ID   INHA_MYCAV              Reviewed;         268 AA.
AC   O07400;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   16-JUN-2009, entry version 51.
DE   RecName: Full=Enoyl-[acyl-carrier-protein] reductase [NADH];
DE            EC=1.3.1.9;
DE   AltName: Full=NADH-dependent enoyl-ACP reductase;
GN   Name=inhA;
OS   Mycobacterium avium.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium;
OC   Mycobacterium avium complex (MAC).
OX   NCBI_TaxID=1764;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=GIR10;
RX   MEDLINE=98195739; PubMed=9534249;
RA   Labo M., Gusberti L., de Rossi E., Speziale P., Riccardi G.;
RT   "Determination of a 15437 bp nucleotide sequence around the inhA gene
RT   of Mycobacterium avium and similarity analysis of the products of
RT   putative ORFs.";
RL   Microbiology 144:807-814(1998).
CC   -!- CATALYTIC ACTIVITY: Acyl-[acyl-carrier-protein] + NAD(+) = trans-
CC       2,3-dehydroacyl-[acyl-carrier-protein] + NADH.
CC   -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases
CC       (SDR) family. FabI subfamily.
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DR   EMBL; AF002133; AAC46204.1; -; Genomic_DNA.
DR   HSSP; P46533; 1ENY.
DR   SMR; O07400; 2-268.
DR   BRENDA; 1.3.1.9; 599.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0004318; F:enoyl-[acyl-carrier-protein] reductase (NAD...; IEA:EC.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR002198; DH_sc/Rdtase_SDR.
DR   InterPro; IPR014358; Enoyl-ACP_Rdtase_NADH.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR19410; ADH_short_C2; 1.
DR   PANTHER; PTHR19410:SF12; Enoyl-ACP_rdct; 1.
PE   3: Inferred from homology;
KW   Fatty acid biosynthesis; Lipid synthesis; NAD; Oxidoreductase.
FT   CHAIN         1    268       Enoyl-[acyl-carrier-protein] reductase
FT                                [NADH].
FT                                /FTId=PRO_0000054914.
FT   NP_BIND     135    164       NAD (Potential).
FT   BINDING     157    157       Substrate (By similarity).
SQ   SEQUENCE   268 AA;  28530 MW;  F73501BD2B0F9990 CRC64;
     MAGLLDGKRI LVTGIITDSS IAFHIAKVAQ EAGAQLVLTG FDRLRLIQRI VDRLPEKAPL
     IELDVQNEEH LNTLAQRVTG EIGEGNKLDG VVHSIASSET GMADQPFFDA PYEDVSKGIH
     ISADSDASLA KALLPIMNPG GSIVGMDFDP SRAMPAYNWM TVAKSALESV NRFVAREAGP
     HGVRSNLVAA GPIRTLAMAG IVGGVLGDQA AEQIRLLEEG WDQRAPIGWN MKDPTPVAKT
     VCALLSDWLP ATTGTIIYAD RGASTQLL
//