Reviewed, UniProtKB/Swiss-Prot O07400 (INHA_MYCAV)

Names and origin

Protein names

Recommended name:
    Enoyl-[acyl-carrier-protein] reductase [NADH]
    EC=1.3.1.9
Alternative name(s):
    NADH-dependent enoyl-ACP reductase

Gene names

Name:

inhA

Organism

Mycobacterium avium

Taxonomic identifier

1764 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length	268 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Acyl-[acyl-carrier-protein] + NAD+ = trans-2,3-dehydroacyl-[acyl-carrier-protein] + NADH.
Pathway	Lipid metabolism; fatty acid biosynthesis.
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro enoyl-[acyl-carrier-protein] reductase (NADH) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 268	268	Enoyl-[acyl-carrier-protein] reductase [NADH]		PRO_0000054914
Regions
	Nucleotide binding	135 – 164	30	NAD Potential
Sites
	Binding site	157	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	O07400-1 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: F73501BD2B0F9990	FASTA	268	28,530
	10 20 30 40 50 60 MAGLLDGKRI LVTGIITDSS IAFHIAKVAQ EAGAQLVLTG FDRLRLIQRI VDRLPEKAPL 70 80 90 100 110 120 IELDVQNEEH LNTLAQRVTG EIGEGNKLDG VVHSIASSET GMADQPFFDA PYEDVSKGIH 130 140 150 160 170 180 ISADSDASLA KALLPIMNPG GSIVGMDFDP SRAMPAYNWM TVAKSALESV NRFVAREAGP 190 200 210 220 230 240 HGVRSNLVAA GPIRTLAMAG IVGGVLGDQA AEQIRLLEEG WDQRAPIGWN MKDPTPVAKT 250 260 VCALLSDWLP ATTGTIIYAD RGASTQLL

References

[1]

"Determination of a 15437 bp nucleotide sequence around the inhA gene of Mycobacterium avium and similarity analysis of the products of putative ORFs." Labo M., Gusberti L., de Rossi E., Speziale P., Riccardi G. Microbiology 144:807-814(1998) [PubMed: 9534249] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: GIR10.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF002133 Genomic DNA. Translation: AAC46204.1.
3D structure databases
HSSP	HSSP built from PDB template 1ENY based on UniProtKB P46533.
SMR	O07400. Positions 2-268.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.3.1.9. 599.
Family and domain databases
InterPro	IPR002198. DH_sc/Rdtase_SDR. IPR014358. Enoyl-ACP_Rdtase_NADH. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR19410. ADH_short_C2. 1 hit. PTHR19410:SF12. Enoyl-ACP_rdct. 1 hit.
ProtoNet	Search...

Entry information

Entry name

INHA_MYCAV

Accession

Primary (citable) accession number: O07400

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	July 1, 1997
Last modified:	June 16, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)