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Protein

Transcriptional regulatory protein TcrA

Gene

tcrA

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Member of the three-protein two-component system HK1/HK2/TcrA.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi146 – 244OmpR/PhoB-typePROSITE-ProRule annotationAdd BLAST99

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • phosphorelay response regulator activity Source: MTBBASE

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation, Two-component regulatory system

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-4737-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulatory protein TcrA
Gene namesi
Name:tcrA
Ordered Locus Names:Rv0602c
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv0602c.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • plasma membrane Source: MTBBASE
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003910821 – 253Transcriptional regulatory protein TcrAAdd BLAST253

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei734-aspartylphosphatePROSITE-ProRule annotation1

Post-translational modificationi

Phosphorylated by HK2.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO07776.

Interactioni

Subunit structurei

Interacts with HK2.1 Publication

Protein-protein interaction databases

STRINGi83332.Rv0602c.

Structurei

3D structure databases

ProteinModelPortaliO07776.
SMRiO07776.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 138Response regulatoryPROSITE-ProRule annotationAdd BLAST115

Sequence similaritiesi

Contains 1 OmpR/PhoB-type DNA-binding domain.PROSITE-ProRule annotation
Contains 1 response regulatory domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105ETX. Bacteria.
COG0745. LUCA.
HOGENOMiHOG000034815.
InParanoidiO07776.
KOiK02483.
OMAiERIWGYE.
PhylomeDBiO07776.

Family and domain databases

CDDicd00383. trans_reg_C. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR001867. OmpR/PhoB-type_DNA-bd.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiPS51755. OMPR_PHOB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O07776-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADETTMRAG RGPGRACGRV SGVRILVVED EPKMTALLAR ALTEEGHTVD
60 70 80 90 100
TVADGRHAVA AVDGGDYDAV VLDVMLPGID GFEVCARLRR QRVWTPVLML
110 120 130 140 150
TARGAVTDRI AGLDGGADDY LTKPFNLDEL FARLRALSRR GPIPRPPTLE
160 170 180 190 200
AGDLRLDPSE HRVWRADTEI RLSHKEFTLL EALIRRPGIV HTRAQLLERC
210 220 230 240 250
WDAAYEARSN IVDVYIRYLR DKIDRPFGVT SLETIRGAGY RLRKDGGRHA

LPR
Length:253
Mass (Da):28,170
Last modified:July 1, 1997 - v1
Checksum:iE4F0DA2EA8E1BA18
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP43341.1.
PIRiE70909.
RefSeqiNP_215116.1. NC_000962.3.
WP_003403148.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiCCP43341; CCP43341; Rv0602c.
GeneIDi887870.
KEGGimtu:Rv0602c.
PATRICi18149834. VBIMycTub87468_0668.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP43341.1.
PIRiE70909.
RefSeqiNP_215116.1. NC_000962.3.
WP_003403148.1. NZ_KK339370.1.

3D structure databases

ProteinModelPortaliO07776.
SMRiO07776.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv0602c.

Proteomic databases

PaxDbiO07776.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCP43341; CCP43341; Rv0602c.
GeneIDi887870.
KEGGimtu:Rv0602c.
PATRICi18149834. VBIMycTub87468_0668.

Organism-specific databases

TubercuListiRv0602c.

Phylogenomic databases

eggNOGiENOG4105ETX. Bacteria.
COG0745. LUCA.
HOGENOMiHOG000034815.
InParanoidiO07776.
KOiK02483.
OMAiERIWGYE.
PhylomeDBiO07776.

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-4737-MONOMER.

Family and domain databases

CDDicd00383. trans_reg_C. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR001867. OmpR/PhoB-type_DNA-bd.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiPS51755. OMPR_PHOB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTCRA1_MYCTU
AccessioniPrimary (citable) accession number: O07776
Secondary accession number(s): L0T499
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: July 1, 1997
Last modified: November 2, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Was identified as a high-confidence drug target.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.