ID   O07430_MYCTU            Unreviewed;       691 AA.
AC   O07430; F2GLY4; I6Y734; Q7DAB2;
DT   01-JUL-1997, integrated into UniProtKB/TrEMBL.
DT   01-JUL-1997, sequence version 1.
DT   27-MAR-2024, entry version 147.
DE   SubName: Full=Probable beta-glucosidase BglS (Gentiobiase) (Cellobiase) (Beta-D-glucoside glucohydrolase) {ECO:0000313|EMBL:CCP42912.1};
GN   Name=bglS {ECO:0000313|EMBL:CCP42912.1};
GN   OrderedLocusNames=Rv0186 {ECO:0000313|EMBL:CCP42912.1};
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332 {ECO:0000313|EMBL:CCP42912.1, ECO:0000313|Proteomes:UP000001584};
RN   [1] {ECO:0000313|EMBL:CCP42912.1, ECO:0000313|Proteomes:UP000001584}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv {ECO:0000313|Proteomes:UP000001584};
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C., Harris D.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III., Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L., Oliver K., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
RA   Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2] {ECO:0007829|PubMed:21969609}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21969609; DOI=10.1074/mcp.M111.011445;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 3 family.
CC       {ECO:0000256|ARBA:ARBA00005336}.
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DR   EMBL; AL123456; CCP42912.1; -; Genomic_DNA.
DR   RefSeq; NP_214700.1; NC_000962.3.
DR   RefSeq; WP_003401122.1; NZ_NVQJ01000001.1.
DR   AlphaFoldDB; O07430; -.
DR   SMR; O07430; -.
DR   STRING; 83332.Rv0186; -.
DR   CAZy; GH3; Glycoside Hydrolase Family 3.
DR   PaxDb; 83332-Rv0186; -.
DR   GeneID; 886780; -.
DR   KEGG; mtu:Rv0186; -.
DR   PATRIC; fig|83332.111.peg.213; -.
DR   TubercuList; Rv0186; -.
DR   eggNOG; COG1472; Bacteria.
DR   InParanoid; O07430; -.
DR   OrthoDB; 3187421at2; -.
DR   PhylomeDB; O07430; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.1700; Glycoside hydrolase family 3 C-terminal domain; 2.
DR   Gene3D; 3.20.20.300; Glycoside hydrolase, family 3, N-terminal domain; 2.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR026891; Fn3-like.
DR   InterPro; IPR002772; Glyco_hydro_3_C.
DR   InterPro; IPR036881; Glyco_hydro_3_C_sf.
DR   InterPro; IPR001764; Glyco_hydro_3_N.
DR   InterPro; IPR036962; Glyco_hydro_3_N_sf.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR013783; Ig-like_fold.
DR   PANTHER; PTHR42715; BETA-GLUCOSIDASE; 1.
DR   PANTHER; PTHR42715:SF10; BETA-GLUCOSIDASE F-RELATED; 1.
DR   Pfam; PF14310; Fn3-like; 1.
DR   Pfam; PF00933; Glyco_hydro_3; 1.
DR   Pfam; PF01915; Glyco_hydro_3_C; 1.
DR   PRINTS; PR00133; GLHYDRLASE3.
DR   SMART; SM01217; Fn3_like; 1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR   SUPFAM; SSF52279; Beta-D-glucan exohydrolase, C-terminal domain; 1.
PE   1: Evidence at protein level;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001584}.
FT   DOMAIN          606..673
FT                   /note="Fibronectin type III-like"
FT                   /evidence="ECO:0000259|SMART:SM01217"
SQ   SEQUENCE   691 AA;  73520 MW;  B700C8C37F24E1F7 CRC64;
     MTDDERFSLL VGLTGASDLW PVRDERIPQG VPMCAGYVPG IPRLGVPALL MSDAGLGVTN
     PGYRPGDTAT ALPAGLALAA SFNPVLARSS GKAIGREARS RGFNVQLAGA INLARDPRNG
     RNFEYLSEDP LLSATMAAES IIGIQQQGVI ATTKHFSLNC NETNRHWLDA VIDPDAHRES
     DLLAFEIVIE RSQPGAVMAA YNKVNGDYAA GNDHLLNDVL KGAWGYRGWV MSDWGGTPSW
     ECALAGLDQE CGAQIDAVLW QSEAFTDRLR AAYADGNLPK GRLSDMVRRI LRSMFAVGID
     RWKPAPAPDM NAHNEIAAQM ARQGIVLLQN RGLLPLAPES AGRIAVIGGY AHLGVPAGYG
     SSAVTPPGGY AGVIPIGGSG LAAGLRNLYL LPSSPLSELR KRLPNAQFEF DPGINPAEAV
     LAARRADIAI VFAIRAEGEG FDSADLSLPW GQDALIAAVA SANANTVVVL ETGNPVTMPW
     RDSVNAIMQA WYPGQAGGQA VAEIVTGQVN PSGRLPITFP VDLGQTPRSQ PPELGAPWGT
     STTIHYTEGA DVGYRWFAST NQTPMFAFGH GLSYTSFEYR DLVVTGGHTV HASFSVTNTG
     DRSGADVPQL YMIAAPGESR LRLLGFERVE LEPGQTRRVR IEADPRLLAR YDGEARSWRI
     EPGGYTVAVG ASAVALKLAA KVKLAGRGFG R
//