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Protein

Putative isocitrate lyase subunit A

Gene

aceAa

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Together with AceAb, they could catalyze the formation of succinate and glyoxylate from isocitrate.Curated

Catalytic activityi

Isocitrate = succinate + glyoxylate.By similarity

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei215UniRule annotation1

GO - Molecular functioni

GO - Biological processi

  • glyoxylate cycle Source: MTBBASE
  • isocitrate metabolic process Source: MTBBASE
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-6112-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative isocitrate lyase subunit ACurated (EC:4.1.3.1By similarity)
Short name:
ICLBy similarity
Alternative name(s):
IsocitraseBy similarity
IsocitrataseBy similarity
Gene namesi
Name:aceAa
Ordered Locus Names:Rv1915, RVBD_1915, LH57_10430
ORF Names:P425_01980
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome
  • UP000031768 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004325661 – 367Putative isocitrate lyase subunit AAdd BLAST367

Proteomic databases

PaxDbiO07718.
PRIDEiO07718.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv1915.

Structurei

3D structure databases

ProteinModelPortaliO07718.
SMRiO07718.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2224. LUCA.
HOGENOMiHOG000215838.
KOiK01637.
OMAiQHRERFS.
PhylomeDBiO07718.

Family and domain databases

Gene3Di3.20.20.60. 1 hit.
InterProiIPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00463. ICL. 1 hit.
[Graphical view]
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O07718-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIAETDTEV HTPFEQDFEK DVAATQRYFD SSRFAGIIRL YTARQVVEQR
60 70 80 90 100
GTIPVDHIVA REAAGAFYER LRELFAARKS ITTFGPYSPG QAVSMKRMGI
110 120 130 140 150
EAIYLGGWAT SAKGSSTEDP GPDLASYPLS QVPDDAAVLV RALLTADRNQ
160 170 180 190 200
HYLRLQMSER QRAATPAYDF RPFIIADAGT GHGGDPHVRN LIRRFVEVGV
210 220 230 240 250
PGYHIEDQRP GTKKCGHQGG KVLVPSDEQI KRLNAARFQL DIMRVPGIIV
260 270 280 290 300
ARTDAEAANL IDSRADERDQ PFLLGATKLD VPSYKSCFLA MVRRFTNWAS
310 320 330 340 350
RSSMVIFSMR LATASTRRPA VGLSAKAFSA WSPTRSTRGG RTASSRSTAF
360
STRSSRGSWR PGRTTRA
Length:367
Mass (Da):40,490
Last modified:July 1, 1997 - v1
Checksum:iEF3481EB46EE0796
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP44682.1.
CP003248 Genomic DNA. Translation: AFN49847.1.
JLDD01000021 Genomic DNA. Translation: KBJ34149.1.
CP009480 Genomic DNA. Translation: AIR14660.1.
RefSeqiNP_216431.1. NC_000962.3.
WP_003906697.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiAFN49847; AFN49847; RVBD_1915.
AIR14660; AIR14660; LH57_10430.
CCP44682; CCP44682; Rv1915.
KBJ34149; KBJ34149; P425_01980.
GeneIDi885639.
KEGGimtu:Rv1915.
mtv:RVBD_1915.
PATRICi18152820. VBIMycTub87468_2139.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP44682.1.
CP003248 Genomic DNA. Translation: AFN49847.1.
JLDD01000021 Genomic DNA. Translation: KBJ34149.1.
CP009480 Genomic DNA. Translation: AIR14660.1.
RefSeqiNP_216431.1. NC_000962.3.
WP_003906697.1. NZ_KK339370.1.

3D structure databases

ProteinModelPortaliO07718.
SMRiO07718.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv1915.

Proteomic databases

PaxDbiO07718.
PRIDEiO07718.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAFN49847; AFN49847; RVBD_1915.
AIR14660; AIR14660; LH57_10430.
CCP44682; CCP44682; Rv1915.
KBJ34149; KBJ34149; P425_01980.
GeneIDi885639.
KEGGimtu:Rv1915.
mtv:RVBD_1915.
PATRICi18152820. VBIMycTub87468_2139.

Phylogenomic databases

eggNOGiCOG2224. LUCA.
HOGENOMiHOG000215838.
KOiK01637.
OMAiQHRERFS.
PhylomeDBiO07718.

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-6112-MONOMER.

Family and domain databases

Gene3Di3.20.20.60. 1 hit.
InterProiIPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00463. ICL. 1 hit.
[Graphical view]
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACEAA_MYCTU
AccessioniPrimary (citable) accession number: O07718
Secondary accession number(s): F2GH80, I6Y7U7, L0T829
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 2015
Last sequence update: July 1, 1997
Last modified: November 2, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.