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O07684

- BGAL_LACAC

UniProt

O07684 - BGAL_LACAC

Protein

Beta-galactosidase large subunit

Gene

lacL

Organism
Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 2 (29 Mar 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei468 – 4681Proton donorBy similarity
    Active sitei536 – 5361NucleophileBy similarity

    GO - Molecular functioni

    1. beta-galactosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Enzyme and pathway databases

    BRENDAi3.2.1.23. 2846.

    Protein family/group databases

    CAZyiGH2. Glycoside Hydrolase Family 2.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-galactosidase large subunit (EC:3.2.1.23)
    Short name:
    Beta-gal large subunit
    Alternative name(s):
    Lactase large subunit
    Gene namesi
    Name:lacL
    Ordered Locus Names:LBA1467
    OrganismiLactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
    Taxonomic identifieri272621 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000006381: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 628628Beta-galactosidase large subunitPRO_0000057665Add
    BLAST

    Interactioni

    Subunit structurei

    Heterodimer of a large and a small subunit.

    Protein-protein interaction databases

    STRINGi272621.LBA1467.

    Structurei

    3D structure databases

    ProteinModelPortaliO07684.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 2 family.Curated

    Phylogenomic databases

    eggNOGiCOG3250.
    HOGENOMiHOG000111236.
    KOiK01190.
    OMAiPYQFGFR.
    OrthoDBiEOG6XWV0T.

    Family and domain databases

    Gene3Di2.60.120.260. 1 hit.
    2.60.40.320. 1 hit.
    3.20.20.80. 1 hit.
    InterProiIPR008979. Galactose-bd-like.
    IPR006101. Glyco_hydro_2.
    IPR013812. Glyco_hydro_2/20_Ig-like.
    IPR023232. Glyco_hydro_2_AS.
    IPR023230. Glyco_hydro_2_CS.
    IPR006102. Glyco_hydro_2_Ig-like.
    IPR006104. Glyco_hydro_2_N.
    IPR006103. Glyco_hydro_2_TIM.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF00703. Glyco_hydro_2. 1 hit.
    PF02836. Glyco_hydro_2_C. 1 hit.
    PF02837. Glyco_hydro_2_N. 1 hit.
    [Graphical view]
    PRINTSiPR00132. GLHYDRLASE2.
    SUPFAMiSSF49303. SSF49303. 1 hit.
    SSF49785. SSF49785. 1 hit.
    SSF51445. SSF51445. 1 hit.
    PROSITEiPS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
    PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O07684-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQANIKWLDD PEIFRVNQLP AHSDHPFFKN YREWQNNHSS FKQSLNGMWQ    50
    FKFSKDPQSR PVDFYKKDFN TSSFTTIPVP SEIELNNFAQ NQYINTLYPW 100
    EGKIFRRPAY ALNKSDAEEG SFSEGKDNTV GSYIKHFDLN PELRDHDIHI 150
    VFEGAERAMY VWLNGHFIGY AEDSFTPSEF DLTKYIKEKD NILAVEVFKH 200
    STASWLEDQD MFRFSGLFRS VELLAFPETH LVDLDLKPTV CDNYQDGIFN 250
    AELKFTGSLN GHVHLSVEDV NGSAILEQDV PLDSEVEFTS STLENIHLWD 300
    NHHPYLYQLL IEVHDENGHL VELIPYQFGF RRIEINQDKV ILLNGKCLII 350
    NGVNRHEWNA KTGRSITLND MEKDIDTFKE NNINAVRTCH YPNQIPWYYL 400
    CDQNGIYMMA ENNLESHGTW QKMGQVEPSD NVPGSVPEWR EAVIDRARNN 450
    YETFKNHTSI LFWSLGNESY AGSNIVAMNE FYKEHDSSRL VHYEGVVHRP 500
    ELKDQISDIE SHMYLPPKEV AEYLRNNPQK PFMECEYMHD MGNSDGGMGS 550
    YIKLIDEYPQ YVGGFIWDFI DQALLVYDPI SKQNVLRYGG DFDDRHSDYE 600
    FSGDGLMFAD RTPKPAMQEV RYYYGLHK 628
    Length:628
    Mass (Da):73,254
    Last modified:March 29, 2005 - v2
    Checksum:iB73F7C691CC6B7E6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti302 – 3021H → N in BAA20536. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB004867 Genomic DNA. Translation: BAA20536.1.
    CP000033 Genomic DNA. Translation: AAV43287.1.
    RefSeqiYP_194318.1. NC_006814.3.

    Genome annotation databases

    EnsemblBacteriaiAAV43287; AAV43287; LBA1467.
    GeneIDi3251483.
    KEGGilac:LBA1467.
    PATRICi22197950. VBILacAci7974_1388.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB004867 Genomic DNA. Translation: BAA20536.1 .
    CP000033 Genomic DNA. Translation: AAV43287.1 .
    RefSeqi YP_194318.1. NC_006814.3.

    3D structure databases

    ProteinModelPortali O07684.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272621.LBA1467.

    Protein family/group databases

    CAZyi GH2. Glycoside Hydrolase Family 2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAV43287 ; AAV43287 ; LBA1467 .
    GeneIDi 3251483.
    KEGGi lac:LBA1467.
    PATRICi 22197950. VBILacAci7974_1388.

    Phylogenomic databases

    eggNOGi COG3250.
    HOGENOMi HOG000111236.
    KOi K01190.
    OMAi PYQFGFR.
    OrthoDBi EOG6XWV0T.

    Enzyme and pathway databases

    BRENDAi 3.2.1.23. 2846.

    Family and domain databases

    Gene3Di 2.60.120.260. 1 hit.
    2.60.40.320. 1 hit.
    3.20.20.80. 1 hit.
    InterProi IPR008979. Galactose-bd-like.
    IPR006101. Glyco_hydro_2.
    IPR013812. Glyco_hydro_2/20_Ig-like.
    IPR023232. Glyco_hydro_2_AS.
    IPR023230. Glyco_hydro_2_CS.
    IPR006102. Glyco_hydro_2_Ig-like.
    IPR006104. Glyco_hydro_2_N.
    IPR006103. Glyco_hydro_2_TIM.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF00703. Glyco_hydro_2. 1 hit.
    PF02836. Glyco_hydro_2_C. 1 hit.
    PF02837. Glyco_hydro_2_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00132. GLHYDRLASE2.
    SUPFAMi SSF49303. SSF49303. 1 hit.
    SSF49785. SSF49785. 1 hit.
    SSF51445. SSF51445. 1 hit.
    PROSITEi PS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
    PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Suzuki M., Saito T., Konno K., Kamio Y., Itoh T.
      Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: JCM 1229 / KCTC 3168.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700396 / NCK56 / N2 / NCFM.

    Entry informationi

    Entry nameiBGAL_LACAC
    AccessioniPrimary (citable) accession number: O07684
    Secondary accession number(s): Q5FJ37
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: March 29, 2005
    Last modified: October 1, 2014
    This is version 87 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3