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O07560

- LEPV_BACSU

UniProt

O07560 - LEPV_BACSU

Protein

Signal peptidase I V

Gene

sipV

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei34 – 341By similarity
    Active sitei75 – 751By similarity

    GO - Molecular functioni

    1. serine-type peptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease

    Enzyme and pathway databases

    BioCyciBSUB:BSU10490-MONOMER.

    Protein family/group databases

    MEROPSiS26.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Signal peptidase I V (EC:3.4.21.89)
    Short name:
    SPase I
    Alternative name(s):
    Leader peptidase I
    Gene namesi
    Name:sipV
    Synonyms:yhjF
    Ordered Locus Names:BSU10490
    OrganismiBacillus subtilis (strain 168)
    Taxonomic identifieri224308 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001570: Chromosome

    Organism-specific databases

    GenoListiBSU10490. [Micado]

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 168168Signal peptidase I VPRO_0000109502Add
    BLAST

    Proteomic databases

    PaxDbiO07560.

    Expressioni

    Inductioni

    Expressed constitutively.

    Interactioni

    Protein-protein interaction databases

    STRINGi224308.BSU10490.

    Structurei

    3D structure databases

    ProteinModelPortaliO07560.
    SMRiO07560. Positions 26-78.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 66CytoplasmicSequence Analysis
    Topological domaini27 – 168142ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2620HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S26 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0681.
    HOGENOMiHOG000003673.
    KOiK03100.
    OMAiFIDYKVE.
    OrthoDBiEOG622PW8.
    PhylomeDBiO07560.

    Family and domain databases

    Gene3Di2.10.109.10. 2 hits.
    InterProiIPR000223. Pept_S26A_signal_pept_1.
    IPR019758. Pept_S26A_signal_pept_1_CS.
    IPR019757. Pept_S26A_signal_pept_1_Lys-AS.
    IPR019756. Pept_S26A_signal_pept_1_Ser-AS.
    IPR028360. Peptidase_S24/S26_b-rbn.
    IPR019759. Peptidase_S24_S26.
    IPR015927. Peptidase_S24_S26A/B/C.
    [Graphical view]
    PANTHERiPTHR12383. PTHR12383. 1 hit.
    PfamiPF00717. Peptidase_S24. 1 hit.
    [Graphical view]
    PRINTSiPR00727. LEADERPTASE.
    SUPFAMiSSF51306. SSF51306. 1 hit.
    TIGRFAMsiTIGR02227. sigpep_I_bact. 1 hit.
    PROSITEiPS00501. SPASE_I_1. 1 hit.
    PS00760. SPASE_I_2. 1 hit.
    PS00761. SPASE_I_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O07560-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKRFWFLAG VVSVVLAIQV KNAVFIDYKV EGVSMNPTFQ EGNELLVNKF    50
    SHRFKTIHRF DIVLFKGPDH KVLIKRVIGL PGETIKYKDD QLYVNGKQVA 100
    EPFLKHLKSV SAGSHVTGDF SLKDVTGTSK VPKGKYFVVG DNRIYSFDSR 150
    HFGPIREKNI VGVISDAE 168
    Length:168
    Mass (Da):18,956
    Last modified:July 1, 1997 - v1
    Checksum:iD70BD09545638604
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y14081 Genomic DNA. Translation: CAA74468.1.
    AL009126 Genomic DNA. Translation: CAB12889.1.
    PIRiA69708.
    RefSeqiNP_388930.1. NC_000964.3.

    Genome annotation databases

    EnsemblBacteriaiCAB12889; CAB12889; BSU10490.
    GeneIDi939318.
    KEGGibsu:BSU10490.
    PATRICi18973800. VBIBacSub10457_1094.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y14081 Genomic DNA. Translation: CAA74468.1 .
    AL009126 Genomic DNA. Translation: CAB12889.1 .
    PIRi A69708.
    RefSeqi NP_388930.1. NC_000964.3.

    3D structure databases

    ProteinModelPortali O07560.
    SMRi O07560. Positions 26-78.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224308.BSU10490.

    Protein family/group databases

    MEROPSi S26.006.

    Proteomic databases

    PaxDbi O07560.

    Protocols and materials databases

    DNASUi 939318.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB12889 ; CAB12889 ; BSU10490 .
    GeneIDi 939318.
    KEGGi bsu:BSU10490.
    PATRICi 18973800. VBIBacSub10457_1094.

    Organism-specific databases

    GenoListi BSU10490. [Micado ]

    Phylogenomic databases

    eggNOGi COG0681.
    HOGENOMi HOG000003673.
    KOi K03100.
    OMAi FIDYKVE.
    OrthoDBi EOG622PW8.
    PhylomeDBi O07560.

    Enzyme and pathway databases

    BioCyci BSUB:BSU10490-MONOMER.

    Family and domain databases

    Gene3Di 2.10.109.10. 2 hits.
    InterProi IPR000223. Pept_S26A_signal_pept_1.
    IPR019758. Pept_S26A_signal_pept_1_CS.
    IPR019757. Pept_S26A_signal_pept_1_Lys-AS.
    IPR019756. Pept_S26A_signal_pept_1_Ser-AS.
    IPR028360. Peptidase_S24/S26_b-rbn.
    IPR019759. Peptidase_S24_S26.
    IPR015927. Peptidase_S24_S26A/B/C.
    [Graphical view ]
    PANTHERi PTHR12383. PTHR12383. 1 hit.
    Pfami PF00717. Peptidase_S24. 1 hit.
    [Graphical view ]
    PRINTSi PR00727. LEADERPTASE.
    SUPFAMi SSF51306. SSF51306. 1 hit.
    TIGRFAMsi TIGR02227. sigpep_I_bact. 1 hit.
    PROSITEi PS00501. SPASE_I_1. 1 hit.
    PS00760. SPASE_I_2. 1 hit.
    PS00761. SPASE_I_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The 172 kb prkA-addAB region from 83 degrees to 97 degrees of the Bacillus subtilis chromosome contains several dysfunctional genes, the glyB marker, many genes encoding transporter proteins, and the ubiquitous hit gene."
      Noback M.A., Holsappel S., Kiewiet R., Terpstra P., Wambutt R., Wedler H., Venema G., Bron S.
      Microbiology 144:859-875(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 168.
    2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
      Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
      , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
      Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 168.
    3. "Protein secretion and possible roles for multiple signal peptidases for precursor processing in bacilli."
      Bron S., Bolhuis A., Tjalsma H., Holsappel S., Venema G., van Dijl J.M.
      J. Biotechnol. 64:3-13(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiLEPV_BACSU
    AccessioniPrimary (citable) accession number: O07560
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2004
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    B.subtilis contains five chromosomal type I signal peptidases: SipS, SipT, SipU, SipV and SipW. They have different, but overlapping, substrate specificities and have different transcription patterns.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Bacillus subtilis
      Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3