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Protein

Signal peptidase I V

Gene

sipV

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Miscellaneous

B.subtilis contains five chromosomal type I signal peptidases: SipS, SipT, SipU, SipV and SipW. They have different, but overlapping, substrate specificities and have different transcription patterns.

Catalytic activityi

Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei34By similarity1
Active sitei75By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease

Enzyme and pathway databases

BioCyciBSUB:BSU10490-MONOMER

Protein family/group databases

MEROPSiS26.006

Names & Taxonomyi

Protein namesi
Recommended name:
Signal peptidase I V (EC:3.4.21.89)
Short name:
SPase I
Alternative name(s):
Leader peptidase I
Gene namesi
Name:sipV
Synonyms:yhjF
Ordered Locus Names:BSU10490
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6CytoplasmicSequence analysis6
Transmembranei7 – 26HelicalSequence analysisAdd BLAST20
Topological domaini27 – 168ExtracellularSequence analysisAdd BLAST142

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001095021 – 168Signal peptidase I VAdd BLAST168

Proteomic databases

PaxDbiO07560
PRIDEiO07560

Expressioni

Inductioni

Expressed constitutively.

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100005811

Structurei

3D structure databases

ProteinModelPortaliO07560
SMRiO07560
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S26 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0681 LUCA
HOGENOMiHOG000003673
InParanoidiO07560
KOiK03100
OMAiELMVNKF
PhylomeDBiO07560

Family and domain databases

InterProiView protein in InterPro
IPR036286 LexA/Signal_pep-like_sf
IPR000223 Pept_S26A_signal_pept_1
IPR019758 Pept_S26A_signal_pept_1_CS
IPR019757 Pept_S26A_signal_pept_1_Lys-AS
IPR019756 Pept_S26A_signal_pept_1_Ser-AS
IPR015927 Peptidase_S24_S26A/B/C
PfamiView protein in Pfam
PF00717 Peptidase_S24, 1 hit
PRINTSiPR00727 LEADERPTASE
SUPFAMiSSF51306 SSF51306, 1 hit
TIGRFAMsiTIGR02227 sigpep_I_bact, 1 hit
PROSITEiView protein in PROSITE
PS00501 SPASE_I_1, 1 hit
PS00760 SPASE_I_2, 1 hit
PS00761 SPASE_I_3, 1 hit

Sequencei

Sequence statusi: Complete.

O07560-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKRFWFLAG VVSVVLAIQV KNAVFIDYKV EGVSMNPTFQ EGNELLVNKF
60 70 80 90 100
SHRFKTIHRF DIVLFKGPDH KVLIKRVIGL PGETIKYKDD QLYVNGKQVA
110 120 130 140 150
EPFLKHLKSV SAGSHVTGDF SLKDVTGTSK VPKGKYFVVG DNRIYSFDSR
160
HFGPIREKNI VGVISDAE
Length:168
Mass (Da):18,956
Last modified:July 1, 1997 - v1
Checksum:iD70BD09545638604
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14081 Genomic DNA Translation: CAA74468.1
AL009126 Genomic DNA Translation: CAB12889.1
PIRiA69708
RefSeqiNP_388930.1, NC_000964.3
WP_003233128.1, NZ_JNCM01000035.1

Genome annotation databases

EnsemblBacteriaiCAB12889; CAB12889; BSU10490
GeneIDi939318
KEGGibsu:BSU10490
PATRICifig|224308.179.peg.1128

Similar proteinsi

Entry informationi

Entry nameiLEPV_BACSU
AccessioniPrimary (citable) accession number: O07560
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: July 1, 1997
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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