Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Cyclase

Gene

lipJ

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi302 – 3021ManganeseCombined sources
Metal bindingi303 – 3031Manganese; via carbonyl oxygenCombined sources
Metal bindingi306 – 3061ManganeseCombined sources
Metal bindingi346 – 3461ManganeseCombined sources

GO - Molecular functioni

  • adenylate cyclase activity Source: MTBBASE
  • guanylate cyclase activity Source: MTBBASE
  • hydrolase activity Source: GO_Central
  • manganese ion binding Source: MTBBASE
  • peroxidase activity Source: UniProtKB-KW
  • protein homodimerization activity Source: MTBBASE

GO - Biological processi

  • cAMP biosynthetic process Source: MTBBASE
  • cGMP biosynthetic process Source: MTBBASE
  • intracellular signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, PeroxidaseImported

Keywords - Ligandi

ManganeseCombined sources, Metal-bindingCombined sources

Enzyme and pathway databases

BioCyciMTBRV:RV1900C-MONOMER.
BRENDAi4.6.1.1. 3445.

Protein family/group databases

ESTHERimyctu-lipJ. 6_AlphaBeta_hydrolase.

Names & Taxonomyi

Protein namesi
Submitted name:
CyclaseImported
Submitted name:
Probable lignin peroxidase LipJImported
Gene namesi
Name:lipJImported
Ordered Locus Names:LH57_10350Imported, Rv1900cImported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome
  • UP000031768 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

GO - Molecular functioni

  • protein homodimerization activity Source: MTBBASE

Protein-protein interaction databases

STRINGi83332.Rv1900c.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YBTX-ray2.31A/B/C/D291-462[»]
1YBUX-ray2.40A/B/C/D291-462[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini297 – 408112Guanylate cyclaseInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiENOG4108TCV. Bacteria.
ENOG4111I0N. LUCA.
HOGENOMiHOG000053897.
OMAiEPSMYRF.
OrthoDBiEOG664CGD.

Family and domain databases

Gene3Di3.30.70.1230. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
PF00211. Guanylate_cyc. 1 hit.
[Graphical view]
SMARTiSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
SSF55073. SSF55073. 1 hit.
PROSITEiPS50125. GUANYLATE_CYCLASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O07732-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQAPHIHRT RYAKCGDMDI AYQVLGDGPT DLLVLPGPFV PIDSIDDEPS
60 70 80 90 100
LYRFHRRLAS FSRVIRLDHR GVGLSSRLAA ITTLGPKFWA QDAIAVMDAV
110 120 130 140 150
GCEQATIFAP SFHAMNGLVL AADYPERVRS LIVVNGSARP LWAPDYPVGA
160 170 180 190 200
QVRRADPFLT VALEPDAVER GFDVLSIVAP TVAGDDVFRA WWDLAGNRAG
210 220 230 240 250
PPSIARAVSK VIAEADVRDV LGHIEAPTLI LHRVGSTYIP VGHGRYLAEH
260 270 280 290 300
IAGSRLVELP GTDTLYWVGD TGPMLDEIEE FITGVRGGAD AERMLATIMF
310 320 330 340 350
TDIVGSTQHA AALGDDRWRD LLDNHDTIVC HEIQRFGGRE VNTAGDGFVA
360 370 380 390 400
TFTSPSAAIA CADDIVDAVA ALGIEVRIGI HAGEVEVRDA SHGTDVAGVA
410 420 430 440 450
VHIGARVCAL AGPSEVLVSS TVRDIVAGSR HRFAERGEQE LKGVPGRWRL
460
CVLMRDDATR TR
Length:462
Mass (Da):49,716
Last modified:July 1, 1997 - v1
Checksum:i6986897B78ED0BAA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR14645.1.
AL123456 Genomic DNA. Translation: CCP44667.1.
RefSeqiNP_216416.1. NC_000962.3.
WP_003916001.1. NC_000962.3.

Genome annotation databases

EnsemblBacteriaiAIR14645; AIR14645; LH57_10350.
CCP44667; CCP44667; Rv1900c.
GeneIDi885151.
KEGGimtu:Rv1900c.
mtv:RVBD_1900c.
PATRICi18152787. VBIMycTub87468_2123.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR14645.1.
AL123456 Genomic DNA. Translation: CCP44667.1.
RefSeqiNP_216416.1. NC_000962.3.
WP_003916001.1. NC_000962.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YBTX-ray2.31A/B/C/D291-462[»]
1YBUX-ray2.40A/B/C/D291-462[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv1900c.

Protein family/group databases

ESTHERimyctu-lipJ. 6_AlphaBeta_hydrolase.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAIR14645; AIR14645; LH57_10350.
CCP44667; CCP44667; Rv1900c.
GeneIDi885151.
KEGGimtu:Rv1900c.
mtv:RVBD_1900c.
PATRICi18152787. VBIMycTub87468_2123.

Phylogenomic databases

eggNOGiENOG4108TCV. Bacteria.
ENOG4111I0N. LUCA.
HOGENOMiHOG000053897.
OMAiEPSMYRF.
OrthoDBiEOG664CGD.

Enzyme and pathway databases

BioCyciMTBRV:RV1900C-MONOMER.
BRENDAi4.6.1.1. 3445.

Family and domain databases

Gene3Di3.30.70.1230. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
PF00211. Guanylate_cyc. 1 hit.
[Graphical view]
SMARTiSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
SSF55073. SSF55073. 1 hit.
PROSITEiPS50125. GUANYLATE_CYCLASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25618 / H37RvImported and H37RvImported.
  2. "Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv."
    Camus J.C., Pryor M.J., Medigue C., Cole S.T.
    Microbiology 148:2967-2973(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: H37RvImported.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: H37RvImported.
  5. Gao Y.W., Fan S.T., Sun H.T., Wang Z., Gao X.L., Li Y.G., Wang T.C., Zhang K., Xu W.W., Yu Z.J., Xia X.Z.
    Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: H37RvImported.
  6. "Phylogenetic analysis of Mycobacterial species using whole genome sequences."
    Hazbon M.H., Riojas M.A., Damon A.M., Alalade R.O., Cantwell B.J., Monaco A., King S., Sohrabi A.
    Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27294 / TMC 102 / H37RvImported and H37RvImported.

Entry informationi

Entry nameiO07732_MYCTU
AccessioniPrimary (citable) accession number: O07732
Secondary accession number(s): I6Y7T0
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: July 1, 1997
Last modified: March 16, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.