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Protein

Probable zinc-binding alcohol dehydrogenase Rv1895

Gene

Rv1895

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi38Zinc 1; catalyticBy similarity1
Metal bindingi59Zinc 1; catalyticBy similarity1
Metal bindingi89Zinc 2By similarity1
Metal bindingi92Zinc 2By similarity1
Metal bindingi95Zinc 2By similarity1
Metal bindingi103Zinc 2By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-6092-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable zinc-binding alcohol dehydrogenase Rv1895 (EC:1.1.1.1)
Gene namesi
Ordered Locus Names:Rv1895
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv1895.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004155041 – 384Probable zinc-binding alcohol dehydrogenase Rv1895Add BLAST384

Proteomic databases

PaxDbiO07737.
PRIDEiO07737.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv1895.

Structurei

3D structure databases

ProteinModelPortaliO07737.
SMRiO07737.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105E2A. Bacteria.
COG1063. LUCA.
HOGENOMiHOG000294694.
InParanoidiO07737.
OMAiILGHEMM.
PhylomeDBiO07737.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O07737-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAVVIDGAG SVRVNTQPDP ALPGPDGVVV AVTAAGICGS DLHFYEGEYP
60 70 80 90 100
FTEPVALGHE AVGTIVEAGP QVRTVGVGDL VMVSSVAGCG VCPGCETHDP
110 120 130 140 150
VMCFSGPMIF GAGVLGGAQA DLLAVPAADF QVLKIPEGIT TEQALLLTDN
160 170 180 190 200
LATGWAAAQR ADISFGSAVA VIGLGAVGLC ALRSAFIHGA ATVFAVDRVK
210 220 230 240 250
GRLQRAATWG ATPIPSPAAE TILAATRGRG ADSVIDAVGT DASMSDALNA
260 270 280 290 300
VRPGGTVSVV GVHDLQPFPV PALTCLLRSI TLRMTMAPVQ RTWPELIPLL
310 320 330 340 350
QSGRLDVDGI FTTTLPLDEA AKGYATARAR SGEELRFCLR PDSRDVLGAH
360 370 380
ETVDLYVHVR RCQSVADLQL EGAADGVDGP SMLN
Length:384
Mass (Da):39,479
Last modified:July 1, 1997 - v1
Checksum:iDAD02DD880B3131A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP44662.1.
PIRiD70517.
RefSeqiNP_216411.1. NC_000962.3.
WP_003911674.1. NC_000962.3.

Genome annotation databases

EnsemblBacteriaiCCP44662; CCP44662; Rv1895.
GeneIDi885148.
KEGGimtu:Rv1895.
mtv:RVBD_1895.
PATRICi18152775. VBIMycTub87468_2117.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP44662.1.
PIRiD70517.
RefSeqiNP_216411.1. NC_000962.3.
WP_003911674.1. NC_000962.3.

3D structure databases

ProteinModelPortaliO07737.
SMRiO07737.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv1895.

Proteomic databases

PaxDbiO07737.
PRIDEiO07737.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCP44662; CCP44662; Rv1895.
GeneIDi885148.
KEGGimtu:Rv1895.
mtv:RVBD_1895.
PATRICi18152775. VBIMycTub87468_2117.

Organism-specific databases

TubercuListiRv1895.

Phylogenomic databases

eggNOGiENOG4105E2A. Bacteria.
COG1063. LUCA.
HOGENOMiHOG000294694.
InParanoidiO07737.
OMAiILGHEMM.
PhylomeDBiO07737.

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-6092-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiY1895_MYCTU
AccessioniPrimary (citable) accession number: O07737
Secondary accession number(s): L0T807
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: July 1, 1997
Last modified: November 2, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.