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O07684

- BGAL_LACAC

UniProt

O07684 - BGAL_LACAC

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Protein

Beta-galactosidase large subunit

Gene

lacL

Organism
Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei468 – 4681Proton donorBy similarity
Active sitei536 – 5361NucleophileBy similarity

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BRENDAi3.2.1.23. 2846.

Protein family/group databases

CAZyiGH2. Glycoside Hydrolase Family 2.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidase large subunit (EC:3.2.1.23)
Short name:
Beta-gal large subunit
Alternative name(s):
Lactase large subunit
Gene namesi
Name:lacL
Ordered Locus Names:LBA1467
OrganismiLactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
Taxonomic identifieri272621 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000006381: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 628628Beta-galactosidase large subunitPRO_0000057665Add
BLAST

Interactioni

Subunit structurei

Heterodimer of a large and a small subunit.

Protein-protein interaction databases

STRINGi272621.LBA1467.

Structurei

3D structure databases

ProteinModelPortaliO07684.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 2 family.Curated

Phylogenomic databases

eggNOGiCOG3250.
HOGENOMiHOG000111236.
KOiK01190.
OMAiPYQFGFR.
OrthoDBiEOG6XWV0T.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
2.60.40.320. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR006103. Glyco_hydro_2_TIM.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view]
PRINTSiPR00132. GLHYDRLASE2.
SUPFAMiSSF49303. SSF49303. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
PROSITEiPS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O07684-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQANIKWLDD PEIFRVNQLP AHSDHPFFKN YREWQNNHSS FKQSLNGMWQ
60 70 80 90 100
FKFSKDPQSR PVDFYKKDFN TSSFTTIPVP SEIELNNFAQ NQYINTLYPW
110 120 130 140 150
EGKIFRRPAY ALNKSDAEEG SFSEGKDNTV GSYIKHFDLN PELRDHDIHI
160 170 180 190 200
VFEGAERAMY VWLNGHFIGY AEDSFTPSEF DLTKYIKEKD NILAVEVFKH
210 220 230 240 250
STASWLEDQD MFRFSGLFRS VELLAFPETH LVDLDLKPTV CDNYQDGIFN
260 270 280 290 300
AELKFTGSLN GHVHLSVEDV NGSAILEQDV PLDSEVEFTS STLENIHLWD
310 320 330 340 350
NHHPYLYQLL IEVHDENGHL VELIPYQFGF RRIEINQDKV ILLNGKCLII
360 370 380 390 400
NGVNRHEWNA KTGRSITLND MEKDIDTFKE NNINAVRTCH YPNQIPWYYL
410 420 430 440 450
CDQNGIYMMA ENNLESHGTW QKMGQVEPSD NVPGSVPEWR EAVIDRARNN
460 470 480 490 500
YETFKNHTSI LFWSLGNESY AGSNIVAMNE FYKEHDSSRL VHYEGVVHRP
510 520 530 540 550
ELKDQISDIE SHMYLPPKEV AEYLRNNPQK PFMECEYMHD MGNSDGGMGS
560 570 580 590 600
YIKLIDEYPQ YVGGFIWDFI DQALLVYDPI SKQNVLRYGG DFDDRHSDYE
610 620
FSGDGLMFAD RTPKPAMQEV RYYYGLHK
Length:628
Mass (Da):73,254
Last modified:March 29, 2005 - v2
Checksum:iB73F7C691CC6B7E6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti302 – 3021H → N in BAA20536. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB004867 Genomic DNA. Translation: BAA20536.1.
CP000033 Genomic DNA. Translation: AAV43287.1.
RefSeqiYP_194318.1. NC_006814.3.

Genome annotation databases

EnsemblBacteriaiAAV43287; AAV43287; LBA1467.
GeneIDi3251483.
KEGGilac:LBA1467.
PATRICi22197950. VBILacAci7974_1388.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB004867 Genomic DNA. Translation: BAA20536.1 .
CP000033 Genomic DNA. Translation: AAV43287.1 .
RefSeqi YP_194318.1. NC_006814.3.

3D structure databases

ProteinModelPortali O07684.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272621.LBA1467.

Protein family/group databases

CAZyi GH2. Glycoside Hydrolase Family 2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV43287 ; AAV43287 ; LBA1467 .
GeneIDi 3251483.
KEGGi lac:LBA1467.
PATRICi 22197950. VBILacAci7974_1388.

Phylogenomic databases

eggNOGi COG3250.
HOGENOMi HOG000111236.
KOi K01190.
OMAi PYQFGFR.
OrthoDBi EOG6XWV0T.

Enzyme and pathway databases

BRENDAi 3.2.1.23. 2846.

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
2.60.40.320. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR008979. Galactose-bd-like.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR006103. Glyco_hydro_2_TIM.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view ]
PRINTSi PR00132. GLHYDRLASE2.
SUPFAMi SSF49303. SSF49303. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
PROSITEi PS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Suzuki M., Saito T., Konno K., Kamio Y., Itoh T.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: JCM 1229 / KCTC 3168.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700396 / NCK56 / N2 / NCFM.

Entry informationi

Entry nameiBGAL_LACAC
AccessioniPrimary (citable) accession number: O07684
Secondary accession number(s): Q5FJ37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: March 29, 2005
Last modified: October 1, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3