen. Genet. 254:433-439(1997) [PubMed: 9180697] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: KOD1.
[2]	"Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes." Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T. Genome Res. 15:352-363(2005) [PubMed: 15710748] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KOD1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D86221 Genomic DNA. Translation: BAA20529.1. Frameshift. AP006878 Genomic DNA. Translation: BAD84324.1.
RefSeq	YP_182548.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3235681.
GenomeReviews	Gene locus TK0135 in contig AP006878_GR.
KEGG	tko:TK0135.
NMPDR	fig|69014.3.peg.303.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	O07836.
OMA	O07836. ALRYINY.
Enzyme and pathway databases
BioCyc	TKOD69014:TK0135-MON.
BRENDA	1.2.7.8. 192130.
Family and domain databases
InterPro	IPR017719. Indolepyruvate_Fd_OxRdtase_bsu. IPR019752. Pyrv/ketoisovalerate_OxRed. [Graphical view]
Gene3D	G3DSA:3.40.920.10. Pyrv_Fd/Flavodoxin_OxRdtase. 1 hit.
Pfam	PF01558. POR. 1 hit. [Graphical view]
TIGRFAMs	TIGR03334. IOR_beta. 1 hit.
ProtoNet	Search...

Entry information

Entry name

IORB_PYRKO

Accession

Primary (citable) accession number: O07836
Secondary accession number(s): Q5JFI1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	March 29, 2005
Last modified:	June 16, 2009
This is version 54 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)