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Protein

Indolepyruvate oxidoreductase subunit IorA

Gene

iorA

Organism
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.

Catalytic activityi

(Indol-3-yl)pyruvate + CoA + 2 oxidized ferredoxin = S-2-(indol-3-yl)acetyl-CoA + CO2 + 2 reduced ferredoxin + H+.

Cofactori

[4Fe-4S] cluster1 PublicationNote: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.1 Publication

Temperature dependencei

Optimum temperature is 70 degrees Celsius.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi594Iron-sulfur 1 (4Fe-4S)1 Publication1
Metal bindingi597Iron-sulfur 1 (4Fe-4S)1 Publication1
Metal bindingi600Iron-sulfur 1 (4Fe-4S)1 Publication1
Metal bindingi606Iron-sulfur 2 (4Fe-4S)1 Publication1
Metal bindingi625Iron-sulfur 2 (4Fe-4S)1 Publication1
Metal bindingi628Iron-sulfur 2 (4Fe-4S)1 Publication1
Metal bindingi631Iron-sulfur 2 (4Fe-4S)1 Publication1
Metal bindingi635Iron-sulfur 1 (4Fe-4S)1 Publication1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Transport
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciTKOD69014:G1G2A-135-MONOMER
BRENDAi1.2.7.8 5246

Names & Taxonomyi

Protein namesi
Recommended name:
Indolepyruvate oxidoreductase subunit IorA (EC:1.2.7.8)
Short name:
IOR
Alternative name(s):
Indolepyruvate ferredoxin oxidoreductase subunit alpha
Gene namesi
Name:iorA
Ordered Locus Names:TK0136
OrganismiThermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Taxonomic identifieri69014 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000000536 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000999301 – 647Indolepyruvate oxidoreductase subunit IorAAdd BLAST647

Interactioni

Subunit structurei

Heterodimer of the IorA and IorB subunits.

Protein-protein interaction databases

STRINGi69014.TK0136

Structurei

3D structure databases

ProteinModelPortaliO07835
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini585 – 6144Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd BLAST30
Domaini616 – 6454Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd BLAST30

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiarCOG01609 Archaea
COG4231 LUCA
HOGENOMiHOG000224871
InParanoidiO07835
KOiK00179
OMAiTFLHTGI
OrthoDBiPOG093Z00SP

Family and domain databases

InterProiView protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR017721 Indolepyruvate_Fd_OxRdtase_asu
IPR002880 Pyrv_Fd/Flavodoxin_OxRdtase_N
IPR029061 THDP-binding
IPR011766 TPP_enzyme-bd_C
IPR009014 Transketo_C/PFOR_II
PfamiView protein in Pfam
PF12838 Fer4_7, 1 hit
PF01855 POR_N, 1 hit
PF02775 TPP_enzyme_C, 1 hit
PIRSFiPIRSF006439 Indolepyruvate_ferr_oxidored, 1 hit
SUPFAMiSSF52518 SSF52518, 2 hits
SSF52922 SSF52922, 1 hit
TIGRFAMsiTIGR03336 IOR_alpha, 1 hit
PROSITEiView protein in PROSITE
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 2 hits

Sequencei

Sequence statusi: Complete.

O07835-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKVTDIVLW DKPGERVLLL GNHAIARGAL EANIAVFAAY PGTPSSELTD
60 70 80 90 100
TMAAVAKKAG VYMEYSTNEK VAFETALAAA WSGLRAMTAM KHVGLNVAAD
110 120 130 140 150
SFLSSVGMGV EGGFVIMVAD DPSMWSSQNE QDTRVYAKFA NVPVLEPSSP
160 170 180 190 200
HEAKEMTKYA FELSEKFKHF VILRTTTRSS HARGDVVLGE LPEEIKTGKR
210 220 230 240 250
KFGKFKKDPT RFVDVPAHAR KFHPLILEKI EKIREELNNC PFNWIEGKED
260 270 280 290 300
AKVGIIAPGL SYAYVKEALA WLGVEDVKIL KLGTPFPVPY GLLGKFFDGL
310 320 330 340 350
EKVLIVEELE PVVEEQVKTW AYDKGLRIPI HGKDLVPRVY EMTTRRAVEA
360 370 380 390 400
IAKFLGLETP INFAEIDEKY EKVSQIVPPR PPSLCPACPH RNSFFAIRKA
410 420 430 440 450
AGPKAIYPSD IGCYTLGVLP PLRTVDTTVA MGASIGIGHG LSIAMNGSLA
460 470 480 490 500
EEEHKEGKEK QIIVATIGDS TFYHTGLPAL ANAIYNRSNV LIVVLDNLVT
510 520 530 540 550
AMTGDQPNPG TGQTPHGMGK RIPIEDVAKA MGADFVAVVD PYDIKATYET
560 570 580 590 600
IKKALEVEGV SVVVSRQVCA LYKIGQMRRR GMKWPIYHVV EDKCTGCKIC
610 620 630 640
INAYGCPAIY WDPETKKAKV DPTMCWGCGG CAQVCPFDAF EPMKEGE
Length:647
Mass (Da):70,900
Last modified:March 29, 2005 - v2
Checksum:iAE24D283C96CDBF7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26A → E in BAA20528 (PubMed:9180697).Curated1
Sequence conflicti50 – 54DTMAA → IRWQT in BAA20528 (PubMed:9180697).Curated5
Sequence conflicti311P → R in BAA20528 (PubMed:9180697).Curated1
Sequence conflicti602 – 603NA → KT in BAA20528 (PubMed:9180697).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86221 Genomic DNA Translation: BAA20528.1
AP006878 Genomic DNA Translation: BAD84325.1
RefSeqiWP_011249091.1, NC_006624.1

Genome annotation databases

EnsemblBacteriaiBAD84325; BAD84325; TK0136
GeneIDi3235682
KEGGitko:TK0136
PATRICifig|69014.16.peg.136

Similar proteinsi

Entry informationi

Entry nameiIORA_THEKO
AccessioniPrimary (citable) accession number: O07835
Secondary accession number(s): Q5JFI0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: March 29, 2005
Last modified: March 28, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health