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Protein

Probable multidrug resistance ABC transporter ATP-binding/permease protein YheI

Gene

yheI

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the transport of four structurally unrelated drugs, including doxorubicin and mitoxantrone. Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation.1 Publication

Miscellaneous

Overexpression reduces the sporulation efficiency possibly by modulating the function of KinA.

Enzyme regulationi

Inhibited by ortho-vanadate.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi371 – 378ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAntibiotic resistance, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBSUB:BSU09710-MONOMER.

Protein family/group databases

TCDBi3.A.1.106.8. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable multidrug resistance ABC transporter ATP-binding/permease protein YheI (EC:3.6.3.-)
Gene namesi
Name:yheI
Ordered Locus Names:BSU09710
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 41HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei57 – 77HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei127 – 147HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei149 – 169HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei249 – 269HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei279 – 299HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003760791 – 585Probable multidrug resistance ABC transporter ATP-binding/permease protein YheIAdd BLAST585

Proteomic databases

PaxDbiO07550.
PRIDEiO07550.

Expressioni

Inductioni

Induced by several classes of structurally unrelated antibiotics, such as erythromycin, fusidic acid or linezolid.1 Publication

Interactioni

Subunit structurei

Heterodimer composed of YheH and YheI.1 Publication

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100005416.

Structurei

3D structure databases

ProteinModelPortaliO07550.
SMRiO07550.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 304ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST286
Domaini337 – 572ABC transporterPROSITE-ProRule annotationAdd BLAST236

Sequence similaritiesi

Belongs to the ABC transporter superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ1. Bacteria.
COG1132. LUCA.
InParanoidiO07550.
KOiK18889.
OMAiLMARGTN.
PhylomeDBiO07550.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O07550-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSVLKKLGW FFKAYWLRYT IAIVLLLAVN VIEMFPPKLL GNAIDDMKAG
60 70 80 90 100
AFTAEGLLFY IGIFFVLTAA VYIMSYFWMH QLFGGANLME KILRTKLMGH
110 120 130 140 150
LLTMSPPFYE KNRTGDLMAR GTNDLQAVSL TTGFGILTLV DSTMFMMTIF
160 170 180 190 200
LTMGFLISWK LTFAAIIPLP VMAIAISLYG SKIHERFTEA QNAFGALNDR
210 220 230 240 250
VLESVSGVRV IRAYVQETND VRRFNEMTAD VYQKNMKVAF IDSLFEPTVK
260 270 280 290 300
LLVGASYLIG LGYGAFLVFR NELTLGELVS FNVYLGMMIW PMFAIGELIN
310 320 330 340 350
VMQRGNASLD RVNETLSYET DVTDPKQPAD LKEPGDIVFS HVSFTYPSST
360 370 380 390 400
SDNLQDISFT VRKGQTVGIA GKTGSGKTTI IKQLLRQYPP GEGSITFSGV
410 420 430 440 450
PIQQIPLDRL RGWIGYVPQD HLLFSRTVKE NILYGKQDAT DKEVQQAIAE
460 470 480 490 500
AHFEKDLHML PSGLETMVGE KGVALSGGQK QRISIARALM ANPEILILDD
510 520 530 540 550
SLSAVDAKTE AAIIKNIREN RKGKTTFILT HRLSAVEHAD LILVMDGGVI
560 570 580
AERGTHQELL ANNGWYREQY ERQQLFTAEE GGAGA
Length:585
Mass (Da):65,112
Last modified:July 1, 1997 - v1
Checksum:iAB82FA64338F8161
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14080 Genomic DNA. Translation: CAA74450.1.
AL009126 Genomic DNA. Translation: CAB12810.1.
PIRiA69829.
RefSeqiNP_388852.1. NC_000964.3.
WP_003245157.1. NZ_JNCM01000035.1.

Genome annotation databases

EnsemblBacteriaiCAB12810; CAB12810; BSU09710.
GeneIDi936278.
KEGGibsu:BSU09710.
PATRICifig|224308.179.peg.1044.

Similar proteinsi

Entry informationi

Entry nameiYHEI_BACSU
AccessioniPrimary (citable) accession number: O07550
Secondary accession number(s): Q796W6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: July 1, 1997
Last modified: June 7, 2017
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families