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O07684

- BGAL_LACAC

UniProt

O07684 - BGAL_LACAC

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Protein

Beta-galactosidase large subunit

Gene
lacL, LBA1467
Organism
Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei468 – 4681Proton donor By similarity
Active sitei536 – 5361Nucleophile By similarity

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BRENDAi3.2.1.23. 2846.

Protein family/group databases

CAZyiGH2. Glycoside Hydrolase Family 2.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidase large subunit (EC:3.2.1.23)
Short name:
Beta-gal large subunit
Alternative name(s):
Lactase large subunit
Gene namesi
Name:lacL
Ordered Locus Names:LBA1467
OrganismiLactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
Taxonomic identifieri272621 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000006381: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 628628Beta-galactosidase large subunitPRO_0000057665Add
BLAST

Interactioni

Subunit structurei

Heterodimer of a large and a small subunit.

Protein-protein interaction databases

STRINGi272621.LBA1467.

Structurei

3D structure databases

ProteinModelPortaliO07684.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3250.
HOGENOMiHOG000111236.
KOiK01190.
OMAiPYQFGFR.
OrthoDBiEOG6XWV0T.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
2.60.40.320. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR006103. Glyco_hydro_2_TIM.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view]
PRINTSiPR00132. GLHYDRLASE2.
SUPFAMiSSF49303. SSF49303. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
PROSITEiPS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O07684-1 [UniParc]FASTAAdd to Basket

« Hide

MQANIKWLDD PEIFRVNQLP AHSDHPFFKN YREWQNNHSS FKQSLNGMWQ    50
FKFSKDPQSR PVDFYKKDFN TSSFTTIPVP SEIELNNFAQ NQYINTLYPW 100
EGKIFRRPAY ALNKSDAEEG SFSEGKDNTV GSYIKHFDLN PELRDHDIHI 150
VFEGAERAMY VWLNGHFIGY AEDSFTPSEF DLTKYIKEKD NILAVEVFKH 200
STASWLEDQD MFRFSGLFRS VELLAFPETH LVDLDLKPTV CDNYQDGIFN 250
AELKFTGSLN GHVHLSVEDV NGSAILEQDV PLDSEVEFTS STLENIHLWD 300
NHHPYLYQLL IEVHDENGHL VELIPYQFGF RRIEINQDKV ILLNGKCLII 350
NGVNRHEWNA KTGRSITLND MEKDIDTFKE NNINAVRTCH YPNQIPWYYL 400
CDQNGIYMMA ENNLESHGTW QKMGQVEPSD NVPGSVPEWR EAVIDRARNN 450
YETFKNHTSI LFWSLGNESY AGSNIVAMNE FYKEHDSSRL VHYEGVVHRP 500
ELKDQISDIE SHMYLPPKEV AEYLRNNPQK PFMECEYMHD MGNSDGGMGS 550
YIKLIDEYPQ YVGGFIWDFI DQALLVYDPI SKQNVLRYGG DFDDRHSDYE 600
FSGDGLMFAD RTPKPAMQEV RYYYGLHK 628
Length:628
Mass (Da):73,254
Last modified:March 29, 2005 - v2
Checksum:iB73F7C691CC6B7E6
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti302 – 3021H → N in BAA20536. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB004867 Genomic DNA. Translation: BAA20536.1.
CP000033 Genomic DNA. Translation: AAV43287.1.
RefSeqiYP_194318.1. NC_006814.3.

Genome annotation databases

EnsemblBacteriaiAAV43287; AAV43287; LBA1467.
GeneIDi3251483.
KEGGilac:LBA1467.
PATRICi22197950. VBILacAci7974_1388.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB004867 Genomic DNA. Translation: BAA20536.1 .
CP000033 Genomic DNA. Translation: AAV43287.1 .
RefSeqi YP_194318.1. NC_006814.3.

3D structure databases

ProteinModelPortali O07684.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272621.LBA1467.

Protein family/group databases

CAZyi GH2. Glycoside Hydrolase Family 2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV43287 ; AAV43287 ; LBA1467 .
GeneIDi 3251483.
KEGGi lac:LBA1467.
PATRICi 22197950. VBILacAci7974_1388.

Phylogenomic databases

eggNOGi COG3250.
HOGENOMi HOG000111236.
KOi K01190.
OMAi PYQFGFR.
OrthoDBi EOG6XWV0T.

Enzyme and pathway databases

BRENDAi 3.2.1.23. 2846.

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
2.60.40.320. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR008979. Galactose-bd-like.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR006103. Glyco_hydro_2_TIM.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view ]
PRINTSi PR00132. GLHYDRLASE2.
SUPFAMi SSF49303. SSF49303. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
PROSITEi PS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Suzuki M., Saito T., Konno K., Kamio Y., Itoh T.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: JCM 1229 / KCTC 3168.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700396 / NCK56 / N2 / NCFM.

Entry informationi

Entry nameiBGAL_LACAC
AccessioniPrimary (citable) accession number: O07684
Secondary accession number(s): Q5FJ37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: March 29, 2005
Last modified: May 14, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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